The structure of allelic diversity in the presence of purifying selection.

Genetic diversity and the structure of genealogies in rapidly adapting populations. Genetics (2012) 1.06

The sampling theory of selectively neutral alleles. Theor Popul Biol (1972) 27.35

The effect of deleterious mutations on neutral molecular variation. Genetics (1993) 20.07

The homozygosity test of neutrality. Genetics (1978) 13.20

The coalescent process in models with selection. Genetics (1988) 10.14

The mutational load with epistatic gene interactions in fitness. Genetics (1966) 7.75

Population genetics of polymorphism and divergence. Genetics (1992) 7.72

The accumulation of deleterious genes in a population--Muller's Ratchet. Theor Popul Biol (1978) 5.51

The effect of background selection against deleterious mutations on weakly selected, linked variants. Genet Res (1994) 5.15

The pattern of neutral molecular variation under the background selection model. Genetics (1995) 5.03

Deleterious background selection with recombination. Genetics (1995) 4.45

The effects of Hill-Robertson interference between weakly selected mutations on patterns of molecular evolution and variation. Genetics (2000) 3.24

The effect of recombination on background selection. Genet Res (1996) 2.77

Population, evolutionary and genomic consequences of interference selection. Genetics (2002) 1.97

Toward a selection theory of molecular evolution. Evolution (2008) 1.61

Maintenance of Genetic Variability under the Joint Effect of Mutation, Selection and Random Drift. Genetics (1978) 1.60

Muller's ratchet and the pattern of variation at a neutral locus. Genetics (2002) 1.54

The effects of deleterious mutations on evolution in non-recombining genomes. Trends Genet (2008) 1.49

The Hill-Robertson effect: evolutionary consequences of weak selection and linkage in finite populations. Heredity (Edinb) (2007) 1.49

Maintenance of genetic variability under mutation and selection pressures in a finite population. Proc Natl Acad Sci U S A (1977) 1.41

Mutation-selection balance: ancestry, load, and maximum principle. Theor Popul Biol (2002) 1.41

The effect of selection on genealogies. Genetics (2004) 1.39

The distribution of rare alleles. J Math Biol (1995) 1.36

The genealogy of a sequence subject to purifying selection at multiple sites. Mol Biol Evol (2002) 1.36

Reduced effectiveness of selection caused by a lack of recombination. Curr Biol (2009) 1.27

Addendum to a paper of W. Ewens. Theor Popul Biol (1972) 1.24

Gene genealogies strongly distorted by weakly interfering mutations in constant environments. Genetics (2009) 1.21

Maintenance of genetic variability under the pressure of neutral and deleterious mutations in a finite population. Genetics (1979) 1.20

The structure of genealogies in the presence of purifying selection: a fitness-class coalescent. Genetics (2011) 1.11

A general method for calculating likelihoods under the coalescent process. Genetics (2011) 1.08

A continuous-state coalescent and the impact of weak selection on the structure of gene genealogies. Mol Biol Evol (2010) 1.04

A coalescent dual process in a Moran model with genic selection. Theor Popul Biol (2009) 0.90

A coalescent dual process in a Moran model with genic selection, and the lambda coalescent limit. Theor Popul Biol (2010) 0.79

Allele frequencies with genic selection. J Math Biol (1983) 0.77

Coding-sequence determinants of gene expression in Escherichia coli. Science (2009) 8.38

The population genetics of dN/dS. PLoS Genet (2008) 3.88

Dynamical resonance can account for seasonality of influenza epidemics. Proc Natl Acad Sci U S A (2004) 3.73

Mortality due to influenza in the United States--an annualized regression approach using multiple-cause mortality data. Am J Epidemiol (2005) 3.58

Statistical mechanics for natural flocks of birds. Proc Natl Acad Sci U S A (2012) 3.23

Seed dispersal and spatial pattern in tropical trees. PLoS Biol (2006) 2.68

Redundancy, antiredundancy, and the robustness of genomes. Proc Natl Acad Sci U S A (2002) 2.42

Prevalence of epistasis in the evolution of influenza A surface proteins. PLoS Genet (2011) 2.41

Maximum entropy models for antibody diversity. Proc Natl Acad Sci U S A (2010) 2.23

Mutational robustness can facilitate adaptation. Nature (2010) 2.17

Rate-limiting steps in yeast protein translation. Cell (2013) 1.99

Inferring the dynamics of diversification: a coalescent approach. PLoS Biol (2010) 1.91

Isolation and characterization of adenoviruses persistently shed from the gastrointestinal tract of non-human primates. PLoS Pathog (2009) 1.85

Live imaging of bicoid-dependent transcription in Drosophila embryos. Curr Biol (2013) 1.80

Reinforcement of pre-zygotic isolation and karyotype evolution in Agrodiaetus butterflies. Nature (2005) 1.76

Aging and gene expression in the primate brain. PLoS Biol (2005) 1.76

Vaccinating to protect a vulnerable subpopulation. PLoS Med (2007) 1.76

Reconciling molecular phylogenies with the fossil record. Proc Natl Acad Sci U S A (2011) 1.72

Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration. Hum Mol Genet (2008) 1.68

Extortion and cooperation in the Prisoner's Dilemma. Proc Natl Acad Sci U S A (2012) 1.62

The dynamics of adaptation on correlated fitness landscapes. Proc Natl Acad Sci U S A (2009) 1.61

Statistical inference of the generation probability of T-cell receptors from sequence repertoires. Proc Natl Acad Sci U S A (2012) 1.59

Using protein complexes to predict phenotypic effects of gene mutation. Genome Biol (2007) 1.57

Immune history shapes specificity of pandemic H1N1 influenza antibody responses. J Exp Med (2013) 1.47

From extortion to generosity, evolution in the Iterated Prisoner's Dilemma. Proc Natl Acad Sci U S A (2013) 1.46

Consequences of defaunation for a tropical tree community. Ecol Lett (2013) 1.42

A statistical theory for sampling species abundances. Ecol Lett (2007) 1.40

Evolution, safety, and highly pathogenic influenza viruses. Science (2012) 1.36

Information transmission in genetic regulatory networks: a review. J Phys Condens Matter (2011) 1.30

The energy landscapes of repeat-containing proteins: topology, cooperativity, and the folding funnels of one-dimensional architectures. PLoS Comput Biol (2008) 1.25

Optimizing information flow in small genetic networks. Phys Rev E Stat Nonlin Soft Matter Phys (2009) 1.23

The polymorphism frequency spectrum of finitely many sites under selection. Genetics (2008) 1.22

Young proteins experience more variable selection pressures than old proteins. Genome Res (2010) 1.19

Abduction and asylum in the lives of transcription factors. Proc Natl Acad Sci U S A (2010) 1.19

Genome landscapes and bacteriophage codon usage. PLoS Comput Biol (2008) 1.18

Identifying signatures of selection in genetic time series. Genetics (2013) 1.16

The structure of genealogies in the presence of purifying selection: a fitness-class coalescent. Genetics (2011) 1.11

Constructing explicit magnetic analogies for the dynamics of glass forming liquids. J Chem Phys (2008) 1.09

Selection biases the prevalence and type of epistasis along adaptive trajectories. Evolution (2013) 1.07

Why transcription factor binding sites are ten nucleotides long. Genetics (2012) 1.07

Evolution and persistence of influenza A and other diseases. Math Biosci (2004) 1.07

Genetic diversity and the structure of genealogies in rapidly adapting populations. Genetics (2012) 1.06

Age-correlated gene expression in normal and neurodegenerative human brain tissues. PLoS One (2010) 1.06

Single hemagglutinin mutations that alter both antigenicity and receptor binding avidity influence influenza virus antigenic clustering. J Virol (2013) 1.04

Some consequences of demographic stochasticity in population genetics. Genetics (2010) 1.02

Persistent expression of Pax3 in the neural crest causes cleft palate and defective osteogenesis in mice. J Clin Invest (2008) 1.01

Spectral solutions to stochastic models of gene expression with bursts and regulation. Phys Rev E Stat Nonlin Soft Matter Phys (2009) 1.01

Genome-wide analysis of natural selection on human cis-elements. PLoS One (2008) 1.00

Spatial patterns in discordant diagnostic test results for Chagas disease: links to transmission hotspots. Clin Infect Dis (2009) 0.98

Retracing micro-epidemics of Chagas disease using epicenter regression. PLoS Comput Biol (2011) 0.98

Generalized population models and the nature of genetic drift. Theor Popul Biol (2011) 0.98

Optimizing information flow in small genetic networks. III. A self-interacting gene. Phys Rev E Stat Nonlin Soft Matter Phys (2012) 0.98

Directionality in the evolution of influenza A haemagglutinin. Proc Biol Sci (2008) 0.97

Reconstructing influenza incidence by deconvolution of daily mortality time series. Proc Natl Acad Sci U S A (2009) 0.96

Extinction and resurrection in gene networks. Proc Natl Acad Sci U S A (2008) 0.96

Matrix dimensions bias demographic inferences: implications for comparative plant demography. Am Nat (2010) 0.96

The role of epistasis in protein evolution. Nature (2013) 0.96

Rational spatio-temporal strategies for controlling a Chagas disease vector in urban environments. J R Soc Interface (2010) 0.95

Dynamics of neutral and selected alleles when the offspring distribution is skewed. Genetics (2012) 0.92

Genome-wide survey of natural selection on functional, structural, and network properties of polymorphic sites in Saccharomyces paradoxus. Mol Biol Evol (2011) 0.92

Influence of decoys on the noise and dynamics of gene expression. Phys Rev E Stat Nonlin Soft Matter Phys (2012) 0.90

Explosive radiation of a bacterial species group. Evolution (2012) 0.88

Weak 5'-mRNA secondary structures in short eukaryotic genes. Genome Biol Evol (2012) 0.88

The evolution of genetic architectures underlying quantitative traits. Proc Biol Sci (2013) 0.83

On the accessibility of adaptive phenotypes of a bacterial metabolic network. PLoS Comput Biol (2009) 0.83

Evolution. In evolution, the sum is less than its parts. Science (2011) 0.82

The evolution of complex gene regulation by low-specificity binding sites. Proc Biol Sci (2013) 0.82

Effect of phenotypic selection on stochastic gene expression. J Phys Chem B (2013) 0.82

Epistasis increases the rate of conditionally neutral substitution in an adapting population. Genetics (2011) 0.82

Information-optimal transcriptional response to oscillatory driving. Phys Rev Lett (2010) 0.81

Absorption and fixation times for neutral and quasi-neutral populations with density dependence. Theor Popul Biol (2008) 0.79

The inevitability of unconditionally deleterious substitutions during adaptation. Evolution (2014) 0.79

Structure and age jointly influence rates of protein evolution. PLoS Comput Biol (2012) 0.79

Molecular evolution: Hidden diversity sparks adaptation. Nature (2011) 0.79

Estimating selection pressures from limited comparative data. Mol Biol Evol (2006) 0.78

The population genetics of cooperative gene regulation. BMC Evol Biol (2012) 0.76

The equilibrium allele frequency distribution for a population with reproductive skew. Genetics (2014) 0.75

Environmental robustness and the adaptability of populations. Evolution (2012) 0.75

Transition path sampling algorithm for discrete many-body systems. Phys Rev E Stat Nonlin Soft Matter Phys (2012) 0.75