Published in Nature on December 25, 2011
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Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone. Nat Neurosci (2009) 1.64
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S100B expression defines a state in which GFAP-expressing cells lose their neural stem cell potential and acquire a more mature developmental stage. Glia (2007) 1.54
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Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell (2005) 17.81
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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci U S A (2008) 11.71
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Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science (2010) 9.78
Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs. Genome Res (2007) 9.61
Akt stimulates aerobic glycolysis in cancer cells. Cancer Res (2004) 9.35
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell (2005) 9.33
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest (2007) 9.33
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol (2004) 8.85
ATP-citrate lyase links cellular metabolism to histone acetylation. Science (2009) 8.82
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature (2012) 8.66
IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature (2012) 7.95
Brick by brick: metabolism and tumor cell growth. Curr Opin Genet Dev (2008) 7.87
The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila. Cell (2007) 7.70
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The CD28 signaling pathway regulates glucose metabolism. Immunity (2002) 6.65
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Glutamine addiction: a new therapeutic target in cancer. Trends Biochem Sci (2010) 6.30
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Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation. Blood (2008) 5.43
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Endogenous RNA interference provides a somatic defense against Drosophila transposons. Curr Biol (2008) 5.22
Suppression of microRNA-silencing pathway by HIV-1 during virus replication. Science (2007) 5.07
Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake. Mol Biol Cell (2002) 5.06
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The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis. Immunity (2007) 4.74
AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science (2009) 4.72
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Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell (2010) 4.62
The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation. Oncogene (2005) 4.28
Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell (2006) 4.20
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Akt-dependent transformation: there is more to growth than just surviving. Oncogene (2005) 3.91
Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol Cell Biol (2003) 3.84
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PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis. Mol Cell (2006) 3.66
Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol Cell (2004) 3.62
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The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol (2002) 3.08
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Distinct mechanisms for microRNA strand selection by Drosophila Argonautes. Mol Cell (2009) 3.02
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Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev (2011) 2.97
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