Published in Nucleic Acids Res on December 30, 2011
TET enzymes, TDG and the dynamics of DNA demethylation. Nature (2013) 3.49
Reversing DNA methylation: mechanisms, genomics, and biological functions. Cell (2014) 3.17
Tet family proteins and 5-hydroxymethylcytosine in development and disease. Development (2012) 2.24
ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection. Biochem Soc Trans (2013) 1.30
Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier. Philos Trans R Soc Lond B Biol Sci (2013) 1.26
Ten-eleven translocation 1 (Tet1) is regulated by O-linked N-acetylglucosamine transferase (Ogt) for target gene repression in mouse embryonic stem cells. J Biol Chem (2013) 1.24
Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells. Genome Biol (2013) 1.22
LIF promotes tumorigenesis and metastasis of breast cancer through the AKT-mTOR pathway. Oncotarget (2014) 1.08
Playing TETris with DNA modifications. EMBO J (2014) 1.07
Histone-fold domain protein NF-Y promotes chromatin accessibility for cell type-specific master transcription factors. Mol Cell (2014) 0.99
Acute versus chronic loss of mammalian Azi1/Cep131 results in distinct ciliary phenotypes. PLoS Genet (2013) 0.98
Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells. Genome Biol (2014) 0.93
Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc Natl Acad Sci U S A (2012) 0.91
TET proteins: on the frenetic hunt for new cytosine modifications. Brief Funct Genomics (2013) 0.91
Chromosome-wide regulation of euchromatin-specific 5mC to 5hmC conversion in mouse ES cells and female human somatic cells. Chromosome Res (2012) 0.88
Integrative framework for identification of key cell identity genes uncovers determinants of ES cell identity and homeostasis. Proc Natl Acad Sci U S A (2014) 0.86
Common stemness regulators of embryonic and cancer stem cells. World J Stem Cells (2015) 0.84
Transcriptional and epigenetic mechanisms of cellular reprogramming to induced pluripotency. Epigenomics (2016) 0.81
MicroRNA-29b/Tet1 regulatory axis epigenetically modulates mesendoderm differentiation in mouse embryonic stem cells. Nucleic Acids Res (2015) 0.78
Deamination features of 5-hydroxymethylcytosine, a radical and enzymatic DNA oxidation product. J Mol Model (2014) 0.77
Tet1-dependent epigenetic modification of BDNF expression in dorsal horn neurons mediates neuropathic pain in rats. Sci Rep (2016) 0.75
miR-29 regulates Tet1 expression and contributes to early differentiation of mouse ESCs. Oncotarget (2016) 0.75
Zinc Chloride Transiently Maintains Mouse Embryonic Stem Cell Pluripotency by Activating Stat3 Signaling. PLoS One (2016) 0.75
Implications of Epigenetic Variability within a Cell Population for "Cell Type" Classification. Front Behav Neurosci (2015) 0.75
Systematic identification of gene family regulators in mouse and human embryonic stem cells. Nucleic Acids Res (2016) 0.75
DNA methylation directs genomic localization of Mbd2 and Mbd3 in embryonic stem cells. Elife (2016) 0.75
Genetic compensation: A phenomenon in search of mechanisms. PLoS Genet (2017) 0.75
Ten-Eleven Translocation 1 and 2 Confer Overlapping Transcriptional Programs for the Proliferation of Cultured Adult Neural Stem Cells. Cell Mol Neurobiol (2016) 0.75
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol (2009) 235.12
The human genome browser at UCSC. Genome Res (2002) 168.23
Bioconductor: open software development for computational biology and bioinformatics. Genome Biol (2004) 143.19
A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics (2003) 82.89
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (2009) 32.97
Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature (2008) 30.29
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell (2008) 28.29
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell (1992) 27.80
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell (1999) 25.75
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet (2006) 20.76
Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell (2003) 20.16
The ground state of embryonic stem cell self-renewal. Nature (2008) 19.44
The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science (2009) 18.82
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature (2010) 18.63
Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data. Nucleic Acids Res (2005) 17.58
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell (2008) 16.38
Mutation in TET2 in myeloid cancers. N Engl J Med (2009) 16.07
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science (2011) 14.29
Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell (2008) 14.17
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science (2011) 13.16
Dissecting self-renewal in stem cells with RNA interference. Nature (2006) 11.66
Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet (2008) 11.17
Active DNA demethylation: many roads lead to Rome. Nat Rev Mol Cell Biol (2010) 9.35
Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation. Nature (2011) 9.33
Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell (2011) 9.16
Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol (2010) 9.01
Genome-wide identification of in vivo protein-DNA binding sites from ChIP-Seq data. Nucleic Acids Res (2008) 8.89
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature (2010) 8.87
The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol Cell Biol (2007) 8.57
Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev (1998) 8.51
The colorful history of active DNA demethylation. Cell (2008) 8.50
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. Nature (2011) 8.31
Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains. Genome Res (2008) 7.41
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell (2011) 7.41
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell (2011) 7.37
Naive and primed pluripotent states. Cell Stem Cell (2009) 7.15
Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol (2010) 7.00
A core Klf circuitry regulates self-renewal of embryonic stem cells. Nat Cell Biol (2008) 6.90
Control of the embryonic stem cell state. Cell (2011) 6.89
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell (2008) 6.86
Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair. Cell (2011) 6.80
The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature (2011) 6.73
Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells. Nature (2011) 6.48
MspI, an isoschizomer of hpaII which cleaves both unmethylated and methylated hpaII sites. Nucleic Acids Res (1978) 6.01
A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells. Nature (2009) 5.46
Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine. Proc Natl Acad Sci U S A (2011) 5.45
Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication. Genes Dev (2006) 5.15
Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells. Mol Cell (2011) 4.89
Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development. Cell Stem Cell (2011) 4.52
Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells. Genes Dev (2011) 4.45
An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity. Cell (2008) 4.27
A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal. Genes Dev (2009) 4.23
Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids. Cell Cycle (2009) 4.14
Replication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryos. Science (2011) 4.12
An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network. Proc Natl Acad Sci U S A (2009) 4.07
DNA demethylation dynamics. Cell (2011) 3.82
An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency. Proc Natl Acad Sci U S A (2009) 3.82
A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity. Cell Stem Cell (2009) 3.55
Oct4 and LIF/Stat3 additively induce Krüppel factors to sustain embryonic stem cell self-renewal. Cell Stem Cell (2009) 3.27
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice. Proc Natl Acad Sci U S A (2011) 3.07
Chromatin connections to pluripotency and cellular reprogramming. Cell (2011) 3.07
Systems biology of stem cell fate and cellular reprogramming. Nat Rev Mol Cell Biol (2009) 2.93
Polycomb complexes act redundantly to repress genomic repeats and genes. Genes Dev (2010) 2.63
The transcriptional and signalling networks of pluripotency. Nat Cell Biol (2011) 2.54
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell (2009) 2.32
esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function. Nat Cell Biol (2011) 2.29
Sall4 regulates distinct transcription circuitries in different blastocyst-derived stem cell lineages. Cell Stem Cell (2008) 2.28
Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal. Nat Cell Biol (2011) 2.13
TET family proteins and their role in stem cell differentiation and transformation. Cell Stem Cell (2011) 1.87
Tet1 and 5-hydroxymethylation: a genome-wide view in mouse embryonic stem cells. Cell Cycle (2011) 1.51
Chromatin regulatory mechanisms in pluripotency. Annu Rev Cell Dev Biol (2010) 1.51
CLEAN: CLustering Enrichment ANalysis. BMC Bioinformatics (2009) 1.29
Genomic approaches to deconstruct pluripotency. Annu Rev Genomics Hum Genet (2011) 1.06
Meta-analysis of differentiating mouse embryonic stem cell gene expression kinetics reveals early change of a small gene set. PLoS Comput Biol (2006) 0.98
Epigenetics: Tet proteins in the limelight. Nature (2011) 0.97
Three LIF-dependent signatures and gene clusters with atypical expression profiles, identified by transcriptome studies in mouse ES cells and early derivatives. BMC Genomics (2009) 0.88
High-resolution profiling of histone methylations in the human genome. Cell (2007) 85.74
Combinatorial patterns of histone acetylations and methylations in the human genome. Nat Genet (2008) 18.28
Dynamic regulation of nucleosome positioning in the human genome. Cell (2008) 15.60
Genome-wide identification of in vivo protein-DNA binding sites from ChIP-Seq data. Nucleic Acids Res (2008) 8.89
Second-generation shRNA libraries covering the mouse and human genomes. Nat Genet (2005) 8.23
Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains. Genome Res (2008) 7.41
Active chromatin domains are defined by acetylation islands revealed by genome-wide mapping. Genes Dev (2005) 7.21
The genomic landscape of histone modifications in human T cells. Proc Natl Acad Sci U S A (2006) 6.09
Cancer proliferation gene discovery through functional genomics. Science (2008) 5.41
A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc Natl Acad Sci U S A (2005) 5.29
MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. Cell (2003) 4.52
Rhythmic histone acetylation underlies transcription in the mammalian circadian clock. Nature (2002) 4.13
An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network. Proc Natl Acad Sci U S A (2009) 4.07
The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo. Proc Natl Acad Sci U S A (2011) 3.40
LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell (2009) 3.34
Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell (2011) 3.27
MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation. Cell (2004) 3.12
The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer. J Biol Chem (2008) 3.01
Mi-2/NuRD: multiple complexes for many purposes. Biochim Biophys Acta (2004) 2.86
SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature (2008) 2.84
Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress. Mol Cell Biol (2004) 2.80
Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types. Immunity (2011) 2.53
5'-triphosphate-dependent activation of PKR by RNAs with short stem-loops. Science (2007) 2.48
The affinity of different MBD proteins for a specific methylated locus depends on their intrinsic binding properties. Nucleic Acids Res (2003) 2.41
WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci. EMBO J (2002) 2.33
esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function. Nat Cell Biol (2011) 2.29
Chromatin poises miRNA- and protein-coding genes for expression. Genome Res (2009) 2.28
Chromatin compaction by human MeCP2. Assembly of novel secondary chromatin structures in the absence of DNA methylation. J Biol Chem (2003) 2.14
Integration of estrogen and Wnt signaling circuits by the polycomb group protein EZH2 in breast cancer cells. Mol Cell Biol (2007) 2.14
A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir. Cell Res (2007) 2.13
Cancer biology and NuRD: a multifaceted chromatin remodelling complex. Nat Rev Cancer (2011) 2.10
The transcription factor snail mediates epithelial to mesenchymal transitions by repression of estrogen receptor-alpha. Mol Endocrinol (2007) 1.95
Pol II and its associated epigenetic marks are present at Pol III-transcribed noncoding RNA genes. Nat Struct Mol Biol (2010) 1.93
The barrier function of an insulator couples high histone acetylation levels with specific protection of promoter DNA from methylation. Genes Dev (2002) 1.89
Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis. Nature (2005) 1.86
Phosphorylation of linker histones regulates ATP-dependent chromatin remodeling enzymes. Nat Struct Biol (2002) 1.71
Nuclear Akt associates with PKC-phosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase-activated DNase. EMBO J (2006) 1.67
Interplay between gene expression noise and regulatory network architecture. Trends Genet (2012) 1.61
DOMINE: a comprehensive collection of known and predicted domain-domain interactions. Nucleic Acids Res (2010) 1.59
Concordance of genomic alterations between primary and recurrent breast cancer. Mol Cancer Ther (2014) 1.57
DOMINE: a database of protein domain interactions. Nucleic Acids Res (2007) 1.54
Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbβ and a GPIbβ/GPIX chimera. Blood (2011) 1.54
Protease activity of urokinase and tumor progression in a syngeneic mammary cancer model. J Natl Cancer Inst (2006) 1.49
Predicting domain-domain interactions using a parsimony approach. Genome Biol (2006) 1.47
NuRD and pluripotency: a complex balancing act. Cell Stem Cell (2012) 1.46
Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells. Nat Immunol (2010) 1.43
Coordinated regulation of AIB1 transcriptional activity by sumoylation and phosphorylation. J Biol Chem (2006) 1.43
Intrinsic disorder and autonomous domain function in the multifunctional nuclear protein, MeCP2. J Biol Chem (2007) 1.42
The transcription factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancer. PLoS One (2011) 1.42
GABP controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells. Blood (2010) 1.40
DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas. J Exp Med (2010) 1.39
The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription. EMBO J (2006) 1.38
The MBD protein family-reading an epigenetic mark? Mutat Res (2008) 1.38
Bivalent recognition of nucleosomes by the tandem PHD fingers of the CHD4 ATPase is required for CHD4-mediated repression. Proc Natl Acad Sci U S A (2012) 1.37
Genome-wide uH2A localization analysis highlights Bmi1-dependent deposition of the mark at repressed genes. PLoS Genet (2009) 1.36
Identification of DNA methylation changes in newborns related to maternal smoking during pregnancy. Environ Health Perspect (2014) 1.35
Endostatin is a potential inhibitor of Wnt signaling. J Cell Biol (2002) 1.34
Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells. Nucleic Acids Res (2013) 1.33
A human-specific de novo protein-coding gene associated with human brain functions. PLoS Comput Biol (2010) 1.31
Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities. J Biol Chem (2003) 1.26
Human tRNA genes function as chromatin insulators. EMBO J (2011) 1.25
The crystal structure of human adenylate kinase 6: An adenylate kinase localized to the cell nucleus. Proc Natl Acad Sci U S A (2005) 1.23
MBD family proteins: reading the epigenetic code. J Cell Sci (2006) 1.22
The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming. Cell Stem Cell (2013) 1.19
Tim-3-Galectin-9 pathway involves the suppression induced by CD4+CD25+ regulatory T cells. Immunobiology (2008) 1.19
WNT4 is required for normal ovarian follicle development and female fertility. FASEB J (2010) 1.19
The NuRD architecture. Cell Mol Life Sci (2013) 1.18
Nucleophosmin/B23, a nuclear PI(3,4,5)P(3) receptor, mediates the antiapoptotic actions of NGF by inhibiting CAD. Mol Cell (2005) 1.18
RNA dimerization promotes PKR dimerization and activation. J Mol Biol (2009) 1.16
A critical role for calponin 2 in vascular development. J Biol Chem (2005) 1.14
Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation. Stem Cells (2012) 1.13
Use of bifunctional cross-linking reagents in mapping genomic distribution of chromatin remodeling complexes. Methods (2004) 1.13
RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo. Nucleic Acids Res (2012) 1.12
Hormonal regulation of metastasis-associated protein 3 transcription in breast cancer cells. Mol Endocrinol (2004) 1.12
Altered microRNA signatures in sputum of patients with active pulmonary tuberculosis. PLoS One (2012) 1.12
Serum microRNA expression as an early marker for breast cancer risk in prospectively collected samples from the Sister Study cohort. Breast Cancer Res (2013) 1.12
Predicting protein domain interactions from coevolution of conserved regions. Proteins (2007) 1.12
Angiogenic effect of saponin extract from Panax notoginseng on HUVECs in vitro and zebrafish in vivo. Phytother Res (2009) 1.12
Mi-2/NuRD complex function is required for normal S phase progression and assembly of pericentric heterochromatin. Mol Biol Cell (2011) 1.09
Effects of cryopreservation on the developmental competence, ultrastructure and cytoskeletal structure of porcine oocytes. Mol Reprod Dev (2006) 1.08
Tanshinone IIA protects neonatal rat cardiomyocytes from adriamycin-induced apoptosis. Transl Res (2007) 1.06
Ldb1-nucleated transcription complexes function as primary mediators of global erythroid gene activation. Blood (2013) 1.05
MeCP2 in Rett syndrome: transcriptional repressor or chromatin architectural protein? Curr Opin Genet Dev (2007) 1.04
ChIP-Seq data analysis: identification of protein-DNA binding sites with SISSRs peak-finder. Methods Mol Biol (2012) 1.03
Critical requirement of GABPalpha for normal T cell development. J Biol Chem (2010) 1.02
Essential oil of Curcuma wenyujin induces apoptosis in human hepatoma cells. World J Gastroenterol (2008) 1.01
JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation. Proc Natl Acad Sci U S A (2009) 1.00
Use of a universal hydroxymethylbilane synthase (HMBS)-based PCR as an endogenous internal control and to enable typing of mammalian DNAs. Appl Microbiol Biotechnol (2014) 0.98
Genome scale portrait of cAMP-receptor protein (CRP) regulons in mycobacteria points to their role in pathogenesis. Gene (2007) 0.96
Heart-specific isoform of tropomyosin4 is essential for heartbeat in zebrafish embryos. Cardiovasc Res (2008) 0.96
An NADPH sensor protein (HSCARG) down-regulates nitric oxide synthesis by association with argininosuccinate synthetase and is essential for epithelial cell viability. J Biol Chem (2008) 0.96
Activation of peroxisome proliferator-activated receptor gamma inhibits endothelin-1-induced cardiac hypertrophy via the calcineurin/NFAT signaling pathway. Mol Cell Biochem (2008) 0.96
Calycosin promotes angiogenesis involving estrogen receptor and mitogen-activated protein kinase (MAPK) signaling pathway in zebrafish and HUVEC. PLoS One (2010) 0.95
The Mi-2/NuRD complex associates with pericentromeric heterochromatin during S phase in rapidly proliferating lymphoid cells. Chromosoma (2009) 0.95
Fip1 regulates mRNA alternative polyadenylation to promote stem cell self-renewal. EMBO J (2014) 0.95