Published in Brain Res on December 31, 2011
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The sigma-1 receptor is enriched in postsynaptic sites of C-terminals in mouse motoneurons. An anatomical and behavioral study. Neuroscience (2010) 1.34
Fluorine-18-labeled benzamide analogues for imaging the sigma2 receptor status of solid tumors with positron emission tomography. J Med Chem (2007) 1.29
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Modulation of cellular calcium by sigma-2 receptors: release from intracellular stores in human SK-N-SH neuroblastoma cells. J Pharmacol Exp Ther (2000) 1.26
Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders. Expert Opin Ther Targets (2011) 1.22
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Formalin-induced pain is reduced in sigma(1) receptor knockout mice. Eur J Pharmacol (2005) 1.21
Characterization of (125)I-IABN, a novel azabicyclononane benzamide selective for D2-like dopamine receptors. Synapse (2000) 1.19
The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke. Brain (2011) 1.18
Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo. Brain Res (2005) 1.16
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A prototypical Sigma-1 receptor antagonist protects against brain ischemia. Brain Res (2007) 0.99
SA4503, a sigma-1 receptor agonist, prevents cultured cortical neurons from oxidative stress-induced cell death via suppression of MAPK pathway activation and glutamate receptor expression. Neurosci Lett (2009) 0.96
Sigma-1 receptor ligand PRE-084 reduced infarct volume, neurological deficits, pro-inflammatory cytokines and enhanced anti-inflammatory cytokines after embolic stroke in rats. Brain Res Bull (2011) 0.93
Estrogens as protectants of the neurovascular unit against ischemic stroke. Curr Drug Targets CNS Neurol Disord (2005) 0.91
Sigma receptors: from discovery to highlights of their implications in the cardiovascular system. Fundam Clin Pharmacol (2002) 0.89
Potential future neuroprotective therapies for neurodegenerative disorders and stroke. Clin Geriatr Med (2010) 0.88
Neuroprotection in Parkinson disease. Arch Intern Med (2003) 0.86
Anti-amnesic and neuroprotective actions of the sigma-1 receptor agonist (-)-MR22 in rats with selective cholinergic lesion and amyloid infusion. J Alzheimers Dis (2011) 0.85
Glutamate-induced cell death in neuronal HT22 cells is attenuated by extracts from St. John's wort (Hypericum perforatum L.). Phytomedicine (2007) 0.84
Anti-amnesic properties of (+/-)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats. J Neurochem (2009) 0.83
Potent sigma 1-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine provides ischemic neuroprotection without altering dopamine accumulation in vivo in rats. Anesth Analg (2003) 0.83
The σ 1 receptor agonist 4-PPBP elicits ERK1/2 phosphorylation in primary neurons: a possible mechanism of neuroprotective action. Neuropharmacology (2010) 0.81
HIF-1alpha contributes to tumour-selective killing by the sigma receptor antagonist rimcazole. Oncogene (2006) 0.81
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Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans. Ann Neurol (2006) 11.23
A roadmap for the prevention of dementia II: Leon Thal Symposium 2008. Alzheimers Dement (2009) 10.21
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell (2007) 6.47
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22
Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. Neuron (2007) 3.98
Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration. Nat Neurosci (2002) 3.89
PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys. Nat Neurosci (2006) 3.13
Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimer's disease. EMBO Mol Med (2009) 2.87
Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ ) deposition. Proc Natl Acad Sci U S A (2010) 2.80
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Mitochondrial localization of estrogen receptor beta. Proc Natl Acad Sci U S A (2004) 2.15
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Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site. Nat Commun (2011) 1.86
Choroidal thickness in healthy Chinese subjects. Invest Ophthalmol Vis Sci (2011) 1.74
Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell (2013) 1.71
Increased beta-secretase activity and expression in rats following transient cerebral ischemia. Brain Res (2004) 1.59
Ratios of activated matrix metalloproteinase-9 to tissue inhibitor of matrix metalloproteinase-1 in wound fluids are inversely correlated with healing of pressure ulcers. Wound Repair Regen (2002) 1.51
Evaluation of 5-ethynyl-2'-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system. Brain Res (2010) 1.50
Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy. Mol Cancer (2007) 1.46
Subcellular localization of sigma-2 receptors in breast cancer cells using two-photon and confocal microscopy. Cancer Res (2007) 1.44
Alternative mitochondrial electron transfer as a novel strategy for neuroprotection. J Biol Chem (2011) 1.41
Progress in developing D3 dopamine receptor ligands as potential therapeutic agents for neurological and neuropsychiatric disorders. Curr Pharm Des (2003) 1.40
Quinol-based cyclic antioxidant mechanism in estrogen neuroprotection. Proc Natl Acad Sci U S A (2003) 1.37
A broadly flavivirus cross-neutralizing monoclonal antibody that recognizes a novel epitope within the fusion loop of E protein. PLoS One (2011) 1.36
Testosterone increases neurotoxicity of glutamate in vitro and ischemia-reperfusion injury in an animal model. J Appl Physiol (1985) (2002) 1.35
Fluorine-18-labeled benzamide analogues for imaging the sigma2 receptor status of solid tumors with positron emission tomography. J Med Chem (2007) 1.29
De novo sequencing and analysis of root transcriptome using 454 pyrosequencing to discover putative genes associated with drought tolerance in Ammopiptanthus mongolicus. BMC Genomics (2012) 1.29
Estrogen attenuates nuclear factor-kappa B activation induced by transient cerebral ischemia. Brain Res (2004) 1.29
Pyruvate protects mitochondria from oxidative stress in human neuroblastoma SK-N-SH cells. Brain Res (2006) 1.28
[3H]N-[4-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)butyl]-2-methoxy-5-methylbenzamide: a novel sigma-2 receptor probe. Eur J Pharmacol (2005) 1.26
Synthesis and in vitro binding of N-phenyl piperazine analogs as potential dopamine D3 receptor ligands. Bioorg Med Chem (2005) 1.26
Mitochondrial mechanisms of estrogen neuroprotection. Biochim Biophys Acta (2009) 1.25
Estrogens and progesterone as neuroprotectants: what animal models teach us. Front Biosci (2008) 1.25
Estrogens directly potentiate neuronal L-type Ca2+ channels. Proc Natl Acad Sci U S A (2008) 1.22
Synthesis of N-substituted 9-azabicyclo[3.3.1]nonan-3alpha-yl carbamate analogs as sigma2 receptor ligands. Bioorg Med Chem (2006) 1.22
Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats. Biochim Biophys Acta (2006) 1.20
17beta-Estradiol attenuates blood-brain barrier disruption induced by cerebral ischemia-reperfusion injury in female rats. Brain Res (2005) 1.18
Reactive oxygen species-mediated TRPC6 protein activation in vascular myocytes, a mechanism for vasoconstrictor-regulated vascular tone. J Biol Chem (2011) 1.17
Differential expression profiles of microRNAs as potential biomarkers for the early diagnosis of esophageal squamous cell carcinoma. Oncol Rep (2012) 1.16
Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo. Brain Res (2005) 1.16
A method for generating uniform size-segregated pyrite particle fractions. Geochem Trans (2007) 1.16
Oxidative damage to human lens epithelial cells in culture: estrogen protection of mitochondrial potential, ATP, and cell viability. Invest Ophthalmol Vis Sci (2003) 1.15
Controlled electrochemical synthesis of conductive polymer nanotube structures. J Am Chem Soc (2007) 1.14
Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis. Bioorg Med Chem Lett (2006) 1.14
Methylene blue as a cerebral metabolic and hemodynamic enhancer. PLoS One (2012) 1.12
Nano-embossing technology on ferroelectric thin film Pb(Zr0.3,Ti0.7)O3 for multi-bit storage application. Nanoscale Res Lett (2011) 1.12
Estrogen actions on mitochondria--physiological and pathological implications. Mol Cell Endocrinol (2008) 1.11
Carbon-11 labeled sigma2 receptor ligands for imaging breast cancer. Nucl Med Biol (2005) 1.11
The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine. Mol Cancer (2010) 1.11
Estrogen-like compounds for ischemic neuroprotection. Stroke (2004) 1.10
Different impacts of blood pressure variability on the progression of cerebral microbleeds and white matter lesions. Stroke (2012) 1.10
Novel mechanisms for estrogen-induced neuroprotection. Exp Biol Med (Maywood) (2006) 1.09
Structure-nongenomic neuroprotection relationship of estrogens and estrogen-derived compounds. Pharmacol Ther (2007) 1.09
Role of PPAR-gamma ligands in neuroprotection against glutamate-induced cytotoxicity in retinal ganglion cells. Invest Ophthalmol Vis Sci (2003) 1.09
In vivo imaging in a murine model of glioblastoma. Neurosurgery (2007) 1.09
Mitochondria play a central role in estrogen-induced neuroprotection. Curr Drug Targets CNS Neurol Disord (2005) 1.08
Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein. Brain Res (2004) 1.08
Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like tauopathy in female rats. J Biol Chem (2004) 1.07
Immunohistochemical localization of EGF, TGF-alpha, TGF-beta, and their receptors in rat corneas during healing of excimer laser ablation. Curr Eye Res (2006) 1.07
Neuroprotective effects of 17beta-estradiol and nonfeminizing estrogens against H2O2 toxicity in human neuroblastoma SK-N-SH cells. Mol Pharmacol (2006) 1.06
Synthesis and characterization of selective dopamine D2 receptor antagonists. Bioorg Med Chem (2005) 1.06
Estrogen protects the inner retina from apoptosis and ischemia-induced loss of Vesl-1L/Homer 1c immunoreactive synaptic connections. Invest Ophthalmol Vis Sci (2003) 1.05