Published in Eur J Hum Genet on February 01, 2012
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IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases. Nat Med (2015) 1.32
Challenges in conducting genome-wide association studies in highly admixed multi-ethnic populations: the Generation R Study. Eur J Epidemiol (2015) 1.16
Integrated enrichment analysis of variants and pathways in genome-wide association studies indicates central role for IL-2 signaling genes in type 1 diabetes, and cytokine signaling genes in Crohn's disease. PLoS Genet (2013) 1.14
Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation. Circulation (2014) 1.11
Imputation of coding variants in African Americans: better performance using data from the exome sequencing project. Bioinformatics (2013) 1.05
Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes. Ann Rheum Dis (2015) 1.02
DDIG-in: discriminating between disease-associated and neutral non-frameshifting micro-indels. Genome Biol (2013) 1.02
A comparison of type 2 diabetes risk allele load between African Americans and European Americans. Hum Genet (2014) 1.01
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Genotype Imputation for Latinos Using the HapMap and 1000 Genomes Project Reference Panels. Front Genet (2012) 0.94
Improving accuracy of rare variant imputation with a two-step imputation approach. Eur J Hum Genet (2014) 0.92
The architecture of risk for type 2 diabetes: understanding Asia in the context of global findings. Int J Endocrinol (2014) 0.91
A comprehensive SNP and indel imputability database. Bioinformatics (2013) 0.90
A flexible approach for the analysis of rare variants allowing for a mixture of effects on binary or quantitative traits. PLoS Genet (2013) 0.88
Genetic Epidemiology of Psoriasis. Curr Dermatol Rep (2014) 0.87
Impact of pre-imputation SNP-filtering on genotype imputation results. BMC Genet (2014) 0.86
Altered immune regulation in type 1 diabetes. Clin Dev Immunol (2013) 0.85
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Genome-wide association studies with metabolomics. Genome Med (2012) 0.84
One thousand genomes imputation in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium aggressive prostate cancer genome-wide association study. Prostate (2012) 0.83
DISSCO: direct imputation of summary statistics allowing covariates. Bioinformatics (2015) 0.83
Genes involved in type 1 diabetes: an update. Genes (Basel) (2013) 0.83
TGFBI (βIG-H3) is a diabetes-risk gene based on mouse and human genetic studies. Hum Mol Genet (2014) 0.83
A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration. Hum Mol Genet (2015) 0.82
T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility. Sci Rep (2014) 0.82
Contrasting the Genetic Background of Type 1 Diabetes and Celiac Disease Autoimmunity. Diabetes Care (2015) 0.80
Fine-mapping inflammatory bowel disease loci to single-variant resolution. Nature (2017) 0.79
Influence of host immunoregulatory genes, ER stress and gut microbiota on the shared pathogenesis of inflammatory bowel disease and Type 1 diabetes. Immunotherapy (2013) 0.78
Systematic assessment of imputation performance using the 1000 Genomes reference panels. Brief Bioinform (2014) 0.78
Enrichment of inflammatory bowel disease and colorectal cancer risk variants in colon expression quantitative trait loci. BMC Genomics (2015) 0.78
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Gene-based rare allele analysis identified a risk gene of Alzheimer's disease. PLoS One (2014) 0.77
Identification of rs671, a common variant of ALDH2, as a gout susceptibility locus. Sci Rep (2016) 0.77
Linkage of type 2 diabetes on chromosome 9p24 in Mexican Americans: additional evidence from the Veterans Administration Genetic Epidemiology Study (VAGES). Hum Hered (2013) 0.77
Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors. Am J Hum Genet (2016) 0.77
Identifying rare and common disease associated variants in genomic data using Parkinson's disease as a model. J Biomed Sci (2014) 0.76
A unified approach for allele frequency estimation, SNP detection and association studies based on pooled sequencing data using EM algorithms. BMC Genomics (2013) 0.76
Discovery of stimulation-responsive immune enhancers with CRISPR activation. Nature (2017) 0.76
Inferring haplotypes and parental genotypes in larger full sib-ships and other pedigrees with missing or erroneous genotype data. BMC Genet (2012) 0.75
PreCimp: Pre-collapsing imputation approach increases imputation accuracy of rare variants in terms of collapsed variables. Genet Epidemiol (2016) 0.75
Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study. PLoS One (2017) 0.75
Association of common polymorphisms in the IL2RA gene with type 1 diabetes: evidence of 32,646 individuals from 10 independent studies. J Cell Mol Med (2015) 0.75
The new perspectives on genetic studies of type 2 diabetes and thyroid diseases. Curr Genomics (2013) 0.75
Exploiting population samples to enhance genome-wide association studies of disease. Genetics (2014) 0.75
Genome-scale characterization of RNA tertiary structures and their functional impact by RNA solvent accessibility prediction. RNA (2016) 0.75
WikiGWA: an open platform for collecting and using genome-wide association results. Eur J Hum Genet (2012) 0.75
Utilization of genetic data can improve the prediction of type 2 diabetes incidence in a Swedish cohort. PLoS One (2017) 0.75
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
A map of human genome variation from population-scale sequencing. Nature (2010) 121.13
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
A method and server for predicting damaging missense mutations. Nat Methods (2010) 78.53
Genomic control for association studies. Biometrics (1999) 64.39
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol (2010) 26.41
Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet (2003) 21.52
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A unified approach to genotype imputation and haplotype-phase inference for large data sets of trios and unrelated individuals. Am J Hum Genet (2009) 17.80
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet (2009) 16.53
A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet (2004) 14.76
Genotype imputation for genome-wide association studies. Nat Rev Genet (2010) 14.59
Practical aspects of imputation-driven meta-analysis of genome-wide association studies. Hum Mol Genet (2008) 13.26
Estimation of the multiple testing burden for genomewide association studies of nearly all common variants. Genet Epidemiol (2008) 11.28
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
So many correlated tests, so little time! Rapid adjustment of P values for multiple correlated tests. Am J Hum Genet (2007) 6.26
The International HapMap Project Web site. Genome Res (2005) 5.96
Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis. Nat Genet (2010) 4.69
Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations. Diabetes (2008) 4.20
Extending rare-variant testing strategies: analysis of noncoding sequence and imputed genotypes. Am J Hum Genet (2010) 3.47
Analyses and comparison of accuracy of different genotype imputation methods. PLoS One (2008) 3.41
A comprehensive evaluation of SNP genotype imputation. Hum Genet (2008) 3.18
Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction. Nat Genet (2011) 2.42
A comparison of approaches to account for uncertainty in analysis of imputed genotypes. Genet Epidemiol (2011) 2.19
Multiple testing corrections for imputed SNPs. Genet Epidemiol (2011) 1.36
A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains. PLoS Genet (2011) 1.35
Cux2 (Cutl2) integrates neural progenitor development with cell-cycle progression during spinal cord neurogenesis. Development (2008) 1.15
Analyses and comparison of imputation-based association methods. PLoS One (2010) 1.12
Pleiotropic genetic effects contribute to the correlation between HDL cholesterol, triglycerides, and LDL particle size in hypertensive sibships. Am J Hypertens (2005) 1.02
Factors affecting the effective number of tests in genetic association studies: a comparative study of three PCA-based methods. J Hum Genet (2011) 0.86
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
A new multipoint method for genome-wide association studies by imputation of genotypes. Nat Genet (2007) 52.68
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (2007) 43.16
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83
METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics (2010) 21.21
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Rare-variant association testing for sequencing data with the sequence kernel association test. Am J Hum Genet (2011) 18.88
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet (2006) 15.14
Genotype imputation for genome-wide association studies. Nat Rev Genet (2010) 14.59
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Widespread RNA and DNA sequence differences in the human transcriptome. Science (2011) 11.45
Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet (2008) 10.52
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet (2009) 9.45
Genotype imputation with thousands of genomes. G3 (Bethesda) (2011) 8.77
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell (2008) 8.43
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet (2011) 7.98
An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people. Science (2012) 7.94
Genotype-imputation accuracy across worldwide human populations. Am J Hum Genet (2009) 7.28
Adaptive particle swarm optimization. IEEE Trans Syst Man Cybern B Cybern (2009) 6.47
15q13.3 microdeletions increase risk of idiopathic generalized epilepsy. Nat Genet (2009) 6.21
Microbial exposure during early life has persistent effects on natural killer T cell function. Science (2012) 5.90
The genome of a songbird. Nature (2010) 5.90
New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease. Nat Genet (2011) 5.58
Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell (2009) 5.55
Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat Genet (2008) 5.55
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet (2008) 5.05
Oligodendroglia metabolically support axons and contribute to neurodegeneration. Nature (2012) 4.95
Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis. Nat Genet (2010) 4.69
Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am J Hum Genet (2008) 4.69
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet (2013) 4.62
CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration. Nat Genet (2006) 4.51
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet (2011) 4.50
Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet (2009) 4.30
Sarcoidosis is associated with a truncating splice site mutation in BTNL2. Nat Genet (2005) 4.23
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet (2012) 4.13
Recurrent microdeletions at 15q11.2 and 16p13.11 predispose to idiopathic generalized epilepsies. Brain (2009) 3.96
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med (2016) 3.88
Clinical and economic implications of the Multicenter Automatic Defibrillator Implantation Trial-II. Ann Intern Med (2005) 3.83
Genetic loci influencing kidney function and chronic kidney disease. Nat Genet (2010) 3.75
Extending rare-variant testing strategies: analysis of noncoding sequence and imputed genotypes. Am J Hum Genet (2010) 3.47
A multinational cohort study of in-center daily hemodialysis and patient survival. Kidney Int (2012) 3.47
Genome-wide copy number variation in epilepsy: novel susceptibility loci in idiopathic generalized and focal epilepsies. PLoS Genet (2010) 3.39
A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5. Gastroenterology (2007) 3.37
Perceptions of patients and physicians regarding phase I cancer clinical trials: implications for physician-patient communication. J Clin Oncol (2003) 3.31
Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eQTL signals. Am J Hum Genet (2010) 3.28
CEP152 is a genome maintenance protein disrupted in Seckel syndrome. Nat Genet (2010) 3.25
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
A comprehensive evaluation of SNP genotype imputation. Hum Genet (2008) 3.18
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18
New insights into the Tyrolean Iceman's origin and phenotype as inferred by whole-genome sequencing. Nat Commun (2012) 3.18
New gene functions in megakaryopoiesis and platelet formation. Nature (2011) 3.14
A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol (2010) 3.09
Interleukin-6 predicts recurrence and survival among head and neck cancer patients. Cancer (2008) 2.98
Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization. Gastroenterology (2008) 2.95
A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat Genet (2015) 2.84
DNA methylome analysis using short bisulfite sequencing data. Nat Methods (2012) 2.77
Genome-wide association analysis identifies three psoriasis susceptibility loci. Nat Genet (2010) 2.76
A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease. Nat Genet (2007) 2.75
Exome sequencing identifies truncating mutations in human SERPINF1 in autosomal-recessive osteogenesis imperfecta. Am J Hum Genet (2011) 2.69
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. Nat Genet (2010) 2.66
Temperature drift compensation for Hemispherical Resonator Gyro based on natural frequency. Sensors (Basel) (2012) 2.62
Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype. Proc Natl Acad Sci U S A (2011) 2.47
Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer. PLoS Genet (2011) 2.47
A statin-dependent QTL for GATM expression is associated with statin-induced myopathy. Nature (2013) 2.46
Association analyses identify six new psoriasis susceptibility loci in the Chinese population. Nat Genet (2010) 2.41
Rare copy number variation discovery and cross-disorder comparisons identify risk genes for ADHD. Sci Transl Med (2011) 2.29
Mutual antagonism of T cells causing psoriasis and atopic eczema. N Engl J Med (2011) 2.28
Force to rebalance control of HRG and suppression of its errors on the basis of FPGA. Sensors (Basel) (2011) 2.22
Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels. Nat Genet (2009) 2.19
A comparison of approaches to account for uncertainty in analysis of imputed genotypes. Genet Epidemiol (2011) 2.19
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. Nat Genet (2012) 2.17
An Fcγ receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells. Cancer Cell (2011) 2.14
Toward the blood-borne miRNome of human diseases. Nat Methods (2011) 2.14
Changes in dialysis treatment modalities during institution of flat rate reimbursement and quality assurance programs. Kidney Int (2013) 2.14
Familial and sporadic 15q13.3 microdeletions in idiopathic generalized epilepsy: precedent for disorders with complex inheritance. Hum Mol Genet (2009) 2.12
TGF-β induces miR-182 to sustain NF-κB activation in glioma subsets. J Clin Invest (2012) 2.10
Wnt signaling and Dupuytren's disease. N Engl J Med (2011) 2.02
Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes. Diabetes (2008) 2.01
Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. Nat Genet (2012) 2.00
Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci. Proc Natl Acad Sci U S A (2007) 1.95