Published in Nat Genet on June 17, 2007
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet (2009) 30.09
MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol (2010) 26.41
Origins and functional impact of copy number variation in the human genome. Nature (2009) 23.63
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
A groupwise association test for rare mutations using a weighted sum statistic. PLoS Genet (2009) 19.64
Genotype imputation. Annu Rev Genomics Hum Genet (2009) 18.64
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
A unified approach to genotype imputation and haplotype-phase inference for large data sets of trios and unrelated individuals. Am J Hum Genet (2009) 17.80
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap. Bioinformatics (2008) 15.77
Genetic mapping in human disease. Science (2008) 15.12
Transcriptome genetics using second generation sequencing in a Caucasian population. Nature (2010) 14.85
Genotype imputation for genome-wide association studies. Nat Rev Genet (2010) 14.59
Practical aspects of imputation-driven meta-analysis of genome-wide association studies. Hum Mol Genet (2008) 13.26
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. Nat Genet (2012) 11.29
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet (2010) 9.90
Detection of sharing by descent, long-range phasing and haplotype imputation. Nat Genet (2008) 9.69
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet (2013) 9.46
Estimation of significance thresholds for genomewide association scans. Genet Epidemiol (2008) 8.88
Genotype imputation with thousands of genomes. G3 (Bethesda) (2011) 8.77
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
Genotype and SNP calling from next-generation sequencing data. Nat Rev Genet (2011) 8.34
A linear complexity phasing method for thousands of genomes. Nat Methods (2011) 8.30
A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature (2012) 8.10
A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet (2009) 7.65
Genome-wide association studies: potential next steps on a genetic journey. Hum Mol Genet (2008) 7.54
Genotype-imputation accuracy across worldwide human populations. Am J Hum Genet (2009) 7.28
Parental origin of sequence variants associated with complex diseases. Nature (2009) 7.21
Linkage disequilibrium--understanding the evolutionary past and mapping the medical future. Nat Rev Genet (2008) 7.08
Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet (2008) 7.07
Practical issues in imputation-based association mapping. PLoS Genet (2008) 6.76
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat Genet (2008) 6.75
Discovery and genotyping of genome structural polymorphism by sequencing on a population scale. Nat Genet (2011) 6.67
Designing genome-wide association studies: sample size, power, imputation, and the choice of genotyping chip. PLoS Genet (2009) 6.61
Powerful SNP-set analysis for case-control genome-wide association studies. Am J Hum Genet (2010) 6.60
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet (2010) 6.49
ProbABEL package for genome-wide association analysis of imputed data. BMC Bioinformatics (2010) 6.46
LDL-cholesterol concentrations: a genome-wide association study. Lancet (2008) 6.44
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet (2009) 6.39
Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking. Mol Psychiatry (2008) 6.37
Sensitive detection of chromosomal segments of distinct ancestry in admixed populations. PLoS Genet (2009) 6.36
Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder. Am J Hum Genet (2009) 5.98
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Revealing the architecture of gene regulation: the promise of eQTL studies. Trends Genet (2008) 5.78
Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies. Am J Hum Genet (2009) 5.65
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Nat Genet (2013) 5.58
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet (2008) 5.49
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat Genet (2009) 5.32
A genome-wide perspective of genetic variation in human metabolism. Nat Genet (2009) 5.00
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet (2009) 4.97
A powerful and flexible multilocus association test for quantitative traits. Am J Hum Genet (2008) 4.96
The Population Reference Sample, POPRES: a resource for population, disease, and pharmacological genetics research. Am J Hum Genet (2008) 4.79
A robust statistical method for case-control association testing with copy number variation. Nat Genet (2008) 4.78
Genomewide association studies: history, rationale, and prospects for psychiatric disorders. Am J Psychiatry (2009) 4.74
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71
Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am J Hum Genet (2008) 4.69
Haplotype phasing: existing methods and new developments. Nat Rev Genet (2011) 4.66
A statistical method for predicting classical HLA alleles from SNP data. Am J Hum Genet (2008) 4.65
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet (2013) 4.62
Validating, augmenting and refining genome-wide association signals. Nat Rev Genet (2009) 4.56
Simple and efficient analysis of disease association with missing genotype data. Am J Hum Genet (2008) 4.52
Common variants at 19p13 are associated with susceptibility to ovarian cancer. Nat Genet (2010) 4.51
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet (2012) 4.46
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet (2010) 4.42
A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. Nat Genet (2009) 4.38
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet (2009) 4.30
Evaluating the effects of imputation on the power, coverage, and cost efficiency of genome-wide SNP platforms. Am J Hum Genet (2008) 4.28
Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. Ann Hum Genet (2010) 4.26
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet (2012) 4.13
GWAMA: software for genome-wide association meta-analysis. BMC Bioinformatics (2010) 4.11
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat Genet (2012) 4.08
Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol (2010) 4.08
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nat Genet (2011) 4.04
Genomic selection using low-density marker panels. Genetics (2009) 4.01
On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants. Am J Hum Genet (2008) 3.95
A rare variant in MYH6 is associated with high risk of sick sinus syndrome. Nat Genet (2011) 3.94
Genome-wide association study identifies three loci associated with melanoma risk. Nat Genet (2009) 3.89
Progress and promise of genome-wide association studies for human complex trait genetics. Genetics (2010) 3.81
Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81
TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis. Nature (2012) 3.73
Identification of common variants associated with human hippocampal and intracranial volumes. Nat Genet (2012) 3.73
Data quality control in genetic case-control association studies. Nat Protoc (2010) 3.68
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. PLoS Genet (2011) 3.68
Missing data imputation and haplotype phase inference for genome-wide association studies. Hum Genet (2008) 3.65
Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA. PLoS Genet (2011) 3.65
Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study. Lancet Neurol (2010) 3.61
Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease. Am J Hum Genet (2009) 3.54
Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Proc Natl Acad Sci U S A (2009) 3.49
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat Genet (2011) 3.46
Rare-variant association analysis: study designs and statistical tests. Am J Hum Genet (2014) 3.42
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30
A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet (2009) 30.09
A fine-scale map of recombination rates and hotspots across the human genome. Science (2005) 26.82
A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet (2003) 26.59
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
The fine-scale structure of recombination rate variation in the human genome. Science (2004) 17.05
Replicating genotype-phenotype associations. Nature (2007) 16.11
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet (2006) 15.63
The effects of human population structure on large genetic association studies. Nat Genet (2004) 14.88
Genome-wide strategies for detecting multiple loci that influence complex diseases. Nat Genet (2005) 14.88
Genotype imputation for genome-wide association studies. Nat Rev Genet (2010) 14.59
New models of collaboration in genome-wide association studies: the Genetic Association Information Network. Nat Genet (2007) 13.76
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Mapping copy number variation by population-scale genome sequencing. Nature (2011) 12.55
A comparison of phasing algorithms for trios and unrelated individuals. Am J Hum Genet (2006) 12.45
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet (2008) 10.52
Transcriptome and genome sequencing uncovers functional variation in humans. Nature (2013) 8.89
Genotype imputation with thousands of genomes. G3 (Bethesda) (2011) 8.77
A common sequence motif associated with recombination hot spots and genome instability in humans. Nat Genet (2008) 8.64
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet (2010) 8.48
Comparison of fine-scale recombination rates in humans and chimpanzees. Science (2005) 7.86
Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet (2013) 7.44
Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination. Science (2009) 7.35
Designing genome-wide association studies: sample size, power, imputation, and the choice of genotyping chip. PLoS Genet (2009) 6.61
Sensitive detection of chromosomal segments of distinct ancestry in admixed populations. PLoS Genet (2009) 6.36
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas. Nat Genet (2012) 6.25
De novo assembly and genotyping of variants using colored de Bruijn graphs. Nat Genet (2012) 5.61
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet (2011) 5.56
Differential confounding of rare and common variants in spatially structured populations. Nat Genet (2012) 5.28
Inference of population structure using dense haplotype data. PLoS Genet (2012) 4.87
Accessibility, sustainability, excellence: how to expand access to research publications. Executive summary. Int Microbiol (2013) 4.66
A statistical method for predicting classical HLA alleles from SNP data. Am J Hum Genet (2008) 4.65
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet (2013) 4.62
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet (2009) 4.61
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet (2010) 4.42
Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet (2009) 4.30
The influence of recombination on human genetic diversity. PLoS Genet (2006) 4.04
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. Nat Genet (2012) 3.40
Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21. Hum Mol Genet (2010) 3.34
Human recombination hot spots hidden in regions of strong marker association. Nat Genet (2005) 3.33
Bayesian refinement of association signals for 14 loci in 3 common diseases. Nat Genet (2012) 3.31
Evolutionary dynamics of Staphylococcus aureus during progression from carriage to disease. Proc Natl Acad Sci U S A (2012) 3.29
Human genome sequence variation and the influence of gene history, mutation and recombination. Nat Genet (2002) 3.24
Great ape genetic diversity and population history. Nature (2013) 2.95
Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nat Genet (2013) 2.87
A fine-scale chimpanzee genetic map from population sequencing. Science (2012) 2.83
Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer. Nature (2012) 2.66
HAPGEN2: simulation of multiple disease SNPs. Bioinformatics (2011) 2.58
Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer. PLoS Genet (2011) 2.47
A statin-dependent QTL for GATM expression is associated with statin-induced myopathy. Nature (2013) 2.46
Multiple instances of ancient balancing selection shared between humans and chimpanzees. Science (2013) 2.32
HLA*IMP--an integrated framework for imputing classical HLA alleles from SNP genotypes. Bioinformatics (2011) 2.21
Estimation of breast burn size. Plast Reconstr Surg (2004) 2.16
Effects of cis and trans genetic ancestry on gene expression in African Americans. PLoS Genet (2008) 2.09
Enhanced statistical tests for GWAS in admixed populations: assessment using African Americans from CARe and a Breast Cancer Consortium. PLoS Genet (2011) 1.94
The origin, evolution, and functional impact of short insertion-deletion variants identified in 179 human genomes. Genome Res (2013) 1.83
Recombination rate estimation in the presence of hotspots. Genome Res (2007) 1.83
A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection. PLoS Genet (2011) 1.83
Is mate choice in humans MHC-dependent? PLoS Genet (2008) 1.66
Including known covariates can reduce power to detect genetic effects in case-control studies. Nat Genet (2012) 1.66
Recombination and population structure in Salmonella enterica. PLoS Genet (2011) 1.61
Human metabolic profiles are stably controlled by genetic and environmental variation. Mol Syst Biol (2011) 1.60
1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data. Eur J Hum Genet (2012) 1.59
Application of coalescent methods to reveal fine-scale rate variation and recombination hotspots. Genetics (2004) 1.59
People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population. Eur J Hum Genet (2011) 1.58
Haplotype estimation using sequencing reads. Am J Hum Genet (2013) 1.56
Comparing algorithms for genotype imputation. Am J Hum Genet (2008) 1.54
Gang membership, violence, and psychiatric morbidity. Am J Psychiatry (2013) 1.54
Mutations in AP2S1 cause familial hypocalciuric hypercalcemia type 3. Nat Genet (2012) 1.53
Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus. Nat Genet (2012) 1.52
A structured ancestral population for the evolution of modern humans. Curr Opin Genet Dev (2004) 1.48
Pneumococcal genome sequencing tracks a vaccine escape variant formed through a multi-fragment recombination event. Nat Genet (2012) 1.43
Multi-population classical HLA type imputation. PLoS Comput Biol (2013) 1.43