Published in Proc Natl Acad Sci U S A on January 30, 2012
A molecular perspective on TH2-promoting cytokine receptors in patients with allergic disease. J Allergy Clin Immunol (2013) 1.73
Activated T cells secrete an alternatively spliced form of common γ-chain that inhibits cytokine signaling and exacerbates inflammation. Immunity (2014) 1.51
Soluble IL7Rα potentiates IL-7 bioactivity and promotes autoimmunity. Proc Natl Acad Sci U S A (2013) 1.07
Structural insights into the common γ-chain family of cytokines and receptors from the interleukin-7 pathway. Immunol Rev (2012) 0.91
Membrane microdomains and cytoskeleton organization shape and regulate the IL-7 receptor signalosome in human CD4 T-cells. J Biol Chem (2013) 0.87
Crystal structure of Lamellipodin implicates diverse functions in actin polymerization and Ras signaling. Protein Cell (2013) 0.82
Structural basis of the proinflammatory signaling complex mediated by TSLP. Nat Struct Mol Biol (2014) 0.80
Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia. Br J Haematol (2014) 0.78
Mechanisms of immunomodulation by mammalian and viral decoy receptors: insights from structures. Nat Rev Immunol (2016) 0.76
Screening for peptides targeted to IL-7Rα for molecular imaging of rheumatoid arthritis synovium. Arthritis Res Ther (2016) 0.75
A Case of IL-7R Deficiency Caused by a Novel Synonymous Mutation and Implications for Mutation Screening in SCID Diagnosis. Front Immunol (2016) 0.75
IL-7 Induces an Epitope Masking of γc Protein in IL-7 Receptor Signaling Complex. Mediators Inflamm (2017) 0.75
Expression of biologically active bovine interleukin 7 and evaluating the activity in vitro. Vet World (2016) 0.75
Association of interleukin 7 receptor gene polymorphism rs6897932 with multiple sclerosis patients in Khuzestan. Iran J Neurol (2014) 0.75
Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28
Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med (2007) 17.06
Cell signaling by receptor tyrosine kinases. Cell (2010) 12.39
New insights into the regulation of T cells by gamma(c) family cytokines. Nat Rev Immunol (2009) 5.57
Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat Genet (2007) 5.09
Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell (1990) 4.15
Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system. Cell (2008) 3.72
Interleukin-7 receptor expression: intelligent design. Nat Rev Immunol (2007) 3.53
Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation. Science (1999) 3.03
Erythropoietin receptor activation by a ligand-induced conformation change. Science (1999) 2.98
Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. Science (2005) 2.64
Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias. J Exp Med (2011) 2.59
Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia. Proc Natl Acad Sci U S A (2009) 2.54
Binding in the growth hormone receptor complex. Proc Natl Acad Sci U S A (1996) 2.48
Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity. Nature (1990) 2.33
Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia. Nat Genet (2011) 2.32
Structural biology of shared cytokine receptors. Annu Rev Immunol (2009) 2.27
Cytokines and immunodeficiency diseases: critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways. Immunol Rev (2004) 2.18
Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain. Proc Natl Acad Sci U S A (2001) 2.00
Novel fold and assembly of the repetitive B region of the Staphylococcus aureus collagen-binding surface protein. Structure (2000) 1.87
Cytokine and cytokine receptor pleiotropy and redundancy. J Biol Chem (2002) 1.85
Model for growth hormone receptor activation based on subunit rotation within a receptor dimer. Nat Struct Mol Biol (2005) 1.83
Dimerization of the extracellular domain of the erythropoietin (EPO) receptor by EPO: one high-affinity and one low-affinity interaction. Biochemistry (1996) 1.52
Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface. Cell (1999) 1.48
Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor. Proc Natl Acad Sci U S A (2006) 1.41
Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosa. J Exp Med (1998) 1.39
Active conformation of the erythropoietin receptor: random and cysteine-scanning mutagenesis of the extracellular juxtamembrane and transmembrane domains. J Biol Chem (2006) 1.37
Structural and biophysical studies of the human IL-7/IL-7Ralpha complex. Structure (2009) 1.07
Homodimerization of interleukin-4 receptor alpha chain can induce intracellular signaling. J Biol Chem (1996) 1.04
IL-2 induces conformational changes in its preassembled receptor core, which then migrates in lipid raft and binds to the cytoskeleton meshwork. J Mol Biol (2010) 1.01
Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patients. J Immunol (2009) 1.01
Interleukin-7 compartmentalizes its receptor signaling complex to initiate CD4 T lymphocyte response. J Biol Chem (2010) 0.99
Cytokine-receptor interactions as drug targets. Curr Opin Chem Biol (2010) 0.98
Ligand-independent homomeric and heteromeric complexes between interleukin-2 or -9 receptor subunits and the gamma chain. J Biol Chem (2008) 0.90
Human IL-Rbeta chains form IL-2 binding homodimers. Eur Cytokine Netw (2008) 0.89
Crystallization and preliminary X-ray diffraction of human interleukin-7 bound to unglycosylated and glycosylated forms of its alpha-receptor. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.86
Structural analysis and modeling of a synthetic interleukin-2 mimetic and its interleukin-2Rbeta2 receptor. J Biol Chem (2003) 0.80
RNA-guided RNA cleavage by a CRISPR RNA-Cas protein complex. Cell (2009) 11.12
Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase. J Biol Chem (2011) 3.21
hsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cells. Brain Res (2008) 3.20
Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A (2002) 3.08
O-mannosyl phosphorylation of alpha-dystroglycan is required for laminin binding. Science (2010) 2.98
Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes. J Clin Endocrinol Metab (2006) 2.64
A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination. Dev Cell (2007) 2.11
The multi-ethnic pediatric eye disease study: design and methods. Ophthalmic Epidemiol (2006) 2.02
Dynamic developmental elaboration of N-linked glycan complexity in the Drosophila melanogaster embryo. J Biol Chem (2007) 1.99
Ubiquitin-like small archaeal modifier proteins (SAMPs) in Haloferax volcanii. Nature (2010) 1.80
White matter hyperintensities and dynamics of postural control. Magn Reson Imaging (2009) 1.60
Structure of the YibK methyltransferase from Haemophilus influenzae (HI0766): a cofactor bound at a site formed by a knot. Proteins (2003) 1.50
Cyclin-dependent kinase 2 signaling regulates myocardial ischemia/reperfusion injury. J Mol Cell Cardiol (2008) 1.44
Role of IL-10-Producing Regulatory B Cells in Chronic Hepatitis B Virus Infection. Dig Dis Sci (2014) 1.44
Site mapping and characterization of O-glycan structures on alpha-dystroglycan isolated from rabbit skeletal muscle. J Biol Chem (2010) 1.43
Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes. J Cell Biol (2011) 1.42
Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc. Nat Chem Biol (2010) 1.41
Combining high-energy C-trap dissociation and electron transfer dissociation for protein O-GlcNAc modification site assignment. J Proteome Res (2011) 1.41
BDNF-hypersecreting human mesenchymal stem cells promote functional recovery, axonal sprouting, and protection of corticospinal neurons after spinal cord injury. J Neurosci (2009) 1.40
Expression of Epstein-Barr virus genes in EBV-associated gastric carcinomas. World J Gastroenterol (2005) 1.39
Supervised learning-based cell image segmentation for p53 immunohistochemistry. IEEE Trans Biomed Eng (2006) 1.36
A reproducible brain tumour model established from human glioblastoma biopsies. BMC Cancer (2009) 1.35
Nonlinear assessment of cerebral autoregulation from spontaneous blood pressure and cerebral blood flow fluctuations. Cardiovasc Eng (2008) 1.35
Cardiac overexpression of metallothionein rescues cardiac contractile dysfunction and endoplasmic reticulum stress but not autophagy in sepsis. J Mol Cell Cardiol (2009) 1.33
Glycomic analyses of mouse models of congenital muscular dystrophy. J Biol Chem (2011) 1.32
O-GlcNAc modifications regulate cell survival and epiboly during zebrafish development. BMC Dev Biol (2009) 1.31
MiR-128 inhibits tumor growth and angiogenesis by targeting p70S6K1. PLoS One (2012) 1.31
Quantitative analysis of both protein expression and serine / threonine post-translational modifications through stable isotope labeling with dithiothreitol. Proteomics (2005) 1.30
Solution structure and functional ligand screening of HI0719, a highly conserved protein from bacteria to humans in the YjgF/YER057c/UK114 family. Biochemistry (2003) 1.30
Human health risk from soil heavy metal contamination under different land uses near Dabaoshan Mine, Southern China. Sci Total Environ (2012) 1.29
Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice. J Clin Invest (2010) 1.28
Divergence of function in the hot dog fold enzyme superfamily: the bacterial thioesterase YciA. Biochemistry (2008) 1.28
Oxygen-sensitive {delta}-opioid receptor-regulated survival and death signals: novel insights into neuronal preconditioning and protection. J Biol Chem (2005) 1.26
β-N-Acetylglucosamine (O-GlcNAc) is a novel regulator of mitosis-specific phosphorylations on histone H3. J Biol Chem (2012) 1.25
Minor proteins and enzymes of the Drosophila eggshell matrix. Dev Biol (2006) 1.20
Elevation of the post-translational modification of proteins by O-linked N-acetylglucosamine leads to deterioration of the glucose-stimulated insulin secretion in the pancreas of diabetic Goto-Kakizaki rats. Glycobiology (2006) 1.20
Diverse regulation of protein function by O-GlcNAc: a nuclear and cytoplasmic carbohydrate post-translational modification. Curr Opin Chem Biol (2002) 1.19
Defining the regulated secreted proteome of rodent adipocytes upon the induction of insulin resistance. J Proteome Res (2008) 1.19
Expanded binding specificity of the human histone chaperone NASP. Nucleic Acids Res (2008) 1.19
Adhesion molecules, altered vasoreactivity, and brain atrophy in type 2 diabetes. Diabetes Care (2011) 1.18
Soil microbial biomass, basal respiration and enzyme activity of main forest types in the Qinling Mountains. PLoS One (2013) 1.16
Identification of candidate biomarkers with cancer-specific glycosylation in the tissue and serum of endometrioid ovarian cancer patients by glycoproteomic analysis. Proteomics (2010) 1.16
Neuropathic pain memory is maintained by Rac1-regulated dendritic spine remodeling after spinal cord injury. J Neurosci (2008) 1.15
Co-suppression of miR-221/222 cluster suppresses human glioma cell growth by targeting p27kip1 in vitro and in vivo. Int J Oncol (2009) 1.15
IDAWG: Metabolic incorporation of stable isotope labels for quantitative glycomics of cultured cells. J Proteome Res (2009) 1.15
MIRAGE: the minimum information required for a glycomics experiment. Glycobiology (2014) 1.14
Intracellular protein glycosylation modulates insulin mediated lifespan in C.elegans. Aging (Albany NY) (2010) 1.14
Targeted glycoproteomic identification of biomarkers for human breast carcinoma. J Proteome Res (2008) 1.14
Glycomics: building upon proteomics to advance glycosciences. Mol Cell Proteomics (2013) 1.12
Identification of N-glycosylated proteins from the central nervous system of Drosophila melanogaster. Glycobiology (2007) 1.12
Structure and mechanism of Pseudomonas aeruginosa PhzD, an isochorismatase from the phenazine biosynthetic pathway. Biochemistry (2003) 1.10
From structure to function: YrbI from Haemophilus influenzae (HI1679) is a phosphatase. Proteins (2002) 1.10
Neuroprotective role of delta-opioid receptors in cortical neurons. Am J Physiol Cell Physiol (2002) 1.09
IDH1/IDH2 mutations define the prognosis and molecular profiles of patients with gliomas: a meta-analysis. PLoS One (2013) 1.08
Soluble IL7Rα potentiates IL-7 bioactivity and promotes autoimmunity. Proc Natl Acad Sci U S A (2013) 1.07
Structural and biophysical studies of the human IL-7/IL-7Ralpha complex. Structure (2009) 1.07
BLOOD FLOW IN THE CIRCLE OF WILLIS: MODELING AND CALIBRATION. Multiscale Model Simul (2008) 1.05
Dissecting the molecular basis of the role of the O-mannosylation pathway in disease: α-dystroglycan and forms of muscular dystrophy. Chembiochem (2013) 1.04
Small-fiber neuropathy Nav1.8 mutation shifts activation to hyperpolarized potentials and increases excitability of dorsal root ganglion neurons. J Neurosci (2013) 1.04
Structure of Escherichia coli aminodeoxychorismate synthase: architectural conservation and diversity in chorismate-utilizing enzymes. Biochemistry (2002) 1.04
Survival and recurrence free benefits with different lymphadenectomy for resectable gastric cancer: a meta-analysis. J Surg Oncol (2013) 1.04
Rapid hypoxia preconditioning protects cortical neurons from glutamate toxicity through delta-opioid receptor. Stroke (2006) 1.04
Structure and function of the phenazine biosynthesis protein PhzF from Pseudomonas fluorescens 2-79. Biochemistry (2004) 1.03
A chromosome-centric human proteome project (C-HPP) to characterize the sets of proteins encoded in chromosome 17. J Proteome Res (2012) 1.03
High preoperative plasma fibrinogen levels are associated with distant metastases and impaired prognosis after curative resection in patients with colorectal cancer. J Surg Oncol (2010) 1.02
Hypertension and cerebral vasoreactivity: a continuous arterial spin labeling magnetic resonance imaging study. Hypertension (2010) 1.02
Abcc6 deficiency causes increased infarct size and apoptosis in a mouse cardiac ischemia-reperfusion model. Arterioscler Thromb Vasc Biol (2011) 1.02
Association of the maternal MTHFR C677T polymorphism with susceptibility to neural tube defects in offsprings: evidence from 25 case-control studies. PLoS One (2012) 1.01
Crystal structure of the YchF protein reveals binding sites for GTP and nucleic acid. J Bacteriol (2003) 1.01
The effects of body mass index on cerebral blood flow velocity. Clin Auton Res (2008) 1.01
Laparoscopy-assisted gastrectomy versus open gastrectomy for resectable gastric cancer: an update meta-analysis based on randomized controlled trials. Surg Endosc (2013) 1.01
Enzymatic basis for N-glycan sialylation: structure of rat α2,6-sialyltransferase (ST6GAL1) reveals conserved and unique features for glycan sialylation. J Biol Chem (2013) 1.01
Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD mice. J Autoimmun (2009) 1.00
[Longitudinal investigation and experimental studies on thelaziasis and the intermediate host of Thelazia callipaeda in Guanghua county of Hubei province]. Zhonghua Liu Xing Bing Xue Za Zhi (2003) 1.00
The adenosine analog tubercidin inhibits glycolysis in Trypanosoma brucei as revealed by an RNA interference library. J Biol Chem (2003) 0.99
Proteomic identification of glycosylphosphatidylinositol anchor-dependent membrane proteins elevated in breast carcinoma. J Biol Chem (2012) 0.99
Overexpression of osteopontin induces angiogenesis of endothelial progenitor cells via the avβ3/PI3K/AKT/eNOS/NO signaling pathway in glioma cells. Eur J Cell Biol (2011) 0.99
Effects of eugenol on Na+ currents in rat dorsal root ganglion neurons. Brain Res (2008) 0.99
Parabiosis in mice: a detailed protocol. J Vis Exp (2013) 0.98
Matrix metalloproteinase-2 and tissue inhibitor of metallo-proteinase-2 in colorectal carcinoma invasion and metastasis. World J Gastroenterol (2005) 0.98
Regulation of glycan structures in murine embryonic stem cells: combined transcript profiling of glycan-related genes and glycan structural analysis. J Biol Chem (2012) 0.97
Expression pattern of osteopontin splice variants and its functions on cell apoptosis and invasion in glioma cells. Neuro Oncol (2010) 0.97
Induction of cell cycle arrest and apoptosis in human nasopharyngeal carcinoma cells by ZD6474, an inhibitor of VEGFR tyrosine kinase with additional activity against EGFR tyrosine kinase. Int J Cancer (2007) 0.97
Hexosamine flux, the O-GlcNAc modification, and the development of insulin resistance in adipocytes. Mol Cell Endocrinol (2009) 0.96
Minicircle-IFNgamma induces antiproliferative and antitumoral effects in human nasopharyngeal carcinoma. Clin Cancer Res (2006) 0.96
Crystal structure of the YjeE protein from Haemophilus influenzae: a putative Atpase involved in cell wall synthesis. Proteins (2002) 0.96
Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion. J Ethnopharmacol (2012) 0.95
Signal transduction pathway for the substance P-induced inhibition of rat Kir3 (GIRK) channel. J Physiol (2005) 0.95
Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells. PLoS One (2012) 0.95
Genome sequence and transcriptome analysis of the radioresistant bacterium Deinococcus gobiensis: insights into the extreme environmental adaptations. PLoS One (2012) 0.95