Published in Eur J Pharm Biopharm on February 18, 2012
Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies. Nat Rev Drug Discov (2014) 2.20
Nanolayer encapsulation of insulin-chitosan complexes improves efficiency of oral insulin delivery. Int J Nanomedicine (2014) 0.86
Liposomes containing bile salts as novel ocular delivery systems for tacrolimus (FK506): in vitro characterization and improved corneal permeation. Int J Nanomedicine (2013) 0.86
Nanoemulsions coated with alginate/chitosan as oral insulin delivery systems: preparation, characterization, and hypoglycemic effect in rats. Int J Nanomedicine (2012) 0.81
Novel nanoliposomal delivery system for polydatin: preparation, characterization, and in vivo evaluation. Drug Des Devel Ther (2015) 0.78
Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine. Int J Nanomedicine (2015) 0.76
Niosomal carriers enhance oral bioavailability of carvedilol: effects of bile salt-enriched vesicles and carrier surface charge. Int J Nanomedicine (2015) 0.76
Enhanced hypoglycemic effect of biotin-modified liposomes loading insulin: effect of formulation variables, intracellular trafficking, and cytotoxicity. Nanoscale Res Lett (2014) 0.76
Preparation, pharmacokinetics and biodistribution of baicalin-loaded liposomes. Int J Nanomedicine (2014) 0.76
Liposomes coated with N-trimethyl chitosan to improve the absorption of harmine in vivo and in vitro. Int J Nanomedicine (2016) 0.76
A New Type of Liquid Silymarin Proliposome Containing Bile Salts: Its Preparation and Improved Hepatoprotective Effects. PLoS One (2015) 0.75
The influence of bile salt on the chemotherapeutic response of docetaxel-loaded thermosensitive nanomicelles. Int J Nanomedicine (2014) 0.75
Liposomal delivery systems for intestinal lymphatic drug transport. Biomater Res (2016) 0.75
Enhanced oral bioavailability of silymarin using liposomes containing a bile salt: preparation by supercritical fluid technology and evaluation in vitro and in vivo. Int J Nanomedicine (2015) 0.75
Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med (2011) 13.18
Assemblathon 1: a competitive assessment of de novo short read assembly methods. Genome Res (2011) 8.38
Predicting overweight and obesity in adulthood from body mass index values in childhood and adolescence. Am J Clin Nutr (2002) 6.19
Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation. J Med Chem (2005) 6.13
Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature (2002) 5.61
Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature (2007) 5.54
The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease. Nat Immunol (2007) 5.33
Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature (2005) 4.88
The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science (2011) 4.76
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35
PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nat Neurosci (2010) 4.28
Maize inbreds exhibit high levels of copy number variation (CNV) and presence/absence variation (PAV) in genome content. PLoS Genet (2009) 3.88
The Forkhead transcription factor Hcm1 regulates chromosome segregation genes and fills the S-phase gap in the transcriptional circuitry of the cell cycle. Genes Dev (2006) 3.58
Draft genome sequence of pigeonpea (Cajanus cajan), an orphan legume crop of resource-poor farmers. Nat Biotechnol (2011) 3.51
Functional nucleic acid sensors. Chem Rev (2009) 3.32
Control and characterization of individual grains and grain boundaries in graphene grown by chemical vapour deposition. Nat Mater (2011) 3.23
Treatment of pressure ulcers: a systematic review. JAMA (2008) 2.96
A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nat Genet (2011) 2.85
A colorimetric lead biosensor using DNAzyme-directed assembly of gold nanoparticles. J Am Chem Soc (2003) 2.77
R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis. Dev Cell (2004) 2.73
Comparative and functional genomic analyses of the pathogenicity of phytopathogen Xanthomonas campestris pv. campestris. Genome Res (2005) 2.65
Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type. Nat Nanotechnol (2007) 2.57
A vast repertoire of Dscam binding specificities arises from modular interactions of variable Ig domains. Cell (2007) 2.50
The effect of computerized physician order entry with clinical decision support on the rates of adverse drug events: a systematic review. J Gen Intern Med (2008) 2.46
Fast colorimetric sensing of adenosine and cocaine based on a general sensor design involving aptamers and nanoparticles. Angew Chem Int Ed Engl (2005) 2.45
Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish. Genes Dev (2005) 2.44
From neural development to cognition: unexpected roles for chromatin. Nat Rev Genet (2013) 2.42
TOS9 regulates white-opaque switching in Candida albicans. Eukaryot Cell (2006) 2.42
Inhibition of tumor necrosis factor-alpha reduces atherosclerosis in apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol (2004) 2.41
Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. Cell (2006) 2.40
Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. Nat Cell Biol (2010) 2.37
NONCODEv4: exploring the world of long non-coding RNA genes. Nucleic Acids Res (2013) 2.37
Memristor-CMOS hybrid integrated circuits for reconfigurable logic. Nano Lett (2009) 2.35
Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers. J Pathol (2011) 2.27
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nat Genet (2012) 2.26
Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells. Nano Lett (2006) 2.24
MAN1, an integral protein of the inner nuclear membrane, binds Smad2 and Smad3 and antagonizes transforming growth factor-beta signaling. Hum Mol Genet (2004) 2.10
The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implications for clinical testing. Clin Cancer Res (2011) 2.09
Act1, a U-box E3 ubiquitin ligase for IL-17 signaling. Sci Signal (2009) 2.05
Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy. Diabetes (2011) 2.03
Levels of prenatal mercury exposure and their relationships to neonatal anthropometry in Wujiang City, China. Environ Pollut (2013) 2.01
The nature of the fourth bond in the ground state of C2: the quadruple bond conundrum. Chemistry (2014) 1.97
Using personal glucose meters and functional DNA sensors to quantify a variety of analytical targets. Nat Chem (2011) 1.93
Gibberellin mobilizes distinct DELLA-dependent transcriptomes to regulate seed germination and floral development in Arabidopsis. Plant Physiol (2006) 1.91
Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction. Nat Biotechnol (2011) 1.91
Oral drug therapy for multiple neglected tropical diseases: a systematic review. JAMA (2007) 1.88
Expression of lymphocytes and lymphocyte subsets in patients with severe acute respiratory syndrome. Clin Infect Dis (2003) 1.84
Systematic review of HIV transmission between heterosexual serodiscordant couples where the HIV-positive partner is fully suppressed on antiretroviral therapy. PLoS One (2013) 1.79
MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation. Proc Natl Acad Sci U S A (2011) 1.77
Time-dependent, protein-directed growth of gold nanoparticles within a single crystal of lysozyme. Nat Nanotechnol (2011) 1.77
Multiple roles of chemokine (C-C motif) ligand 2 in promoting prostate cancer growth. J Natl Cancer Inst (2010) 1.74
Up-regulation of miR-21 mediates resistance to trastuzumab therapy for breast cancer. J Biol Chem (2011) 1.73
Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/BL6 mouse model. Proc Natl Acad Sci U S A (2012) 1.71
Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis. Clin Dev Immunol (2012) 1.70
A new look at state-space models for neural data. J Comput Neurosci (2009) 1.69
Gene expression in relation to exhaled nitric oxide identifies novel asthma phenotypes with unique biomolecular pathways. Am J Respir Crit Care Med (2014) 1.69
Rationally tuning the reduction potential of a single cupredoxin beyond the natural range. Nature (2009) 1.68
Mentoring. Linking student interests to science curricula. Science (2007) 1.68
Agonistic monoclonal antibodies potentiate tumorigenic and invasive activities of splicing variant of the RON receptor tyrosine kinase. Cancer Biol Ther (2006) 1.67
The critical role of epithelial-derived Act1 in IL-17- and IL-25-mediated pulmonary inflammation. J Immunol (2009) 1.67
Dscam2 mediates axonal tiling in the Drosophila visual system. Nature (2007) 1.66
DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function. Hum Mol Genet (2007) 1.65
Validation of the simplified criteria for diagnosis of autoimmune hepatitis in Chinese patients. J Hepatol (2010) 1.63
Dissecting metal ion-dependent folding and catalysis of a single DNAzyme. Nat Chem Biol (2007) 1.63
Quadruple bonding in C2 and analogous eight-valence electron species. Nat Chem (2012) 1.62
ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas. Gynecol Oncol (2013) 1.61
Characterization of a sub-family of Arabidopsis genes with the SPX domain reveals their diverse functions in plant tolerance to phosphorus starvation. Plant J (2008) 1.60
Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: results from the Malaysia-Singapore ALL Study Group. Leuk Res (2009) 1.60
Preparation of aptamer-linked gold nanoparticle purple aggregates for colorimetric sensing of analytes. Nat Protoc (2006) 1.60
Rational design of a structural and functional nitric oxide reductase. Nature (2009) 1.60
Inhibition of interleukin-6 with CNTO328, an anti-interleukin-6 monoclonal antibody, inhibits conversion of androgen-dependent prostate cancer to an androgen-independent phenotype in orchiectomized mice. Cancer Res (2006) 1.59
The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development. Development (2008) 1.59
PD-1 upregulation is associated with HBV-specific T cell dysfunction in chronic hepatitis B patients. Mol Immunol (2007) 1.58
Bone morphogenetic protein-6 promotes osteoblastic prostate cancer bone metastases through a dual mechanism. Cancer Res (2005) 1.56
A catalytic beacon sensor for uranium with parts-per-trillion sensitivity and millionfold selectivity. Proc Natl Acad Sci U S A (2007) 1.56
Unique autonomic profile of the pulmonary veins and posterior left atrium. J Am Coll Cardiol (2007) 1.56
Soluble receptor activator of nuclear factor kappaB Fc diminishes prostate cancer progression in bone. Cancer Res (2003) 1.55
Meta-analysis of human lung cancer microRNA expression profiling studies comparing cancer tissues with normal tissues. J Exp Clin Cancer Res (2012) 1.55
Vapor-phase self-assembled monolayer for improved mold release in nanoimprint lithography. Langmuir (2005) 1.55
Antimicrobial susceptibility testing using high surface-to-volume ratio microchannels. Anal Chem (2010) 1.54
Accelerated color change of gold nanoparticles assembled by DNAzymes for simple and fast colorimetric Pb2+ detection. J Am Chem Soc (2004) 1.53
A modular microfluidic architecture for integrated biochemical analysis. Proc Natl Acad Sci U S A (2005) 1.52
An efficient algorithm for energy gradients and orbital optimization in valence bond theory. J Comput Chem (2009) 1.52
Circuit fabrication at 17 nm half-pitch by nanoimprint lithography. Nano Lett (2006) 1.51
Reversible cell-specific drug delivery with aptamer-functionalized liposomes. Angew Chem Int Ed Engl (2009) 1.50
Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population. Nat Genet (2012) 1.49
The Min oscillator uses MinD-dependent conformational changes in MinE to spatially regulate cytokinesis. Cell (2011) 1.49
Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease. J Am Soc Nephrol (2013) 1.49
A double S shape provides the structural basis for the extraordinary binding specificity of Dscam isoforms. Cell (2008) 1.48
Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NFkappaB activation pathways bifurcate at IL-1 receptor-associated kinase modification. J Biol Chem (2006) 1.48
Safety and viability of microencapsulated human islets transplanted into diabetic humans. Diabetes Care (2009) 1.48
Surgical safety checklist: implementation in an ambulatory surgical facility. Can J Anaesth (2013) 1.48
Levels of vasoactive intestinal peptide, cholecystokinin and calcitonin gene-related peptide in plasma and jejunum of rats following traumatic brain injury and underlying significance in gastrointestinal dysfunction. World J Gastroenterol (2004) 1.48
Platinum sensitivity-related germline polymorphism discovered via a cell-based approach and analysis of its association with outcome in ovarian cancer patients. Clin Cancer Res (2011) 1.47
Allicin, a major component of garlic, inhibits apoptosis in vital organs in rats with trauma/hemorrhagic shock. Crit Care Med (2008) 1.47
Competencies: a cure for pre-med curriculum. Science (2011) 1.47
Quantitative analysis of vascular endothelial growth factor, microvascular density and their clinicopathologic features in human hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int (2005) 1.47
Sarcophaga (Hoa)flexuosa Ho (Diptera: Sarcophagidae): association of sexes using morphological and molecular approaches, and a redefinition of Hoa Rohdendorf. Zootaxa (2013) 1.46
Meta-analysis of the relationship between Parkinson disease and melanoma. Neurology (2011) 1.45
Tumour necrosis factor-α and its receptors in the beneficial effects of vagal stimulation after myocardial infarction in rats. Clin Exp Pharmacol Physiol (2011) 1.45