Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy.

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Published in Cell Death Dis on March 01, 2012

Authors

W-Y Shi1, D Xiao, L Wang, L-H Dong, Z-X Yan, Z-X Shen, S-J Chen, Y Chen, W-L Zhao

Author Affiliations

1: State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Shanghai Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Associated clinical trials:

Rituximab, Cyclophosphamide, Vincristine and Prednisone (R-CHOP) Plus Metformin in Diffuse Large-B-cell Lymphoma | NCT03200015

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