Published in Am J Physiol Gastrointest Liver Physiol on March 01, 2012
Cell death and cell death responses in liver disease: mechanisms and clinical relevance. Gastroenterology (2014) 1.73
Lactate reduces liver and pancreatic injury in Toll-like receptor- and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity. Gastroenterology (2014) 1.70
Inflammasome activation and function in liver disease. Nat Rev Gastroenterol Hepatol (2015) 1.13
Purinergic receptor antagonist A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation. Toxicol Sci (2012) 1.05
Sterile inflammation in the liver and pancreas. J Gastroenterol Hepatol (2013) 0.89
Therapeutic strategies in inflammasome mediated diseases of the liver. J Hepatol (2012) 0.85
Promising Therapy Candidates for Liver Fibrosis. Front Physiol (2016) 0.85
Altered responsiveness to extracellular ATP enhances acetaminophen hepatotoxicity. Cell Commun Signal (2013) 0.84
The sterile inflammation in the exacerbation of HBV-associated liver injury. Mediators Inflamm (2015) 0.83
Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice. J Hepatol (2015) 0.83
Purinergic signalling in the liver in health and disease. Purinergic Signal (2013) 0.83
Pathological roles of purinergic signaling in the liver. J Hepatol (2012) 0.82
Increased plasma levels of microparticles expressing CD39 and CD133 in acute liver injury. Transplantation (2013) 0.80
P2X7 receptor inhibition protects against ischemic acute kidney injury in mice. Am J Physiol Cell Physiol (2015) 0.79
The inflammasome and danger molecule signaling: at the crossroads of inflammation and pathogen persistence in the oral cavity. Periodontol 2000 (2015) 0.78
Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses. Food Chem Toxicol (2015) 0.78
Application of IL-36 receptor antagonist weakens CCL20 expression and impairs recovery in the late phase of murine acetaminophen-induced liver injury. Sci Rep (2015) 0.77
Chitohexaose protects against acetaminophen-induced hepatotoxicity in mice. Cell Death Dis (2016) 0.77
Xenobiotic and Endobiotic Mediated Interactions Between the Cytochrome P450 System and the Inflammatory Response in the Liver. Adv Pharmacol (2015) 0.76
Lipoapoptosis induced by saturated free fatty acids stimulates monocyte migration: a novel role for Pannexin1 in liver cells. Purinergic Signal (2015) 0.76
P2X receptors regulate adenosine diphosphate release from hepatic cells. Purinergic Signal (2014) 0.76
Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity. Pharmacol Res (2016) 0.76
Sterile inflammation in acute liver injury: myth or mystery? Expert Rev Gastroenterol Hepatol (2015) 0.75
STAT3, a Key Parameter of Cytokine-Driven Tissue Protection during Sterile Inflammation - the Case of Experimental Acetaminophen (Paracetamol)-Induced Liver Damage. Front Immunol (2016) 0.75
Role of the Inflammasome in Acetaminophen-induced Liver Injury and Acute Liver Failure. J Hepatol (2016) 0.75
Purinergic receptor X7 mediates leptin induced GLUT4 function in stellate cells in nonalcoholic steatohepatitis. Biochim Biophys Acta (2015) 0.75
Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity. J Clin Transl Res (2015) 0.75
Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology. J Clin Transl Res (2017) 0.75
Purinergic Signalling: Therapeutic Developments. Front Pharmacol (2017) 0.75
The Impact of Sterile Inflammation in Acute Liver Injury. J Clin Transl Res (2017) 0.75
Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology (2005) 10.66
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature (1998) 8.93
Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest (2005) 8.58
Intravascular danger signals guide neutrophils to sites of sterile inflammation. Science (2010) 5.84
Altered cytokine production in mice lacking P2X(7) receptors. J Biol Chem (2001) 5.74
Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. J Clin Invest (2009) 5.09
Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation. Nat Med (1999) 4.44
Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proc Natl Acad Sci U S A (2009) 3.99
Neutrophil depletion protects against murine acetaminophen hepatotoxicity. Hepatology (2006) 3.70
The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance. Purinergic Signal (2006) 3.52
Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release. Am J Physiol Cell Physiol (2003) 2.61
Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity. Gastroenterology (2004) 2.26
Purinergic signaling and vascular cell proliferation and death. Arterioscler Thromb Vasc Biol (2002) 1.97
Sensing pathogens and danger signals by the inflammasome. Curr Opin Immunol (2009) 1.91
Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis. Am J Respir Crit Care Med (2010) 1.84
Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species. Hepatology (1999) 1.68
Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice. Toxicol Appl Pharmacol (1998) 1.63
Cyclophilin A is a damage-associated molecular pattern molecule that mediates acetaminophen-induced liver injury. J Immunol (2011) 1.63
NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor. Immunity (2003) 1.60
Acetaminophen hepatoxicity: what do we know, what don't we know, and what do we do next? Hepatology (2004) 1.51
The role of damage associated molecular pattern molecules in acetaminophen-induced liver injury in mice. Toxicol Lett (2009) 1.42
TLR9 and the NLRP3 inflammasome link acinar cell death with inflammation in acute pancreatitis. Gastroenterology (2011) 1.39
Role of innate immunity in acetaminophen-induced hepatotoxicity. Expert Opin Drug Metab Toxicol (2006) 1.35
Role of inflammation in the mechanism of acetaminophen-induced hepatotoxicity. Expert Opin Drug Metab Toxicol (2005) 1.24
The role of purinergic signaling in the liver and in transplantation: effects of extracellular nucleotides on hepatic graft vascular injury, rejection and metabolism. Front Biosci (2008) 1.24
Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury. Toxicol Appl Pharmacol (2011) 1.21
Opposite roles of neutrophils and macrophages in the pathogenesis of acetaminophen-induced acute liver injury. Eur J Immunol (2006) 1.20
TLR9 and the recognition of self and non-self nucleic acids. Ann N Y Acad Sci (2006) 1.18
Regulated catalysis of extracellular nucleotides by vascular CD39/ENTPD1 is required for liver regeneration. Gastroenterology (2008) 1.15
NAD+ and ATP released from injured cells induce P2X7-dependent shedding of CD62L and externalization of phosphatidylserine by murine T cells. J Immunol (2009) 1.09
Role of macrophages and inflammatory mediators in chemically induced toxicity. Toxicology (2001) 1.01
Cytokine-induced inflammatory liver injuries. Curr Mol Med (2003) 0.93
Temporal variation in hepatotoxicity and metabolism of acetaminophen in mice. Toxicology (1998) 0.89
Isolation of mouse intrahepatic lymphocytes. Curr Protoc Immunol (2001) 0.86
Expression of P2X receptors on immune cells in the rat liver during postnatal development. Histochem Cell Biol (2006) 0.84
Toxicology. Protecting liver from painkiller's lethal dose. Science (2002) 0.83
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature (2012) 10.74
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med (2007) 10.00
Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science (2006) 6.55
Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. J Clin Invest (2009) 5.09
Purinergic signaling during inflammation. N Engl J Med (2012) 4.08
Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors. J Exp Med (2003) 3.71
Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med (2004) 3.58
Activation-induced cell death of hepatic stellate cells by the innate immune system. Gastroenterology (2006) 3.41
CD39 is the dominant Langerhans cell-associated ecto-NTPDase: modulatory roles in inflammation and immune responsiveness. Nat Med (2002) 3.18
Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism. Blood (2004) 2.80
Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes. Gastroenterology (2004) 2.54
Phosphatidylserine receptor is required for clearance of apoptotic cells. Science (2003) 2.38
Dysfunctional CD39(POS) regulatory T cells and aberrant control of T-helper type 17 cells in autoimmune hepatitis. Hepatology (2014) 2.29
ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function. Circ Res (2006) 2.23
Sterile inflammation in the liver. Gastroenterology (2012) 2.17
CD39/ectonucleoside triphosphate diphosphohydrolase 1 provides myocardial protection during cardiac ischemia/reperfusion injury. Circulation (2007) 2.09
Coagulopathy in cirrhosis - the role of the platelet in hemostasis. J Hepatol (2013) 2.01
Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injury. FASEB J (2007) 1.84
Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression. Immunity (2012) 1.82
Thrombotic microangiopathic glomerulopathy in human decay accelerating factor-transgenic swine-to-baboon kidney xenografts. J Am Soc Nephrol (2005) 1.79
Central role of Sp1-regulated CD39 in hypoxia/ischemia protection. Blood (2008) 1.79
From the Cover: CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease. Proc Natl Acad Sci U S A (2009) 1.75
The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cells. Cancer Res (2008) 1.71
CD39/ENTPD1 expression by CD4+Foxp3+ regulatory T cells promotes hepatic metastatic tumor growth in mice. Gastroenterology (2010) 1.69
Retracted Requirement of voltage-gated calcium channel beta4 subunit for T lymphocyte functions. Science (2005) 1.68
CD39 and control of cellular immune responses. Purinergic Signal (2007) 1.68
Promotion of liver regeneration by natural killer cells in a murine model is dependent on extracellular adenosine triphosphate phosphohydrolysis. Hepatology (2013) 1.66
Salutary effects of adiponectin on colon cancer: in vivo and in vitro studies in mice. Gut (2012) 1.65
Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation. J Clin Invest (2004) 1.61
Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage. Proc Natl Acad Sci U S A (2010) 1.60
Sublethal heat treatment promotes epithelial-mesenchymal transition and enhances the malignant potential of hepatocellular carcinoma. Hepatology (2013) 1.59
alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months. Transplantation (2005) 1.56
Extracellular UDP enhances P2X-mediated bladder smooth muscle contractility via P2Y(6) activation of the phospholipase C/inositol trisphosphate pathway. FASEB J (2013) 1.51
IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39. Nat Immunol (2013) 1.50
Carbon monoxide orchestrates a protective response through PPARgamma. Immunity (2006) 1.47
Ectonucleotidases as regulators of purinergic signaling in thrombosis, inflammation, and immunity. Adv Pharmacol (2011) 1.45
Adenosine inhibits cytosolic calcium signals and chemotaxis in hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol (2006) 1.42
HGF and SDF-1-mediated mobilization of CD133+ BMSC for hepatic regeneration following extensive liver resection. Liver Int (2013) 1.42
Extracellular nucleotide signaling in adult neural stem cells: synergism with growth factor-mediated cellular proliferation. Development (2006) 1.41
Modulation of endothelial cell migration by extracellular nucleotides: involvement of focal adhesion kinase and phosphatidylinositol 3-kinase-mediated pathways. Thromb Haemost (2005) 1.38
Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-8. Biochemistry (2004) 1.36
Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboons. Am J Pathol (2008) 1.36
The ecto-nucleoside triphosphate diphosphohydrolase NTPDase2/CD39L1 is expressed in a novel functional compartment within the liver. Hepatology (2002) 1.34
Vascular CD39/ENTPD1 directly promotes tumor cell growth by scavenging extracellular adenosine triphosphate. Neoplasia (2011) 1.34
Disordered purinergic signaling inhibits pathological angiogenesis in cd39/Entpd1-null mice. Am J Pathol (2007) 1.32
Expression of the ecto-ATPase NTPDase2 in the germinal zones of the developing and adult rat brain. Eur J Neurosci (2003) 1.31
SP1-dependent induction of CD39 facilitates hepatic ischemic preconditioning. J Immunol (2010) 1.31
Ecto-nucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1/CD39) regulates neutrophil chemotaxis by hydrolyzing released ATP to adenosine. J Biol Chem (2008) 1.31
Beneficial effects of CD39/ecto-nucleoside triphosphate diphosphohydrolase-1 in murine intestinal ischemia-reperfusion injury. Thromb Haemost (2004) 1.31
Natural killer T cell dysfunction in CD39-null mice protects against concanavalin A-induced hepatitis. Hepatology (2008) 1.27
Predictors of endoscopic inflammation in patients with ulcerative colitis in clinical remission. Inflamm Bowel Dis (2013) 1.27
Expression of P2Y nucleotide receptors and ectonucleotidases in quiescent and activated rat hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol (2004) 1.27
Ecto-nucleotidases of the CD39/NTPDase family modulate platelet activation and thrombus formation: Potential as therapeutic targets. Blood Cells Mol Dis (2006) 1.24
The role of purinergic signaling in the liver and in transplantation: effects of extracellular nucleotides on hepatic graft vascular injury, rejection and metabolism. Front Biosci (2008) 1.24
Modulation of cell adhesion and motility in the immune system by Myo1f. Science (2006) 1.22
Upregulation of CD39/NTPDases and P2 receptors in human pancreatic disease. Am J Physiol Gastrointest Liver Physiol (2006) 1.19
Deletion of cd39/entpd1 results in hepatic insulin resistance. Diabetes (2008) 1.18
Purinergic signaling during inflammation. N Engl J Med (2013) 1.17
Clinical lung xenotransplantation--what donor genetic modifications may be necessary? Xenotransplantation (2012) 1.16
Sterile inflammatory response in acute pancreatitis. Pancreas (2012) 1.15
Regulated catalysis of extracellular nucleotides by vascular CD39/ENTPD1 is required for liver regeneration. Gastroenterology (2008) 1.15
Expression of NTPDase1 and NTPDase2 in murine kidney: relevance to regulation of P2 receptor signaling. Am J Physiol Renal Physiol (2005) 1.14
Adenosine deamination sustains dendritic cell activation in inflammation. J Immunol (2007) 1.13
Association of the ecto-ATPase NTPDase2 with glial cells of the peripheral nervous system. Glia (2004) 1.12
Critical role for the beta regulatory subunits of Cav channels in T lymphocyte function. Proc Natl Acad Sci U S A (2006) 1.11
NTPDase1 governs P2X7-dependent functions in murine macrophages. Eur J Immunol (2010) 1.09
CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death. Blood (2011) 1.09
Deletion of CD39 on natural killer cells attenuates hepatic ischemia/reperfusion injury in mice. Hepatology (2010) 1.09
Adenosine induces loss of actin stress fibers and inhibits contraction in hepatic stellate cells via Rho inhibition. Hepatology (2009) 1.09
The ectonucleotidase cd39/ENTPDase1 modulates purinergic-mediated microglial migration. Glia (2008) 1.08
Expression and distribution of ectonucleotidases in mouse urinary bladder. PLoS One (2011) 1.08
Acute vascular rejection of xenografts: roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity. Transplantation (2004) 1.07
Extracellular nucleotides as negative modulators of immunity. Curr Opin Pharmacol (2009) 1.07
Possible effects of microbial ecto-nucleoside triphosphate diphosphohydrolases on host-pathogen interactions. Microbiol Mol Biol Rev (2008) 1.07
Biological functions of ecto-enzymes in regulating extracellular adenosine levels in neoplastic and inflammatory disease states. J Mol Med (Berl) (2013) 1.06
TLR stimulation initiates a CD39-based autoregulatory mechanism that limits macrophage inflammatory responses. Blood (2013) 1.06
Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer. Purinergic Signal (2011) 1.06
RanBPM associates with CD39 and modulates ecto-nucleotidase activity. Biochem J (2006) 1.05
Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response. Proc Natl Acad Sci U S A (2011) 1.04
P2X7 integrates PI3K/AKT and AMPK-PRAS40-mTOR signaling pathways to mediate tumor cell death. PLoS One (2013) 1.03
Role of the ectonucleotidase NTPDase2 in taste bud function. Proc Natl Acad Sci U S A (2013) 1.03
Heme oxygenase-1-generated biliverdin ameliorates experimental murine colitis. Inflamm Bowel Dis (2005) 1.02
The vascular ectonucleotidase ENTPD1 is a novel renoprotective factor in diabetic nephropathy. Diabetes (2007) 1.02
Gaucher disease gene GBA functions in immune regulation. Proc Natl Acad Sci U S A (2012) 1.02
Transgenic swine: expression of human CD39 protects against myocardial injury. J Mol Cell Cardiol (2012) 1.02
CD39 is incorporated into plasma microparticles where it maintains functional properties and impacts endothelial activation. Br J Haematol (2008) 1.00
Disordered pancreatic inflammatory responses and inhibition of fibrosis in CD39-null mice. Gastroenterology (2007) 1.00
Making sense of regulatory T cell suppressive function. Semin Immunol (2011) 1.00
Inhibition of interleukin-17 promotes differentiation of CD25⁻ cells into stable T regulatory cells in patients with autoimmune hepatitis. Gastroenterology (2012) 0.99
GalT-KO pigs: is the cup half empty or half full? Transplantation (2007) 0.99
O-linked glycosylation and functional incompatibility of porcine von Willebrand factor for human platelet GPIb receptors. Xenotransplantation (2005) 0.99
The transgenic expression of human CD39 on murine islets inhibits clotting of human blood. Transplantation (2006) 0.98
Transgenic over expression of ectonucleotide triphosphate diphosphohydrolase-1 protects against murine myocardial ischemic injury. J Mol Cell Cardiol (2011) 0.95
The impact of purinergic signaling on renal ischemia-reperfusion injury. Transplantation (2008) 0.95
Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages. J Immunol (2007) 0.95
Adenosine inhibits chemotaxis and induces hepatocyte-specific genes in bone marrow mesenchymal stem cells. Hepatology (2010) 0.94