Published in Cell on July 01, 1979
Transformation of mouse fibroblasts to methotrexate resistance by a recombinant plasmid expressing a prokaryotic dihydrofolate reductase. Proc Natl Acad Sci U S A (1981) 5.38
Expression of the mouse dihydrofolate reductase complementary deoxyribonucleic acid in simian virus 40 vectors. Mol Cell Biol (1981) 5.00
Comparison of intron-dependent and intron-independent gene expression. Mol Cell Biol (1988) 4.75
Splicing as a requirement for biogenesis of functional 16S mRNA of simian virus 40. Proc Natl Acad Sci U S A (1979) 3.89
A quantitative analysis of intron effects on mammalian gene expression. RNA (2003) 2.80
Expression of simian virus 40-rat preproinsulin recombinants in monkey kidney cells: use of preproinsulin RNA processing signals. Proc Natl Acad Sci U S A (1981) 2.76
A generic intron increases gene expression in transgenic mice. Mol Cell Biol (1991) 2.75
The in vivo kinetics of RNA polymerase II elongation during co-transcriptional splicing. PLoS Biol (2011) 2.58
Structure of a chromosomal gene for human interferon beta. Proc Natl Acad Sci U S A (1981) 2.50
Nuclear history of a pre-mRNA determines the translational activity of cytoplasmic mRNA. EMBO J (1998) 2.24
Simian virus 40 late transcripts lacking excisable intervening sequences are defective in both stability in the nucleus and transport to the cytoplasm. J Virol (1989) 2.10
Replication and expression of thymidine kinase and human globin genes microinjected into mouse fibroblasts. Proc Natl Acad Sci U S A (1980) 2.10
Modification of the Creator recombination system for proteomics applications--improved expression by addition of splice sites. BMC Biotechnol (2006) 2.01
Splicing promotes rapid and efficient mRNA export in mammalian cells. Proc Natl Acad Sci U S A (2008) 1.98
Unspliced functional late 19S mRNAs containing intervening sequences are produced by a late leader mutant of simian virus 40. Proc Natl Acad Sci U S A (1981) 1.71
Sequences within the last intron function in RNA 3'-end formation in cultured cells. Mol Cell Biol (1993) 1.67
Expression of complete chicken thymidine kinase gene inserted in a retrovirus vector. Mol Cell Biol (1984) 1.58
The function of introns. Front Genet (2012) 1.42
Introns are inconsequential to efficient formation of cellular thymidine kinase mRNA in mouse L cells. Mol Cell Biol (1987) 1.41
Altered utilization of splice sites and 5' termini in late RNAs produced by leader region mutants of simian virus 40. J Virol (1982) 1.40
Construction and expression in vivo of an internally deleted mouse alpha-fetoprotein gene: presence of a transcribed Alu-like repeat within the first intervening sequence. Nucleic Acids Res (1982) 1.40
Recovery of recombinant bacterial plasmids from E. coli transformed with DNA from microinjected mouse cells. Nucleic Acids Res (1981) 1.39
Lentiviral vectors in gene therapy: their current status and future potential. Arch Immunol Ther Exp (Warsz) (2010) 1.29
A cis-acting repressive sequence that overlaps the Rev-responsive element of human immunodeficiency virus type 1 regulates nuclear retention of env mRNAs independently of known splice signals. Proc Natl Acad Sci U S A (1994) 1.26
Synthesis of predominantly unspliced cytoplasmic RNAs by chimeric herpes simplex virus type 1 thymidine kinase-human beta-globin genes. Mol Cell Biol (1985) 1.24
Synthesis of stable unspliced mRNA from an intronless simian virus 40--rat preproinsulin gene recombinant. Proc Natl Acad Sci U S A (1981) 1.18
Introduction and expression of a fetal human globin gene in mouse fibroblasts. Mol Cell Biol (1982) 1.16
Binding of p53 and p105-RB is not sufficient for oncogenic transformation by a hybrid polyomavirus-simian virus 40 large T antigen. J Virol (1990) 1.13
Polyomavirus late pre-mRNA processing: DNA replication-associated changes in leader exon multiplicity suggest a role for leader-to-leader splicing in the early-late switch. J Virol (1990) 1.10
A suboptimal 5' splice site is a cis-acting determinant of nuclear export of polyomavirus late mRNAs. Mol Cell Biol (1996) 1.00
Splicing of the maize Sh1 first intron is essential for enhancement of gene expression, and a T-rich motif increases expression without affecting splicing. Plant Physiol (2002) 0.96
Plant spliceosomal introns: not only cut and paste. Curr Genomics (2008) 0.94
Secondary structures for splice junctions in eukaryotic and viral messenger RNA precursors. Nucleic Acids Res (1980) 0.92
Splice site requirement for the efficient accumulation of polyoma virus late mRNAs. Nucleic Acids Res (1991) 0.91
The sequence and context of the 5' splice site govern the nuclear stability of polyoma virus late RNAs. Nucleic Acids Res (1995) 0.84
Molecular-genetic imaging of cancer. Adv Cancer Res (2014) 0.81
A novel BK virus-based episomal vector for expression of foreign genes in mammalian cells. Nucleic Acids Res (1991) 0.81
Polymorphism rs2239185 in vitamin D receptor gene is associated with severe community-acquired pneumonia of children in Chinese Han population: a case-control study. Eur J Pediatr (2014) 0.76
Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. Proc Natl Acad Sci U S A (1972) 83.88
Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell (1983) 17.87
Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation. Proc Natl Acad Sci U S A (1984) 17.51
Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science (1996) 16.04
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature (2001) 14.24
Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants. Proc Natl Acad Sci U S A (1977) 13.87
EK2 derivatives of bacteriophage lambda useful in the cloning of DNA from higher organisms: the lambdagtWES system. Science (1977) 13.24
Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell (1995) 12.39
Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. Proc Natl Acad Sci U S A (1982) 10.50
The sequence of the chromosomal mouse beta-globin major gene: homologies in capping, splicing and poly(A) sites. Cell (1978) 9.73
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci U S A (2000) 9.67
Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene. Proc Natl Acad Sci U S A (1979) 9.31
Structure of the human immunoglobulin mu locus: characterization of embryonic and rearranged J and D genes. Cell (1981) 9.09
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell (1991) 8.99
Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments. Cell (1980) 8.77
The human c-myc oncogene: structural consequences of translocation into the IgH locus in Burkitt lymphoma. Cell (1983) 8.54
Metallothionein. Annu Rev Biochem (1986) 8.12
The evolution and sequence comparison of two recently diverged mouse chromosomal beta--globin genes. Cell (1979) 8.11
In vitro synthesis of DNA complementary to purified rabbit globin mRNA (RNA-dependent DNA polymerase-reticulocyte-hemoglobin-density gradient centrifugation-oligo(dT) primer). Proc Natl Acad Sci U S A (1972) 7.89
Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell (1996) 7.70
Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Cell (1988) 7.50
The death domain kinase RIP mediates the TNF-induced NF-kappaB signal. Immunity (1998) 7.35
The nucleotide sequence of a 5.5-kilobase DNA segment containing the mouse kappa immunoglobulin J and C region genes. J Biol Chem (1981) 7.26
Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes. Cell (1984) 6.71
A kappa-immunoglobulin gene is formed by site-specific recombination without further somatic mutation. Nature (1979) 6.54
Protein synthesis directed by encephalomyocarditis virus RNA: properties of a transfer RNA-dependent system. Proc Natl Acad Sci U S A (1971) 6.52
c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities. Cell (1988) 6.24
Translocations among antibody genes in human cancer. Science (1983) 6.20
The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor. Proc Natl Acad Sci U S A (1978) 6.20
The complete sequence of a chromosomal mouse alpha--globin gene reveals elements conserved throughout vertebrate evolution. Cell (1979) 6.05
RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell (1995) 5.73
Chromatin structure and protein binding in the putative regulatory region of the c-myc gene in Burkitt lymphoma. Cell (1984) 5.61
Protein synthesis directed by encephalomyocarditis virus RNA. II. The in vitro synthesis of high molecular weight proteins and elements of the viral capsid. Biochem Biophys Res Commun (1971) 5.60
Organization and complete sequence of identical embryonic and plasmacytoma kappa V-region genes. J Biol Chem (1980) 5.59
Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo. Cell (1987) 5.57
Purification and properties of biologically active messenger RNA for a myeloma light chain. Proc Natl Acad Sci U S A (1972) 5.28
Cloning specific segments of the mammalian genome: bacteriophage lambda containing mouse globin and surrounding gene sequences. Proc Natl Acad Sci U S A (1977) 5.28
RNA codewords and protein synthesis, VII. On the general nature of the RNA code. Proc Natl Acad Sci U S A (1965) 5.17
Antibody diversity. Science (1978) 5.06
The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus. Cell (1990) 4.91
The arrangement and rearrangement of antibody genes. Nature (1979) 4.88
Clustered arrangement of immunoglobulin lambda constant region genes in man. Nature (1981) 4.87
Splicing and the formation of stable RNA. Cell (1979) 4.71
Functional role for c-myc in mitogenic response to platelet-derived growth factor. Nature (1984) 4.56
Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages. Proc Natl Acad Sci U S A (1999) 4.49
The kit ligand: a cell surface molecule altered in steel mutant fibroblasts. Cell (1990) 4.43
Butyric acid, a potent inducer of erythroid differentiation in cultured erythroleukemic cells. Cell (1975) 4.32
Processed genes: a dispersed human immunoglobulin gene bearing evidence of RNA-type processing. Nature (1982) 4.14
Human immunoglobulin heavy chain genes map to a region of translocations in malignant B lymphocytes. Science (1982) 4.05
Intervening sequence of DNA identified in the structural portion of a mouse beta-globin gene. Proc Natl Acad Sci U S A (1978) 4.02
Globin messenger-RNA induction during erythroid differentiation of cultured leukemia cells. Proc Natl Acad Sci U S A (1972) 4.02
Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes Dev (1994) 3.97
Daptomycin-resistant, methicillin-resistant Staphylococcus aureus bacteremia. Clin Infect Dis (2005) 3.90
Multiple related immunoglobulin variable-region genes identified by cloning and sequence analysis. Proc Natl Acad Sci U S A (1978) 3.88
Purification and cloning of a mouse ribosomal gene fragment in coliphage lambda. Gene (1977) 3.79
An eosinophil-dependent mechanism for the antitumor effect of interleukin-4. Science (1992) 3.78
Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proc Natl Acad Sci U S A (1996) 3.78
Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells. Proc Natl Acad Sci U S A (1981) 3.73
Consequences of widespread deregulation of the c-myc gene in transgenic mice: multiple neoplasms and normal development. Cell (1986) 3.70
The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts. Blood (1998) 3.69
Activation and somatic mutation of the translocated c-myc gene in burkitt lymphoma cells. Cell (1984) 3.66
Human immunoglobulin kappa light-chain genes are deleted or rearranged in lambda-producing B cells. Nature (1981) 3.64
Antibodies to human c-myc oncogene product: evidence of an evolutionarily conserved protein induced during cell proliferation. Science (1984) 3.63
Translation of artemether-lumefantrine treatment policy into paediatric clinical practice: an early experience from Kenya. Trop Med Int Health (2008) 3.62
Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant. Cell (1991) 3.60
Murine interleukin-4 displays potent anti-tumor activity in vivo. Cell (1989) 3.43
High capacity gel preparative electrophoresis for purification of fragments of genomic DNA. Anal Biochem (1978) 3.42
Evolution of human immunoglobulin kappa J region genes. J Biol Chem (1982) 3.41
Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells. Mol Cell Biol (1992) 3.41
Initiation of protein synthesis II. A convenient assay for the ribosome-dependent synthesis of N-formyl-C14-methionylpuromycin. Biochem Biophys Res Commun (1966) 3.39
Transcription of mouse kappa chain genes: implications for allelic exclusion. Proc Natl Acad Sci U S A (1980) 3.38
Expression of the hepatitis B virus surface antigen gene in cell culture by using a simian virus 40 vector. Proc Natl Acad Sci U S A (1981) 3.38
Molecular cloning of DNA fragments produced by restriction endonucleases Sa1I and BamI. Proc Natl Acad Sci U S A (1976) 3.32
Nuclear localization and DNA binding properties of a protein expressed by human c-myc oncogene. Science (1984) 3.24
Origin of the human L1 elements: proposed progenitor genes deduced from a consensus DNA sequence. Genomics (1987) 3.21
Unusual alpha-globin-like gene that has cleanly lost both globin intervening sequences. Proc Natl Acad Sci U S A (1980) 3.19
Regulation of a metallothionein-growth hormone hybrid gene in bovine papilloma virus. Proc Natl Acad Sci U S A (1983) 3.06
An inherited limb deformity created by insertional mutagenesis in a transgenic mouse. Nature (1985) 3.05
Differentiation in erythroleukemic cells and their somatic hybrids. Proc Natl Acad Sci U S A (1975) 3.05
Human immunoglobulin D segments encoded in tandem multigenic families. Nature (1981) 2.99
Isolation and characterization of a major tandem repeat family from the human X chromosome. Nucleic Acids Res (1983) 2.94
Casein kinase II alpha transgene-induced murine lymphoma: relation to theileriosis in cattle. Science (1995) 2.92
Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins. J Clin Invest (1983) 2.91
Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development (1998) 2.90
IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice. Cell (1990) 2.86
RNA codewords and protein synthesis, 8. Nucleotide sequences of synonym codons for arginine, valine, cysteine, and alanine. Proc Natl Acad Sci U S A (1965) 2.86
Parental-specific methylation of an imprinted transgene is established during gametogenesis and progressively changes during embryogenesis. Cell (1991) 2.85
The cytomegalovirus enhancer: a pan-active control element in transgenic mice. Mol Cell Biol (1990) 2.80
Effects of revised diagnostic recommendations on malaria treatment practices across age groups in Kenya. Trop Med Int Health (2008) 2.79
Parental legacy determines methylation and expression of an autosomal transgene: a molecular mechanism for parental imprinting. Cell (1987) 2.78
Variable amplification of immunoglobulin lambda light-chain genes in human populations. Nature (1983) 2.75
Duplicated heavy metal control sequences of the mouse metallothionein-I gene. Proc Natl Acad Sci U S A (1984) 2.69
The IP-10 chemokine binds to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation. J Exp Med (1995) 2.68
Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. J Exp Med (1997) 2.68
Regulation in vivo of a cloned mammalian gene: cadmium induces the transcription of a mouse metallothionein gene in SV40 vectors. J Mol Appl Genet (1982) 2.61
Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. Nat Med (1996) 2.55
Dispersion of alpha-like globin genes of the mouse to three different chromosomes. Nature (1981) 2.44
Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin mu. Science (1987) 2.44