Published in Heart Rhythm on April 20, 2012
The road to biological pacing. Nat Rev Cardiol (2011) 1.27
Biological pacemaker created by minimally invasive somatic reprogramming in pigs with complete heart block. Sci Transl Med (2014) 1.12
Ca²⁺-dependent phosphorylation of Ca²⁺ cycling proteins generates robust rhythmic local Ca²⁺ releases in cardiac pacemaker cells. Sci Signal (2013) 0.86
Stem cell-based biological pacemakers from proof of principle to therapy: a review. Cytotherapy (2014) 0.86
Pacemaker Created in Human Ventricle by Depressing Inward-Rectifier K(+) Current: A Simulation Study. Biomed Res Int (2016) 0.75
Gene Therapy for Cardiac Arrhythmias. Zhonghua Minguo Xin Zang Xue Hui Za Zhi (2013) 0.75
Biological pacemakers: the oscillatory road ahead. Heart Rhythm (2012) 0.75
Current state of the art for cardiac arrhythmia gene therapy. Pharmacol Ther (2017) 0.75
Induced Pluripotent Stem Cell-Derived Cardiomyocytes Provide In Vivo Biological Pacemaker Function. Circ Arrhythm Electrophysiol (2017) 0.75
Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet (2012) 56.72
Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet (2012) 41.47
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet (2012) 26.95
Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010. Lancet (2012) 11.32
The state of US health, 1990-2010: burden of diseases, injuries, and risk factors. JAMA (2013) 10.43
Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial. Lancet (2012) 9.86
Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens. Circulation (2007) 8.62
A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. Nat Genet (2006) 6.39
Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmia susceptibility in patients with left ventricular dysfunction. Circulation (2007) 5.09
Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice. Circ Res (2010) 4.19
Synchronized whole cell oscillations in mitochondrial metabolism triggered by a local release of reactive oxygen species in cardiac myocytes. J Biol Chem (2003) 3.93
Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells. J Am Coll Cardiol (2012) 3.48
Engraftment, differentiation, and functional benefits of autologous cardiosphere-derived cells in porcine ischemic cardiomyopathy. Circulation (2009) 3.45
Population-based analysis of sudden cardiac death with and without left ventricular systolic dysfunction: two-year findings from the Oregon Sudden Unexpected Death Study. J Am Coll Cardiol (2006) 3.44
Late gadolinium enhancement by cardiovascular magnetic resonance heralds an adverse prognosis in nonischemic cardiomyopathy. J Am Coll Cardiol (2008) 2.99
Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop. Circulation (2010) 2.94
Validation of the cardiosphere method to culture cardiac progenitor cells from myocardial tissue. PLoS One (2009) 2.89
Quantification of diffuse myocardial fibrosis and its association with myocardial dysfunction in congenital heart disease. Circ Cardiovasc Imaging (2010) 2.86
Biological pacemaker created by gene transfer. Nature (2002) 2.83
Role of sarcolemmal K(ATP) channels in cardioprotection against ischemia/reperfusion injury in mice. J Clin Invest (2002) 2.74
Combined cardiac magnetic resonance imaging and C-reactive protein levels identify a cohort at low risk for defibrillator firings and death. Circ Cardiovasc Imaging (2012) 2.62
Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations. Circulation (2009) 2.55
An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Biophys J (2003) 2.52
Antiarrhythmic engineering of skeletal myoblasts for cardiac transplantation. Circ Res (2005) 2.44
Magnetic resonance imaging overestimates ferumoxide-labeled stem cell survival after transplantation in the heart. Circulation (2008) 2.37
Prolonged Tpeak-to-tend interval on the resting ECG is associated with increased risk of sudden cardiac death. Circ Arrhythm Electrophysiol (2011) 2.35
Magnetic targeting enhances engraftment and functional benefit of iron-labeled cardiosphere-derived cells in myocardial infarction. Circ Res (2010) 2.33
Ectopic expression of the sodium-iodide symporter enables imaging of transplanted cardiac stem cells in vivo by single-photon emission computed tomography or positron emission tomography. J Am Coll Cardiol (2008) 2.33
Socioeconomic status and incidence of sudden cardiac arrest. CMAJ (2011) 2.31
Safety and efficacy of allogeneic cell therapy in infarcted rats transplanted with mismatched cardiosphere-derived cells. Circulation (2011) 2.29
Cardiac cell therapy: where we've been, where we are, and where we should be headed. Br Med Bull (2011) 2.26
Proteomic analysis of pharmacological preconditioning: novel protein targets converge to mitochondrial metabolism pathways. Circ Res (2006) 2.20
Noninvasive quantification and optimization of acute cell retention by in vivo positron emission tomography after intramyocardial cardiac-derived stem cell delivery. J Am Coll Cardiol (2009) 2.20
Novel functional properties of Ca(2+) channel beta subunits revealed by their expression in adult rat heart cells. J Physiol (2002) 2.18
Intramyocardial injection of autologous cardiospheres or cardiosphere-derived cells preserves function and minimizes adverse ventricular remodeling in pigs with heart failure post-myocardial infarction. J Am Coll Cardiol (2011) 2.15
Cardioprotection by N-acetylglucosamine linkage to cellular proteins. Circulation (2008) 2.11
Cardiospheres recapitulate a niche-like microenvironment rich in stemness and cell-matrix interactions, rationalizing their enhanced functional potency for myocardial repair. Stem Cells (2010) 2.10
Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression. Mol Cell (2003) 2.09
Mutual functional destruction of HIV-1 Vpu and host TASK-1 channel. Mol Cell (2004) 2.05
Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heart. EMBO Mol Med (2013) 2.04
Assessment and optimization of cell engraftment after transplantation into the heart. Circ Res (2010) 1.90
Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes. Circ Res (2003) 1.89
Dedifferentiation and proliferation of mammalian cardiomyocytes. PLoS One (2010) 1.89
Isolation and expansion of functionally-competent cardiac progenitor cells directly from heart biopsies. J Mol Cell Cardiol (2010) 1.88
Creation of a genetic calcium channel blocker by targeted gem gene transfer in the heart. Circ Res (2004) 1.87
Gadolinium-enhanced magnetic resonance imaging for detection and quantification of fibrosis in human myocardium in vitro. Int J Cardiovasc Imaging (2007) 1.86
Endogenous cardiac stem cells. Prog Cardiovasc Dis (2007) 1.79
Functional role of inward rectifier current in heart probed by Kir2.1 overexpression and dominant-negative suppression. J Clin Invest (2003) 1.78
Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18. Nat Biotechnol (2012) 1.74
Increased left ventricular mass and decreased left ventricular systolic function have independent pathways to ventricular arrhythmogenesis in coronary artery disease. Heart Rhythm (2011) 1.73
Frequency and determinants of implantable cardioverter defibrillator deployment among primary prevention candidates with subsequent sudden cardiac arrest in the community. Circulation (2013) 1.72
Disproportionate enhancement of myocardial contractility by the xanthine oxidase inhibitor oxypurinol in failing rat myocardium. Cardiovasc Res (2003) 1.70
Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart. Circ Res (2002) 1.70
A computational model integrating electrophysiology, contraction, and mitochondrial bioenergetics in the ventricular myocyte. Biophys J (2006) 1.69
Prolonged QRS duration on the resting ECG is associated with sudden death risk in coronary disease, independent of prolonged ventricular repolarization. Heart Rhythm (2011) 1.69
Prevention of atrial fibrillation with omega-3 fatty acids: a meta-analysis of randomised clinical trials. Heart (2011) 1.66
CAPON modulates cardiac repolarization via neuronal nitric oxide synthase signaling in the heart. Proc Natl Acad Sci U S A (2008) 1.66
Physiological levels of reactive oxygen species are required to maintain genomic stability in stem cells. Stem Cells (2010) 1.63
Isoform-specific modulation of voltage-gated Na(+) channels by calmodulin. Circ Res (2002) 1.62
Multiprotein complex containing succinate dehydrogenase confers mitochondrial ATP-sensitive K+ channel activity. Proc Natl Acad Sci U S A (2004) 1.60
Magnetic resonance-based anatomical analysis of scar-related ventricular tachycardia: implications for catheter ablation. Circ Res (2007) 1.58
Resting heart rate and risk of sudden cardiac death in the general population: influence of left ventricular systolic dysfunction and heart rate-modulating drugs. Heart Rhythm (2013) 1.56
ECG quantification of myocardial scar in cardiomyopathy patients with or without conduction defects: correlation with cardiac magnetic resonance and arrhythmogenesis. Circ Arrhythm Electrophysiol (2008) 1.55
Mixed results for bone marrow–derived cell therapy for ischemic heart disease. JAMA (2012) 1.53
Proarrhythmic potential of mesenchymal stem cell transplantation revealed in an in vitro coculture model. Circulation (2006) 1.52
Validation of contrast-enhanced magnetic resonance imaging to monitor regenerative efficacy after cell therapy in a porcine model of convalescent myocardial infarction. Circulation (2013) 1.51
Kidney-derived stromal cells modulate dendritic and T cell responses. J Am Soc Nephrol (2009) 1.51
Myofilament properties comprise the rate-limiting step for cardiac relaxation at body temperature in the rat. Am J Physiol Heart Circ Physiol (2002) 1.49
Association between angiotensin-converting enzyme insertion/deletion gene polymorphism and atrial fibrillation: a meta-analysis. Europace (2010) 1.49
Warning Symptoms Are Associated With Survival From Sudden Cardiac Arrest. Ann Intern Med (2016) 1.49
Independent contribution of diabetes to increased prevalence and incidence of atrial fibrillation. Diabetes Care (2009) 1.49
A common missense variant in the neuregulin 1 gene is associated with both schizophrenia and sudden cardiac death. Heart Rhythm (2013) 1.47
Contribution of sudden cardiac death to total mortality in India - a population based study. Int J Cardiol (2010) 1.43
Genomics in sudden cardiac death. Circ Res (2004) 1.42
Spontaneously alternating forms of the atrioventricular node reentrant tachycardia. Pacing Clin Electrophysiol (2011) 1.42
Expansion of human cardiac stem cells in physiological oxygen improves cell production efficiency and potency for myocardial repair. Cardiovasc Res (2010) 1.41
Pharmacological preconditioning ameliorates neurological injury in a model of spinal cord ischemia. Ann Thorac Surg (2002) 1.41
Molecular correlates of altered expression of potassium currents in failing rabbit myocardium. Am J Physiol Heart Circ Physiol (2005) 1.39
Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals. PLoS Genet (2011) 1.38
Identification and functionality of proteomes secreted by rat cardiac stem cells and neonatal cardiomyocytes. Proteomics (2010) 1.38
Meta-analysis of obstructive sleep apnea as predictor of atrial fibrillation recurrence after catheter ablation. Am J Cardiol (2011) 1.36
Human cardiospheres are a source of stem cells with cardiomyogenic potential. Stem Cells (2010) 1.33
Public health burden of sudden cardiac death in the United States. Circ Arrhythm Electrophysiol (2014) 1.30
Molecular dissection of the inward rectifier potassium current (IK1) in rabbit cardiomyocytes: evidence for heteromeric co-assembly of Kir2.1 and Kir2.2. J Physiol (2003) 1.30
Allogeneic cardiospheres safely boost cardiac function and attenuate adverse remodeling after myocardial infarction in immunologically mismatched rat strains. J Am Coll Cardiol (2013) 1.28
Non-equilibrium behavior of HCN channels: insights into the role of HCN channels in native and engineered pacemakers. Cardiovasc Res (2005) 1.28
Magnetic enhancement of cell retention, engraftment, and functional benefit after intracoronary delivery of cardiac-derived stem cells in a rat model of ischemia/reperfusion. Cell Transplant (2012) 1.28
Mechanistically distinct steps in the mitochondrial death pathway triggered by oxidative stress in cardiac myocytes. Circ Res (2003) 1.26
Incidence of sudden cardiac arrest is higher in areas of low socioeconomic status: a prospective two year study in a large United States community. Resuscitation (2006) 1.25