Published in Stem Cells on July 01, 2010
Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial. Lancet (2012) 9.86
Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells. J Am Coll Cardiol (2012) 3.48
Expansion of human cardiac stem cells in physiological oxygen improves cell production efficiency and potency for myocardial repair. Cardiovasc Res (2010) 1.41
Culture of human mesenchymal stem cells at low oxygen tension improves growth and genetic stability by activating glycolysis. Cell Death Differ (2011) 1.23
Redox regulation of stem/progenitor cells and bone marrow niche. Free Radic Biol Med (2012) 1.15
Nutrient-sensing pathways and metabolic regulation in stem cells. J Cell Biol (2013) 1.08
Inducing iPSCs to escape the dish. Cell Stem Cell (2011) 1.03
Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen. Nat Protoc (2011) 1.01
Transplantation of platelet gel spiked with cardiosphere-derived cells boosts structural and functional benefits relative to gel transplantation alone in rats with myocardial infarction. Biomaterials (2012) 1.00
Finding Expandable Induced Cardiovascular Progenitor Cells. Circ Res (2016) 0.96
Recurrent genomic instability of chromosome 1q in neural derivatives of human embryonic stem cells. J Clin Invest (2012) 0.95
Derivation of neural precursor cells from human ES cells at 3% O(2) is efficient, enhances survival and presents no barrier to regional specification and functional differentiation. Cell Death Differ (2011) 0.94
Physiological normoxia and absence of EGF is required for the long-term propagation of anterior neural precursors from human pluripotent cells. PLoS One (2014) 0.92
Proinflammatory Cytokines Stimulate Mitochondrial Superoxide Flashes in Articular Chondrocytes In Vitro and In Situ. PLoS One (2013) 0.90
ROCK inhibitor Y-27632 increases the cloning efficiency of limbal stem/progenitor cells by improving their adherence and ROS-scavenging capacity. Tissue Eng Part C Methods (2012) 0.89
Reactive oxygen species in vascular formation and development. Oxid Med Cell Longev (2013) 0.87
Regenerative medicine for the heart: perspectives on stem-cell therapy. Antioxid Redox Signal (2014) 0.87
Accelerated hematopoietic stem cell aging in a mouse model of dyskeratosis congenita responds to antioxidant treatment. Aging Cell (2011) 0.87
Antioxidant proteins and reactive oxygen species are decreased in a murine epidermal side population with stem cell-like characteristics. Histochem Cell Biol (2011) 0.87
Sensitivity and dose dependency of radiation-induced injury in hematopoietic stem/progenitor cells in mice. Sci Rep (2015) 0.85
Neural precursor cells cultured at physiologically relevant oxygen tensions have a survival advantage following transplantation. Stem Cells Transl Med (2013) 0.85
Placental extract protects bone marrow-derived stem/progenitor cells against radiation injury through anti-inflammatory activity. J Radiat Res (2012) 0.84
Nicaraven attenuates radiation-induced injury in hematopoietic stem/progenitor cells in mice. PLoS One (2013) 0.84
Chromosomal instability in in vitro cultured mouse hematopoietic cells associated with oxidative stress. Am J Blood Res (2012) 0.84
Controlling Redox Status for Stem Cell Survival, Expansion, and Differentiation. Oxid Med Cell Longev (2015) 0.84
Effects of antioxidants on the quality and genomic stability of induced pluripotent stem cells. Sci Rep (2014) 0.81
Cardiac stem cells: biology and clinical applications. Antioxid Redox Signal (2014) 0.80
Maintenance of genomic stability in mouse embryonic stem cells: relevance in aging and disease. Int J Mol Sci (2013) 0.80
Tualang honey improves human corneal epithelial progenitor cell migration and cellular resistance to oxidative stress in vitro. PLoS One (2014) 0.78
Redox signaling in cardiac renewal. Antioxid Redox Signal (2014) 0.77
Hyperbaric oxygen, vasculogenic stem cells, and wound healing. Antioxid Redox Signal (2014) 0.77
The role of Hibiscus sabdariffa L. (Roselle) in maintenance of ex vivo murine bone marrow-derived hematopoietic stem cells. ScientificWorldJournal (2014) 0.77
Reactive oxygen species adversely impacts bone marrow microenvironment in diabetes. Antioxid Redox Signal (2014) 0.76
Virgin birth: engineered heart muscle from parthenogenetic stem cells. J Clin Invest (2013) 0.75
Phenotypic, Functional, and Safety Control at Preimplantation Phase of MSC-Based Therapy. Stem Cells Int (2016) 0.75
Immunotheranostic Polymersomes Modularly Assembled from Tetrablock and Diblock Copolymers with Oxidation-Responsive Fluorescence. Cell Mol Bioeng (2017) 0.75
Effects of Antioxidant Supplements on the Survival and Differentiation of Stem Cells. Oxid Med Cell Longev (2017) 0.75
Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med (2004) 17.79
Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci U S A (1993) 13.27
Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA (2007) 11.87
Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens. Circulation (2007) 8.62
Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA (2008) 8.32
Reactive oxygen species produced by NADPH oxidase regulate plant cell growth. Nature (2003) 8.30
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature (2007) 7.72
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature (2005) 7.45
Chromosomal stability and the DNA double-stranded break connection. Nat Rev Genet (2001) 6.77
Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J Heart Lung Transplant (2005) 5.87
A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature (2009) 5.55
Retracted Spontaneous human adult stem cell transformation. Cancer Res (2005) 4.95
Adaptation to culture of human embryonic stem cells and oncogenesis in vivo. Nat Biotechnol (2007) 4.53
Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci U S A (1996) 4.45
Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation. Nature (2009) 4.26
Genomic alterations in cultured human embryonic stem cells. Nat Genet (2005) 3.89
Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice. Cell (2007) 3.54
ATM stabilizes DNA double-strand-break complexes during V(D)J recombination. Nature (2006) 3.35
Validation of the cardiosphere method to culture cardiac progenitor cells from myocardial tissue. PLoS One (2009) 2.89
Reduced oxygen tension attenuates differentiation capacity of human mesenchymal stem cells and prolongs their lifespan. Aging Cell (2007) 2.70
ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. Nature (2001) 2.50
A review of the interaction among dietary antioxidants and reactive oxygen species. J Nutr Biochem (2007) 2.16
Hypoxia or in situ normoxia: The stem cell paradigm. J Cell Physiol (2009) 2.14
Derivation of euploid human embryonic stem cells from aneuploid embryos. Stem Cells (2008) 1.38
Chromosome 7 and 19 trisomy in cultured human neural progenitor cells. PLoS One (2009) 1.13
A transformed cell population derived from cultured mesenchymal stem cells has no functional effect after transplantation into the injured heart. Cell Transplant (2009) 1.08
Establishment of new mouse embryonic stem cell lines is improved by physiological glucose and oxygen. Cloning Stem Cells (2006) 1.05
Post-transplant lymphoproliferative disorder subtypes correlate with different recurring chromosomal abnormalities. Genes Chromosomes Cancer (2006) 0.93
ATM-mediated transcriptional elevation of prion in response to copper-induced oxidative stress. J Biol Chem (2008) 0.91
High-dose alpha-tocopherol therapy does not affect HDL subfractions in patients with coronary artery disease on statin therapy. Clin Chem (2007) 0.88
The nitrone disodium 2,4-sulphophenyl-N-tert-butylnitrone is without cytoprotective effect on sodium nitroprusside-induced cell death in N1E-115 neuroblastoma cells in vitro. J Cereb Blood Flow Metab (2007) 0.85
Enhanced tumorigenesis in p53 knockout mice exposed in utero to high-dose vitamin E. Carcinogenesis (2006) 0.82
Reduced tumorigenesis in p53 knockout mice exposed in utero to low-dose vitamin E. Cancer (2009) 0.79
Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial. Lancet (2012) 9.86
Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens. Circulation (2007) 8.62
A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. Nat Genet (2006) 6.39
Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmia susceptibility in patients with left ventricular dysfunction. Circulation (2007) 5.09
Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice. Circ Res (2010) 4.19
Synchronized whole cell oscillations in mitochondrial metabolism triggered by a local release of reactive oxygen species in cardiac myocytes. J Biol Chem (2003) 3.93
Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells. J Am Coll Cardiol (2012) 3.48
Engraftment, differentiation, and functional benefits of autologous cardiosphere-derived cells in porcine ischemic cardiomyopathy. Circulation (2009) 3.45
Late gadolinium enhancement by cardiovascular magnetic resonance heralds an adverse prognosis in nonischemic cardiomyopathy. J Am Coll Cardiol (2008) 2.99
Validation of the cardiosphere method to culture cardiac progenitor cells from myocardial tissue. PLoS One (2009) 2.89
Biological pacemaker created by gene transfer. Nature (2002) 2.83
Role of sarcolemmal K(ATP) channels in cardioprotection against ischemia/reperfusion injury in mice. J Clin Invest (2002) 2.74
Combined cardiac magnetic resonance imaging and C-reactive protein levels identify a cohort at low risk for defibrillator firings and death. Circ Cardiovasc Imaging (2012) 2.62
Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations. Circulation (2009) 2.55
An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Biophys J (2003) 2.52
Antiarrhythmic engineering of skeletal myoblasts for cardiac transplantation. Circ Res (2005) 2.44
Magnetic resonance imaging overestimates ferumoxide-labeled stem cell survival after transplantation in the heart. Circulation (2008) 2.37
Magnetic targeting enhances engraftment and functional benefit of iron-labeled cardiosphere-derived cells in myocardial infarction. Circ Res (2010) 2.33
Ectopic expression of the sodium-iodide symporter enables imaging of transplanted cardiac stem cells in vivo by single-photon emission computed tomography or positron emission tomography. J Am Coll Cardiol (2008) 2.33
Safety and efficacy of allogeneic cell therapy in infarcted rats transplanted with mismatched cardiosphere-derived cells. Circulation (2011) 2.29
Cardiac cell therapy: where we've been, where we are, and where we should be headed. Br Med Bull (2011) 2.26
Proteomic analysis of pharmacological preconditioning: novel protein targets converge to mitochondrial metabolism pathways. Circ Res (2006) 2.20
Noninvasive quantification and optimization of acute cell retention by in vivo positron emission tomography after intramyocardial cardiac-derived stem cell delivery. J Am Coll Cardiol (2009) 2.20
Novel functional properties of Ca(2+) channel beta subunits revealed by their expression in adult rat heart cells. J Physiol (2002) 2.18
Intramyocardial injection of autologous cardiospheres or cardiosphere-derived cells preserves function and minimizes adverse ventricular remodeling in pigs with heart failure post-myocardial infarction. J Am Coll Cardiol (2011) 2.15
Cardioprotection by N-acetylglucosamine linkage to cellular proteins. Circulation (2008) 2.11
Cardiospheres recapitulate a niche-like microenvironment rich in stemness and cell-matrix interactions, rationalizing their enhanced functional potency for myocardial repair. Stem Cells (2010) 2.10
Mutual functional destruction of HIV-1 Vpu and host TASK-1 channel. Mol Cell (2004) 2.05
Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heart. EMBO Mol Med (2013) 2.04
Assessment and optimization of cell engraftment after transplantation into the heart. Circ Res (2010) 1.90
Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes. Circ Res (2003) 1.89
Dedifferentiation and proliferation of mammalian cardiomyocytes. PLoS One (2010) 1.89
Isolation and expansion of functionally-competent cardiac progenitor cells directly from heart biopsies. J Mol Cell Cardiol (2010) 1.88
Creation of a genetic calcium channel blocker by targeted gem gene transfer in the heart. Circ Res (2004) 1.87
Endogenous cardiac stem cells. Prog Cardiovasc Dis (2007) 1.79
Functional role of inward rectifier current in heart probed by Kir2.1 overexpression and dominant-negative suppression. J Clin Invest (2003) 1.78
Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18. Nat Biotechnol (2012) 1.74
Disproportionate enhancement of myocardial contractility by the xanthine oxidase inhibitor oxypurinol in failing rat myocardium. Cardiovasc Res (2003) 1.70
Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart. Circ Res (2002) 1.70
A computational model integrating electrophysiology, contraction, and mitochondrial bioenergetics in the ventricular myocyte. Biophys J (2006) 1.69
CAPON modulates cardiac repolarization via neuronal nitric oxide synthase signaling in the heart. Proc Natl Acad Sci U S A (2008) 1.66
Isoform-specific modulation of voltage-gated Na(+) channels by calmodulin. Circ Res (2002) 1.62
Multiprotein complex containing succinate dehydrogenase confers mitochondrial ATP-sensitive K+ channel activity. Proc Natl Acad Sci U S A (2004) 1.60
Magnetic resonance-based anatomical analysis of scar-related ventricular tachycardia: implications for catheter ablation. Circ Res (2007) 1.58
ECG quantification of myocardial scar in cardiomyopathy patients with or without conduction defects: correlation with cardiac magnetic resonance and arrhythmogenesis. Circ Arrhythm Electrophysiol (2008) 1.55
Biological pacemaker created by percutaneous gene delivery via venous catheters in a porcine model of complete heart block. Heart Rhythm (2012) 1.54
Mixed results for bone marrow–derived cell therapy for ischemic heart disease. JAMA (2012) 1.53
Proarrhythmic potential of mesenchymal stem cell transplantation revealed in an in vitro coculture model. Circulation (2006) 1.52
Validation of contrast-enhanced magnetic resonance imaging to monitor regenerative efficacy after cell therapy in a porcine model of convalescent myocardial infarction. Circulation (2013) 1.51
Kidney-derived stromal cells modulate dendritic and T cell responses. J Am Soc Nephrol (2009) 1.51
Myofilament properties comprise the rate-limiting step for cardiac relaxation at body temperature in the rat. Am J Physiol Heart Circ Physiol (2002) 1.49
Expansion of human cardiac stem cells in physiological oxygen improves cell production efficiency and potency for myocardial repair. Cardiovasc Res (2010) 1.41
Pharmacological preconditioning ameliorates neurological injury in a model of spinal cord ischemia. Ann Thorac Surg (2002) 1.41
Molecular correlates of altered expression of potassium currents in failing rabbit myocardium. Am J Physiol Heart Circ Physiol (2005) 1.39
Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals. PLoS Genet (2011) 1.38
Identification and functionality of proteomes secreted by rat cardiac stem cells and neonatal cardiomyocytes. Proteomics (2010) 1.38
Human cardiospheres are a source of stem cells with cardiomyogenic potential. Stem Cells (2010) 1.33
Non-equilibrium behavior of HCN channels: insights into the role of HCN channels in native and engineered pacemakers. Cardiovasc Res (2005) 1.28
Allogeneic cardiospheres safely boost cardiac function and attenuate adverse remodeling after myocardial infarction in immunologically mismatched rat strains. J Am Coll Cardiol (2013) 1.28
Magnetic enhancement of cell retention, engraftment, and functional benefit after intracoronary delivery of cardiac-derived stem cells in a rat model of ischemia/reperfusion. Cell Transplant (2012) 1.28
Mechanistically distinct steps in the mitochondrial death pathway triggered by oxidative stress in cardiac myocytes. Circ Res (2003) 1.26
Chronic treatment with allopurinol boosts survival and cardiac contractility in murine postischemic cardiomyopathy. Circ Res (2004) 1.24
Gene therapy to inhibit the calcium channel beta subunit: physiological consequences and pathophysiological effects in models of cardiac hypertrophy. Circ Res (2007) 1.24
Physiological determinants of contractile force generation and calcium handling in mouse myocardium. J Mol Cell Cardiol (2002) 1.23
Biological therapies for cardiac arrhythmias: can genes and cells replace drugs and devices? Circ Res (2010) 1.21
Is Kir6.1 a subunit of mitoK(ATP)? Biochem Biophys Res Commun (2007) 1.19
Stem cells in the heart: what's the buzz all about? Part 2: Arrhythmic risks and clinical studies. Heart Rhythm (2008) 1.19
Lentiviral vector-mediated expression of GFP or Kir2.1 alters the electrophysiology of neonatal rat ventricular myocytes without inducing cytotoxicity. Am J Physiol Heart Circ Physiol (2007) 1.18
Cardioprotective role of the mitochondrial ATP-binding cassette protein 1. Circ Res (2005) 1.17
Dominant-negative suppression of HCN1- and HCN2-encoded pacemaker currents by an engineered HCN1 construct: insights into structure-function relationships and multimerization. Circ Res (2002) 1.15
Differential actions of cardioprotective agents on the mitochondrial death pathway. Circ Res (2003) 1.14
Functional performance of human cardiosphere-derived cells delivered in an in situ polymerizable hyaluronan-gelatin hydrogel. Biomaterials (2012) 1.14
Lentiviral vectors bearing the cardiac promoter of the Na+-Ca2+ exchanger report cardiogenic differentiation in stem cells. Mol Ther (2008) 1.13
Brief report: Mechanism of extravasation of infused stem cells. Stem Cells (2012) 1.13
Simvastatin attenuates oxidant-induced mitochondrial dysfunction in cardiac myocytes. Circ Res (2003) 1.12
Stem cells in the heart: what's the buzz all about?--Part 1: preclinical considerations. Heart Rhythm (2008) 1.11
Cariporide (HOE642), a selective Na+-H+ exchange inhibitor, inhibits the mitochondrial death pathway. Circulation (2003) 1.10
Nanopatterned cardiac cell patches promote stem cell niche formation and myocardial regeneration. Integr Biol (Camb) (2012) 1.08
IK1 heterogeneity affects genesis and stability of spiral waves in cardiac myocyte monolayers. Circ Res (2009) 1.07
Cellular and molecular determinants of altered Ca2+ handling in the failing rabbit heart: primary defects in SR Ca2+ uptake and release mechanisms. Am J Physiol Heart Circ Physiol (2006) 1.05
Xanthine oxidase inhibitors improve energetics and function after infarction in failing mouse hearts. Am J Physiol Heart Circ Physiol (2005) 1.04
Transcriptional suppression of connexin43 by TBX18 undermines cell-cell electrical coupling in postnatal cardiomyocytes. J Biol Chem (2011) 1.04
Abnormal sympathetic innervation of viable myocardium and the substrate of ventricular tachycardia after myocardial infarction. J Am Coll Cardiol (2008) 1.04
Myocardial substrate and route of administration determine acute cardiac retention and lung bio-distribution of cardiosphere-derived cells. J Nucl Cardiol (2011) 1.02
Antiapoptotic effect of nicorandil mediated by mitochondrial atp-sensitive potassium channels in cultured cardiac myocytes. J Am Coll Cardiol (2002) 1.02
Gene transfer of connexin43 mutants attenuates coupling in cardiomyocytes: novel basis for modulation of cardiac conduction by gene therapy. Circ Res (2007) 1.02
Spiral waves and reentry dynamics in an in vitro model of the healed infarct border zone. Circ Res (2009) 1.02
Gene transfer of a synthetic pacemaker channel into the heart: a novel strategy for biological pacing. Circulation (2006) 1.00
Macrophages mediate cardioprotective cellular postconditioning in acute myocardial infarction. J Clin Invest (2015) 1.00
Transplantation of platelet gel spiked with cardiosphere-derived cells boosts structural and functional benefits relative to gel transplantation alone in rats with myocardial infarction. Biomaterials (2012) 1.00
Importance of cell-cell contact in the therapeutic benefits of cardiosphere-derived cells. Stem Cells (2014) 0.99
Creation of a biological pacemaker by cell fusion. Circ Res (2007) 0.99
Mitochondrial ATP-sensitive potassium channel activation protects cerebellar granule neurons from apoptosis induced by oxidative stress. Stroke (2003) 0.98
Molecular basis of isoform-specific micro-conotoxin block of cardiac, skeletal muscle, and brain Na+ channels. J Biol Chem (2002) 0.98
Enhanced infarct border zone function and altered mechanical activation predict inducibility of monomorphic ventricular tachycardia in patients with ischemic cardiomyopathy. Radiology (2007) 0.97
Dose-dependent functional benefit of human cardiosphere transplantation in mice with acute myocardial infarction. J Cell Mol Med (2012) 0.96
Heart to heart: The elusive mechanism of cell therapy. Circulation (2010) 0.96
Murine strain differences in contractile function are temperature- and frequency-dependent. Pflugers Arch (2006) 0.95
Intramyocardial injection of platelet gel promotes endogenous repair and augments cardiac function in rats with myocardial infarction. J Am Coll Cardiol (2012) 0.95