The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF.

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Published in Cancer Res on July 23, 2014

Authors

Ian R Watson1, Liren Li1,2, Peter K Cabeceiras1, Mozhdeh Mahdavi1, Tony Gutschner1, Giannicola Genovese1, Guocan Wang3, Zhuangna Fang1,2, James M Tepper1, Katherine Stemke-Hale4, Kenneth Y Tsai5, Michael A Davies4,6, Gordon B Mills4, Lynda Chin1,7

Author Affiliations

1: Department of Genomic Medicine The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
2: State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China.
3: Department of Cancer Biology The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
4: Department of Systems Biology The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
5: Department of Dermatology The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
6: Department of Melanoma Medical Oncology The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
7: Institute for Applied Cancer Science The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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