Published in J Biol Chem on June 07, 2012
53BP1: pro choice in DNA repair. Trends Cell Biol (2013) 1.75
Activated Protein C Ameliorates Renal Ischemia-Reperfusion Injury by Restricting Y-Box Binding Protein-1 Ubiquitination. J Am Soc Nephrol (2015) 1.48
Push back to respond better: regulatory inhibition of the DNA double-strand break response. Nat Rev Mol Cell Biol (2013) 1.29
Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways. Proc Natl Acad Sci U S A (2013) 1.12
OTUB1 modulates c-IAP1 stability to regulate signalling pathways. EMBO J (2013) 1.09
Deubiquitylating enzymes and DNA damage response pathways. Cell Biochem Biophys (2013) 1.03
OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3. Nat Commun (2013) 1.01
OTUB1 promotes metastasis and serves as a marker of poor prognosis in colorectal cancer. Mol Cancer (2014) 0.94
Deubiquitinating enzymes as oncotargets. Oncotarget (2015) 0.91
Structural mechanisms underlying signaling in the cellular response to DNA double strand breaks. Mutat Res (2013) 0.86
Deubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1. World J Biol Chem (2014) 0.84
Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy. Curr Pharm Des (2013) 0.84
The emerging roles of deubiquitylating enzymes (DUBs) in the TGFβ and BMP pathways. Cell Signal (2014) 0.82
Decoding ubiquitin for mitosis. Genes Cancer (2012) 0.82
OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination. EMBO Mol Med (2016) 0.82
Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization. Sci Signal (2015) 0.79
Downregulation of Ubiquitin-conjugating Enzyme UBE2D3 Promotes Telomere Maintenance and Radioresistance of Eca-109 Human Esophageal Carcinoma Cells. J Cancer (2016) 0.78
Mechanisms for regulating deubiquitinating enzymes. Protein Sci (2014) 0.78
Writers, Readers, and Erasers of Histone Ubiquitylation in DNA Double-Strand Break Repair. Front Genet (2016) 0.78
MJD and OTU deubiquitinating enzymes in Schistosoma mansoni. Parasitol Res (2015) 0.76
Ubc13: the Lys63 ubiquitin chain building machine. Oncotarget (2016) 0.76
A ubiquitin shuttle DC-UbP/UBTD2 reconciles protein ubiquitination and deubiquitination via linking UbE1 and USP5 enzymes. PLoS One (2014) 0.75
Inhibition of Ubc13-mediated ubiquitination by GPS2 regulates multiple stages of B cell development. J Biol Chem (2016) 0.75
Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo. Acta Neuropathol (2017) 0.75
Opposing roles of RNF8/RNF168 and deubiquitinating enzymes in ubiquitination-dependent DNA double-strand break response signaling and DNA-repair pathway choice. J Radiat Res (2016) 0.75
DUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic Targets. Front Genet (2016) 0.75
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev (2002) 16.10
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell (2007) 9.25
Breaking the chains: structure and function of the deubiquitinases. Nat Rev Mol Cell Biol (2009) 8.85
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell (2007) 8.71
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science (2007) 7.61
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Cell (2009) 6.89
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science (2007) 6.77
RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. Science (2007) 6.70
Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Cell (1999) 6.56
The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage. Cell (2009) 5.96
Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response. Science (2007) 5.88
Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucleic Acids Res (2008) 4.79
Mms2-Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation. Nat Struct Mol Biol (2006) 3.71
Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer. Cell (2001) 3.09
A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Mol Cell Proteomics (2008) 2.56
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. Nature (2010) 2.47
Linkage-specific avidity defines the lysine 63-linked polyubiquitin-binding preference of rap80. Mol Cell (2009) 2.39
A direct nanoflow liquid chromatography-tandem mass spectrometry system for interaction proteomics. Anal Chem (2002) 2.18
Regulatory ubiquitylation in response to DNA double-strand breaks. DNA Repair (Amst) (2009) 2.17
The spatial and temporal organization of ubiquitin networks. Nat Rev Mol Cell Biol (2011) 2.15
Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80. EMBO J (2009) 2.14
RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling. Proc Natl Acad Sci U S A (2007) 1.79
The mechanism of OTUB1-mediated inhibition of ubiquitination. Nature (2012) 1.70
OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function. Mol Cell (2012) 1.58
RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites. Cancer Lett (2008) 1.50
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science (2007) 7.61
The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage. Cell (2009) 5.96
Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains. Cell (2002) 5.64
Structural basis of abscisic acid signalling. Nature (2009) 3.29
Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains. Nature (2008) 2.94
Conformational transition of Sec machinery inferred from bacterial SecYE structures. Nature (2008) 2.48
Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80. EMBO J (2009) 2.14
Crystal structure of the MgtE Mg2+ transporter. Nature (2007) 2.00
Crystal structure of the homologous-pairing domain from the human Rad52 recombinase in the undecameric form. Mol Cell (2002) 1.98
Deep knot structure for construction of active site and cofactor binding site of tRNA modification enzyme. Structure (2004) 1.53
Snapshots of tRNA sulphuration via an adenylated intermediate. Nature (2006) 1.51
Structure and function of a membrane component SecDF that enhances protein export. Nature (2011) 1.51
Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by NZF domains of TAB2 and TAB3. EMBO J (2009) 1.48
Structural basis of RNA-dependent recruitment of glutamine to the genetic code. Science (2006) 1.45
Mutational separation of two pathways for editing by a class I tRNA synthetase. Mol Cell (2002) 1.42
Structural insight into the membrane insertion of tail-anchored proteins by Get3. Genes Cells (2009) 1.40
Structural basis for template-independent RNA polymerization. Nature (2004) 1.35
Structural basis for anticodon recognition by methionyl-tRNA synthetase. Nat Struct Mol Biol (2005) 1.34
A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase. Nat Struct Mol Biol (2004) 1.34
Roles of conserved amino acid sequence motifs in the SpoU (TrmH) RNA methyltransferase family. J Biol Chem (2005) 1.30
Crystal structure of the Sec4p.Sec2p complex in the nucleotide exchanging intermediate state. Proc Natl Acad Sci U S A (2007) 1.24
Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex. Proc Natl Acad Sci U S A (2011) 1.18
Complete crystallographic analysis of the dynamics of CCA sequence addition. Nature (2006) 1.17
Crystal structure of the NEMO ubiquitin-binding domain in complex with Lys 63-linked di-ubiquitin. FEBS Lett (2009) 1.16
Crystal structure of γ-hexachlorocyclohexane Dehydrochlorinase LinA from Sphingobium japonicum UT26. J Mol Biol (2010) 1.12
Structural basis for the Rho- and phosphoinositide-dependent localization of the exocyst subunit Sec3. Nat Struct Mol Biol (2010) 1.11
Crystal structures of leucyl/phenylalanyl-tRNA-protein transferase and its complex with an aminoacyl-tRNA analog. EMBO J (2006) 1.11
Asymmetric coiled-coil structure with Guanine nucleotide exchange activity. Structure (2007) 1.10
A congenital mutation of the novel gene LRRC8 causes agammaglobulinemia in humans. J Clin Invest (2003) 1.09
Structural basis for sulfur relay to RNA mediated by heterohexameric TusBCD complex. Structure (2006) 1.08
A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions. PLoS Genet (2007) 1.06
Structural basis for lysidine formation by ATP pyrophosphatase accompanied by a lysine-specific loop and a tRNA-recognition domain. Proc Natl Acad Sci U S A (2005) 1.04
Crystal structure of archaeosine tRNA-guanine transglycosylase. J Mol Biol (2002) 1.03
Crystal structure of human DAAM1 formin homology 2 domain. Genes Cells (2007) 1.02
Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases. J Biol Chem (2009) 1.02
Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets. J Biol Chem (2008) 1.02
Functional categorization of the conserved basic amino acid residues in TrmH (tRNA (Gm18) methyltransferase) enzymes. J Biol Chem (2006) 1.00
Retracted The ATPase activity of BfpD is greatly enhanced by zinc and allosteric interactions with other Bfp proteins. J Biol Chem (2005) 1.00
Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism. Blood (2011) 1.00
Differentiating analogous tRNA methyltransferases by fragments of the methyl donor. RNA (2011) 0.97
Mechanism for the definition of elongation and termination by the class II CCA-adding enzyme. EMBO J (2009) 0.95
Regulation of platelet dense granule secretion by the Ral GTPase-exocyst pathway. J Biol Chem (2007) 0.91
Crystal structures of the CP1 domain from Thermus thermophilus isoleucyl-tRNA synthetase and its complex with L-valine. J Biol Chem (2003) 0.91
Clear cell tumor of the lung: surgical and immunohistochemical findings. Gen Thorac Cardiovasc Surg (2010) 0.90
Purification, crystallization and preliminary X-ray diffraction of SecDF, a translocon-associated membrane protein, from Thermus thermophilus. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.90
Crystal structure of zebrafish hatching enzyme 1 from the zebrafish Danio rerio. J Mol Biol (2010) 0.88
Crystal structure of KaiC-like protein PH0186 from hyperthermophilic archaea Pyrococcus horikoshii OT3. Proteins (2009) 0.86
Crystallographic and mutational studies on the tRNA thiouridine synthetase TtuA. Proteins (2013) 0.85
A cysteine endopeptidase ("dionain") is involved in the digestive fluid of Dionaea muscipula (Venus's fly-trap). Biosci Biotechnol Biochem (2011) 0.85
Get1 stabilizes an open dimer conformation of get3 ATPase by binding two distinct interfaces. J Mol Biol (2012) 0.85
Identification of a glutamine residue essential for catalytic activity of aspergilloglutamic peptidase by site-directed mutagenesis. FEBS Lett (2004) 0.83
Structural and phylogenetic comparison of three pepsinogens from Pacific bluefin tuna: molecular evolution of fish pepsinogens. Comp Biochem Physiol B Biochem Mol Biol (2008) 0.83
Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection. Sci Rep (2013) 0.82
Widespread tissue expression of nepenthesin-like aspartic protease genes in Arabidopsis thaliana. Plant Physiol Biochem (2008) 0.80
Crystallization and preliminary X-ray diffraction analysis of GCIP/HHM transcriptional regulator. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.80
Expression, purification, crystallization and preliminary X-ray analysis of the KaiC-like protein PH0187 from the hyperthermophilic archaeon Pyrococcus horikoshii OT3. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.80
Crystallization and preliminary X-ray diffraction analysis of the full-length Mg2+ transporter MgtE. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.79
Tacrolimus-related encephalopathy following allogeneic stem cell transplantation in children. Int J Hematol (2005) 0.79
Identification and characterization of polymorphic variations of the ataxia telangiectasia mutated (ATM) gene in childhood Hodgkin disease. Blood (2003) 0.79
Switching and emergence of CTL epitopes in HIV-1 infection. Retrovirology (2014) 0.78
Purification, crystallization and preliminary X-ray analysis of OsAREB8 from rice, a member of the AREB/ABF family of bZIP transcription factors, in complex with its cognate DNA. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.78
Crystal structure of Methanocaldococcus jannaschii Trm4 complexed with sinefungin. J Mol Biol (2010) 0.78
Crystallization and preliminary X-ray analysis of flap endonuclease 1 (FEN1) from Desulfurococcus amylolyticus. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.78
Crystal structure of TTHA1429, a novel metallo-beta-lactamase superfamily protein from Thermus thermophilus HB8. Proteins (2008) 0.78
Crystallization and preliminary X-ray analysis of gamma-hexachlorocyclohexane dehydrochlorinase LinA from Sphingobium japonicum UT26. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.78
Crystallization and preliminary X-ray analysis of ZHE1, a hatching enzyme from the zebrafish Danio rerio. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.77
Crystallization and preliminary X-ray analysis of the tRNA thiolation enzyme MnmA from Escherichia coli complexed with tRNA(Glu). Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.76
Caffeine yields aneuploidy through asymmetrical cell division caused by misalignment of chromosomes. Cancer Sci (2008) 0.76
Structure of flap endonuclease 1 from the hyperthermophilic archaeon Desulfurococcus amylolyticus. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.76
The P1 and P1' residue specificities of physarolisin I, a serine-carboxyl peptidase from the true slime mold Physarum polycephalum. Biosci Biotechnol Biochem (2009) 0.75
Crystallization and preliminary X-ray diffraction analysis of the cytosolic domain of the Mg2+ transporter MgtE. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.75
The crystal structure of an intermediate dimer of aspergilloglutamic peptidase that mimics the enzyme-activation product complex produced upon autoproteolysis. J Biochem (2012) 0.75
Crystallization and crystallographic analysis of yeast Sec2p, a guanine nucleotide-exchange factor for the yeast Rab GTPase Sec4p. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.75
[The regulation of cell function by linkage-specific polyubiquitin binding]. Seikagaku (2012) 0.75
[The problems with pediatric home care]. Gan To Kagaku Ryoho (2004) 0.75
[Structural basis of synaptic organizer complexes for inducing synapse formation in the central nervous system]. Seikagaku (2016) 0.75
Structural change of tRNA (Gm18) methyltransferase by binding of methyl donor analogues. Nucleic Acids Symp Ser (Oxf) (2005) 0.75
[A case of recurrent transverse colon cancer invading the pancreas and duodenum successfully treated with biliary and duodenal stenting]. Gan To Kagaku Ryoho (2013) 0.75