Published in Nucleic Acids Res on July 30, 2012
Role of base excision repair in maintaining the genetic and epigenetic integrity of CpG sites. DNA Repair (Amst) (2015) 1.01
Structural basis of the versatile DNA recognition ability of the methyl-CpG binding domain of methyl-CpG binding domain protein 4. J Biol Chem (2013) 0.99
Divergent mechanisms for enzymatic excision of 5-formylcytosine and 5-carboxylcytosine from DNA. J Am Chem Soc (2013) 0.93
Selective excision of 5-carboxylcytosine by a thymine DNA glycosylase mutant. J Mol Biol (2013) 0.89
Mechanisms for enzymatic cleavage of the N-glycosidic bond in DNA. Org Biomol Chem (2014) 0.88
Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pH. DNA Repair (Amst) (2013) 0.84
Effects of Tet-induced oxidation products of 5-methylcytosine on Dnmt1- and DNMT3a-mediated cytosine methylation. Mol Biosyst (2014) 0.83
The Mechanisms of Generation, Recognition, and Erasure of DNA 5-Methylcytosine and Thymine Oxidations. J Biol Chem (2015) 0.83
MBD4 cooperates with DNMT1 to mediate methyl-DNA repression and protects mammalian cells from oxidative stress. Epigenetics (2014) 0.82
Transcriptional repressor domain of MBD1 is intrinsically disordered and interacts with its binding partners in a selective manner. Sci Rep (2014) 0.79
An interplay of the base excision repair and mismatch repair pathways in active DNA demethylation. Nucleic Acids Res (2016) 0.78
Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage. Chem Res Toxicol (2016) 0.78
Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues. Nucleic Acids Res (2016) 0.77
Aberrant repair initiated by mismatch-specific thymine-DNA glycosylases provides a mechanism for the mutational bias observed in CpG islands. Nucleic Acids Res (2014) 0.77
5-methylcytosine recognition by Arabidopsis thaliana DNA glycosylases DEMETER and DML3. Biochemistry (2014) 0.77
Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins. DNA Repair (Amst) (2015) 0.77
Structural and mutation studies of two DNA demethylation related glycosylases: MBD4 and TDG. Biophysics (Nagoya-shi) (2014) 0.75
Search for Modified DNA Sites with the Human Methyl-CpG-Binding Enzyme MBD4. Acta Naturae (2017) 0.75
Structural Basis for Excision of 5-Formylcytosine by Thymine DNA Glycosylase. Biochemistry (2016) 0.75
5-hydroxymethylcytosine marks regions with reduced mutation frequency in human DNA. Elife (2016) 0.75
Role of Base Excision "Repair" Enzymes in Erasing Epigenetic Marks from DNA. Chem Rev (2016) 0.75
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Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (2009) 32.97
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature (2010) 18.63
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science (2011) 14.29
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science (2011) 13.16
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Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell (2011) 9.16
DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. Cell (2008) 8.62
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Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair. Cell (2011) 6.80
Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites. J Biol Chem (2011) 4.64
The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites. Nature (1999) 4.63
Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure. EMBO J (1995) 3.80
Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability. Nature (2011) 3.28
Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice. Science (2002) 2.73
Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription. Mol Cell (2002) 2.69
Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation. Nucleic Acids Res (2012) 2.55
The enigmatic thymine DNA glycosylase. DNA Repair (Amst) (2006) 2.36
Mutational spectra of human cancer. Hum Genet (2009) 2.26
The intricate structural chemistry of base excision repair machinery: implications for DNA damage recognition, removal, and repair. DNA Repair (Amst) (2007) 2.26
Excision of hypoxanthine from DNA containing dIMP residues by the Escherichia coli, yeast, rat, and human alkylpurine DNA glycosylases. Proc Natl Acad Sci U S A (1994) 2.15
MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1. Proc Natl Acad Sci U S A (1999) 1.99
Mbd4 inactivation increases Cright-arrowT transition mutations and promotes gastrointestinal tumor formation. Proc Natl Acad Sci U S A (2002) 1.77
DNA glycosylase recognition and catalysis. Curr Opin Struct Biol (2004) 1.74
Biphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylase. J Biol Chem (2000) 1.73
Excision of 5-halogenated uracils by human thymine DNA glycosylase. Robust activity for DNA contexts other than CpG. J Biol Chem (2007) 1.46
Investigation of the substrate spectrum of the human mismatch-specific DNA N-glycosylase MED1 (MBD4): fundamental role of the catalytic domain. J Cell Physiol (2000) 1.35
Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis. Proc Natl Acad Sci U S A (2003) 1.29
Mismatch repair in methylated DNA. Structure and activity of the mismatch-specific thymine glycosylase domain of methyl-CpG-binding protein MBD4. J Biol Chem (2002) 1.16
Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice. Nucleic Acids Res (2012) 1.13
DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNEIL1 and hNTH1 enzymes in human cells. DNA Repair (Amst) (2005) 1.06
MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos. Development (2009) 0.97
Characterization of Dnmt3b:thymine-DNA glycosylase interaction and stimulation of thymine glycosylase-mediated repair by DNA methyltransferase(s) and RNA. J Mol Biol (2008) 0.97
Crystal structure of human methyl-binding domain IV glycosylase bound to abasic DNA. J Mol Biol (2012) 0.93
Putting the DNA back into DNA methylation. Nat Genet (2011) 0.92
New insights in the removal of the hydantoins, oxidation product of pyrimidines, via the base excision and nucleotide incision repair pathways. PLoS One (2011) 0.84
Crystal structure of the mismatch-specific thymine glycosylase domain of human methyl-CpG-binding protein MBD4. Biochem Biophys Res Commun (2011) 0.83
Conformational change and protein-protein interactions of the fusion protein of Semliki Forest virus. Nature (2004) 4.02
Inhibitory signalling to the Arp2/3 complex steers cell migration. Nature (2013) 2.06
The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway. Nucleic Acids Res (2004) 1.42
The hMsh2-hMsh6 complex acts in concert with monoubiquitinated PCNA and Pol η in response to oxidative DNA damage in human cells. Mol Cell (2011) 1.34
Enzymology of repair of etheno-adducts. Mutat Res (2003) 1.15
The 3'->5' exonuclease of Apn1 provides an alternative pathway to repair 7,8-dihydro-8-oxodeoxyguanosine in Saccharomyces cerevisiae. Mol Cell Biol (2005) 1.14
Cisplatin resistance associated with PARP hyperactivation. Cancer Res (2013) 1.11
The picobirnavirus crystal structure provides functional insights into virion assembly and cell entry. EMBO J (2009) 1.10
Real-time studies of conformational dynamics of the repair enzyme E. coli formamidopyrimidine-DNA glycosylase and its DNA complexes during catalytic cycle. Mutat Res (2009) 1.09
Characterisation of new substrate specificities of Escherichia coli and Saccharomyces cerevisiae AP endonucleases. Nucleic Acids Res (2003) 1.08
Identification of structural and molecular determinants of the tyrosine-kinase Wzc and implications in capsular polysaccharide export. Mol Microbiol (2010) 1.07
A molecular beacon assay for measuring base excision repair activities. Biochem Biophys Res Commun (2004) 1.06
The Pih1-Tah1 cochaperone complex inhibits Hsp90 molecular chaperone ATPase activity. J Biol Chem (2010) 1.05
DNA repair and the origins of urinary oxidized 2'-deoxyribonucleosides. Mutagenesis (2010) 1.05
Pre-steady-state kinetics shows differences in processing of various DNA lesions by Escherichia coli formamidopyrimidine-DNA glycosylase. Nucleic Acids Res (2004) 1.02
Central ions and lateral asparagine/glutamine zippers stabilize the post-fusion hairpin conformation of the SARS coronavirus spike glycoprotein. Virology (2005) 1.01
Characterisation of the substrate specificity of homogeneous vaccinia virus uracil-DNA glycosylase. Nucleic Acids Res (2003) 1.01
Major oxidative products of cytosine are substrates for the nucleotide incision repair pathway. DNA Repair (Amst) (2006) 0.99
Stopped-flow kinetic studies of the interaction between Escherichia coli Fpg protein and DNA substrates. Biochemistry (2002) 0.98
Alpha-anomeric deoxynucleotides, anoxic products of ionizing radiation, are substrates for the endonuclease IV-type AP endonucleases. Biochemistry (2004) 0.98
Structure of the yeast Pml1 splicing factor and its integration into the RES complex. Nucleic Acids Res (2008) 0.97
Actin polymerization controls the organization of WASH domains at the surface of endosomes. PLoS One (2012) 0.94
Purification and crystallization reveal two types of interactions of the fusion protein homotrimer of Semliki Forest virus. J Virol (2004) 0.93
A conserved mechanism of GABA binding and antagonism is revealed by structure-function analysis of the periplasmic binding protein Atu2422 in Agrobacterium tumefaciens. J Biol Chem (2010) 0.92
Von Hippel-Lindau: how a rare disease illuminates cancer biology. Semin Cancer Biol (2012) 0.90
Recognition of damaged DNA by Escherichia coli Fpg protein: insights from structural and kinetic data. Mutat Res (2003) 0.89
Apoptotic topoisomerase I-DNA complexes induced by staurosporine-mediated oxygen radicals. J Biol Chem (2004) 0.89
2'-deoxyribonolactone lesion produces G->A transitions in Escherichia coli. Nucleic Acids Res (2004) 0.88
Crystal structures of A. acidocaldarius endoglucanase Cel9A in complex with cello-oligosaccharides: strong -1 and -2 subsites mimic cellobiohydrolase activity. J Mol Biol (2009) 0.87
Structural basis for selective GABA binding in bacterial pathogens. Mol Microbiol (2012) 0.87
KIN17 encodes an RNA-binding protein and is expressed during mouse spermatogenesis. J Cell Sci (2004) 0.87
Genetic and biochemical characterization of human AP endonuclease 1 mutants deficient in nucleotide incision repair activity. PLoS One (2010) 0.86
Thermodynamic, kinetic and structural basis for recognition and repair of abasic sites in DNA by apurinic/apyrimidinic endonuclease from human placenta. Nucleic Acids Res (2004) 0.86
Characterization of two independent amino acid substitutions that disrupt the DNA repair functions of the yeast Apn1. Biochemistry (2003) 0.85
Coupling of the nucleotide incision and 3'-->5' exonuclease activities in Escherichia coli endonuclease IV: Structural and genetic evidences. Mutat Res (2009) 0.85
Step-by-step mechanism of DNA damage recognition by human 8-oxoguanine DNA glycosylase. Biochim Biophys Acta (2013) 0.84
Substrate specificity of homogeneous monkeypox virus uracil-DNA glycosylase. Biochemistry (2007) 0.84
New insights in the removal of the hydantoins, oxidation product of pyrimidines, via the base excision and nucleotide incision repair pathways. PLoS One (2011) 0.84
The Fanconi anemia pathway promotes DNA glycosylase-dependent excision of interstrand DNA crosslinks. Environ Mol Mutagen (2010) 0.84
Insight into mechanisms of 3'-5' exonuclease activity and removal of bulky 8,5'-cyclopurine adducts by apurinic/apyrimidinic endonucleases. Proc Natl Acad Sci U S A (2013) 0.82
A metagenomic study highlights phylogenetic proximity of quorum-quenching and xenobiotic-degrading amidases of the AS-family. PLoS One (2013) 0.82
Effect of the multifunctional proteins RPA, YB-1, and XPC repair factor on AP site cleavage by DNA glycosylase NEIL1. J Mol Recognit (2012) 0.82
The mechanism of human tyrosyl-DNA phosphodiesterase 1 in the cleavage of AP site and its synthetic analogs. DNA Repair (Amst) (2013) 0.82
Systematic bioinformatics and experimental validation of yeast complexes reduces the rate of attrition during structural investigations. Structure (2010) 0.82
Uracil in duplex DNA is a substrate for the nucleotide incision repair pathway in human cells. Proc Natl Acad Sci U S A (2013) 0.81
Excision of 8-oxoguanine from methylated CpG dinucleotides by human 8-oxoguanine DNA glycosylase. FEBS Lett (2013) 0.81
Plant ALDH10 family: identifying critical residues for substrate specificity and trapping a thiohemiacetal intermediate. J Biol Chem (2013) 0.80
Action of multiple base excision repair enzymes on the 2'-deoxyribonolactone. Biochem Biophys Res Commun (2005) 0.80
Functional characterization of the Caenorhabditis elegans DNA repair enzyme APN-1. DNA Repair (Amst) (2012) 0.80
African swine fever virus AP endonuclease is a redox-sensitive enzyme that repairs alkylating and oxidative damage to DNA. Virology (2009) 0.79
Endogenous DNA damage clusters in human hematopoietic stem and progenitor cells. Free Radic Biol Med (2008) 0.79
Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance. Cancer Cell (2016) 0.78
A potential fortuitous binding of inhibitors of an inverting family GH9 β-glycosidase derived from isofagomine. Org Biomol Chem (2011) 0.78
Highly mutagenic exocyclic DNA adducts are substrates for the human nucleotide incision repair pathway. PLoS One (2012) 0.78
Presence of base excision repair enzymes in the wheat aleurone and their activation in cells undergoing programmed cell death. Plant Physiol Biochem (2011) 0.78
Characterization of Caenorhabditis elegans exonuclease-3 and evidence that a Mg2+-dependent variant exhibits a distinct mode of action on damaged DNA. Biochemistry (2005) 0.78
7,8-Dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases. Nucleic Acids Res (2012) 0.77
Age-dependent increase of 8-oxoguanine-, hypoxanthine-, and uracil- DNA glycosylase activities in liver extracts from OXYS rats with inherited overgeneration of free radicals and Wistar rats. Med Sci Monit (2003) 0.77
Mismatch dependent uracil/thymine-DNA glycosylases excise exocyclic hydroxyethano and hydroxypropano cytosine adducts. Acta Biochim Pol (2005) 0.77
Crystallization and preliminary X-ray analysis of human endonuclease 1 (APE1) in complex with an oligonucleotide containing a 5,6-dihydrouracil (DHU) or an alpha-anomeric 2'-deoxyadenosine (alphadA) modified base. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.77
Structure and function of nucleoside hydrolases from Physcomitrella patens and maize catalyzing the hydrolysis of purine, pyrimidine, and cytokinin ribosides. Plant Physiol (2013) 0.77
Sequence-specific p53 gene damage by chloroacetaldehyde and its repair kinetics in Escherichia coli. Acta Biochim Pol (2006) 0.76
High resolution characterization of formamidopyrimidine-DNA glycosylase interaction with its substrate by chemical cross-linking and mass spectrometry using substrate analogs. J Biol Chem (2006) 0.76
Lys98 substitution in human AP endonuclease 1 affects the kinetic mechanism of enzyme action in base excision and nucleotide incision repair pathways. PLoS One (2011) 0.75
Effect of concentration of anionic polymethine dye in poly-N-epoxypropylcarbazole polymer film composite on the spectral-luminescent properties and photoconductivity. Spectrochim Acta A Mol Biomol Spectrosc (2012) 0.75
Electronic structure and solvatochromism of merocyanines NMR spectroscopic point of view. Spectrochim Acta A Mol Biomol Spectrosc (2006) 0.75
Direct DNA Lesion Reversal and Excision Repair in Escherichia coli. Ecosal Plus (2013) 0.75