Published in Annu Rev Immunol on January 01, 2006
TGFbeta in Cancer. Cell (2008) 17.44
Cellular and molecular mechanisms of fibrosis. J Pathol (2008) 14.01
Immunosuppressive strategies that are mediated by tumor cells. Annu Rev Immunol (2007) 8.31
Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J Clin Invest (2007) 6.56
Cancer immunotherapy via dendritic cells. Nat Rev Cancer (2012) 5.37
TGFbeta signalling: a complex web in cancer progression. Nat Rev Cancer (2010) 5.27
Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice. Nature (2007) 4.94
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TGF-beta: a master of all T cell trades. Cell (2008) 4.60
Th17 cells in human disease. Immunol Rev (2008) 4.27
Tregs and rethinking cancer immunotherapy. J Clin Invest (2007) 3.77
The polarization of immune cells in the tumour environment by TGFbeta. Nat Rev Immunol (2010) 3.57
Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science (2009) 3.47
Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease. Cell Host Microbe (2011) 3.46
Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition. J Cell Biol (2006) 3.44
Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis. Immunity (2008) 3.40
Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression. J Immunol (2008) 3.37
Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum. Crit Care Med (2009) 3.16
Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nat Med (2008) 3.15
Heterogeneity of microglial activation in the innate immune response in the brain. J Neuroimmune Pharmacol (2009) 3.04
Th17 cells: effector T cells with inflammatory properties. Semin Immunol (2007) 2.81
CD8+ CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cells. J Immunol (2008) 2.69
TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression. Trends Immunol (2010) 2.61
An antibiotic-responsive mouse model of fulminant ulcerative colitis. PLoS Med (2008) 2.50
Retracted FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancer. J Clin Invest (2011) 2.44
Langerhans cells are not required for efficient skin graft rejection. J Invest Dermatol (2008) 2.41
Development and characterization of IL-21-producing CD4+ T cells. J Exp Med (2008) 2.34
Obesity- and aging-induced excess of central transforming growth factor-β potentiates diabetic development via an RNA stress response. Nat Med (2014) 2.33
An anti-transforming growth factor beta antibody suppresses metastasis via cooperative effects on multiple cell compartments. Cancer Res (2008) 2.19
Targeting of SMAD5 links microRNA-155 to the TGF-beta pathway and lymphomagenesis. Proc Natl Acad Sci U S A (2010) 2.07
Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells. Immunity (2009) 2.04
Designing vaccines based on biology of human dendritic cell subsets. Immunity (2010) 2.04
Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells. J Exp Med (2007) 2.00
Regulatory T cells in asthma. Immunity (2009) 2.00
'Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation. Immunol Rev (2007) 1.98
Transforming growth factor beta (TGF-beta) and inflammation in cancer. Cytokine Growth Factor Rev (2009) 1.95
Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo. Immunity (2009) 1.94
The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1. Nat Immunol (2008) 1.91
TGFbeta promotes conversion of CD16+ peripheral blood NK cells into CD16- NK cells with similarities to decidual NK cells. Proc Natl Acad Sci U S A (2007) 1.91
Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity. Curr Opin Pharmacol (2009) 1.81
Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation. Blood (2011) 1.80
The TGF-beta paradox in human cancer: an update. Future Oncol (2009) 1.79
Glia-dependent TGF-beta signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis. J Clin Invest (2007) 1.78
Rosiglitazone abrogates bleomycin-induced scleroderma and blocks profibrotic responses through peroxisome proliferator-activated receptor-gamma. Am J Pathol (2009) 1.76
Recent developments in cancer vaccines. J Immunol (2011) 1.76
Expansion and activation of CD4(+)CD25(+) regulatory T cells in Heligmosomoides polygyrus infection. Eur J Immunol (2007) 1.75
Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation. Immunity (2011) 1.72
Cellular and molecular basis for the regulation of inflammation by TGF-beta. J Biochem (2010) 1.69
MicroRNA-155 targets SMAD2 and modulates the response of macrophages to transforming growth factor-{beta}. J Biol Chem (2010) 1.67
Transforming growth factor-β and the hallmarks of cancer. Cell Signal (2010) 1.66
TGF-beta promotes Th17 cell development through inhibition of SOCS3. J Immunol (2009) 1.66
The stumpy gene is required for mammalian ciliogenesis. Proc Natl Acad Sci U S A (2008) 1.66
The macrophage in HIV-1 infection: from activation to deactivation? Retrovirology (2010) 1.64
TGF-β activation and function in immunity. Annu Rev Immunol (2013) 1.63
Cells of the synovium in rheumatoid arthritis. T lymphocytes. Arthritis Res Ther (2007) 1.63
A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection. PLoS One (2010) 1.62
Natural regulatory T cells and persistent viral infection. J Virol (2007) 1.62
Cross talk among TGF-β signaling pathways, integrins, and the extracellular matrix. Cold Spring Harb Perspect Biol (2011) 1.60
Sequential exposure to carbon nanotubes and bacteria enhances pulmonary inflammation and infectivity. Am J Respir Cell Mol Biol (2007) 1.60
Human uterine epithelial cell secretions regulate dendritic cell differentiation and responses to TLR ligands. J Leukoc Biol (2010) 1.59
Connective tissue growth factor promotes fibrosis downstream of TGFbeta and IL-6 in chronic cardiac allograft rejection. Am J Transplant (2009) 1.59
Platelet-derived growth factor and transforming growth factor beta synergistically potentiate inflammatory mediator synthesis by fibroblast-like synoviocytes. Arthritis Res Ther (2010) 1.59
Mechanisms of regulatory T-cell suppression - a diverse arsenal for a moving target. Immunology (2008) 1.59
Stranger in a strange land. Immunol Rev (2006) 1.58
TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation. Nat Immunol (2012) 1.58
The Th17 family: flexibility follows function. Immunol Rev (2013) 1.58
Intestinal dendritic cells specialize to activate transforming growth factor-β and induce Foxp3+ regulatory T cells via integrin αvβ8. Gastroenterology (2011) 1.56
MicroRNA-155 controls RB phosphorylation in normal and malignant B lymphocytes via the noncanonical TGF-β1/SMAD5 signaling module. Blood (2013) 1.52
TGF-beta and regulatory T cell in immunity and autoimmunity. J Clin Immunol (2008) 1.49
TGF-beta induces p65 acetylation to enhance bacteria-induced NF-kappaB activation. EMBO J (2007) 1.49
The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Nat Immunol (2011) 1.45
A novel probiotic mixture exerts a therapeutic effect on experimental autoimmune encephalomyelitis mediated by IL-10 producing regulatory T cells. PLoS One (2010) 1.45
How diverse--CD4 effector T cells and their functions. J Mol Cell Biol (2009) 1.44
Transforming growth factor-β: activation by neuraminidase and role in highly pathogenic H5N1 influenza pathogenesis. PLoS Pathog (2010) 1.44
TGF-beta utilizes SMAD3 to inhibit CD16-mediated IFN-gamma production and antibody-dependent cellular cytotoxicity in human NK cells. J Immunol (2008) 1.43
Transforming growth factor-beta signaling: emerging stem cell target in metastatic breast cancer? Breast Cancer Res Treat (2008) 1.41
Molecular mechanisms of treg-mediated T cell suppression. Front Immunol (2012) 1.41
Decreased transforming growth factor beta1 in autism: a potential link between immune dysregulation and impairment in clinical behavioral outcomes. J Neuroimmunol (2008) 1.41
Prediction of graft-versus-host disease in humans by donor gene-expression profiling. PLoS Med (2007) 1.40
Role of transforming growth factor Beta in corneal function, biology and pathology. Curr Mol Med (2010) 1.39
Immune therapy for type 1 diabetes mellitus-what is unique about anti-CD3 antibodies? Nat Rev Endocrinol (2010) 1.39
The kynurenine system and immunoregulation. J Neural Transm (Vienna) (2011) 1.38
Systemic blockade of transforming growth factor-beta signaling augments the efficacy of immunogene therapy. Cancer Res (2008) 1.38
Mechanisms of lung development: contribution to adult lung disease and relevance to chronic obstructive pulmonary disease. Proc Am Thorac Soc (2009) 1.38
S100A9 interaction with TLR4 promotes tumor growth. PLoS One (2012) 1.37
Immunoregulatory mechanisms triggered by viral infections protect from type 1 diabetes in mice. J Clin Invest (2009) 1.37
Drug development against metastasis-related genes and their pathways: a rationale for cancer therapy. Biochim Biophys Acta (2008) 1.36
Review of the activation of TGF-beta in immunity. J Leukoc Biol (2008) 1.35
Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis. PLoS Pathog (2011) 1.34
Small intestinal CD8+TCRgammadelta+NKG2A+ intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease. J Clin Invest (2008) 1.34
A T cell-dependent mechanism for the induction of human mucosal homing immunoglobulin A-secreting plasmablasts. Immunity (2009) 1.33
Selective enrichment of newly synthesized proteins for quantitative secretome analysis. Nat Biotechnol (2012) 1.32
Dendritic cells and immunity against cancer. J Intern Med (2011) 1.32
Transforming growth factor-beta receptor blockade augments the effectiveness of adoptive T-cell therapy of established solid cancers. Clin Cancer Res (2008) 1.32
Down-regulation of the forkhead transcription factor Foxp1 is required for monocyte differentiation and macrophage function. Blood (2008) 1.31
CD4+CD25+Foxp3+ regulatory T cells depletion may attenuate the development of silica-induced lung fibrosis in mice. PLoS One (2010) 1.31
TGFbeta1 and Treg cells: alliance for tolerance. Trends Mol Med (2007) 1.30
Local immunity by tissue-resident CD8(+) memory T cells. Front Immunol (2012) 1.30
GARP regulates the bioavailability and activation of TGFβ. Mol Biol Cell (2012) 1.28
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science (2005) 11.31
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature (2012) 10.74
Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity (2006) 10.58
NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell (2011) 9.75
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature (2008) 9.16
Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci U S A (2004) 9.00
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proc Natl Acad Sci U S A (2006) 8.27
MAP kinases in the immune response. Annu Rev Immunol (2001) 7.62
Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat Med (2004) 7.49
Interchromosomal associations between alternatively expressed loci. Nature (2005) 7.45
IRAK-M is a negative regulator of Toll-like receptor signaling. Cell (2002) 6.79
T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity (2007) 6.61
Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature (2007) 6.58
Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science (2006) 6.55
A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat Immunol (2007) 6.20
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity (2006) 6.00
Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc Natl Acad Sci U S A (2005) 5.96
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature (2002) 5.95
Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity (2006) 5.91
Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity (2007) 5.73
The Nalp3 inflammasome is essential for the development of silicosis. Proc Natl Acad Sci U S A (2008) 5.59
Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell (2004) 5.50
Toll-like receptor 3 promotes cross-priming to virus-infected cells. Nature (2005) 5.32
A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nat Immunol (2009) 5.26
A toll-like receptor that prevents infection by uropathogenic bacteria. Science (2004) 5.26
Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science (2009) 5.24
Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. J Clin Invest (2009) 5.09
Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome. J Exp Med (2007) 4.95
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc Natl Acad Sci U S A (2004) 4.88
TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science (2005) 4.86
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med (2005) 4.85
The NLR gene family: a standard nomenclature. Immunity (2008) 4.77
The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection. Nat Immunol (2006) 4.70
Long-range intrachromosomal interactions in the T helper type 2 cytokine locus. Nat Immunol (2004) 4.67
Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity (2008) 4.67
TGF-beta: a master of all T cell trades. Cell (2008) 4.60
Transforming growth factor-beta in T-cell biology. Nat Rev Immunol (2002) 4.50
Inflammation and atherosclerosis. Annu Rev Pathol (2006) 4.47
Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. J Exp Med (2007) 4.47
Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease. Nat Immunol (2006) 4.44
T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells. J Exp Med (2005) 4.28
Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med (2006) 4.28
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat Immunol (2003) 4.15
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature (2002) 4.15
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc Natl Acad Sci U S A (2004) 4.12
Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. Immunity (2007) 4.07
Control of TH17 cells occurs in the small intestine. Nature (2011) 4.03
Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse. Immunity (2006) 4.02
Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nat Rev Cancer (2013) 4.02
Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proc Natl Acad Sci U S A (2009) 3.99
Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis. J Exp Med (2006) 3.76
Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proc Natl Acad Sci U S A (2006) 3.74
The inflammasome: first line of the immune response to cell stress. Cell (2006) 3.73
The polarization of immune cells in the tumour environment by TGFbeta. Nat Rev Immunol (2010) 3.57
Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC. Cell Host Microbe (2007) 3.52
STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci U S A (2003) 3.46
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus. J Exp Med (2005) 3.43
ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity. J Exp Med (2008) 3.39
Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. Immunity (2011) 3.38
OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands. J Clin Invest (2004) 3.38
Mechanism of p38 MAP kinase activation in vivo. Genes Dev (2003) 3.36
T helper cell differentiation: regulation by cis elements and epigenetics. Immunity (2006) 3.33
Chemical genetic analysis of the time course of signal transduction by JNK. Mol Cell (2006) 3.32
Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10. Immunity (2008) 3.26
TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes. Proc Natl Acad Sci U S A (2004) 3.26
Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo. J Immunol (2010) 3.25
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity (2007) 3.19
Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nat Med (2008) 3.15
JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science (2012) 3.12
An essential role of the transcription factor GATA-3 for the function of regulatory T cells. Immunity (2011) 3.11
The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol (2002) 3.08
Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation. J Immunol (2002) 3.04
Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma. Nat Immunol (2005) 2.96
CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes. Proc Natl Acad Sci U S A (2003) 2.94
Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J Clin Invest (2008) 2.91
Regulation of the Th2 cytokine locus by a locus control region. Immunity (2003) 2.84
A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system. Cell Host Microbe (2010) 2.84
Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. J Exp Med (2004) 2.84
An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance. Immunity (2009) 2.82
Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med (2002) 2.77
Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria. Proc Natl Acad Sci U S A (2006) 2.75
Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. J Cell Biol (2005) 2.75
The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR. Nat Immunol (2009) 2.73
Does Toll-like receptor 3 play a biological role in virus infections? Virology (2004) 2.73
Caspase activity mediates the differentiation of embryonic stem cells. Cell Stem Cell (2008) 2.68
Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. Immunity (2009) 2.66
The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat Immunol (2006) 2.65
Molecular mechanism of NLRP3 inflammasome activation. J Clin Immunol (2010) 2.61
Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis. J Exp Med (2009) 2.61
Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation. J Exp Med (2002) 2.60
Humanized mice for modeling human infectious disease: challenges, progress, and outlook. Cell Host Microbe (2009) 2.58
Transcriptional regulation of th2 differentiation by inducible costimulator. Immunity (2003) 2.56
STAT3 is required for Flt3L-dependent dendritic cell differentiation. Immunity (2003) 2.54
Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity (2012) 2.54
TH2, allergy and group 2 innate lymphoid cells. Nat Immunol (2013) 2.52