Clostridium difficile spore-macrophage interactions: spore survival.

PubWeight™: 0.97‹?› | Rank: Top 15%

🔗 View Article (PMC 3428350)

Published in PLoS One on August 27, 2012

Authors

Daniel Paredes-Sabja1, Glenda Cofre-Araneda, Christian Brito-Silva, Marjorie Pizarro-Guajardo, Mahfuzur R Sarker

Author Affiliations

1: Laboratorio de Mecanismos de Patogénesis Bacteriana, Departamento de Ciencias Biológicas, Facultad de Ciencias Biológicas, Universidad Andres Bello, Santiago, Chile. daniel.paredes.sabja@gmail.com

Articles citing this

Clostridium difficile spore biology: sporulation, germination, and spore structural proteins. Trends Microbiol (2014) 1.73

The spore differentiation pathway in the enteric pathogen Clostridium difficile. PLoS Genet (2013) 1.14

Clostridium difficile infection. Nat Rev Dis Prim (2016) 0.99

The Clostridium difficile exosporium cysteine (CdeC)-rich protein is required for exosporium morphogenesis and coat assembly. J Bacteriol (2013) 0.98

The host immune response to Clostridium difficile infection. Ther Adv Infect Dis (2013) 0.96

The Exosporium Layer of Bacterial Spores: a Connection to the Environment and the Infected Host. Microbiol Mol Biol Rev (2015) 0.92

Characterization of the Dynamic Germination of Individual Clostridium difficile Spores Using Raman Spectroscopy and Differential Interference Contrast Microscopy. J Bacteriol (2015) 0.88

Clostridium novyi-NT can cause regression of orthotopically implanted glioblastomas in rats. Oncotarget (2015) 0.86

Ultrastructural Variability of the Exosporium Layer of Clostridium difficile Spores. Appl Environ Microbiol (2016) 0.83

EP4 and EP2 receptor activation of protein kinase A by prostaglandin E2 impairs macrophage phagocytosis of Clostridium sordellii. Am J Reprod Immunol (2013) 0.82

Identification and characterization of glycoproteins on the spore surface of Clostridium difficile. J Bacteriol (2014) 0.79

Ultrastructure Variability of the Exosporium Layer of Clostridium difficile Spores from Sporulating Cultures and Biofilms. Appl Environ Microbiol (2016) 0.76

Immunogenicity and protective efficacy of Clostridium difficile spore proteins. Anaerobe (2015) 0.75

Surface layer proteins from virulent Clostridium difficile ribotypes exhibit signatures of positive selection with consequences for innate immune response. BMC Evol Biol (2017) 0.75

Structural Characterization of Clostridium sordellii Spores of Diverse Human, Animal, and Environmental Origin and Comparison to Clostridium difficile Spores. mSphere (2017) 0.75

Articles cited by this

The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome. Nat Genet (2006) 8.02

Clostridium difficile infection: new developments in epidemiology and pathogenesis. Nat Rev Microbiol (2009) 7.89

Spore germination. Curr Opin Microbiol (2003) 6.02

Phagocytosis of the Legionnaires' disease bacterium (Legionella pneumophila) occurs by a novel mechanism: engulfment within a pseudopod coil. Cell (1984) 4.00

Structure, assembly, and function of the spore surface layers. Annu Rev Microbiol (2007) 3.50

Germination of Bacillus anthracis spores within alveolar macrophages. Mol Microbiol (1999) 3.49

Bile salts and glycine as cogerminants for Clostridium difficile spores. J Bacteriol (2008) 3.37

Antibiotic treatment of clostridium difficile carrier mice triggers a supershedder state, spore-mediated transmission, and severe disease in immunocompromised hosts. Infect Immun (2009) 3.36

Investigation of an outbreak of antibiotic-associated colitis by various typing methods. J Clin Microbiol (1982) 2.86

The cell biology of phagocytosis. Annu Rev Pathol (2011) 2.71

Fate of germinated Bacillus anthracis spores in primary murine macrophages. Mol Microbiol (2001) 2.30

Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages. J Exp Med (1996) 2.25

Complement driven by conformational changes. Nat Rev Immunol (2008) 2.21

Identification and characterization of a germination operon on the virulence plasmid pXO1 of Bacillus anthracis. Mol Microbiol (1999) 2.12

A hospital outbreak of Clostridium difficile disease associated with isolates carrying binary toxin genes. Clin Infect Dis (2004) 1.96

Proteomic and genomic characterization of highly infectious Clostridium difficile 630 spores. J Bacteriol (2009) 1.96

Murine macrophages kill the vegetative form of Bacillus anthracis. Infect Immun (2005) 1.91

Persistence of skin contamination and environmental shedding of Clostridium difficile during and after treatment of C. difficile infection. Infect Control Hosp Epidemiol (2010) 1.73

Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen. J Immunol (2011) 1.63

Bacterial metastasis: the host plasminogen system in bacterial invasion. Trends Microbiol (2005) 1.59

Molecular mechanisms of phagocytic uptake in mammalian cells. Cell Mol Life Sci (2008) 1.57

Characterization of Clostridium perfringens spores that lack SpoVA proteins and dipicolinic acid. J Bacteriol (2008) 1.53

Chenodeoxycholate is an inhibitor of Clostridium difficile spore germination. J Bacteriol (2008) 1.53

New trends in Clostridium difficile virulence and pathogenesis. Int J Antimicrob Agents (2009) 1.52

Role of GerD in germination of Bacillus subtilis spores. J Bacteriol (2006) 1.44

A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins. PLoS Pathog (2011) 1.39

Distinctive profiles of infection and pathology in hamsters infected with Clostridium difficile strains 630 and B1. Infect Immun (2009) 1.35

Activity of vancomycin against epidemic Clostridium difficile strains in a human gut model. J Antimicrob Chemother (2008) 1.23

Investigating the role of small, acid-soluble spore proteins (SASPs) in the resistance of Clostridium perfringens spores to heat. BMC Microbiol (2006) 1.19

The germination-specific lytic enzymes SleB, CwlJ1, and CwlJ2 each contribute to Bacillus anthracis spore germination and virulence. J Bacteriol (2009) 1.15

Antisense-RNA-mediated decreased synthesis of small, acid-soluble spore proteins leads to decreased resistance of clostridium perfringens spores to moist heat and UV radiation. Appl Environ Microbiol (2007) 1.12

Mycobacterial protein HbhA binds human complement component C3. Infect Immun (2001) 1.11

Factors involved in the germination and inactivation of Bacillus anthracis spores in murine primary macrophages. FEMS Microbiol Lett (2007) 1.04

Adherence of Clostridium difficile spores to Caco-2 cells in culture. J Med Microbiol (2012) 1.00

Surface-associated plasminogen binding of Cryptococcus neoformans promotes extracellular matrix invasion. PLoS One (2009) 0.98

GPIIb-IIIa antagonists cause rapid disaggregation of platelets pre-treated with cytochalasin D. Evidence that the stability of platelet aggregates depends on normal cytoskeletal assembly. Platelets (1998) 0.95

Roles of DacB and spm proteins in clostridium perfringens spore resistance to moist heat, chemicals, and UV radiation. Appl Environ Microbiol (2008) 0.94

The anaerobic pathogen Clostridium perfringens can escape the phagosome of macrophages under aerobic conditions. Cell Microbiol (2000) 0.90

Bacillus anthracis interacts with plasmin(ogen) to evade C3b-dependent innate immunity. PLoS One (2011) 0.88

Molecular basis of early stages of Clostridium difficile infection: germination and colonization. Future Microbiol (2012) 0.88

Histidine acts as a co-germinant with glycine and taurocholate for Clostridium difficile spores. J Appl Microbiol (2011) 0.87

The extracellular processing of HIV-1 envelope glycoprotein gp160 by human plasmin. FEBS Lett (1999) 0.86

Interactions between Clostridium perfringens spores and Raw 264.7 macrophages. Anaerobe (2011) 0.86

Germination response of spores of the pathogenic bacterium Clostridium perfringens and Clostridium difficile to cultured human epithelial cells. Anaerobe (2011) 0.85

Role of small, acid-soluble spore proteins in the resistance of Clostridium perfringens spores to chemicals. Int J Food Microbiol (2007) 0.84

Host serum factor triggers germination of Clostridium perfringens spores lacking the cortex hydrolysis machinery. J Med Microbiol (2011) 0.80

Articles by these authors

Germination of spores of Bacillales and Clostridiales species: mechanisms and proteins involved. Trends Microbiol (2010) 2.24

Association of beta2 toxin production with Clostridium perfringens type A human gastrointestinal disease isolates carrying a plasmid enterotoxin gene. Mol Microbiol (2005) 2.06

Characterization of Clostridium perfringens spores that lack SpoVA proteins and dipicolinic acid. J Bacteriol (2008) 1.53

Disruption of the gene (spo0A) encoding sporulation transcription factor blocks endospore formation and enterotoxin production in enterotoxigenic Clostridium perfringens type A. FEMS Microbiol Lett (2004) 1.39

Genotyping and phenotyping of beta2-toxigenic Clostridium perfringens fecal isolates associated with gastrointestinal diseases in piglets. J Clin Microbiol (2003) 1.32

Clostridium perfringens spore germination: characterization of germinants and their receptors. J Bacteriol (2007) 1.24

SleC is essential for cortex peptidoglycan hydrolysis during germination of spores of the pathogenic bacterium Clostridium perfringens. J Bacteriol (2009) 1.22

Investigating the role of small, acid-soluble spore proteins (SASPs) in the resistance of Clostridium perfringens spores to heat. BMC Microbiol (2006) 1.19

Antisense-RNA-mediated decreased synthesis of small, acid-soluble spore proteins leads to decreased resistance of clostridium perfringens spores to moist heat and UV radiation. Appl Environ Microbiol (2007) 1.12

Carbon catabolite repression of type IV pilus-dependent gliding motility in the anaerobic pathogen Clostridium perfringens. J Bacteriol (2007) 1.08

The protease CspB is essential for initiation of cortex hydrolysis and dipicolinic acid (DPA) release during germination of spores of Clostridium perfringens type A food poisoning isolates. Microbiology (2009) 1.07

Adherence of Clostridium difficile spores to Caco-2 cells in culture. J Med Microbiol (2012) 1.00

The Clostridium difficile exosporium cysteine (CdeC)-rich protein is required for exosporium morphogenesis and coat assembly. J Bacteriol (2013) 0.98

Inorganic phosphate induces spore morphogenesis and enterotoxin production in the intestinal pathogen Clostridium perfringens. Infect Immun (2006) 0.98

Strategy to inactivate Clostridium perfringens spores in meat products. Food Microbiol (2009) 0.95

CodY is a global regulator of virulence-associated properties for Clostridium perfringens type D strain CN3718. MBio (2013) 0.95

Roles of DacB and spm proteins in clostridium perfringens spore resistance to moist heat, chemicals, and UV radiation. Appl Environ Microbiol (2008) 0.94

Regulated expression of the beta2-toxin gene (cpb2) in Clostridium perfringens type a isolates from horses with gastrointestinal diseases. J Clin Microbiol (2005) 0.94

Further characterization of Clostridium perfringens small acid soluble protein-4 (Ssp4) properties and expression. PLoS One (2009) 0.93

Role of GerKB in germination and outgrowth of Clostridium perfringens spores. Appl Environ Microbiol (2009) 0.92

Efficient inhibition of germination of coat-deficient bacterial spores by multivalent metal cations, including terbium (Tb³+). Appl Environ Microbiol (2011) 0.92

Germination of spores of Clostridium difficile strains, including isolates from a hospital outbreak of Clostridium difficile-associated disease (CDAD). Microbiology (2008) 0.92

Inorganic phosphate and sodium ions are cogerminants for spores of Clostridium perfringens type A food poisoning-related isolates. Appl Environ Microbiol (2009) 0.88

Comparison of the levels of heat resistance of wild-type, cpe knockout, and cpe plasmid-cured Clostridium perfringens type A strains. Appl Environ Microbiol (2005) 0.87

Interactions between Clostridium perfringens spores and Raw 264.7 macrophages. Anaerobe (2011) 0.86

Complementation of a Clostridium perfringens spo0A mutant with wild-type spo0A from other Clostridium species. Appl Environ Microbiol (2006) 0.86

Epidemic Clostridium difficile ribotype 027 in Chile. Emerg Infect Dis (2012) 0.85

Germination response of spores of the pathogenic bacterium Clostridium perfringens and Clostridium difficile to cultured human epithelial cells. Anaerobe (2011) 0.85

The Clostridium perfringens germinant receptor protein GerKC is located in the spore inner membrane and is crucial for spore germination. J Bacteriol (2013) 0.85

Molecular characterization of Clostridium perfringens isolates from humans with sporadic diarrhea: evidence for transcriptional regulation of the beta2-toxin-encoding gene. Appl Environ Microbiol (2005) 0.84

Role of small, acid-soluble spore proteins in the resistance of Clostridium perfringens spores to chemicals. Int J Food Microbiol (2007) 0.84

Clostridium perfringens sporulation and its relevance to pathogenesis. Future Microbiol (2009) 0.84

Unique regulatory mechanism of sporulation and enterotoxin production in Clostridium perfringens. J Bacteriol (2013) 0.84

GerO, a putative Na+/H+-K+ antiporter, is essential for normal germination of spores of the pathogenic bacterium Clostridium perfringens. J Bacteriol (2009) 0.83

Production of small, acid-soluble spore proteins in Clostridium perfringens nonfoodborne gastrointestinal disease isolates. Can J Microbiol (2007) 0.83

Microbiological food safety: a dilemma of developing societies. Crit Rev Microbiol (2012) 0.80

Clostridium perfringens tpeL is expressed during sporulation. Microb Pathog (2011) 0.80

Host serum factor triggers germination of Clostridium perfringens spores lacking the cortex hydrolysis machinery. J Med Microbiol (2011) 0.80

Identification of structural genes for Clostridium botulinum type C neurotoxin-converting phage particles. FEMS Microbiol Lett (2007) 0.80

Inhibitory effects of polyphosphates on Clostridium perfringens growth, sporulation and spore outgrowth. Food Microbiol (2008) 0.80

Effect of the cortex-lytic enzyme SleC from non-food-borne Clostridium perfringens on the germination properties of SleC-lacking spores of a food poisoning isolate. Can J Microbiol (2010) 0.79

Inhibitory effects of nisin against Clostridium perfringens food poisoning and nonfood-borne isolates. J Food Sci (2011) 0.79

Inactivation strategy for Clostridium perfringens spores adhered to food contact surfaces. Food Microbiol (2013) 0.79

Clostridium perfringens Sporulation and Sporulation-Associated Toxin Production. Microbiol Spectr (2016) 0.78

Effect of a small, acid-soluble spore protein from Clostridium perfringens on the resistance properties of Bacillus subtilis spores. J Bacteriol (2007) 0.76