Published in Mol Cell on October 07, 2011
Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system. Nat Cell Biol (2012) 3.90
The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks. Nat Struct Mol Biol (2011) 2.23
Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication. Science (2014) 1.69
Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions. J Biol Chem (2012) 1.09
Chromatin retention of DNA damage sensors DDB2 and XPC through loss of p97 segregase causes genotoxicity. Nat Commun (2014) 1.08
Signal-induced disassembly of the SCF ubiquitin ligase complex by Cdc48/p97. Mol Cell (2012) 0.96
The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A. J Cell Biol (2013) 0.95
Structure and function of the AAA+ ATPase p97/Cdc48p. Gene (2016) 0.94
Role of p97/VCP (Cdc48) in genome stability. Front Genet (2013) 0.94
CRL2(Lrr1) promotes unloading of the vertebrate replisome from chromatin during replication termination. Genes Dev (2017) 0.91
RNAi-Based Suppressor Screens Reveal Genetic Interactions Between the CRL2LRR-1 E3-Ligase and the DNA Replication Machinery in Caenorhabditis elegans. G3 (Bethesda) (2016) 0.89
Termination of DNA replication forks: "Breaking up is hard to do". Nucleus (2015) 0.86
The p97-UFD1L-NPL4 protein complex mediates cytokine-induced IκBα proteolysis. Mol Cell Biol (2013) 0.84
Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression. Nat Commun (2016) 0.84
VBP1 facilitates proteasome and autophagy-mediated degradation of MutS homologue hMSH4. FASEB J (2013) 0.83
Concerted action of the ubiquitin-fusion degradation protein 1 (Ufd1) and Sumo-targeted ubiquitin ligases (STUbLs) in the DNA-damage response. PLoS One (2013) 0.81
Revoking the cellular license to replicate: yet another AAA assignment. Mol Cell (2011) 0.81
Ring of Change: CDC48/p97 Drives Protein Dynamics at Chromatin. Front Genet (2016) 0.81
The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation. Cell Cycle (2014) 0.81
Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication. Chromosoma (2016) 0.81
The 26S proteasome and initiation of gene transcription. Biomolecules (2014) 0.79
The Transitional Endoplasmic Reticulum ATPase p97 Regulates the Alternative Nuclear Factor NF-κB Signaling via Partial Degradation of the NF-κB Subunit p100. J Biol Chem (2015) 0.78
A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells. Nat Commun (2016) 0.77
CUL-2(LRR-1) and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis. Nat Cell Biol (2017) 0.76
Ufd1-Npl4 Recruit Cdc48 for Disassembly of Ubiquitylated CMG Helicase at the End of Chromosome Replication. Cell Rep (2017) 0.75
E4 ligase-specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis. Nat Struct Mol Biol (2016) 0.75
Conducting the finale of DNA replication. Genes Dev (2017) 0.75
Eukaryotic Replicative Helicase Subunit Interaction with DNA and Its Role in DNA Replication. Genes (Basel) (2017) 0.75
Mechanisms of DNA replication termination. Nat Rev Mol Cell Biol (2017) 0.75
A Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase. Front Mol Biosci (2017) 0.75
The genetics of Caenorhabditis elegans. Genetics (1974) 102.14
DNA replication in eukaryotic cells. Annu Rev Biochem (2001) 13.39
Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev (2001) 12.46
Cell cycle extracts. Methods Cell Biol (1991) 9.47
Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans. Genome Biol (2000) 9.01
The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol. Nature (2001) 7.59
GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat Cell Biol (2006) 6.36
Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase. Proc Natl Acad Sci U S A (2006) 5.66
Cold-sensitive cell-division-cycle mutants of yeast: isolation, properties, and pseudoreversion studies. Genetics (1982) 4.66
Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins. Mol Cell (2010) 4.24
Dual inhibition of sister chromatid separation at metaphase. Cell (2001) 4.23
Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48. Nat Cell Biol (2002) 4.06
AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation. Mol Cell Biol (2002) 3.77
Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication. Mol Cell (2006) 3.77
Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone. Cell (2001) 3.62
XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis. Nature (2000) 3.25
Eukaryotic chromosome DNA replication: where, when, and how? Annu Rev Biochem (2010) 3.17
CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing. Nature (2003) 3.07
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression. Mol Cell (2006) 3.00
Diverse functions with a common regulator: ubiquitin takes command of an AAA ATPase. J Struct Biol (2006) 2.66
An abundant and ubiquitous homo-oligomeric ring-shaped ATPase particle related to the putative vesicle fusion proteins Sec18p and NSF. EMBO J (1990) 2.60
UBX domain proteins: major regulators of the AAA ATPase Cdc48/p97. Cell Mol Life Sci (2008) 2.59
Differential activation of the DNA replication checkpoint contributes to asynchrony of cell division in C. elegans embryos. Curr Biol (2003) 2.33
Central role for cdc45 in establishing an initiation complex of DNA replication in Xenopus egg extracts. Genes Cells (2000) 2.12
The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. Nature (2005) 2.01
DNA replication and progression through S phase. Oncogene (2005) 1.99
Docking of a specialized PIP Box onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt2. Mol Cell (2009) 1.97
Cdc48/p97 mediates UV-dependent turnover of RNA Pol II. Mol Cell (2011) 1.91
Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis. EMBO J (2004) 1.88
Two loci required for cytoplasmic organization in early embryos of Caenorhabditis elegans. Dev Biol (1986) 1.86
Different forms of soluble cytoplasmic mRNA binding proteins and particles in Xenopus laevis oocytes and embryos. J Cell Biol (1991) 1.63
DNA replication defects delay cell division and disrupt cell polarity in early Caenorhabditis elegans embryos. Dev Biol (2000) 1.61
CDK- and Cdc45-dependent priming of the MCM complex on chromatin during S-phase in Xenopus egg extracts: possible activation of MCM helicase by association with Cdc45. Genes Cells (2003) 1.57
Ordered assembly of Sld3, GINS and Cdc45 is distinctly regulated by DDK and CDK for activation of replication origins. EMBO J (2006) 1.44
Cdt1 degradation to prevent DNA re-replication: conserved and non-conserved pathways. Cell Div (2007) 1.42
The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication. Nucleic Acids Res (2009) 1.35
Anterior-posterior polarity in C. elegans and Drosophila--PARallels and differences. Science (2002) 1.35
Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication. Proc Natl Acad Sci U S A (2008) 1.29
Multiple genetic pathways involving the Caenorhabditis elegans Bloom's syndrome genes him-6, rad-51, and top-3 are needed to maintain genome stability in the germ line. Mol Cell Biol (2004) 1.16
Coupling the cell cycle to development. Development (2009) 1.13
A conserved role of Caenorhabditis elegans CDC-48 in ER-associated protein degradation. J Struct Biol (2006) 1.01
Prolyl isomerase Pin1 acts as a switch to control the degree of substrate ubiquitylation. Nat Cell Biol (2009) 0.99
RBX1 (RING box protein 1) E3 ubiquitin ligase is required for genomic integrity by modulating DNA replication licensing proteins. J Biol Chem (2010) 0.99
Caenorhabditis elegans p97/CDC-48 is crucial for progression of meiosis I. Biochem Biophys Res Commun (2007) 0.92
Analysis of the two p97/VCP/Cdc48p proteins of Caenorhabditis elegans and their suppression of polyglutamine-induced protein aggregation. J Struct Biol (2004) 0.91
The AAA-ATPase p97-Ufd1-Npl4 is required for ERAD but not for spindle disassembly in Xenopus egg extracts. J Cell Sci (2007) 0.86
The ubiquitin-selective chaperone CDC-48/p97, a new player in DNA replication. Cell Cycle (2009) 0.85
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell (2008) 5.38
Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress. Genes Dev (2007) 4.60
Combined functional genomic maps of the C. elegans DNA damage response. Science (2002) 3.74
Live-cell imaging reveals replication of individual replicons in eukaryotic replication factories. Cell (2006) 3.56
Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2. Cell (2010) 3.43
Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress. J Cell Biol (2006) 3.27
Genetic and cytological characterization of the recombination protein RAD-51 in Caenorhabditis elegans. Chromosoma (2003) 2.29
The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks. Nat Struct Mol Biol (2011) 2.23
Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis. Cell (2005) 2.21
DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance. Nature (2013) 2.13
Regulating the licensing of DNA replication origins in metazoa. Curr Opin Cell Biol (2006) 2.08
Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosis. Curr Biol (2002) 2.06
The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy. Nat Cell Biol (2007) 2.04
Cell type-specific responses of human cells to inhibition of replication licensing. Oncogene (2002) 1.91
The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation. J Cell Biol (2004) 1.89
Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus. EMBO J (2004) 1.84
Deregulated replication licensing causes DNA fragmentation consistent with head-to-tail fork collision. Mol Cell (2006) 1.73
Characterization of a novel ATR-dependent, Chk1-independent, intra-S-phase checkpoint that suppresses initiation of replication in Xenopus. J Cell Sci (2004) 1.72
Mutual inhibition of separase and Cdk1 by two-step complex formation. Mol Cell (2005) 1.72
Increased bone adiposity and peroxisomal proliferator-activated receptor-gamma2 expression in type I diabetic mice. Endocrinology (2005) 1.70
An item response analysis of the motor and behavioral subscales of the unified Huntington's disease rating scale in huntington disease gene expansion carriers. Mov Disord (2011) 1.68
Essential CDK1-inhibitory role for separase during meiosis I in vertebrate oocytes. Nat Cell Biol (2006) 1.68
Otd/Crx, a dual regulator for the specification of ommatidia subtypes in the Drosophila retina. Dev Cell (2003) 1.67
Distinction between color photoreceptor cell fates is controlled by Prospero in Drosophila. Dev Cell (2003) 1.63
Geminin becomes activated as an inhibitor of Cdt1/RLF-B following nuclear import. Curr Biol (2002) 1.63
Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories. J Cell Biol (2010) 1.63
ELYS/MEL-28 chromatin association coordinates nuclear pore complex assembly and replication licensing. Curr Biol (2007) 1.61
MCM2-7 form double hexamers at licensed origins in Xenopus egg extract. J Biol Chem (2011) 1.55
Cleavage of cohesin rings coordinates the separation of centrioles and chromatids. Nat Cell Biol (2011) 1.54
BRCA1/BARD1 orthologs required for DNA repair in Caenorhabditis elegans. Curr Biol (2004) 1.52
Mammalian nuclei become licensed for DNA replication during late telophase. J Cell Sci (2002) 1.51
The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegans. J Cell Biol (2007) 1.49
Non-proteolytic inactivation of geminin requires CDK-dependent ubiquitination. Nat Cell Biol (2004) 1.45
C. elegans SIR-2.1 translocation is linked to a proapoptotic pathway parallel to cep-1/p53 during DNA damage-induced apoptosis. Genes Dev (2008) 1.41
Think locally: control of ubiquitin-dependent protein degradation in neurons. EMBO Rep (2008) 1.33
Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication. Proc Natl Acad Sci U S A (2008) 1.29
Stable-isotope labeling with amino acids in nematodes. Nat Methods (2011) 1.28
Centromere DNA decatenation depends on cohesin removal and is required for mammalian cell division. J Cell Sci (2010) 1.28
Sirtuin/Sir2 phylogeny, evolutionary considerations and structural conservation. Mol Cells (2009) 1.27
Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I. J Cell Sci (2009) 1.24
Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Nat Chem Biol (2013) 1.23
Protein quality control gets muscle into shape. Trends Cell Biol (2008) 1.23
trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase. PLoS Genet (2006) 1.23
Bod1, a novel kinetochore protein required for chromosome biorientation. J Cell Biol (2007) 1.22
The requirement of yeast replication origins for pre-replication complex proteins is modulated by transcription. Nucleic Acids Res (2005) 1.22
Motor inhibition in patients with Gilles de la Tourette syndrome: functional activation patterns as revealed by EEG coherence. Brain (2004) 1.21
DNA replication licensing in somatic and germ cells. J Cell Sci (2004) 1.21
Growing sphere of influence: Cdc48/p97 orchestrates ubiquitin-dependent extraction from chromatin. Trends Cell Biol (2012) 1.21
The Caenorhabditis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair. PLoS Genet (2010) 1.21
Replication factory activation can be decoupled from the replication timing program by modulating Cdk levels. J Cell Biol (2010) 1.20
Replication of mitochondrial DNA occurs throughout the mitochondria of cultured human cells. Exp Cell Res (2003) 1.19
Phylogeny and function of the invertebrate p53 superfamily. Cold Spring Harb Perspect Biol (2010) 1.19
The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo. J Cell Biol (2002) 1.19
Prophase pathway-dependent removal of cohesin from human chromosomes requires opening of the Smc3-Scc1 gate. EMBO J (2013) 1.19
The Caenorhabditis elegans AMP-activated protein kinase AAK-2 is phosphorylated by LKB1 and is required for resistance to oxidative stress and for normal motility and foraging behavior. J Biol Chem (2008) 1.19
LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis. Science (2012) 1.18
Multiple genetic pathways involving the Caenorhabditis elegans Bloom's syndrome genes him-6, rad-51, and top-3 are needed to maintain genome stability in the germ line. Mol Cell Biol (2004) 1.16
Functional domains of the Xenopus replication licensing factor Cdt1. Nucleic Acids Res (2005) 1.16
Clusters, factories and domains: The complex structure of S-phase comes into focus. Cell Cycle (2010) 1.15
Kinetochores coordinate pericentromeric cohesion and early DNA replication by Cdc7-Dbf4 kinase recruitment. Mol Cell (2013) 1.14
Combinatorial regulation of meiotic holliday junction resolution in C. elegans by HIM-6 (BLM) helicase, SLX-4, and the SLX-1, MUS-81 and XPF-1 nucleases. PLoS Genet (2013) 1.13
Deficiency for the ubiquitin ligase UBE3B in a blepharophimosis-ptosis-intellectual-disability syndrome. Am J Hum Genet (2012) 1.13
Abnormal peripheral chemokine profile in Huntington's disease. PLoS Curr (2011) 1.12
PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192. Dev Cell (2013) 1.12
The dynamics of replication licensing in live Caenorhabditis elegans embryos. J Cell Biol (2012) 1.11
Transcriptional profiling in C. elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family. BMC Genomics (2008) 1.11
Dying cell clearance and its impact on the outcome of tumor radiotherapy. Front Oncol (2012) 1.08
The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis. Nat Cell Biol (2011) 1.08
Methods for studying the DNA damage response in the Caenorhabdatis elegans germ line. Methods Cell Biol (2012) 1.08
Is it a tic?--Twenty seconds to make a diagnosis. Mov Disord (2010) 1.07
Shugoshin is a Mad1/Cdc20-like interactor of Mad2. EMBO J (2011) 1.06
A Xenopus Dbf4 homolog is required for Cdc7 chromatin binding and DNA replication. BMC Mol Biol (2004) 1.06
Securin is not required for chromosomal stability in human cells. PLoS Biol (2005) 1.06
A Caenorhabditis elegans Parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress. Hum Mol Genet (2005) 1.06
The NM23 family in development. Mol Cell Biochem (2009) 1.05
Protein phosphatase 2A and separase form a complex regulated by separase autocleavage. J Biol Chem (2007) 1.05
Sgol2 provides a regulatory platform that coordinates essential cell cycle processes during meiosis I in oocytes. Elife (2013) 1.04
Temporal profiling of the chromatin proteome reveals system-wide responses to replication inhibition. Curr Biol (2008) 1.04
Rapid induction of pluripotency genes after exposure of human somatic cells to mouse ES cell extracts. Exp Cell Res (2008) 1.03
What evidence is there for the existence of individual genes with antagonistic pleiotropic effects? Mech Ageing Dev (2005) 1.03
Structural changes in the somatosensory system correlate with tic severity in Gilles de la Tourette syndrome. Brain (2009) 1.02
Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation. J Cell Sci (2012) 1.02
The elusive determinants of replication origins. EMBO Rep (2007) 1.01
A conserved role of Caenorhabditis elegans CDC-48 in ER-associated protein degradation. J Struct Biol (2006) 1.01
Dissecting the Gilles de la Tourette spectrum: a factor analytic study on 639 patients. J Neurol Neurosurg Psychiatry (2011) 1.00
Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template. Genes Dev (2013) 1.00
Regulation of Caenorhabditis elegans p53/CEP-1-dependent germ cell apoptosis by Ras/MAPK signaling. PLoS Genet (2011) 1.00
Observing Huntington's disease: the European Huntington's Disease Network's REGISTRY. J Neurol Neurosurg Psychiatry (2010) 1.00
Dormant origins, the licensing checkpoint, and the response to replicative stresses. Cold Spring Harb Perspect Biol (2012) 0.99
Replisome stall events have shaped the distribution of replication origins in the genomes of yeasts. Nucleic Acids Res (2013) 0.99
Ubiquitin C-terminal hydrolase-L1 potentiates cancer chemosensitivity by stabilizing NOXA. Cell Rep (2013) 0.99
Multispectral brain morphometry in Tourette syndrome persisting into adulthood. Brain (2010) 0.99
Functional dissection of Caenorhabditis elegans CLK-2/TEL2 cell cycle defects during embryogenesis and germline development. PLoS Genet (2009) 0.98
Cell-nonautonomous regulation of C. elegans germ cell death by kri-1. Curr Biol (2010) 0.98
The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans. Cell (2013) 0.98
Domain structure of separase and its binding to securin as determined by EM. Nat Struct Mol Biol (2005) 0.98