Published in Channels (Austin) on September 01, 2012
STIM1/Orai1-mediated SOCE: current perspectives and potential roles in cardiac function and pathology. Am J Physiol Heart Circ Physiol (2013) 1.04
Complex role of STIM1 in the activation of store-independent Orai1/3 channels. J Gen Physiol (2014) 0.99
Mechanisms of STIM1 activation of store-independent leukotriene C4-regulated Ca2+ channels. Mol Cell Biol (2013) 0.93
Molecular basis of activation of the arachidonate-regulated Ca2+ (ARC) channel, a store-independent Orai channel, by plasma membrane STIM1. J Physiol (2013) 0.93
Anchoring protein AKAP79-mediated PKA phosphorylation of STIM1 determines selective activation of the ARC channel, a store-independent Orai channel. J Physiol (2015) 0.84
Emerging roles of Orai3 in pathophysiology. Channels (Austin) (2013) 0.84
Members of the thrombospondin gene family bind stromal interaction molecule 1 and regulate calcium channel activity. Matrix Biol (2014) 0.81
Exploring the unique features of the ARC channel, a store-independent Orai channel. Channels (Austin) (2013) 0.79
Orai channel-mediated Ca2+ signals in vascular and airway smooth muscle. Am J Physiol Cell Physiol (2015) 0.78
Arachidonate-regulated Ca(2+) influx in human airway smooth muscle. Am J Respir Cell Mol Biol (2014) 0.78
Selective activation of distinct Orai channels by STIM1. Cell Calcium (2016) 0.75
Orai3 Surface Accumulation and Calcium Entry Evoked by Vascular Endothelial Growth Factor. Arterioscler Thromb Vasc Biol (2015) 0.75
ORAI Calcium Channels. Physiology (Bethesda) (2017) 0.75
STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx. Curr Biol (2005) 14.53
STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane. Nature (2005) 8.96
STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1. Cell (2009) 6.92
Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane. J Cell Biol (2006) 6.88
A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane. Cell (1990) 6.08
STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels. Nat Cell Biol (2006) 5.68
Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. J Biol Chem (2006) 5.32
Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion. Proc Natl Acad Sci U S A (2007) 5.31
SOAR and the polybasic STIM1 domains gate and regulate Orai channels. Nat Cell Biol (2009) 4.73
Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation. J Biol Chem (2008) 4.20
Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation. Nature (2008) 3.67
STIM1: a novel phosphoprotein located at the cell surface. Biochim Biophys Acta (2000) 3.67
Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum. Proc Natl Acad Sci U S A (2006) 3.47
The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers. Nature (2008) 3.46
Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry. Cell (2008) 3.43
Stored Ca2+ depletion-induced oligomerization of stromal interaction molecule 1 (STIM1) via the EF-SAM region: An initiation mechanism for capacitive Ca2+ entry. J Biol Chem (2006) 3.39
STIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channels. Proc Natl Acad Sci U S A (2006) 3.32
Functional stoichiometry of the unitary calcium-release-activated calcium channel. Proc Natl Acad Sci U S A (2008) 3.07
Mapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activation. J Biol Chem (2007) 3.05
A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels. J Biol Chem (2009) 2.97
Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3. J Biol Chem (2008) 2.75
Stromal interaction molecule 1 (STIM1), a transmembrane protein with growth suppressor activity, contains an extracellular SAM domain modified by N-linked glycosylation. Biochim Biophys Acta (2002) 2.74
Orai1 subunit stoichiometry of the mammalian CRAC channel pore. J Physiol (2007) 2.69
STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ Entry. Curr Biol (2006) 2.38
A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels. Biochem Biophys Res Commun (2009) 2.28
STIM1 regulates Ca2+ entry via arachidonate-regulated Ca2+-selective (ARC) channels without store depletion or translocation to the plasma membrane. J Physiol (2006) 2.17
Functional roles for fatty acylated amino-terminal domains in subcellular localization. Mol Biol Cell (1999) 1.82
Essential role for the CRAC activation domain in store-dependent oligomerization of STIM1. Mol Biol Cell (2010) 1.77
STIM protein coupling in the activation of Orai channels. Proc Natl Acad Sci U S A (2009) 1.70
I(ARC), a novel arachidonate-regulated, noncapacitative Ca(2+) entry channel. J Biol Chem (2000) 1.66
Retargeting of cytosolic proteins to the plasma membrane by the Lck protein tyrosine kinase dual acylation motif. J Cell Sci (1997) 1.58
Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif. Biochem J (1994) 1.56
Both Orai1 and Orai3 are essential components of the arachidonate-regulated Ca2+-selective (ARC) channels. J Physiol (2007) 1.54
A hexahistidine-Zn2+-dye label reveals STIM1 surface exposure. Proc Natl Acad Sci U S A (2007) 1.52
The molecular architecture of the arachidonate-regulated Ca2+-selective ARC channel is a pentameric assembly of Orai1 and Orai3 subunits. J Physiol (2009) 1.34
Location and function of STIM1 in the activation of Ca2+ entry signals. J Biol Chem (2008) 1.30
Mutational and biochemical analysis of plasma membrane targeting mediated by the farnesylated, polybasic carboxy terminus of K-ras4B. Biochemistry (2000) 1.29
Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry. Proc Natl Acad Sci U S A (2011) 1.09
Intrinsic signals in the unique domain target p56(lck) to the plasma membrane independently of CD4. J Cell Biol (1997) 1.07
Amino-terminal palmitate or polybasic domain can provide required second signal to myristate for membrane binding of p56lck. Biochem Biophys Res Commun (1995) 1.03
Orai channel-dependent activation of phospholipase C-δ: a novel mechanism for the effects of calcium entry on calcium oscillations. J Physiol (2011) 0.91
Serine 6 of Lck tyrosine kinase: a critical site for Lck myristoylation, membrane localization, and function in T lymphocytes. J Immunol (2000) 0.90
Orai1 subunit stoichiometry of the mammalian CRAC channel pore. J Physiol (2007) 2.69
STIM1 regulates Ca2+ entry via arachidonate-regulated Ca2+-selective (ARC) channels without store depletion or translocation to the plasma membrane. J Physiol (2006) 2.17
Both Orai1 and Orai3 are essential components of the arachidonate-regulated Ca2+-selective (ARC) channels. J Physiol (2007) 1.54
Phosphorylation of inositol 1,4,5-trisphosphate receptors in parotid acinar cells. A mechanism for the synergistic effects of cAMP on Ca2+ signaling. J Biol Chem (2001) 1.51
Ca2+ selectivity and fatty acid specificity of the noncapacitative, arachidonate-regulated Ca2+ (ARC) channels. J Biol Chem (2003) 1.35
The molecular architecture of the arachidonate-regulated Ca2+-selective ARC channel is a pentameric assembly of Orai1 and Orai3 subunits. J Physiol (2009) 1.34
Agonist activation of arachidonate-regulated Ca2+-selective (ARC) channels in murine parotid and pancreatic acinar cells. J Physiol (2005) 1.19
Cytosolic Ca(2+) and Ca(2+)-activated Cl(-) current dynamics: insights from two functionally distinct mouse exocrine cells. J Physiol (2002) 1.11
Calcineurin directs the reciprocal regulation of calcium entry pathways in nonexcitable cells. J Biol Chem (2003) 1.06
The Orai1 severe combined immune deficiency mutation and calcium release-activated Ca2+ channel function in the heterozygous condition. J Biol Chem (2008) 1.03
A mathematical model of fluid secretion from a parotid acinar cell. J Theor Biol (2007) 1.01
A dynamic model of saliva secretion. J Theor Biol (2010) 0.99
Modulation of [Ca2+]i signaling dynamics and metabolism by perinuclear mitochondria in mouse parotid acinar cells. J Biol Chem (2003) 0.99
How many Orai's does it take to make a CRAC channel? Sci Rep (2013) 0.97
The N-terminal domain of Orai3 determines selectivity for activation of the store-independent ARC channel by arachidonic acid. Channels (Austin) (2010) 0.94
Molecular basis of activation of the arachidonate-regulated Ca2+ (ARC) channel, a store-independent Orai channel, by plasma membrane STIM1. J Physiol (2013) 0.93
Orai channel-dependent activation of phospholipase C-δ: a novel mechanism for the effects of calcium entry on calcium oscillations. J Physiol (2011) 0.91
Ca2+-dependent protein kinase--a modulation of the plasma membrane Ca2+-ATPase in parotid acinar cells. J Biol Chem (2002) 0.88
Carboxyamidotriazole-induced inhibition of mitochondrial calcium import blocks capacitative calcium entry and cell proliferation in HEK-293 cells. J Cell Sci (2005) 0.88
Arachidonate-regulated Ca2+-selective (ARC) channel activity is modulated by phosphorylation and involves an A-kinase anchoring protein. J Physiol (2005) 0.86
Anchoring protein AKAP79-mediated PKA phosphorylation of STIM1 determines selective activation of the ARC channel, a store-independent Orai channel. J Physiol (2015) 0.84
Modelling the effects of calcium waves and oscillations on saliva secretion. J Theor Biol (2012) 0.80
Orai channels - new insights, new ideas. J Physiol (2012) 0.78
Control of rectal gland secretion by blood acid-base status in the intact dogfish shark (Squalus acanthias). Respir Physiol Neurobiol (2006) 0.77
The ARC channel--an endogenous store-independent Orai channel. Curr Top Membr (2013) 0.76