Published in J Biol Chem on January 10, 2008
STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1. Cell (2009) 6.92
Molecular basis of calcium signaling in lymphocytes: STIM and ORAI. Annu Rev Immunol (2010) 5.11
SOAR and the polybasic STIM1 domains gate and regulate Orai channels. Nat Cell Biol (2009) 4.73
Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation. Nature (2008) 3.67
The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers. Nature (2008) 3.46
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Store-independent activation of Orai1 by SPCA2 in mammary tumors. Cell (2010) 2.29
A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels. Biochem Biophys Res Commun (2009) 2.28
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A role for Orai in TRPC-mediated Ca2+ entry suggests that a TRPC:Orai complex may mediate store and receptor operated Ca2+ entry. Proc Natl Acad Sci U S A (2009) 1.57
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An endoplasmic reticulum/plasma membrane junction: STIM1/Orai1/TRPCs. FEBS Lett (2009) 1.39
Dependence of STIM1/Orai1-mediated calcium entry on plasma membrane phosphoinositides. J Biol Chem (2009) 1.36
A Ca2(+ )release-activated Ca2(+) (CRAC) modulatory domain (CMD) within STIM1 mediates fast Ca2(+)-dependent inactivation of ORAI1 channels. J Biol Chem (2009) 1.35
Native Store-operated Ca2+ Influx Requires the Channel Function of Orai1 and TRPC1. J Biol Chem (2009) 1.34
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Orai1 contributes to the establishment of an apoptosis-resistant phenotype in prostate cancer cells. Cell Death Dis (2010) 1.29
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New developments in the signaling mechanisms of the store-operated calcium entry pathway. Pflugers Arch (2008) 1.28
Resting state Orai1 diffuses as homotetramer in the plasma membrane of live mammalian cells. J Biol Chem (2010) 1.28
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Microparticles: a critical component in the nexus between inflammation, immunity, and thrombosis. Semin Immunopathol (2011) 1.26
STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry. Nat Commun (2013) 1.25
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A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating. J Gen Physiol (2010) 1.24
Arachidonic acid, ARC channels, and Orai proteins. Cell Calcium (2009) 1.21
Tetrameric Orai1 is a teardrop-shaped molecule with a long, tapered cytoplasmic domain. J Biol Chem (2009) 1.21
STIM and Orai: the long-awaited constituents of store-operated calcium entry. Trends Pharmacol Sci (2009) 1.20
Regulation of Ca2+ signaling with particular focus on mast cells. Crit Rev Immunol (2009) 1.20
Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation. Mol Cell Biol (2011) 1.18
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Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site. Nat Commun (2014) 1.16
Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways. Br J Pharmacol (2012) 1.14
The C- and N-terminal STIM1 binding sites on Orai1 are required for both trapping and gating CRAC channels. J Physiol (2013) 1.12
Competitive modulation of Ca2+ release-activated Ca2+ channel gating by STIM1 and 2-aminoethyldiphenyl borate. J Biol Chem (2010) 1.12
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Protein kinase C-induced phosphorylation of Orai1 regulates the intracellular Ca2+ level via the store-operated Ca2+ channel. J Biol Chem (2010) 1.09
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Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry. Proc Natl Acad Sci U S A (2011) 1.09
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Differential roles of the C and N termini of Orai1 protein in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation. J Biol Chem (2013) 1.06
Orai1-NFAT signalling pathway triggered by T cell receptor stimulation. Mol Cells (2013) 1.05
Bombyx mori homologs of STIM1 and Orai1 are essential components of the signal transduction cascade that regulates sex pheromone production. J Biol Chem (2009) 1.05
The physiological function of store-operated calcium entry. Neurochem Res (2011) 1.05
The extended transmembrane Orai1 N-terminal (ETON) region combines binding interface and gate for Orai1 activation by STIM1. J Biol Chem (2013) 1.05
Calcium signaling by STIM and Orai: intimate coupling details revealed. Sci Signal (2010) 1.04
Molecular regulation of CRAC channels and their role in lymphocyte function. Cell Mol Life Sci (2012) 1.03
STIM1-dependent and STIM1-independent function of transient receptor potential canonical (TRPC) channels tunes their store-operated mode. J Biol Chem (2010) 1.03
Permeation, selectivity and gating in store-operated CRAC channels. J Physiol (2012) 1.03
Constitutive recycling of the store-operated Ca2+ channel Orai1 and its internalization during meiosis. J Cell Biol (2010) 1.03
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The action of selective CRAC channel blockers is affected by the Orai pore geometry. Cell Calcium (2012) 1.02
Capacitative Ca2+ entry via Orai1 and stromal interacting molecule 1 (STIM1) regulates adenylyl cyclase type 8. Mol Pharmacol (2009) 1.01
Emerging roles of store-operated Ca²⁺ entry through STIM and ORAI proteins in immunity, hemostasis and cancer. Channels (Austin) (2013) 1.00
Structural and functional mechanisms of CRAC channel regulation. J Mol Biol (2014) 1.00
STIM1 triggers a gating rearrangement at the extracellular mouth of the ORAI1 channel. Nat Commun (2014) 0.98
How strict is the correlation between STIM1 and Orai1 expression, puncta formation, and ICRAC activation? Am J Physiol Cell Physiol (2008) 0.98
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Translocation between PI(4,5)P2-poor and PI(4,5)P2-rich microdomains during store depletion determines STIM1 conformation and Orai1 gating. Nat Commun (2014) 0.97
STIM proteins: integrators of signalling pathways in development, differentiation and disease. J Cell Mol Med (2010) 0.97
Store-operated Ca²+ signaling in dendritic cells occurs independently of STIM1. J Leukoc Biol (2010) 0.96
Evidence for an interaction between Golli and STIM1 in store-operated calcium entry. Biochem J (2010) 0.96
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The N-terminal domain of Orai3 determines selectivity for activation of the store-independent ARC channel by arachidonic acid. Channels (Austin) (2010) 0.94
A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels. J Biol Chem (2009) 2.97
STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation. EMBO J (2011) 1.80
C-terminal modulator controls Ca2+-dependent gating of Ca(v)1.4 L-type Ca2+ channels. Nat Neurosci (2006) 1.69
Store-independent Orai1/3 channels activated by intracrine leukotriene C4: role in neointimal hyperplasia. Circ Res (2013) 1.68
Cholesterol- and caveolin-rich membrane domains are essential for phospholipase A2-dependent EDHF formation. Cardiovasc Res (2004) 1.66
TRPC channels are necessary mediators of pathologic cardiac hypertrophy. Proc Natl Acad Sci U S A (2010) 1.66
2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size. J Biol Chem (2008) 1.66
Micropatterning for quantitative analysis of protein-protein interactions in living cells. Nat Methods (2008) 1.66
Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant. J Biol Chem (2009) 1.65
Mrs2p forms a high conductance Mg2+ selective channel in mitochondria. Biophys J (2007) 1.59
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Increased hydrophobicity at the N terminus/membrane interface impairs gating of the severe combined immunodeficiency-related ORAI1 mutant. J Biol Chem (2009) 1.39
TRPC3 and TRPC4 associate to form a redox-sensitive cation channel. Evidence for expression of native TRPC3-TRPC4 heteromeric channels in endothelial cells. J Biol Chem (2006) 1.39
Dynamic but not constitutive association of calmodulin with rat TRPV6 channels enables fine tuning of Ca2+-dependent inactivation. J Physiol (2006) 1.35
A Ca2(+ )release-activated Ca2(+) (CRAC) modulatory domain (CMD) within STIM1 mediates fast Ca2(+)-dependent inactivation of ORAI1 channels. J Biol Chem (2009) 1.35
The STIM/Orai coupling machinery. Channels (Austin) (2008) 1.35
Ca(2+) signaling by TRPC3 involves Na(+) entry and local coupling to the Na(+)/Ca(2+) exchanger. J Biol Chem (2004) 1.32
Modulation of voltage- and Ca2+-dependent gating of CaV1.3 L-type calcium channels by alternative splicing of a C-terminal regulatory domain. J Biol Chem (2008) 1.32
Resting state Orai1 diffuses as homotetramer in the plasma membrane of live mammalian cells. J Biol Chem (2010) 1.28
Mechanistic view on domains mediating STIM1-Orai coupling. Immunol Rev (2009) 1.24
Cytosolic Ca2+ prevents the subplasmalemmal clustering of STIM1: an intrinsic mechanism to avoid Ca2+ overload. J Cell Sci (2008) 1.17
Functional consequences of P/Q-type Ca2+ channel Cav2.1 missense mutations associated with episodic ataxia type 2 and progressive ataxia. J Biol Chem (2001) 1.16
CaT1 knock-down strategies fail to affect CRAC channels in mucosal-type mast cells. J Physiol (2004) 1.14
User-friendly, miniature biosensor flow cell for fragile high fundamental frequency quartz crystal resonators. Biosens Bioelectron (2009) 1.12
Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry. Proc Natl Acad Sci U S A (2011) 1.09
Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel. Proc Natl Acad Sci U S A (2009) 1.07
Voltage-gated rearrangements associated with differential beta-subunit modulation of the L-type Ca(2+) channel inactivation. Biophys J (2004) 1.05
The extended transmembrane Orai1 N-terminal (ETON) region combines binding interface and gate for Orai1 activation by STIM1. J Biol Chem (2013) 1.05