HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes.

PubWeight™: 2.18‹?› | Rank: Top 2%

🔗 View Article (PMID 23018291)

Published in Nat Rev Immunol on September 28, 2012

Authors

Jean-Philippe Girard1, Christine Moussion, Reinhold Förster

Author Affiliations

1: CNRS, Institut de Pharmacologie et de Biologie Structurale (IPBS), 205 Route de Narbonne, F-31077 Toulouse, France. Jean-Philippe.Girard@ipbs.fr

Articles citing this

(truncated to the top 100)

Structural and functional features of central nervous system lymphatic vessels. Nature (2015) 8.73

Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature (2013) 1.61

Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing. Nat Immunol (2014) 1.57

WNK1 kinase balances T cell adhesion versus migration in vivo. Nat Immunol (2016) 1.39

A High-Salt Diet Differentially Modulates Mechanical Activity of Afferent and Efferent Collecting Lymphatics in Murine Iliac Lymph Nodes. Lymphat Res Biol (2015) 1.38

Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses. Immunity (2017) 1.38

Characteristics of tertiary lymphoid structures in primary cancers. Oncoimmunology (2013) 1.35

Trapping of naive lymphocytes triggers rapid growth and remodeling of the fibroblast network in reactive murine lymph nodes. Proc Natl Acad Sci U S A (2013) 1.19

Dendritic cells control fibroblastic reticular network tension and lymph node expansion. Nature (2014) 1.19

The two faces of IL-6 in the tumor microenvironment. Semin Immunol (2014) 1.10

Fever and the thermal regulation of immunity: the immune system feels the heat. Nat Rev Immunol (2015) 1.09

Emerging roles of lymphatic endothelium in regulating adaptive immunity. J Clin Invest (2014) 1.09

Lymphatic vessels and tertiary lymphoid organs. J Clin Invest (2014) 1.08

Immunotherapy in Cancer: A Combat between Tumors and the Immune System; You Win Some, You Lose Some. Front Immunol (2015) 0.98

Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation. Sci Transl Med (2017) 0.98

Cell-to-Cell Transmission of HIV-1 Is Required to Trigger Pyroptotic Death of Lymphoid-Tissue-Derived CD4 T Cells. Cell Rep (2015) 0.97

IL-17 promotes neutrophil entry into tumor-draining lymph nodes following induction of sterile inflammation. J Immunol (2013) 0.96

Tertiary Lymphoid Structure-Associated B Cells are Key Players in Anti-Tumor Immunity. Front Immunol (2015) 0.96

Fibroblastic reticular cells of the lymph node are required for retention of resting but not activated CD8+ T cells. Proc Natl Acad Sci U S A (2014) 0.93

Predicting lymph node output efficiency using systems biology. J Theor Biol (2013) 0.92

A role for LFA-1 in delaying T-lymphocyte egress from lymph nodes. EMBO J (2013) 0.91

Ectoenzymes in leukocyte migration and their therapeutic potential. Semin Immunopathol (2014) 0.90

Lymphotoxin signalling in immune homeostasis and the control of microorganisms. Nat Rev Immunol (2013) 0.90

Harnessing biomaterials to engineer the lymph node microenvironment for immunity or tolerance. AAPS J (2014) 0.89

Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity. Nat Commun (2015) 0.89

Laminins affect T cell trafficking and allograft fate. J Clin Invest (2014) 0.88

From sewer to saviour - targeting the lymphatic system to promote drug exposure and activity. Nat Rev Drug Discov (2015) 0.85

Leukocyte Trafficking to the Small Intestine and Colon. Gastroenterology (2015) 0.85

Intratumoral tertiary lymphoid organ is a favourable prognosticator in patients with pancreatic cancer. Br J Cancer (2015) 0.84

Tertiary Lymphoid Organs in Cancer Tissues. Front Immunol (2016) 0.84

Binding of Hyaluronan to the Native Lymphatic Vessel Endothelial Receptor LYVE-1 Is Critically Dependent on Receptor Clustering and Hyaluronan Organization. J Biol Chem (2016) 0.84

Modes of Antigen Presentation by Lymph Node Stromal Cells and Their Immunological Implications. Front Immunol (2015) 0.83

Role of lymphatic vasculature in regional and distant metastases. Microvasc Res (2014) 0.83

Mathematical modeling reveals kinetics of lymphocyte recirculation in the whole organism. PLoS Comput Biol (2014) 0.83

Defining minimum essential factors to derive highly pure human endothelial cells from iPS/ES cells in an animal substance-free system. Sci Rep (2015) 0.82

Evidence of Th2 polarization of the sentinel lymph node (SLN) in melanoma. Oncoimmunology (2015) 0.82

Taking the lymphatic route: dendritic cell migration to draining lymph nodes. Semin Immunopathol (2014) 0.82

Dendritic cell migration in health and disease. Nat Rev Immunol (2016) 0.81

Peripheral tissue homing receptor control of naïve, effector, and memory CD8 T cell localization in lymphoid and non-lymphoid tissues. Front Immunol (2013) 0.81

Spatial modeling of HIV cryptic viremia and 2-LTR formation during raltegravir intensification. J Theor Biol (2013) 0.81

Preconditioning thermal therapy: flipping the switch on IL-6 for anti-tumour immunity. Int J Hyperthermia (2013) 0.80

Role of high endothelial venule-expressed heparan sulfate in chemokine presentation and lymphocyte homing. J Immunol (2013) 0.80

Glycopeptide analogues of PSGL-1 inhibit P-selectin in vitro and in vivo. Nat Commun (2015) 0.80

Dissecting How CD4 T Cells Are Lost During HIV Infection. Cell Host Microbe (2016) 0.80

Immune senescence: significance of the stromal microenvironment. Clin Exp Immunol (2016) 0.80

Dynamic changes in endothelial cell adhesion molecule nepmucin/CD300LG expression under physiological and pathological conditions. PLoS One (2013) 0.80

The expression of mouse CLEC-2 on leucocyte subsets varies according to their anatomical location and inflammatory state. Eur J Immunol (2015) 0.79

T Lymphocyte-Endothelial Interactions: Emerging Understanding of Trafficking and Antigen-Specific Immunity. Front Immunol (2015) 0.79

Extravascular CX3CR1+ cells extend intravascular dendritic processes into intact central nervous system vessel lumen. Microsc Microanal (2013) 0.79

Hypertrophy of infected Peyer's patches arises from global, interferon-receptor, and CD69-independent shutdown of lymphocyte egress. Mucosal Immunol (2013) 0.79

Targeted Programming of the Lymph Node Environment Causes Evolution of Local and Systemic Immunity. Cell Mol Bioeng (2016) 0.78

The Role of Lymphatic Niches in T Cell Differentiation. Mol Cells (2016) 0.78

The Lymphatic System: Integral Roles in Immunity. Annu Rev Immunol (2016) 0.78

Lymphotoxin organizes contributions to host defense and metabolic illness from innate lymphoid cells. Cytokine Growth Factor Rev (2013) 0.78

Dendritic cell interactions with lymphatic endothelium. Lymphat Res Biol (2013) 0.78

Network representations of immune system complexity. Wiley Interdiscip Rev Syst Biol Med (2015) 0.78

Control of CD8 T-Cell Infiltration into Tumors by Vasculature and Microenvironment. Adv Cancer Res (2015) 0.78

Modeling Lymph Flow and Fluid Exchange with Blood Vessels in Lymph Nodes. Lymphat Res Biol (2015) 0.78

Cellular imaging in rheumatic diseases. Nat Rev Rheumatol (2015) 0.78

Molecular mechanisms of CD8(+) T cell trafficking and localization. Cell Mol Life Sci (2015) 0.78

Follicular dendritic cell disruption as a novel mechanism of virus-induced immunosuppression. Proc Natl Acad Sci U S A (2016) 0.78

Protection from septic peritonitis by rapid neutrophil recruitment through omental high endothelial venules. Nat Commun (2016) 0.77

Primary Tumor-Secreted Lymphangiogenic Factors Induce Pre-Metastatic Lymphvascular Niche Formation at Sentinel Lymph Nodes in Oral Squamous Cell Carcinoma. PLoS One (2015) 0.77

Organ-wide 3D-imaging and topological analysis of the continuous microvascular network in a murine lymph node. Sci Rep (2015) 0.77

Mucin-type O-glycosylation is critical for vascular integrity. Glycobiology (2014) 0.77

Inducible Bronchus-Associated Lymphoid Tissue: Taming Inflammation in the Lung. Front Immunol (2016) 0.77

Lymphangiogenesis and angiogenesis during human fetal pancreas development. Vasc Cell (2014) 0.77

Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility. Elife (2016) 0.77

Herpesvirus-Associated Lymphadenitis Distorts Fibroblastic Reticular Cell Microarchitecture and Attenuates CD8 T Cell Responses to Neurotropic Infection in Mice Lacking the STING-IFNα/β Defense Pathways. J Immunol (2016) 0.76

Lymph Node Stromal Fiber ER-TR7 Modulates CD4+ T Cell Lymph Node Trafficking and Transplant Tolerance. Transplantation (2015) 0.76

B lymphocyte compartments in the human splenic red pulp: capillary sheaths and periarteriolar regions. Histochem Cell Biol (2013) 0.76

Understanding high endothelial venules: Lessons for cancer immunology. Oncoimmunology (2015) 0.76

Predictive Value of Tertiary Lymphoid Structures Assessed by High Endothelial Venule Counts in the Neoadjuvant Setting of Triple-Negative Breast Cancer. Cancer Res Treat (2016) 0.75

VEGF-C improves regeneration and lymphatic reconnection of transplanted autologous lymph node fragments: An animal model for secondary lymphedema treatment. Immun Inflamm Dis (2014) 0.75

Distinct mechanisms of B and T lymphocyte accumulation generate tumor-draining lymph node hypertrophy. Oncoimmunology (2016) 0.75

High Endothelial Venules and Other Blood Vessels: Critical Regulators of Lymphoid Organ Development and Function. Front Immunol (2017) 0.75

Microfilament-coordinated adhesion dynamics drives single cell migration and shapes whole tissues. F1000Res (2017) 0.75

Differential control of immune cell homeostasis by Foxp3(+) regulatory T cells in murine peripheral lymph nodes and spleen. Eur J Microbiol Immunol (Bp) (2014) 0.75

T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy. Lab Invest (2017) 0.75

Transient Migration of Large Numbers of CD14(++) CD16(+) Monocytes to the Draining Lymph Node after Onset of Inflammation. Front Immunol (2016) 0.75

C-type lectins facilitate tumor metastasis. Oncol Lett (2016) 0.75

Tumor-induced MDSC act via remote control to inhibit L-selectin-dependent adaptive immunity in lymph nodes. Elife (2016) 0.75

Adventitial lymphatic capillary expansion impacts on plaque T cell accumulation in atherosclerosis. Sci Rep (2017) 0.75

Presentation of Autoantigen in Peripheral Lymph Nodes Is Sufficient for Priming Autoreactive CD8(+) T Cells. Front Immunol (2017) 0.75

Multi-cellular natural killer (NK) cell clusters enhance NK cell activation through localizing IL-2 within the cluster. Sci Rep (2017) 0.75

Ex vivo microperfusion system of the adipose organ: a new approach to studying the mobilization of adipose cell populations. Int J Obes (Lond) (2013) 0.75

Plasmalemma vesicle-associated protein: A crucial component of vascular homeostasis. Exp Ther Med (2016) 0.75

Role of Dietary Metabolites in Regulating the Host Immune Response in Gastrointestinal Disease. Front Immunol (2017) 0.75

Graft Site Microenvironment Determines Dendritic Cell Trafficking Through the CCR7-CCL19/21 Axis. Invest Ophthalmol Vis Sci (2016) 0.75

Regulation of tumor-associated high-endothelial venules by dendritic cells: A new opportunity to promote lymphocyte infiltration into breast cancer? Oncoimmunology (2013) 0.75

The Role of the Tumor Vasculature in the Host Immune Response: Implications for Therapeutic Strategies Targeting the Tumor Microenvironment. Front Immunol (2016) 0.75

Unique Transcompartmental Bridge: Antigen-Presenting Cells Sampling across Endothelial and Mucosal Barriers. Front Immunol (2016) 0.75

Tertiary lymphoid structures are confined to patients presenting with unifocal Langerhans Cell Histiocytosis. Oncoimmunology (2016) 0.75

Optical tracer size differences allow quantitation of active pumping rate versus Stokes-Einstein diffusion in lymphatic transport. J Biomed Opt (2016) 0.75

T Cell Trafficking through Lymphatic Vessels. Front Immunol (2016) 0.75

Neuroimmune Interaction in the Regulation of Peripheral Opioid-Mediated Analgesia in Inflammation. Front Immunol (2016) 0.75

Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling. Stem Cells Int (2016) 0.75

Estradiol Synthesis in Gut-Associated Lymphoid Tissue: Leukocyte Regulation by a Sexually Monomorphic System. Endocrinology (2016) 0.75

Bidirectional Crosstalk between Lymphatic Endothelial Cell and T Cell and Its Implications in Tumor Immunity. Front Immunol (2017) 0.75

Vascular heterogeneity and specialization in development and disease. Nat Rev Mol Cell Biol (2017) 0.75

Articles cited by this

THE ROUTE OF RE-CIRCULATION OF LYMPHOCYTES IN THE RAT. Proc R Soc Lond B Biol Sci (1964) 20.20

Lymphocyte homing and homeostasis. Science (1996) 13.26

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature (2004) 12.72

CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell (1999) 12.50

T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature (2004) 11.14

Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science (2002) 8.94

Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science (2002) 8.63

Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature (2008) 7.28

Homing and cellular traffic in lymph nodes. Nat Rev Immunol (2003) 7.23

Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity (2006) 7.22

CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature (2006) 7.17

The recirculation of lymphocytes from blood to lymph in the rat. J Physiol (1959) 7.09

THE MIGRATION OF LYMPHOCYTES THROUGH THE ENDOTHELIUM OF VENULES IN LYMPH NODES: AN ELECTRON MICROSCOPE STUDY. Proc R Soc Lond B Biol Sci (1964) 6.93

A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature (2000) 6.89

In vivo analysis of dendritic cell development and homeostasis. Science (2009) 6.42

Naive and memory T cells show distinct pathways of lymphocyte recirculation. J Exp Med (1990) 5.54

Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science (2005) 5.50

CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity (2004) 5.48

CCR7 and its ligands: balancing immunity and tolerance. Nat Rev Immunol (2008) 5.35

Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nat Immunol (2007) 5.22

Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu Rev Immunol (2005) 5.10

IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo. Proc Natl Acad Sci U S A (2006) 5.08

Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature (2007) 4.88

The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node. Immunity (2005) 4.72

Immunohistologic and functional characterization of a vascular addressin involved in lymphocyte homing into peripheral lymph nodes. J Cell Biol (1988) 4.63

Dendritic-cell trafficking to lymph nodes through lymphatic vessels. Nat Rev Immunol (2005) 4.59

Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells. Nat Immunol (2007) 4.46

Ligands for L-selectin: homing, inflammation, and beyond. Annu Rev Immunol (2004) 4.35

Functionally specialized junctions between endothelial cells of lymphatic vessels. J Exp Med (2007) 4.10

Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells. Science (2006) 3.84

The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis. Cell (1996) 3.82

Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat Immunol (2005) 3.70

Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in lymph node cortex. J Exp Med (2000) 3.63

B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node. Immunity (2007) 3.55

Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs. Annu Rev Immunol (2011) 3.15

Lymphoid organ development: from ontogeny to neogenesis. Nat Immunol (2006) 3.15

Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines. Nat Immunol (2005) 3.07

S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress. Immunity (2007) 3.05

Conduits mediate transport of low-molecular-weight antigen to lymph node follicles. Immunity (2009) 2.98

High endothelial venules (HEVs): specialized endothelium for lymphocyte migration. Immunol Today (1995) 2.95

Choreography of cell motility and interaction dynamics imaged by two-photon microscopy in lymphoid organs. Annu Rev Immunol (2008) 2.86

Stromal cell contributions to the homeostasis and functionality of the immune system. Nat Rev Immunol (2009) 2.82

CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo. J Exp Med (2007) 2.81

Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes. J Exp Med (2004) 2.68

Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs. Nat Immunol (2008) 2.64

Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit. J Exp Med (2005) 2.57

Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin. Immunity (2009) 2.50

Critical functions of N-glycans in L-selectin-mediated lymphocyte homing and recruitment. Nat Immunol (2007) 2.41

Afferent lymph-derived T cells and DCs use different chemokine receptor CCR7-dependent routes for entry into the lymph node and intranodal migration. Nat Immunol (2011) 2.37

Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. J Exp Med (2009) 2.34

Mechanisms and consequences of dendritic cell migration. Immunity (2008) 2.25

Human solid tumors contain high endothelial venules: association with T- and B-lymphocyte infiltration and favorable prognosis in breast cancer. Cancer Res (2011) 2.24

Lymphocyte trafficking across high endothelial venules: dogmas and enigmas. Nat Rev Immunol (2004) 2.24

EBI2 mediates B cell segregation between the outer and centre follicle. Nature (2009) 2.20

Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells. Immunity (2010) 2.18

Intravital microscopy of the peripheral lymph node microcirculation in mice. Microcirculation (1996) 2.14

The strategy of T cell antigen-presenting cell encounter in antigen-draining lymph nodes revealed by imaging of initial T cell activation. J Exp Med (2003) 2.12

Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses. Immunity (2009) 2.09

Monitoring cellular movement in vivo with photoconvertible fluorescence protein "Kaede" transgenic mice. Proc Natl Acad Sci U S A (2008) 2.04

Synchrony of high endothelial venules and lymphatic vessels revealed by immunization. J Immunol (2006) 2.04

Endothelial heparan sulfate controls chemokine presentation in recruitment of lymphocytes and dendritic cells to lymph nodes. Immunity (2010) 2.00

Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells. Nat Immunol (2008) 1.96

Lymphotoxin-beta receptor signaling is required for the homeostatic control of HEV differentiation and function. Immunity (2005) 1.94

Organizer-like reticular stromal cell layer common to adult secondary lymphoid organs. J Immunol (2008) 1.92

N-acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules. Nat Immunol (2005) 1.91

CC chemokine receptor 7 contributes to Gi-dependent T cell motility in the lymph node. J Immunol (2007) 1.91

Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase. Cell (2001) 1.90

A major class of L-selectin ligands is eliminated in mice deficient in two sulfotransferases expressed in high endothelial venules. Nat Immunol (2005) 1.89

Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels. J Exp Med (2009) 1.83

Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules. Nature (2011) 1.80

Ectopic LT alpha beta directs lymphoid organ neogenesis with concomitant expression of peripheral node addressin and a HEV-restricted sulfotransferase. J Exp Med (2003) 1.78

Highways, byways and breadcrumbs: directing lymphocyte traffic in the lymph node. Trends Immunol (2007) 1.73

DC mobilization from the skin requires docking to immobilized CCL21 on lymphatic endothelium and intralymphatic crawling. J Exp Med (2011) 1.63

Regulation of lymph node vascular growth by dendritic cells. J Exp Med (2006) 1.62

Lymph node cortical sinus organization and relationship to lymphocyte egress dynamics and antigen exposure. Proc Natl Acad Sci U S A (2010) 1.56

Identification of a major carbohydrate capping group of the L-selectin ligand on high endothelial venules in human lymph nodes as 6-sulfo sialyl Lewis X. J Biol Chem (1998) 1.48

B lymphocytes exit lymph nodes through cortical lymphatic sinusoids by a mechanism independent of sphingosine-1-phosphate-mediated chemotaxis. Immunity (2009) 1.47

GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. Science (2011) 1.40

The influence of afferent lymphatic vessel interruption on vascular addressin expression. J Cell Biol (1991) 1.38

Cloning from purified high endothelial venule cells of hevin, a close relative of the antiadhesive extracellular matrix protein SPARC. Immunity (1995) 1.37

Lymph node homing of T cells and dendritic cells via afferent lymphatics. Trends Immunol (2012) 1.36

Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing. Blood (2010) 1.22

Nepmucin, a novel HEV sialomucin, mediates L-selectin-dependent lymphocyte rolling and promotes lymphocyte adhesion under flow. J Exp Med (2006) 1.21

Suppression of tumor formation in lymph nodes by L-selectin-mediated natural killer cell recruitment. J Exp Med (2005) 1.21

Lymph node T cell homeostasis relies on steady state homing of dendritic cells. Immunity (2011) 1.15

Distinct roles for LFA-1 affinity regulation during T-cell adhesion, diapedesis, and interstitial migration in lymph nodes. Blood (2009) 1.15

CCR7 essentially contributes to the homing of plasmacytoid dendritic cells to lymph nodes under steady-state as well as inflammatory conditions. J Immunol (2011) 1.13

Plasticity of endothelial cells: rapid dedifferentiation of freshly isolated high endothelial venule endothelial cells outside the lymphoid tissue microenvironment. Blood (2004) 1.13

Coordinated roles of ST3Gal-VI and ST3Gal-IV sialyltransferases in the synthesis of selectin ligands. Blood (2012) 1.09

High endothelial venules as traffic control points maintaining lymphocyte population homeostasis in lymph nodes. Blood (2011) 1.08

Involvement of the lysophosphatidic acid-generating enzyme autotaxin in lymphocyte-endothelial cell interactions. Am J Pathol (2008) 1.08

CCR7 mediates the migration of Foxp3+ regulatory T cells to the paracortical areas of peripheral lymph nodes through high endothelial venules. J Leukoc Biol (2007) 1.04

Lymph node B lymphocyte trafficking is constrained by anatomy and highly dependent upon chemoattractant desensitization. Blood (2011) 1.03

Novel anti-carbohydrate antibodies reveal the cooperative function of sulfated N- and O-glycans in lymphocyte homing. J Biol Chem (2010) 1.00

Expression of GlyCAM-1, an endothelial ligand for L-selectin, is affected by afferent lymphatic flow. J Immunol (1993) 0.97

Molecular cloning and functional analysis of SUT-1, a sulfate transporter from human high endothelial venules. Proc Natl Acad Sci U S A (1999) 0.96

Functional contributions of N- and O-glycans to L-selectin ligands in murine and human lymphoid organs. Am J Pathol (2010) 0.85

Enhanced FTY720-mediated lymphocyte homing requires G alpha i signaling and depends on beta 2 and beta 7 integrin. J Immunol (2006) 0.78

Articles by these authors

(truncated to the top 100)

Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature (2008) 7.28

Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing. J Exp Med (2005) 5.89

CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity (2004) 5.48

Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells. J Exp Med (2006) 4.30

Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. Immunity (2011) 3.92

Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position. Nature (2002) 3.35

CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo. J Exp Med (2007) 2.81

Chemokine requirements for B cell entry to lymph nodes and Peyer's patches. J Exp Med (2002) 2.68

Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells. Blood (2002) 2.61

CD103- and CD103+ bronchial lymph node dendritic cells are specialized in presenting and cross-presenting innocuous antigen to CD4+ and CD8+ T cells. J Immunol (2007) 2.61

Interstitial dendritic cell guidance by haptotactic chemokine gradients. Science (2013) 2.61

Afferent lymph-derived T cells and DCs use different chemokine receptor CCR7-dependent routes for entry into the lymph node and intranodal migration. Nat Immunol (2011) 2.37

Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help. Blood (2005) 2.20

Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells. Immunity (2010) 2.18

Stromal mesenteric lymph node cells are essential for the generation of gut-homing T cells in vivo. J Exp Med (2008) 2.15

Induced bronchus-associated lymphoid tissue serves as a general priming site for T cells and is maintained by dendritic cells. J Exp Med (2009) 2.10

Alloantigen-specific de novo-induced Foxp3+ Treg revert in vivo and do not protect from experimental GVHD. Eur J Immunol (2009) 2.07

Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma. Blood (2002) 2.03

Chemokine receptor CCR9 contributes to the localization of plasma cells to the small intestine. J Exp Med (2004) 1.97

CCR6 and NK1.1 distinguish between IL-17A and IFN-gamma-producing gammadelta effector T cells. Eur J Immunol (2009) 1.83

Regulatory T cells interfere with the development of bronchus-associated lymphoid tissue. J Exp Med (2007) 1.74

CC chemokine receptor 7 and 9 double-deficient hematopoietic progenitors are severely impaired in seeding the adult thymus. Blood (2009) 1.73

Dendritic cells govern induction and reprogramming of polarized tissue-selective homing receptor patterns of T cells: important roles for soluble factors and tissue microenvironments. Eur J Immunol (2005) 1.73

Induction of tolerance to innocuous inhaled antigen relies on a CCR7-dependent dendritic cell-mediated antigen transport to the bronchial lymph node. J Immunol (2006) 1.69

IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs. J Exp Med (2014) 1.67

Development and functional specialization of CD103+ dendritic cells. Immunol Rev (2010) 1.65

Cryptopatches and isolated lymphoid follicles: dynamic lymphoid tissues dispensable for the generation of intraepithelial lymphocytes. Eur J Immunol (2005) 1.63

CCR9 is a homing receptor for plasmacytoid dendritic cells to the small intestine. Proc Natl Acad Sci U S A (2007) 1.56

Cooperating mechanisms of CXCR5 and CCR7 in development and organization of secondary lymphoid organs. J Exp Med (2003) 1.53

Development of interleukin-17-producing γδ T cells is restricted to a functional embryonic wave. Immunity (2012) 1.52

Thymic T cell development and progenitor localization depend on CCR7. J Exp Med (2004) 1.48

Sphingosine-1-phosphate mediates migration of mature dendritic cells. J Immunol (2005) 1.46

Pillars Article: CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs. Cell. 1999. 99: 23-33. J Immunol (2016) 1.39

CXCR5-dependent seeding of follicular niches by B and Th cells augments antiviral B cell responses. J Immunol (2005) 1.37

Retinoic acid induces homing of protective T and B cells to the gut after subcutaneous immunization in mice. J Clin Invest (2011) 1.30

Mesenteric lymph nodes confine dendritic cell-mediated dissemination of Salmonella enterica serovar Typhimurium and limit systemic disease in mice. Infect Immun (2009) 1.28

Adaptation of solitary intestinal lymphoid tissue in response to microbiota and chemokine receptor CCR7 signaling. J Immunol (2006) 1.28

IFN-γ production by allogeneic Foxp3+ regulatory T cells is essential for preventing experimental graft-versus-host disease. J Immunol (2012) 1.26

Lymph node stromal cells support dendritic cell-induced gut-homing of T cells. J Immunol (2009) 1.26

Chemokine receptor 7 knockout attenuates atherosclerotic plaque development. Circulation (2010) 1.24

Generalized multi-organ autoimmunity in CCR7-deficient mice. Eur J Immunol (2007) 1.23

Common gamma-chain-dependent signals confer selective survival of eosinophils in the murine small intestine. J Immunol (2009) 1.21

High TCR diversity ensures optimal function and homeostasis of Foxp3+ regulatory T cells. Eur J Immunol (2011) 1.19

Prediction of lymph node metastasis in colorectal carcinoma by expressionof chemokine receptor CCR7. Int J Cancer (2005) 1.18

Lymph node T cell homeostasis relies on steady state homing of dendritic cells. Immunity (2011) 1.15

CCR7 essentially contributes to the homing of plasmacytoid dendritic cells to lymph nodes under steady-state as well as inflammatory conditions. J Immunol (2011) 1.13

Micronodular thymoma: an epithelial tumour with abnormal chemokine expression setting the stage for lymphoma development. J Pathol (2005) 1.12

Impact of CCR7 on priming and distribution of antiviral effector and memory CTL. J Immunol (2004) 1.11

CCR7-mediated LFA-1 functions in T cells are regulated by 2 independent ADAP/SKAP55 modules. Blood (2011) 1.10

In vivo application of mAb directed against the gammadelta TCR does not deplete but generates "invisible" gammadelta T cells. Eur J Immunol (2009) 1.08

CX3CR1+ c-kit+ bone marrow cells give rise to CD103+ and CD103- dendritic cells with distinct functional properties. J Immunol (2008) 1.07

Solitary intestinal lymphoid tissue provides a productive port of entry for Salmonella enterica serovar Typhimurium. Infect Immun (2007) 1.06

Chemokine receptor CCR7 contributes to a rapid and efficient clearance of lytic murine gamma-herpes virus 68 from the lung, whereas bronchus-associated lymphoid tissue harbors virus during latency. J Immunol (2009) 1.06

Multifaceted activities of CCR7 regulate T-cell homeostasis in health and disease. Eur J Immunol (2012) 1.05

A key role for CCR7 in establishing central and peripheral tolerance. Trends Immunol (2007) 1.04

Intra- and intercompartmental movement of gammadelta T cells: intestinal intraepithelial and peripheral gammadelta T cells represent exclusive nonoverlapping populations with distinct migration characteristics. J Immunol (2010) 1.04

Impaired responsiveness to T-cell receptor stimulation and defective negative selection of thymocytes in CCR7-deficient mice. Blood (2007) 1.04

The peritoneal micromilieu commits B cells to home to body cavities and the small intestine. Blood (2007) 1.00

T cell-dendritic cell interaction dynamics during the induction of respiratory tolerance and immunity. J Immunol (2009) 1.00

Peptide-specific CD8+ T-cell evolution in vivo: response to peptide vaccination with Melan-A/MART-1. Int J Cancer (2002) 1.00

Sphingosine-1 phosphate signaling regulates positioning of dendritic cells within the spleen. J Immunol (2007) 1.00

Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells. Blood (2009) 0.99

Chemokine receptor CXCR5 supports solitary intestinal lymphoid tissue formation, B cell homing, and induction of intestinal IgA responses. J Immunol (2009) 0.99

Direct activation of human endothelial cells by Plasmodium falciparum-infected erythrocytes. Infect Immun (2005) 0.98

Pillars article: two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 1999. 401: 708-712. J Immunol (2014) 0.98

Single cell detection of latent cytomegalovirus reactivation in host tissue. J Gen Virol (2011) 0.97

Expression of miRNAs miR-133b and miR-206 in the Il17a/f locus is co-regulated with IL-17 production in αβ and γδ T cells. PLoS One (2011) 0.95

Characterization and identification of Tage4 as the murine orthologue of human poliovirus receptor/CD155. Biochem Biophys Res Commun (2003) 0.95

Dendritic cell-independent B cell activation during acute virus infection: a role for early CCR7-driven B-T helper cell collaboration. J Immunol (2007) 0.95

Cutting edge: egress of newly generated plasma cells from peripheral lymph nodes depends on beta 2 integrin. J Immunol (2005) 0.95

Differential molecular and anatomical basis for B cell migration into the peritoneal cavity and omental milky spots. J Immunol (2008) 0.95

The impact of cell-bound antigen transport on mucosal tolerance induction. J Leukoc Biol (2007) 0.94

The adhesion receptor CD155 determines the magnitude of humoral immune responses against orally ingested antigens. Eur J Immunol (2007) 0.94

CCR7 signaling inhibits T cell proliferation. J Immunol (2007) 0.92

Ectopic expression of CCL19 impairs alloimmune response in mice. Immunology (2004) 0.92

Anti-inflammatory effects of an inflammatory chemokine: CCL2 inhibits lymphocyte homing by modulation of CCL21-triggered integrin-mediated adhesions. Blood (2008) 0.89

Induction of BALT in the absence of IL-17. Nat Immunol (2011) 0.87

The origin and maturity of dendritic cells determine the pattern of sphingosine 1-phosphate receptors expressed and required for efficient migration. J Immunol (2010) 0.87

Elucidating the functional anatomy of secondary lymphoid organs. Curr Opin Immunol (2004) 0.86

Trafficking on serpentines: molecular insight on how maturating T cells find their winding paths in the thymus. Immunol Rev (2006) 0.86

Prolongation of allograft survival in ccr7-deficient mice. Transplantation (2004) 0.86

Tolerance induction towards cardiac allografts under costimulation blockade is impaired in CCR7-deficient animals but can be restored by adoptive transfer of syngeneic plasmacytoid dendritic cells. Eur J Immunol (2011) 0.86

Chemokines as organizers of primary and secondary lymphoid organs. Semin Immunol (2003) 0.85

Dynamics and function of solitary intestinal lymphoid tissue. Crit Rev Immunol (2008) 0.85

CCR9 and inflammatory bowel disease. Expert Opin Ther Targets (2009) 0.84

Absence of CD155 aggravates acute graft-versus-host disease. Proc Natl Acad Sci U S A (2011) 0.84

Antigen-dependent rescue of nose-associated lymphoid tissue (NALT) development independent of LTbetaR and CXCR5 signaling. Eur J Immunol (2009) 0.84

CCR7 and IRF4-dependent dendritic cells regulate lymphatic collecting vessel permeability. J Clin Invest (2016) 0.84

T cell migration dynamics within lymph nodes during steady state: an overview of extracellular and intracellular factors influencing the basal intranodal T cell motility. Curr Top Microbiol Immunol (2009) 0.84

Abundance of follicular helper T cells in Peyer's patches is modulated by CD155. Eur J Immunol (2009) 0.83

Deficient CCR7 signaling promotes TH2 polarization and B-cell activation in vivo. Eur J Immunol (2011) 0.83

Shift of graft-versus-host-disease target organ tropism by dietary vitamin A. PLoS One (2012) 0.83

Factors governing the intranodal migration behavior of T lymphocytes. Immunol Rev (2008) 0.82

Inactivation of T-cell receptor-mediated integrin activation prolongs allograft survival in ADAP-deficient mice. Transplantation (2007) 0.82

CXCR5/CXCL13 interaction is important for double-negative regulatory T cell homing to cardiac allografts. J Immunol (2006) 0.81

Differential postselection proliferation dynamics of αβ T cells, Foxp3+ regulatory T cells, and invariant NKT cells monitored by genetic pulse labeling. J Immunol (2013) 0.81

CCR7-mediated migration in the thymus controls γδ T-cell development. Eur J Immunol (2014) 0.81

IkappaBalpha is required for marginal zone B cell lineage development. Eur J Immunol (2008) 0.81

Enhanced FTY720-mediated lymphocyte homing requires G alpha i signaling and depends on beta 2 and beta 7 integrin. J Immunol (2006) 0.78

Neonatal lymph node stromal cells drive myelodendritic lineage cells into a distinct population of CX3CR1+CD11b+F4/80+ regulatory macrophages in mice. Blood (2012) 0.78