Published in Science on September 09, 2005
Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity (2006) 7.22
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FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation. Proc Natl Acad Sci U S A (2010) 2.49
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Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. J Exp Med (2009) 2.34
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A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress. J Exp Med (2007) 1.71
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Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer. Proc Natl Acad Sci U S A (2006) 1.63
The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. J Clin Invest (2012) 1.54
Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism. J Exp Med (2006) 1.51
Local not systemic modulation of dendritic cell S1P receptors in lung blunts virus-specific immune responses to influenza. Mol Pharmacol (2008) 1.48
S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release. Blood (2012) 1.47
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S1P1 receptor directs the release of immature B cells from bone marrow into blood. J Exp Med (2010) 1.43
Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions. PLoS One (2009) 1.42
The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. Blood (2006) 1.41
The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat Immunol (2011) 1.39
The vascular S1P gradient-cellular sources and biological significance. Biochim Biophys Acta (2008) 1.38
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Fingolimod is a potential novel therapy for multiple sclerosis. Nat Rev Neurol (2010) 1.36
Sphingosine 1-phosphate in coagulation and inflammation. Semin Immunopathol (2011) 1.34
Insights into the pharmacological relevance of lysophospholipid receptors. Br J Pharmacol (2012) 1.31
Thymic emigration: when and how T cells leave home. J Immunol (2008) 1.31
Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors. Chem Rev (2011) 1.29
Mouse SPNS2 functions as a sphingosine-1-phosphate transporter in vascular endothelial cells. PLoS One (2012) 1.28
Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking. J Biol Chem (2010) 1.27
Therapeutic potential of autotaxin/lysophospholipase d inhibitors. Curr Drug Targets (2008) 1.27
Sphingosine-1-phosphate and immune regulation: trafficking and beyond. Trends Pharmacol Sci (2010) 1.27
Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function. Adv Enzyme Regul (2009) 1.26
Thymic progenitor homing and lymphocyte homeostasis are linked via S1P-controlled expression of thymic P-selectin/CCL25. J Exp Med (2009) 1.25
Characterization of the ATP-dependent sphingosine 1-phosphate transporter in rat erythrocytes. J Biol Chem (2009) 1.24
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Lipid phosphate phosphatase 3 enables efficient thymic egress. J Exp Med (2011) 1.23
Tre1 GPCR initiates germ cell transepithelial migration by regulating Drosophila melanogaster E-cadherin. J Cell Biol (2008) 1.23
Regulation of vascular physiology and pathology by the S1P2 receptor subtype. Cardiovasc Res (2009) 1.22
A novel method to quantify sphingosine 1-phosphate by immobilized metal affinity chromatography (IMAC). Prostaglandins Other Lipid Mediat (2007) 1.21
A role for S1P and S1P1 in immature-B cell egress from mouse bone marrow. PLoS One (2010) 1.20
The role of sphingosine-1-phosphate transporter Spns2 in immune system function. J Immunol (2012) 1.20
A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis. J Exp Med (2012) 1.18
Defining the quantitative limits of intravital two-photon lymphocyte tracking. Proc Natl Acad Sci U S A (2011) 1.17
The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner. Cell Signal (2011) 1.15
Sphingosine-1-phosphate receptors: biology and therapeutic potential in kidney disease. Kidney Int (2008) 1.14
Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression. Am J Respir Cell Mol Biol (2010) 1.13
Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium. J Exp Med (2007) 1.13
Sphingosine kinase and sphingosine 1-phosphate in cardioprotection. J Cardiovasc Pharmacol (2009) 1.10
Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network. FASEB J (2012) 1.09
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Mast cell chemotaxis - chemoattractants and signaling pathways. Front Immunol (2012) 1.07
Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs. J Clin Invest (2014) 1.07
(S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity. Cell Signal (2010) 1.07
Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway. PLoS One (2012) 1.06
Shaping the landscape: metabolic regulation of S1P gradients. Biochim Biophys Acta (2012) 1.06
Sphingosine-1-phosphate lyase in development and disease: sphingolipid metabolism takes flight. Biochim Biophys Acta (2008) 1.06
Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation. Nat Immunol (2013) 1.05
Retracted Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice. J Clin Invest (2010) 1.05
S1P3 confers differential S1P-induced migration by autoreactive and non-autoreactive immature B cells and is required for normal B-cell development. Eur J Immunol (2010) 1.04
Sphingosine-1-phosphate in allergic responses, asthma and anaphylaxis. Pharmacol Ther (2007) 1.04
Novel trafficking routes for hematopoietic stem and progenitor cells. Ann N Y Acad Sci (2009) 1.04
Lymph node B lymphocyte trafficking is constrained by anatomy and highly dependent upon chemoattractant desensitization. Blood (2011) 1.03
Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo. J Clin Invest (2014) 1.03
A pivotal role of vitamin B9 in the maintenance of regulatory T cells in vitro and in vivo. PLoS One (2012) 1.02
S1P is associated with protection in human and experimental cerebral malaria. Mol Med (2011) 1.02
Lyase to live by: sphingosine phosphate lyase as a therapeutic target. Expert Opin Ther Targets (2009) 1.02
S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart. Am J Physiol Heart Circ Physiol (2011) 1.02
Involvement of sphingosine 1-phosphate (SIP)/S1P3 signaling in cholestasis-induced liver fibrosis. Am J Pathol (2009) 1.01
Local antigen in nonlymphoid tissue promotes resident memory CD8+ T cell formation during viral infection. J Exp Med (2016) 1.01
The transporter Spns2 is required for secretion of lymph but not plasma sphingosine-1-phosphate. Cell Rep (2012) 1.01
An emerging role for the lipid mediator sphingosine-1-phosphate in mast cell effector function and allergic disease. Adv Exp Med Biol (2011) 0.99
Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 - Jekyll Hidden behind Hyde. Am J Cancer Res (2011) 0.99
Truth and consequences of sphingosine-1-phosphate lyase. Adv Biol Regul (2012) 0.98
Development of small-molecule inhibitors of sphingosine-1-phosphate signaling. Pharmacol Ther (2011) 0.98
Targeting cells in motion: migrating toward improved therapies. Eur J Immunol (2013) 0.98
Pharmacokinetics and pharmacodynamics of ponesimod, a selective S1P1 receptor modulator, in the first-in-human study. Br J Clin Pharmacol (2013) 0.98
Characterization of sphingosine-1-phosphate lyase activity by electrospray ionization-liquid chromatography/tandem mass spectrometry quantitation of (2E)-hexadecenal. Anal Biochem (2010) 0.97
Membrane lipid rafts, master regulators of hematopoietic stem cell retention in bone marrow and their trafficking. Leukemia (2015) 0.97
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature (2004) 12.72
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc Natl Acad Sci U S A (2009) 8.25
CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature (2006) 7.17
Langerhans cells renew in the skin throughout life under steady-state conditions. Nat Immunol (2002) 7.03
Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science (2007) 6.04
Germinal-center organization and cellular dynamics. Immunity (2007) 5.62
Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nat Immunol (2007) 5.22
Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J Immunol (2007) 5.14
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Imaging of germinal center selection events during affinity maturation. Science (2006) 4.86
Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells. Nat Immunol (2007) 4.46
Finding a way out: lymphocyte egress from lymphoid organs. Nat Immunol (2007) 4.42
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Probable person to person transmission of novel avian influenza A (H7N9) virus in Eastern China, 2013: epidemiological investigation. BMJ (2013) 4.17
Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease. Sci Transl Med (2010) 4.07
Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol (2005) 4.01
Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF. Immunity (2004) 4.00
Estimating accuracy of RNA-Seq and microarrays with proteomics. BMC Genomics (2009) 3.87
The kinase domain of mitochondrial PINK1 faces the cytoplasm. Proc Natl Acad Sci U S A (2008) 3.65
Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone. Nat Immunol (2004) 3.65
Follicular shuttling of marginal zone B cells facilitates antigen transport. Nat Immunol (2007) 3.63
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Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces. Nat Immunol (2007) 3.41
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Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position. Nature (2002) 3.35
The transcriptional repressor DEC2 regulates sleep length in mammals. Science (2009) 3.12
High-resolution genome-wide mapping of transposon integration in mammals. Mol Cell Biol (2005) 3.10
S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress. Immunity (2007) 3.05
Mapping abeta amyloid fibril secondary structure using scanning proline mutagenesis. J Mol Biol (2004) 3.05
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Integrin-mediated long-term B cell retention in the splenic marginal zone. Science (2002) 3.00
Aligned single-crystalline Si nanowire arrays for photovoltaic applications. Small (2005) 2.98
Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells. Immunity (2005) 2.97
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A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature (2010) 2.88
MicroRNA-29 regulates T-box transcription factors and interferon-γ production in helper T cells. Immunity (2011) 2.71
FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. Am J Transplant (2004) 2.70
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CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity. Immunity (2002) 2.67
Regulation of homeostatic chemokine expression and cell trafficking during immune responses. Science (2007) 2.67
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Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit. J Exp Med (2005) 2.57
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Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation. Nat Immunol (2009) 2.49
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Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. J Exp Med (2009) 2.34
Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production. Nat Immunol (2009) 2.29
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EBI2 mediates B cell segregation between the outer and centre follicle. Nature (2009) 2.20
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Cutting edge: Identification of a motile IL-17-producing gammadelta T cell population in the dermis. J Immunol (2011) 2.16
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The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency. Nat Immunol (2008) 1.97
Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids. Nat Immunol (2009) 1.96
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