Published in FEBS J on November 22, 2012
I-TASSER: a unified platform for automated protein structure and function prediction. Nat Protoc (2010) 22.66
The Jpred 3 secondary structure prediction server. Nucleic Acids Res (2008) 13.32
Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set. Anal Biochem (2000) 11.10
Tetraspanin functions and associated microdomains. Nat Rev Mol Cell Biol (2005) 6.22
GOR method for predicting protein secondary structure from amino acid sequence. Methods Enzymol (1996) 5.50
Natural beta-sheet proteins use negative design to avoid edge-to-edge aggregation. Proc Natl Acad Sci U S A (2002) 4.66
Mutations in the human retinal degeneration slow (RDS) gene can cause either retinitis pigmentosa or macular dystrophy. Nat Genet (1993) 3.62
Mutations in the human retinal degeneration slow gene in autosomal dominant retinitis pigmentosa. Nature (1991) 3.00
Functional domains in tetraspanin proteins. Trends Biochem Sci (2003) 2.71
Localization of peripherin/rds in the disk membranes of cone and rod photoreceptors: relationship to disk membrane morphogenesis and retinal degeneration. J Cell Biol (1992) 2.17
Photoreceptor peripherin is the normal product of the gene responsible for retinal degeneration in the rds mouse. Proc Natl Acad Sci U S A (1991) 2.11
CD81 extracellular domain 3D structure: insight into the tetraspanin superfamily structural motifs. EMBO J (2001) 1.90
Molecular cloning, primary structure, and orientation of the vertebrate photoreceptor cell protein peripherin in the rod outer segment disk membrane. Biochemistry (1990) 1.76
Absence of receptor outer segments in the retina of rds mutant mice. Neurosci Lett (1981) 1.72
Disulfide-mediated oligomerization of Peripherin/Rds and Rom-1 in photoreceptor disk membranes. Implications for photoreceptor outer segment morphogenesis and degeneration. J Biol Chem (2000) 1.61
The C terminus of peripherin/rds participates in rod outer segment targeting and alignment of disk incisures. Mol Biol Cell (2004) 1.58
Heterologous expression of photoreceptor peripherin/rds and Rom-1 in COS-1 cells: assembly, interactions, and localization of multisubunit complexes. Biochemistry (1995) 1.53
Structure of the tetraspanin main extracellular domain. A partially conserved fold with a structurally variable domain insertion. J Biol Chem (2001) 1.49
The R172W mutation in peripherin/rds causes a cone-rod dystrophy in transgenic mice. Hum Mol Genet (2004) 1.48
Cysteine residues of photoreceptor peripherin/rds: role in subunit assembly and autosomal dominant retinitis pigmentosa. Biochemistry (1998) 1.45
Defective subunit assembly underlies a digenic form of retinitis pigmentosa linked to mutations in peripherin/rds and rom-1. Proc Natl Acad Sci U S A (1996) 1.43
Development and degeneration of retina in rds mutant mice: electron microscopy. J Comp Neurol (1984) 1.35
The Cys214-->Ser mutation in peripherin/rds causes a loss-of-function phenotype in transgenic mice. Biochem J (2005) 1.28
Subunit association and conformational flexibility in the head subdomain of human CD81 large extracellular loop. Biol Chem (2002) 1.17
Differential requirements for retinal degeneration slow intermolecular disulfide-linked oligomerization in rods versus cones. Hum Mol Genet (2008) 1.15
The tetraspanin protein peripherin-2 forms a complex with melanoregulin, a putative membrane fusion regulator. Biochemistry (2007) 1.15
Asn244His mutation of the peripherin/RDS gene causing autosomal dominant cone-rod degeneration. Hum Mol Genet (1994) 1.14
Development and degeneration of retina in rds mutant mice: the electroretinogram. Neurosci Lett (1984) 1.13
Outer segment oligomerization of Rds: evidence from mouse models and subcellular fractionation. Biochemistry (2008) 1.12
Role of the second intradiscal loop of peripherin/rds in homo and hetero associations. Biochemistry (2005) 1.05
Identification of two topologically independent domains in RAG1 and their role in macromolecular interactions relevant to V(D)J recombination. J Biol Chem (2001) 1.05
A novel Cys-214-Ser mutation in the peripherin/RDS gene in a Japanese family with autosomal dominant retinitis pigmentosa. Hum Genet (1993) 1.04
Differences in RDS trafficking, assembly and function in cones versus rods: insights from studies of C150S-RDS. Hum Mol Genet (2010) 1.03
Full characterization of the maculopathy associated with an Arg-172-Trp mutation in the RDS/peripherin gene. Ophthalmic Genet (1996) 0.98
Self-association and conformational properties of RAG1: implications for formation of the V(D)J recombinase. Nucleic Acids Res (2003) 0.98
A soluble peripherin/Rds C-terminal polypeptide promotes membrane fusion and changes conformation upon membrane association. Exp Eye Res (2003) 0.96
Expression and characterization of peripherin/rds-rom-1 complexes and mutants implicated in retinal degenerative diseases. Methods Enzymol (2000) 0.94
A novel mutation (Asn244Lys) in the peripherin/RDS gene causing autosomal dominant retinitis pigmentosa associated with bull's-eye maculopathy detected by nonradioisotopic SSCP. Genomics (1994) 0.92
A point mutation in the RDS-peripherin gene in a Spanish family with central areolar choroidal dystrophy. Ophthalmic Genet (1995) 0.91
Late-onset cone photoreceptor degeneration induced by R172W mutation in Rds and partial rescue by gene supplementation. Invest Ophthalmol Vis Sci (2007) 0.90
Biochemical analysis of phenotypic diversity associated with mutations in codon 244 of the retinal degeneration slow gene. Biochemistry (2010) 0.90
Macular dystrophy associated with monogenic Arg172Trp mutation of the peripherin/RDS gene in a Japanese family. Retina (1995) 0.90
Autosomal dominant cone-rod dystrophy associated with a Val200Glu mutation of the peripherin/RDS gene. Retina (1996) 0.89
Structural and functional relationships between photoreceptor tetraspanins and other superfamily members. Cell Mol Life Sci (2011) 0.88
Predicted and measured disorder in peripherin/rds, a retinal tetraspanin. Protein Pept Lett (2005) 0.87
Calcium-dependent association of calmodulin with the C-terminal domain of the tetraspanin protein peripherin/rds. Biochemistry (2007) 0.87
A zinc site in the C-terminal domain of RAG1 is essential for DNA cleavage activity. J Mol Biol (2009) 0.84
Elucidating the domain architecture and functions of non-core RAG1: the capacity of a non-core zinc-binding domain to function in nuclear import and nucleic acid binding. BMC Biochem (2011) 0.84
The function of oligomerization-incompetent RDS in rods. Adv Exp Med Biol (2010) 0.78
Expression and structural characterization of peripherin/RDS, a membrane protein implicated in photoreceptor outer segment morphology. Eur Biophys J (2009) 0.76
Expression of cone-photoreceptor-specific antigens in a cell line derived from retinal tumors in transgenic mice. Invest Ophthalmol Vis Sci (2004) 1.92
Efficient non-viral ocular gene transfer with compacted DNA nanoparticles. PLoS One (2006) 1.71
Retention of function without normal disc morphogenesis occurs in cone but not rod photoreceptors. J Cell Biol (2006) 1.70
The R172W mutation in peripherin/rds causes a cone-rod dystrophy in transgenic mice. Hum Mol Genet (2004) 1.48
RPE65: role in the visual cycle, human retinal disease, and gene therapy. Ophthalmic Genet (2009) 1.39
A partial structural and functional rescue of a retinitis pigmentosa model with compacted DNA nanoparticles. PLoS One (2009) 1.37
Modulating expression of peripherin/rds in transgenic mice: critical levels and the effect of overexpression. Invest Ophthalmol Vis Sci (2004) 1.32
The Cys214-->Ser mutation in peripherin/rds causes a loss-of-function phenotype in transgenic mice. Biochem J (2005) 1.28
Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins. Biochemistry (2003) 1.23
Gene delivery to mitotic and postmitotic photoreceptors via compacted DNA nanoparticles results in improved phenotype in a mouse model of retinitis pigmentosa. FASEB J (2009) 1.22
Effect of Rds abundance on cone outer segment morphogenesis, photoreceptor gene expression, and outer limiting membrane integrity. J Comp Neurol (2007) 1.20
Putting the pieces together: identification and characterization of structural domains in the V(D)J recombination protein RAG1. Immunol Rev (2004) 1.20
DNA nanoparticle-mediated ABCA4 delivery rescues Stargardt dystrophy in mice. J Clin Invest (2012) 1.19
Retinal stem cells transplanted into models of late stages of retinitis pigmentosa preferentially adopt a glial or a retinal ganglion cell fate. Invest Ophthalmol Vis Sci (2007) 1.16
Differential requirements for retinal degeneration slow intermolecular disulfide-linked oligomerization in rods versus cones. Hum Mol Genet (2008) 1.15
Outer segment oligomerization of Rds: evidence from mouse models and subcellular fractionation. Biochemistry (2008) 1.12
P2Y(2) receptor agonist INS37217 enhances functional recovery after detachment caused by subretinal injection in normal and rds mice. Invest Ophthalmol Vis Sci (2003) 1.10
Ocular delivery of compacted DNA-nanoparticles does not elicit toxicity in the mouse retina. PLoS One (2009) 1.06
Role of the second intradiscal loop of peripherin/rds in homo and hetero associations. Biochemistry (2005) 1.05
The role of Rds in outer segment morphogenesis and human retinal disease. Ophthalmic Genet (2006) 1.04
Differences in RDS trafficking, assembly and function in cones versus rods: insights from studies of C150S-RDS. Hum Mol Genet (2010) 1.03
Retinal angiogenesis in the Ins2(Akita) mouse model of diabetic retinopathy. Invest Ophthalmol Vis Sci (2013) 1.02
Self-association and conformational properties of RAG1: implications for formation of the V(D)J recombinase. Nucleic Acids Res (2003) 0.98
A non-sequence-specific DNA binding mode of RAG1 is inhibited by RAG2. J Mol Biol (2009) 0.98
Molecular characterization of the skate peripherin/rds gene: relationship to its orthologues and paralogues. Invest Ophthalmol Vis Sci (2003) 0.97
S/MAR-containing DNA nanoparticles promote persistent RPE gene expression and improvement in RPE65-associated LCA. Hum Mol Genet (2013) 0.97
Nanoparticle-mediated gene transfer specific to retinal pigment epithelial cells. Biomaterials (2011) 0.96
The central domain of core RAG1 preferentially recognizes single-stranded recombination signal sequence heptamer. J Biol Chem (2003) 0.96
Comparative analysis of DNA nanoparticles and AAVs for ocular gene delivery. PLoS One (2012) 0.96
Nanoparticles for retinal gene therapy. Prog Retin Eye Res (2010) 0.95
Direct gene transfer with compacted DNA nanoparticles in retinal pigment epithelial cells: expression, repeat delivery and lack of toxicity. Nanomedicine (Lond) (2012) 0.93
Drug and gene delivery to the back of the eye: from bench to bedside. Invest Ophthalmol Vis Sci (2014) 0.93
Expression profiling after retinal detachment and reattachment: a possible role for aquaporin-0. Invest Ophthalmol Vis Sci (2008) 0.92
Defects in the outer limiting membrane are associated with rosette development in the Nrl-/- retina. PLoS One (2012) 0.92
Longitudinal decline in lung function: evaluation of interleukin-10 genetic polymorphisms in firefighters. J Occup Environ Med (2004) 0.91
Increased cone sensitivity to ABCA4 deficiency provides insight into macular vision loss in Stargardt's dystrophy. Biochim Biophys Acta (2011) 0.91
Genetic supplementation of RDS alleviates a loss-of-function phenotype in C214S model of retinitis pigmentosa. Adv Exp Med Biol (2008) 0.90
Biochemical analysis of phenotypic diversity associated with mutations in codon 244 of the retinal degeneration slow gene. Biochemistry (2010) 0.90
DNA cleavage of a cryptic recombination signal sequence by RAG1 and RAG2. Implications for partial V(H) gene replacement. J Biol Chem (2006) 0.90
Late-onset cone photoreceptor degeneration induced by R172W mutation in Rds and partial rescue by gene supplementation. Invest Ophthalmol Vis Sci (2007) 0.90
The disease-causing mutations in the carboxyl terminus of the cone cyclic nucleotide-gated channel CNGA3 subunit alter the local secondary structure and interfere with the channel active conformational change. Biochemistry (2010) 0.89
Structural and functional relationships between photoreceptor tetraspanins and other superfamily members. Cell Mol Life Sci (2011) 0.88
Absence of functional and structural abnormalities associated with expression of EGFP in the retina. Invest Ophthalmol Vis Sci (2004) 0.88
Differential distribution of proteins and lipids in detergent-resistant and detergent-soluble domains in rod outer segment plasma membranes and disks. J Neurochem (2007) 0.88
Glycosylation of Skp1 affects its conformation and promotes binding to a model f-box protein. Biochemistry (2014) 0.87
Gene therapy for Stargardt disease associated with ABCA4 gene. Adv Exp Med Biol (2014) 0.87
A review of therapeutic prospects of non-viral gene therapy in the retinal pigment epithelium. Biomaterials (2013) 0.85
Nonviral ocular gene therapy: assessment and future directions. Curr Opin Mol Ther (2008) 0.85
Expression and role of p53 in the retina. Invest Ophthalmol Vis Sci (2012) 0.85
DNA cleavage activity of the V(D)J recombination protein RAG1 is autoregulated. Mol Cell Biol (2004) 0.84
Elucidating the domain architecture and functions of non-core RAG1: the capacity of a non-core zinc-binding domain to function in nuclear import and nucleic acid binding. BMC Biochem (2011) 0.84
A zinc site in the C-terminal domain of RAG1 is essential for DNA cleavage activity. J Mol Biol (2009) 0.84
Persistence of non-viral vector mediated RPE65 expression: case for viability as a gene transfer therapy for RPE-based diseases. J Control Release (2013) 0.83
Differential developmental deficits in retinal function in the absence of either protein tyrosine sulfotransferase-1 or -2. PLoS One (2012) 0.83
RDS in cones does not interact with the beta subunit of the cyclic nucleotide gated channel. Adv Exp Med Biol (2010) 0.82
Mouse models of human retinal disease caused by expression of mutant rhodopsin. A valuable tool for the assessment of novel gene therapies. Adv Exp Med Biol (2003) 0.81
Thermal dependency of RAG1 self-association properties. BMC Biochem (2008) 0.80
Fibulin 2, a tyrosine O-sulfated protein, is up-regulated following retinal detachment. J Biol Chem (2014) 0.80
AAV and compacted DNA nanoparticles for the treatment of retinal disorders: challenges and future prospects. Invest Ophthalmol Vis Sci (2011) 0.80
Synthesis and characterization of glycol chitosan DNA nanoparticles for retinal gene delivery. ChemMedChem (2013) 0.80
Mechanism involved in the modulation of photoreceptor-specific cyclic nucleotidegated channel by the tyrosine kinase adapter protein Grb14. Protein Cell (2011) 0.80
Aquaporin-1 expression and conventional aqueous outflow in human eyes. Exp Eye Res (2008) 0.80
A perspective on the role of the extracellular matrix in progressive retinal degenerative disorders. Invest Ophthalmol Vis Sci (2013) 0.80
Episomal maintenance of S/MAR-containing non-viral vectors for RPE-based diseases. Adv Exp Med Biol (2014) 0.79
A 350 bp region of the proximal promoter of Rds drives cell-type specific gene expression. Exp Eye Res (2010) 0.79
Barriers to productive transfection of trabecular meshwork cells. Mol Vis (2005) 0.78
Binding to lipid membrane induces conformational changes in RPE65: implications for its isomerohydrolase activity. Biochem J (2011) 0.78
Focus on molecules: RDS. Exp Eye Res (2009) 0.78
Gene therapy in the Retinal Degeneration Slow model of retinitis pigmentosa. Adv Exp Med Biol (2010) 0.78
An interdomain boundary in RAG1 facilitates cooperative binding to RAG2 in formation of the V(D)J recombinase complex. Protein Sci (2015) 0.78
The function of oligomerization-incompetent RDS in rods. Adv Exp Med Biol (2010) 0.78
Mislocalization of oligomerization-incompetent RDS is associated with mislocalization of cone opsins and cone transducin. Adv Exp Med Biol (2012) 0.77
Transgenic animal studies of human retinal disease caused by mutations in peripherin/rds. Adv Exp Med Biol (2006) 0.76
In vitro analysis of ribozyme-mediated knockdown of an ADRP associated rhodopsin mutation. Adv Exp Med Biol (2008) 0.76
A unique loop structure in oncostatin M determines binding affinity toward oncostatin M receptor and leukemia inhibitory factor receptor. J Biol Chem (2012) 0.75
Overexpression of ROM-1 in the cone-dominant retina. Adv Exp Med Biol (2012) 0.75
Light/dark translocation of alphatransducin in mouse photoreceptor cells expressing G90D mutant opsin. Adv Exp Med Biol (2006) 0.75
Overexpression of retinal degeneration slow (RDS) protein adversely affects rods in the rd7 model of enhanced S-cone syndrome. PLoS One (2013) 0.75