Published in Protein Sci on April 02, 2015
Riches in RAGs: Revealing the V(D)J Recombinase through High-Resolution Structures. Trends Biochem Sci (2016) 0.75
H3K4me3 induces allosteric conformational changes in the DNA-binding and catalytic regions of the V(D)J recombinase. Proc Natl Acad Sci U S A (2017) 0.75
Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals. Cell (1987) 4.70
The 2.3-A resolution structure of the maltose- or maltodextrin-binding protein, a primary receptor of bacterial active transport and chemotaxis. J Biol Chem (1991) 3.42
Partial V(D)J recombination activity leads to Omenn syndrome. Cell (1998) 3.18
A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex. Nature (2004) 2.92
V(D)J recombination: mechanisms of initiation. Annu Rev Genet (2011) 2.70
The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2. Proc Natl Acad Sci U S A (2007) 2.53
The homeodomain region of Rag-1 reveals the parallel mechanisms of bacterial and V(D)J recombination. Cell (1996) 2.36
Probing protein structure by limited proteolysis. Acta Biochim Pol (2004) 2.32
RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex. Mol Cell Biol (1999) 1.59
A zinc-binding domain involved in the dimerization of RAG1. J Mol Biol (1996) 1.53
The V(D)J recombination activating protein RAG2 consists of a six-bladed propeller and a PHD fingerlike domain, as revealed by sequence analysis. Cell Mol Life Sci (1998) 1.52
Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis. Nat Struct Mol Biol (2009) 1.40
A RAG-1/RAG-2 tetramer supports 12/23-regulated synapsis, cleavage, and transposition of V(D)J recombination signals. Mol Cell Biol (2002) 1.36
A dimer of the lymphoid protein RAG1 recognizes the recombination signal sequence and the complex stably incorporates the high mobility group protein HMG2. Nucleic Acids Res (1999) 1.36
Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination. Mol Cell (2001) 1.33
Long-range cooperative binding effects in a T cell receptor variable domain. Proc Natl Acad Sci U S A (2006) 1.26
Mutations in conserved regions of the predicted RAG2 kelch repeats block initiation of V(D)J recombination and result in primary immunodeficiencies. Mol Cell Biol (2000) 1.20
Putting the pieces together: identification and characterization of structural domains in the V(D)J recombination protein RAG1. Immunol Rev (2004) 1.20
Definition of minimal domains of interaction within the recombination-activating genes 1 and 2 recombinase complex. J Immunol (2000) 1.14
Initial stages of V(D)J recombination: the organization of RAG1/2 and RSS DNA in the postcleavage complex. Mol Cell (2009) 1.13
Identification of basic residues in RAG2 critical for DNA binding by the RAG1-RAG2 complex. Mol Cell (2001) 1.12
The roles of the RAG1 and RAG2 "non-core" regions in V(D)J recombination and lymphocyte development. Arch Immunol Ther Exp (Warsz) (2009) 1.08
Use of flow cytometric methods to quantify protein-protein interactions. Curr Protoc Cytom (2010) 1.07
A C-terminal region of RAG1 contacts the coding DNA during V(D)J recombination. Mol Cell Biol (2001) 1.06
Identification of two topologically independent domains in RAG1 and their role in macromolecular interactions relevant to V(D)J recombination. J Biol Chem (2001) 1.05
Autoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombination. Proc Natl Acad Sci U S A (2010) 1.04
Definition of a large region of RAG1 that is important for coimmunoprecipitation of RAG2. J Immunol (1997) 1.03
Molecular mechanism underlying RAG1/RAG2 synaptic complex formation. J Biol Chem (2009) 1.03
A non-sequence-specific DNA binding mode of RAG1 is inhibited by RAG2. J Mol Biol (2009) 0.98
Self-association and conformational properties of RAG1: implications for formation of the V(D)J recombinase. Nucleic Acids Res (2003) 0.98
RAG1-DNA binding in V(D)J recombination. Specificity and DNA-induced conformational changes revealed by fluorescence and CD spectroscopy. J Biol Chem (2002) 0.96
The central domain of core RAG1 preferentially recognizes single-stranded recombination signal sequence heptamer. J Biol Chem (2003) 0.96
Analysis on multi-domain cooperation for predicting protein-protein interactions. BMC Bioinformatics (2007) 0.95
Mechanism of fragility at BCL2 gene minor breakpoint cluster region during t(14;18) chromosomal translocation. J Biol Chem (2012) 0.92
DNA cleavage of a cryptic recombination signal sequence by RAG1 and RAG2. Implications for partial V(H) gene replacement. J Biol Chem (2006) 0.90
Ku70/Ku80 and DNA-dependent protein kinase catalytic subunit modulate RAG-mediated cleavage: implications for the enforcement of the 12/23 rule. J Biol Chem (2004) 0.86
Mechanistic basis for RAG discrimination between recombination sites and the off-target sites of human lymphomas. Mol Cell Biol (2011) 0.86
Elucidating the domain architecture and functions of non-core RAG1: the capacity of a non-core zinc-binding domain to function in nuclear import and nucleic acid binding. BMC Biochem (2011) 0.84
DNA cleavage activity of the V(D)J recombination protein RAG1 is autoregulated. Mol Cell Biol (2004) 0.84
A zinc site in the C-terminal domain of RAG1 is essential for DNA cleavage activity. J Mol Biol (2009) 0.84
Making genes green: creating green fluorescent protein (GFP) fusions with blunt-end PCR products. Biotechniques (1998) 0.82
Amino acid residues in RAG1 responsible for the interaction with RAG2 during the V(D)J recombination process. J Biol Chem (2003) 0.82
Thermal dependency of RAG1 self-association properties. BMC Biochem (2008) 0.80
Cytoskeleton-membrane interactions in membrane raft structure. Cell Mol Life Sci (2009) 1.59
Clustering of membrane raft proteins by the actin cytoskeleton. J Biol Chem (2007) 1.42
Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins. Biochemistry (2003) 1.23
Putting the pieces together: identification and characterization of structural domains in the V(D)J recombination protein RAG1. Immunol Rev (2004) 1.20
Compartmentalization of phosphatidylinositol 4,5-bisphosphate signaling evidenced using targeted phosphatases. J Biol Chem (2008) 1.15
Stimulated association of STIM1 and Orai1 is regulated by the balance of PtdIns(4,5)P₂ between distinct membrane pools. J Cell Sci (2011) 1.12
Surgical staging in patients with ovarian tumors of low malignant potential. Obstet Gynecol (2002) 1.09
Prospective comparison of brush cytology, viral culture, and histology for the diagnosis of ulcerative esophagitis in AIDS. Clin Gastroenterol Hepatol (2004) 1.01
Self-association and conformational properties of RAG1: implications for formation of the V(D)J recombinase. Nucleic Acids Res (2003) 0.98
A non-sequence-specific DNA binding mode of RAG1 is inhibited by RAG2. J Mol Biol (2009) 0.98
The central domain of core RAG1 preferentially recognizes single-stranded recombination signal sequence heptamer. J Biol Chem (2003) 0.96
Visualization of antigen presentation by actin-mediated targeting of glycolipid-enriched membrane domains to the immune synapse of B cell APCs. J Immunol (2004) 0.95
Visualization of inositol phosphate-dependent mobility of Ku: depletion of the DNA-PK cofactor InsP6 inhibits Ku mobility. Nucleic Acids Res (2004) 0.93
T cell glycolipid-enriched membrane domains are constitutively assembled as membrane patches that translocate to immune synapses. J Immunol (2003) 0.90
DNA cleavage of a cryptic recombination signal sequence by RAG1 and RAG2. Implications for partial V(H) gene replacement. J Biol Chem (2006) 0.90
Signal-dependent slow leukocyte rolling does not require cytoskeletal anchorage of P-selectin glycoprotein ligand-1 (PSGL-1) or integrin αLβ2. J Biol Chem (2012) 0.89
The disease-causing mutations in the carboxyl terminus of the cone cyclic nucleotide-gated channel CNGA3 subunit alter the local secondary structure and interfere with the channel active conformational change. Biochemistry (2010) 0.89
Glycosylation of Skp1 affects its conformation and promotes binding to a model f-box protein. Biochemistry (2014) 0.87
T cell signal regulation by the actin cytoskeleton. J Biol Chem (2010) 0.86
Very good inter-rater reliability of Engel and ILAE epilepsy surgery outcome classifications in a series of 76 patients. Seizure (2011) 0.85
DNA cleavage activity of the V(D)J recombination protein RAG1 is autoregulated. Mol Cell Biol (2004) 0.84
Elucidating the domain architecture and functions of non-core RAG1: the capacity of a non-core zinc-binding domain to function in nuclear import and nucleic acid binding. BMC Biochem (2011) 0.84
A zinc site in the C-terminal domain of RAG1 is essential for DNA cleavage activity. J Mol Biol (2009) 0.84
Early and dynamic polarization of T cell membrane rafts and constituents prior to TCR stop signals. J Immunol (2007) 0.82
Proteomic profiling of mature CD10+ B-cell lymphomas. Am J Clin Pathol (2005) 0.81
Cytoplasmic domain of P-selectin glycoprotein ligand-1 facilitates dimerization and export from the endoplasmic reticulum. J Biol Chem (2011) 0.81
Mechanism involved in the modulation of photoreceptor-specific cyclic nucleotidegated channel by the tyrosine kinase adapter protein Grb14. Protein Cell (2011) 0.80
Thermal dependency of RAG1 self-association properties. BMC Biochem (2008) 0.80
Cytoskeletal modulation of lipid interactions regulates Lck kinase activity. J Biol Chem (2012) 0.80
Binding to lipid membrane induces conformational changes in RPE65: implications for its isomerohydrolase activity. Biochem J (2011) 0.78
Spatial Segregation of Phosphatidylinositol 4,5-Bisphosphate (PIP(2)) Signaling in Immune Cell Functions. Immunol Endocr Metab Agents Med Chem (2008) 0.78
CD28 sensitizes TCR Ca²⁺ signaling during Ag-independent polarization of plasma membrane rafts. J Immunol (2013) 0.78
Structural characterization of the second intra-discal loop of the photoreceptor tetraspanin RDS. FEBS J (2012) 0.77
Unusual fallopian tube neoplasm in a 10-year-old patient with Proteus syndrome: a case report and review of the literature. Pediatr Dev Pathol (2006) 0.75
Visualization of transfer of a fluorescently-labeled membrane raft protein to T cells using lentivirus. Gene Ther Mol Biol (2005) 0.75
A unique loop structure in oncostatin M determines binding affinity toward oncostatin M receptor and leukemia inhibitory factor receptor. J Biol Chem (2012) 0.75
Fabrication of metallized nanoporous films from the self-assembly of a block copolymer and homopolymer mixture. Langmuir (2007) 0.75
Atypical lymphoid cells in cerebrospinal fluid in acute Epstein Barr virus infection: a case report demonstrating a pitfall in cerebrospinal fluid cytology. Acta Cytol (2008) 0.75
Tuning the arrangement of mono-crown ether-substituted phthalocyanines in Langmuir-Blodgett films by the length of alkyl chains and the cation in subphase. J Colloid Interface Sci (2005) 0.75