Published in Science on December 12, 2003
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Regulation of p53 localization and activity by Ubc13. Mol Cell Biol (2006) 1.26
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Gambogic acid reduced bcl-2 expression via p53 in human breast MCF-7 cancer cells. J Cancer Res Clin Oncol (2009) 1.05
The nucleolus directly regulates p53 export and degradation. J Cell Biol (2011) 1.04
E6-associated protein (E6-AP) is a dual function coactivator of steroid hormone receptors. Nucl Recept Signal (2008) 1.04
Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway. J Virol (2009) 1.03
p53 Regulates oxidative stress-mediated retrograde signaling: a novel mechanism for chemotherapy-induced cardiac injury. PLoS One (2011) 1.03
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Inhibition of Thr-55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage. Proc Natl Acad Sci U S A (2008) 1.02
Ubiquitylation, phosphorylation and Orc2 modulate the subcellular location of Orc1 and prevent it from inducing apoptosis. J Cell Sci (2006) 1.01
White spot syndrome virus open reading frame 222 encodes a viral E3 ligase and mediates degradation of a host tumor suppressor via ubiquitination. J Virol (2006) 1.01
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Prolyl isomerase Pin1 acts as a switch to control the degree of substrate ubiquitylation. Nat Cell Biol (2009) 0.99
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RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage. Proc Natl Acad Sci U S A (2010) 0.98
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Acetylation is indispensable for p53 activation. Cell (2008) 5.70
Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell (2006) 5.64
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SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell (2007) 5.30
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell (2005) 5.04
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SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab (2008) 4.89
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Acetylation inactivates the transcriptional repressor BCL6. Nat Genet (2002) 3.00
The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin. J Biol Chem (2003) 2.89
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol (2006) 2.85
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