Published in Nat Cell Biol on February 11, 2007
MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis. Proc Natl Acad Sci U S A (2008) 3.77
The origin of allosteric functional modulation: multiple pre-existing pathways. Structure (2009) 2.33
Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. J Biol Chem (2008) 2.19
Multiple faces of the SAGA complex. Curr Opin Cell Biol (2010) 1.67
The Mediator complex and transcription regulation. Crit Rev Biochem Mol Biol (2013) 1.64
GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA. Genes Dev (2009) 1.62
CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53. Proc Natl Acad Sci U S A (2009) 1.53
Adipose tissue-derived mesenchymal stem cells in long-term dialysis patients display downregulation of PCAF expression and poor angiogenesis activation. PLoS One (2014) 1.52
The MDM2-p53 pathway revisited. J Biomed Res (2013) 1.52
p53 regulation by ubiquitin. FEBS Lett (2011) 1.51
Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation. Mol Cell Biol (2008) 1.46
Detection of a microRNA signal in an in vivo expression set of mRNAs. PLoS One (2007) 1.40
Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms. Cell Death Differ (2011) 1.39
A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes. J Cell Biol (2009) 1.30
PCAF is an HIF-1alpha cofactor that regulates p53 transcriptional activity in hypoxia. Oncogene (2008) 1.26
Regulation of p53: a collaboration between Mdm2 and Mdmx. Oncotarget (2012) 1.24
The histone acetyltransferase PCAF regulates p21 transcription through stress-induced acetylation of histone H3. Cell Cycle (2012) 1.24
Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation. J Cell Sci (2010) 1.18
Restoration of DNA-binding and growth-suppressive activity of mutant forms of p53 via a PCAF-mediated acetylation pathway. J Cell Physiol (2010) 1.05
MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition. Oncotarget (2015) 1.05
Degradation of cyclin A is regulated by acetylation. Oncogene (2009) 1.02
XIAP inhibits autophagy via XIAP-Mdm2-p53 signalling. EMBO J (2013) 1.02
Histone modifications and chromatin dynamics: a focus on filamentous fungi. FEMS Microbiol Rev (2008) 1.01
PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress. Cell Death Differ (2013) 1.00
Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2. J Biol Chem (2010) 0.99
BRMS1 suppresses lung cancer metastases through an E3 ligase function on histone acetyltransferase p300. Cancer Res (2012) 0.97
p53 Acetylation: Regulation and Consequences. Cancers (Basel) (2014) 0.97
Mechanisms of radiation toxicity in transformed and non-transformed cells. Int J Mol Sci (2013) 0.92
MicroRNAs: New Players in Multiple Myeloma. Front Genet (2011) 0.91
Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice. J Clin Invest (2010) 0.91
HAF : the new player in oxygen-independent HIF-1alpha degradation. Cell Cycle (2009) 0.90
The Many Faces of MDM2 Binding Partners. Genes Cancer (2012) 0.90
Dual Roles of MDM2 in the Regulation of p53: Ubiquitination Dependent and Ubiquitination Independent Mechanisms of MDM2 Repression of p53 Activity. Genes Cancer (2012) 0.85
Pre-apoptotic response to therapeutic DNA damage involves protein modulation of Mcl-1, Hdm2 and Flt3 in acute myeloid leukemia cells. Mol Cancer (2007) 0.84
The transcriptional co-activator PCAF regulates cdk2 activity. Nucleic Acids Res (2009) 0.84
Proteomic snapshot of breast cancer cell cycle: G1/S transition point. Proteomics (2013) 0.84
MPP8 and SIRT1 crosstalk in E-cadherin gene silencing and epithelial-mesenchymal transition. EMBO Rep (2015) 0.83
It Takes 15 to Tango: Making Sense of the Many Ubiquitin Ligases of p53. Genes Cancer (2012) 0.83
The multifaceted role of lysine acetylation in cancer: prognostic biomarker and therapeutic target. Oncotarget (2016) 0.83
Acetylation and deacetylation--novel factors in muscle wasting. Metabolism (2012) 0.82
NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2. EMBO Rep (2016) 0.81
MicroRNAs and Glucocorticoid-Induced Apoptosis in Lymphoid Malignancies. ISRN Hematol (2013) 0.80
Therapeutic considerations for Mdm2: not just a one trick pony. Expert Opin Drug Discov (2008) 0.79
Dissecting the complex regulation of Mad4 in glioblastoma multiforme cells. Cancer Biol Ther (2012) 0.79
The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a. Oncogene (2013) 0.78
A functional genomics screen identifies PCAF and ADA3 as regulators of human granzyme B-mediated apoptosis and Bid cleavage. Cell Death Differ (2014) 0.78
SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity. BMC Mol Biol (2012) 0.76
Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis. Transl Cancer Res (2016) 0.76
PCAF acts as a gastric cancer suppressor through a novel PCAF-p16-CDK4 axis. Am J Cancer Res (2016) 0.75
The p53-HAT connection: PCAF rules? Cell Cycle (2012) 0.75
Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain. J Med Chem (2016) 0.75
Pulling a Ligase out of a "HAT": pCAF Mediates Ubiquitination of the Class II Transactivator. Int J Cell Biol (2017) 0.75
Opposite effects of GCN5 and PCAF knockdowns on the alternative mechanism of telomere maintenance. Oncotarget (2017) 0.75
Differential Effects of Histone Acetyltransferase GCN5 or PCAF Knockdown on Urothelial Carcinoma Cells. Int J Mol Sci (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx. Nature (2011) 9.30
The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination. Nature (2003) 6.11
Towards an HIV cure: a global scientific strategy. Nat Rev Immunol (2012) 5.52
Suppression of microRNA-silencing pathway by HIV-1 during virus replication. Science (2007) 5.07
The Lin28/let-7 axis regulates glucose metabolism. Cell (2011) 4.65
Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell (2003) 3.86
Evidence that HIV-1 encodes an siRNA and a suppressor of RNA silencing. Immunity (2005) 3.70
HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP. Mol Cell (2010) 3.49
Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65. J Biol Chem (2002) 3.48
SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells. Retrovirology (2012) 2.92
Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein. Cell Host Microbe (2012) 2.66
Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1. Cell Rep (2013) 2.56
E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation. Cell (2006) 2.50
Suv39H1 and HP1gamma are responsible for chromatin-mediated HIV-1 transcriptional silencing and post-integration latency. EMBO J (2007) 2.37
A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway. Nature (2013) 2.34
SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage. Blood (2013) 2.18
Changes in microRNA expression profiles in HIV-1-transfected human cells. Retrovirology (2005) 1.95
A hypermorphic IkappaBalpha mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency. J Clin Invest (2003) 1.92
Requirement for SWI/SNF chromatin-remodeling complex in Tat-mediated activation of the HIV-1 promoter. EMBO J (2006) 1.87
Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac. Retrovirology (2012) 1.87
Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome. J Exp Med (2009) 1.83
A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter. Nat Cell Biol (2003) 1.82
Recruitment of Drosophila Polycomb group proteins to chromatin by DSP1. Nature (2005) 1.80
IL-8 expression and its possible relationship with estrogen-receptor-negative status of breast cancer cells. Oncogene (2003) 1.72
Post-transcriptional control of DGCR8 expression by the Microprocessor. RNA (2009) 1.67
The proteasome regulates HIV-1 transcription by both proteolytic and nonproteolytic mechanisms. Mol Cell (2007) 1.56
Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin. Proc Natl Acad Sci U S A (2011) 1.56
Microprocessor, Setx, Xrn2, and Rrp6 co-operate to induce premature termination of transcription by RNAPII. Cell (2012) 1.49
NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function. Mol Cell (2012) 1.44
Suppression of HIV-1 replication by microRNA effectors. Retrovirology (2009) 1.44
MCM8 is an MCM2-7-related protein that functions as a DNA helicase during replication elongation and not initiation. Cell (2005) 1.40
Genome-wide mapping of boundary element-associated factor (BEAF) binding sites in Drosophila melanogaster links BEAF to transcription. Mol Cell Biol (2009) 1.40
A capsid-encoded PPxY-motif facilitates adenovirus entry. PLoS Pathog (2010) 1.29
Differential acetylation of Tat coordinates its interaction with the co-activators cyclin T1 and PCAF. EMBO J (2002) 1.27
Interferon-induced exonuclease ISG20 exhibits an antiviral activity against human immunodeficiency virus type 1. J Gen Virol (2005) 1.27
The AT-hook protein D1 is essential for Drosophila melanogaster development and is implicated in position-effect variegation. Mol Cell Biol (2002) 1.26
Ubiquitination of human T-cell leukemia virus type 1 tax modulates its activity. J Virol (2004) 1.22
Displacement of D1, HP1 and topoisomerase II from satellite heterochromatin by a specific polyamide. EMBO J (2006) 1.22
Tat and trans-activation-responsive (TAR) RNA-independent induction of HIV-1 long terminal repeat by human and murine cyclin T1 requires Sp1. J Biol Chem (2002) 1.19
p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain. J Biol Chem (2005) 1.16
Competition for XPO5 binding between Dicer mRNA, pre-miRNA and viral RNA regulates human Dicer levels. Nat Struct Mol Biol (2011) 1.16
How SAMHD1 changes our view of viral restriction. Trends Immunol (2011) 1.15
HIV-1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses. EMBO J (2005) 1.14
The E4F protein is required for mitotic progression during embryonic cell cycles. Mol Cell Biol (2004) 1.12
Small non-coding RNAs, mammalian cells, and viruses: regulatory interactions? Retrovirology (2007) 1.12
BEAF regulates cell-cycle genes through the controlled deposition of H3K9 methylation marks into its conserved dual-core binding sites. PLoS Biol (2008) 1.11
Peroxisome proliferator-activated receptor gamma recruits the positive transcription elongation factor b complex to activate transcription and promote adipogenesis. Mol Endocrinol (2006) 1.09
Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing. J Clin Invest (2010) 1.08
Tat acetyl-acceptor lysines are important for human immunodeficiency virus type-1 replication. J Biol Chem (2002) 1.07
ERK5 activates NF-kappaB in leukemic T cells and is essential for their growth in vivo. J Immunol (2006) 1.06
Hyperthermia stimulates HIV-1 replication. PLoS Pathog (2012) 1.04
Roles of chromatin insulator proteins in higher-order chromatin organization and transcription regulation. Nucleus (2011) 1.02
Lessons from interconnected ubiquitylation and acetylation of p53: think metastable networks. Biochem Soc Trans (2010) 1.02
Regulation of human SRY subcellular distribution by its acetylation/deacetylation. EMBO J (2004) 1.02
Proteasome inhibitors: Dozens of molecules and still counting. Biochimie (2010) 1.01
Endogenous retroviruses: Thierry Heidmann wins the 2009 Retrovirology prize. Retrovirology (2009) 1.01
Par2 inactivation inhibits early production of TSLP, but not cutaneous inflammation, in Netherton syndrome adult mouse model. J Invest Dermatol (2010) 0.98
Identification of novel neuronal isoforms of the Rho-GEF Trio. Biol Cell (2006) 0.95
Regulation of bovine papillomavirus replicative helicase e1 by the ubiquitin-proteasome pathway. J Virol (2002) 0.94
Simian virus 40-based replication of catalytically inactive human immunodeficiency virus type 1 integrase mutants in nonpermissive T cells and monocyte-derived macrophages. J Virol (2004) 0.94
A hypophosphorylated form of RPA34 is a specific component of pre-replication centers. J Cell Sci (2004) 0.92
Transcription factor E4F1 is essential for epidermal stem cell maintenance and skin homeostasis. Proc Natl Acad Sci U S A (2010) 0.92
A novel role for PA28gamma-proteasome in nuclear speckle organization and SR protein trafficking. Mol Biol Cell (2008) 0.91
Multiple phosphorylation events control mitotic degradation of the muscle transcription factor Myf5. BMC Biochem (2005) 0.91
Modification of position-effect variegation by competition for binding to Drosophila satellites. EMBO Rep (2002) 0.90
Methyltransferase PRMT1 is a binding partner of HBx and a negative regulator of hepatitis B virus transcription. J Virol (2013) 0.89
βTrCP-dependent degradation of CDC25B phosphatase at the metaphase-anaphase transition is a pre-requisite for correct mitotic exit. Cell Cycle (2010) 0.87
The HIV-1 Tat protein stimulates reverse transcription in vitro. Curr HIV Res (2007) 0.86
A B-myb promoter corepressor site facilitates in vivo occupation of the adjacent E2F site by p107 x E2F and p130 x E2F complexes. J Biol Chem (2002) 0.86
E4F1 deficiency results in oxidative stress-mediated cell death of leukemic cells. J Exp Med (2011) 0.85
RNA interference and HIV-1: hits and misses. Curr Opin HIV AIDS (2006) 0.85
Identification of histone 3 variant 2 interacting factors. Nucleic Acids Res (2014) 0.85
Regulation of the 26S proteasome activities by peptides mimicking cleavage products. Biochem Biophys Res Commun (2002) 0.83
Spt6 levels are modulated by PAAF1 and proteasome to regulate the HIV-1 LTR. Retrovirology (2012) 0.83