TGF-β-Smad3 signaling in emphysema and pulmonary fibrosis: an epigenetic aberration of normal development?

PubWeight™: 1.15‹?› | Rank: Top 10%

🔗 View Article (PMC 4073936)

Published in Am J Physiol Lung Cell Mol Physiol on November 16, 2012

Authors

David Warburton1, Wei Shi, Bing Xu

Author Affiliations

1: Saban Research Institute, Children's Hospital Los Angeles, 4650 Sunset Blvd. MS35, Los Angeles, CA 90027, USA. dwarburton@chla.usc.edu

Articles citing this

Rho/Rock cross-talks with transforming growth factor-β/Smad pathway participates in lung fibroblast-myofibroblast differentiation. Biomed Rep (2014) 0.90

Vitamin D deficiency causes airway hyperresponsiveness, increases airway smooth muscle mass, and reduces TGF-β expression in the lungs of female BALB/c mice. Physiol Rep (2014) 0.89

Galangin Induces Autophagy via Deacetylation of LC3 by SIRT1 in HepG2 Cells. Sci Rep (2016) 0.81

Perinatal factors in neonatal and pediatric lung diseases. Expert Rev Respir Med (2013) 0.81

Cigarette smoke enhances proliferation and extracellular matrix deposition by human fetal airway smooth muscle. Am J Physiol Lung Cell Mol Physiol (2014) 0.81

Cross regulation between hypoxia-inducible transcription factor-1α (HIF-1α) and transforming growth factor (TGF)-ß1 mediates nickel oxide nanoparticles (NiONPs)-induced pulmonary fibrosis. Am J Transl Res (2015) 0.81

Endocytic deficiency induced by ITSN-1s knockdown alters the Smad2/3-Erk1/2 signaling balance downstream of Alk5. J Cell Sci (2015) 0.80

Organizing pneumonia in mice and men. J Transl Med (2016) 0.80

Glucocorticoids recruit Tgfbr3 and Smad1 to shift transforming growth factor-β signaling from the Tgfbr1/Smad2/3 axis to the Acvrl1/Smad1 axis in lung fibroblasts. J Biol Chem (2013) 0.79

FOSL2 positively regulates TGF-β1 signalling in non-small cell lung cancer. PLoS One (2014) 0.79

Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution. Am J Respir Crit Care Med (2016) 0.79

Epigenetics in lung fibrosis: from pathobiology to treatment perspective. Curr Opin Pulm Med (2015) 0.79

Naja naja atra venom ameliorates pulmonary fibrosis by inhibiting inflammatory response and oxidative stress. BMC Complement Altern Med (2014) 0.78

Transforming Growth Factor β1 (TGF-β1) Activates Hepcidin mRNA Expression in Hepatocytes. J Biol Chem (2016) 0.78

Epithelial neoplasia coincides with exacerbated injury and fibrotic response in the lungs of Gprc5a-knockout mice following silica exposure. Oncotarget (2015) 0.77

Madecassoside ameliorates bleomycin-induced pulmonary fibrosis in mice through promoting the generation of hepatocyte growth factor via PPAR-γ in colon. Br J Pharmacol (2016) 0.77

Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling. Proc Natl Acad Sci U S A (2015) 0.77

Telomerase Deficiency Causes Alveolar Stem Cell Senescence-associated Low-grade Inflammation in Lungs. J Biol Chem (2015) 0.77

The roles of microRNAs and protein components of the microRNA pathway in lung development and diseases. Am J Respir Cell Mol Biol (2015) 0.76

How well do whole exome sequencing results correlate with medical findings? A study of 89 Mayo Clinic Biobank samples. Front Genet (2015) 0.76

Hydrogen sulfide inhibits transforming growth factor beta-1 induced bronchial epithelial-mesenchymal transition. Chin Med J (Engl) (2015) 0.76

Krüppel-Like Factor 4 Inhibits the Transforming Growth Factor-β1-Promoted Epithelial-to-Mesenchymal Transition via Downregulating Plasminogen Activator Inhibitor-1 in Lung Epithelial Cells. Dis Markers (2015) 0.76

Regulation of Gene Expression by Sodium Valproate in Epithelial-to-Mesenchymal Transition. Lung (2015) 0.76

Advances in understanding COPD. F1000Res (2016) 0.75

Upregulation of long non-coding RNA HIF 1α-anti-sense 1 induced by transforming growth factor-β-mediated targeting of sirtuin 1 promotes osteoblastic differentiation of human bone marrow stromal cells. Mol Med Rep (2015) 0.75

Effects of the Rho-Kinase Inhibitor Y-27632 on Extraocular Muscle Surgery in Rabbits. J Ophthalmol (2017) 0.75

Articles cited by this

Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung. J Clin Invest (1997) 5.77

Lessons on the pathogenesis of aneurysm from heritable conditions. Nature (2011) 2.97

Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol (2002) 2.83

Lung organogenesis. Curr Top Dev Biol (2010) 2.30

Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer. Genes Dev (2002) 2.13

TGF-beta and Smad3 signaling link inflammation to chronic fibrogenesis. J Immunol (2005) 1.85

Overexpression of transforming growth factor-beta1 in fetal monkey lung results in prenatal pulmonary fibrosis. Eur Respir J (2010) 1.75

Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema. Am J Physiol Lung Cell Mol Physiol (2004) 1.56

Fibrillin controls TGF-beta activation. Nat Genet (2003) 1.53

Transfer of the active form of transforming growth factor-beta 1 gene to newborn rat lung induces changes consistent with bronchopulmonary dysplasia. Am J Pathol (2003) 1.53

CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis. Fibrogenesis Tissue Repair (2012) 1.49

Bronchopulmonary dysplasia of the premature baby: an immunohistochemical study. Pediatr Pulmonol (1997) 1.35

TGF-beta receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung. Eur Respir J (2008) 1.22

Bioactive transforming growth factor-beta in the lungs of extremely low birthweight neonates predicts the need for home oxygen supplementation. Biol Neonate (2000) 1.16

Progressive pulmonary fibrosis is mediated by TGF-beta isoform 1 but not TGF-beta3. Int J Biochem Cell Biol (2007) 1.11

Lung alveolar septation defects in Ltbp-3-null mice. Am J Pathol (2005) 1.08

Adenovirus-mediated decorin gene transfer prevents TGF-beta-induced inhibition of lung morphogenesis. Am J Physiol (1999) 1.02

Spatial-specific TGF-beta1 adenoviral expression determines morphogenetic phenotypes in embryonic mouse lung. Eur J Cell Biol (1999) 0.94

Epithelium-specific adenoviral transfer of a dominant-negative mutant TGF-beta type II receptor stimulates embryonic lung branching morphogenesis in culture and potentiates EGF and PDGF-AA. Mech Dev (1998) 0.88

Developmental responses to lung injury: repair or fibrosis. Fibrogenesis Tissue Repair (2012) 0.88

Cigarette smoke exposure aggravates air space enlargement and alveolar cell apoptosis in Smad3 knockout mice. Am J Physiol Lung Cell Mol Physiol (2011) 0.86

Molecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice. Am J Physiol Lung Cell Mol Physiol (2012) 0.86

Articles by these authors

(truncated to the top 100)

Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01. Science (2010) 10.69

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics (2013) 9.98

voom: Precision weights unlock linear model analysis tools for RNA-seq read counts. Genome Biol (2014) 8.13

Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing. Science (2011) 7.92

Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy. Nat Med (2011) 4.68

The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote. Nucleic Acids Res (2013) 4.45

The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells. Nat Immunol (2011) 3.44

DJ-1, a novel regulator of the tumor suppressor PTEN. Cancer Cell (2005) 3.12

Multifunctional magnetic nanoparticles: design, synthesis, and biomedical applications. Acc Chem Res (2009) 3.04

MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors. J Clin Invest (2010) 2.87

Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol (2002) 2.83

Comprehensive MicroRNA profiling for head and neck squamous cell carcinomas. Clin Cancer Res (2010) 2.79

Dopamine as a robust anchor to immobilize functional molecules on the iron oxide shell of magnetic nanoparticles. J Am Chem Soc (2004) 2.54

The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells. Nat Immunol (2013) 2.48

Antigen-specific transforming growth factor β-induced Treg cells, but not natural Treg cells, ameliorate autoimmune arthritis in mice by shifting the Th17/Treg cell balance from Th17 predominance to Treg cell predominance. Arthritis Rheum (2012) 2.43

Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues. Lab Invest (2009) 2.43

Spatial analysis of hemorrhagic fever with renal syndrome in China. BMC Infect Dis (2006) 2.42

Lung organogenesis. Curr Top Dev Biol (2010) 2.30

Design and synthesis of 3d-4f metal-based zeolite-type materials with a 3D nanotubular structure encapsulated "water" pipe. J Am Chem Soc (2004) 2.30

Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells. J Immunol (2010) 2.20

MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway. Cancer Res (2011) 2.15

Comparative efficacy of neutralizing antibodies elicited by recombinant hemagglutinin proteins from avian H5N1 influenza virus. J Virol (2008) 2.14

Environmental factors contributing to the spread of H5N1 avian influenza in mainland China. PLoS One (2008) 2.14

Synthesis, crystal structure, magnetic properties and theoretical studies on a one-dimensional polynuclear copper(II) complex [Cu2(mu1,3-SCN)2(mu'1,3-SCN)2(MPyO)2]n. Dalton Trans (2005) 2.12

Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals. Chromosoma (2002) 2.03

Enzymatic hydrogelation of small molecules. Acc Chem Res (2008) 2.02

Relationship between syphilis and HIV infections among men who have sex with men in Beijing, China. Sex Transm Dis (2007) 2.00

Efficacy and safety of intracameral triamcinolone acetonide to control postoperative inflammation after phacotrabeculectomy. J Cataract Refract Surg (2013) 2.00

Multitarget therapy for induction treatment of lupus nephritis: a randomized trial. Ann Intern Med (2015) 1.99

Heterochromatin and tri-methylated lysine 20 of histone H4 in animals. J Cell Sci (2004) 1.98

Visual and anatomical outcomes of macular epiretinal membrane peeling after previous rhegmatogenous retinal detachment repair. Retina (2015) 1.98

Molecular mechanisms of early lung specification and branching morphogenesis. Pediatr Res (2005) 1.97

Outcomes of sulfur hexafluoride (SF6) versus perfluoropropane (C3F8) gas tamponade for macular hole surgery. Retina (2008) 1.89

Biofunctional magnetic nanoparticles for protein separation and pathogen detection. Chem Commun (Camb) (2006) 1.85

Nosocomial acute-onset postoperative endophthalmitis at a university teaching hospital (2002-2009). Am J Ophthalmol (2010) 1.82

Spatio-temporal distribution of malaria in Yunnan Province, China. Am J Trop Med Hyg (2009) 1.81

VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis. Dev Biol (2005) 1.81

A dual role for A-type lamins in DNA double-strand break repair. Cell Cycle (2011) 1.80

FePt@CoS(2) yolk-shell nanocrystals as a potent agent to kill HeLa cells. J Am Chem Soc (2007) 1.80

Reproducibility of peripapillary retinal nerve fiber layer thickness and optic nerve head parameters measured with cirrus HD-OCT in glaucomatous eyes. Invest Ophthalmol Vis Sci (2010) 1.77

Draft genome of the kiwifruit Actinidia chinensis. Nat Commun (2013) 1.72

Mutations in the rpoB gene of multidrug-resistant Mycobacterium tuberculosis isolates from China. J Clin Microbiol (2003) 1.71

Enzyme-instructed molecular self-assembly confers nanofibers and a supramolecular hydrogel of taxol derivative. J Am Chem Soc (2009) 1.67

Incidence of HIV-1, syphilis, hepatitis B, and hepatitis C virus infections and predictors associated with retention in a 12-month follow-up study among men who have sex with men in Beijing, China. J Acquir Immune Defic Syndr (2009) 1.60

Facile one-pot synthesis of bifunctional heterodimers of nanoparticles: a conjugate of quantum dot and magnetic nanoparticles. J Am Chem Soc (2004) 1.59

Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema. Am J Physiol Lung Cell Mol Physiol (2004) 1.56

miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution. Dev Biol (2009) 1.56

Risk factors for syphilis and prevalence of HIV, hepatitis B and C among men who have sex with men in Beijing, China: implications for HIV prevention. AIDS Behav (2008) 1.55

Characteristics of the Energetic Igniters Through Integrating B/Ti Nano-Multilayers on TaN Film Bridge. Nanoscale Res Lett (2015) 1.54

Delayed build-up of Arctic ice sheets during 400,000-year minima in insolation variability. Nature (2012) 1.53

Efficacy and safety of traditional chinese medicine (Shenqi particle) for patients with idiopathic membranous nephropathy: a multicenter randomized controlled clinical trial. Am J Kidney Dis (2013) 1.50

Small molecule Me6TREN mobilizes hematopoietic stem/progenitor cells by activating MMP-9 expression and disrupting SDF-1/CXCR4 axis. Blood (2013) 1.49

Imaging the modulation of adenoviral kinetics and biodistribution for cancer gene therapy. Mol Ther (2007) 1.48

Stem/progenitor cells in lung development, injury repair, and regeneration. Proc Am Thorac Soc (2008) 1.45

Nitrilotriacetic acid-modified magnetic nanoparticles as a general agent to bind histidine-tagged proteins. J Am Chem Soc (2004) 1.45

Developed and developing world responsibilities for historical climate change and CO2 mitigation. Proc Natl Acad Sci U S A (2012) 1.44

Molecular hydrogels of therapeutic agents. Chem Soc Rev (2009) 1.44

The hepatitis B virus X protein disrupts innate immunity by downregulating mitochondrial antiviral signaling protein. J Immunol (2010) 1.44

Versatile small-molecule motifs for self-assembly in water and the formation of biofunctional supramolecular hydrogels. Langmuir (2010) 1.39

Using biofunctional magnetic nanoparticles to capture vancomycin-resistant enterococci and other gram-positive bacteria at ultralow concentration. J Am Chem Soc (2003) 1.39

Gene therapy for acute myeloid leukemia using Sindbis vectors expressing a fusogenic membrane glycoprotein. Cancer Biol Ther (2010) 1.39

An effective non-parametric method for globally clustering genes from expression profiles. Med Biol Eng Comput (2007) 1.39

Multivariate detection limits of on-line NIR model for extraction process of chlorogenic acid from Lonicera japonica. J Pharm Biomed Anal (2013) 1.39

NIR spectroscopy as a process analytical technology (PAT) tool for monitoring and understanding of a hydrolysis process. Bioresour Technol (2013) 1.36

Stenotrophomonas maltophilia resistance to trimethoprim/sulfamethoxazole mediated by acquisition of sul and dfrA genes in a plasmid-mediated class 1 integron. Int J Antimicrob Agents (2011) 1.35

Correlates of incident infections for HIV, syphilis, and hepatitis B virus in a cohort of men who have sex with men in Beijing. AIDS Patient Care STDS (2010) 1.34

Supramolecular hydrogels respond to ligand-receptor interaction. J Am Chem Soc (2003) 1.34

Targeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotype. J Immunol (2011) 1.33

Bond formations between two nucleophiles: transition metal catalyzed oxidative cross-coupling reactions. Chem Rev (2011) 1.33

Requirement for the lymphocyte semaphorin, CD100, in the induction of antigen-specific T cells and the maturation of dendritic cells. J Immunol (2002) 1.33

Mouse models of prostate adenocarcinoma with the capacity to monitor spontaneous carcinogenesis by bioluminescence or fluorescence. Cancer Res (2007) 1.33

Global changes in the mammary epigenome are induced by hormonal cues and coordinated by Ezh2. Cell Rep (2013) 1.33

Heterodimers of nanoparticles: formation at a liquid-liquid interface and particle-specific surface modification by functional molecules. J Am Chem Soc (2005) 1.32

Efficient, tunable, and coherent 0.18-5.27-THz source based on GaSe crystal. Opt Lett (2002) 1.32

Imaging enzyme-triggered self-assembly of small molecules inside live cells. Nat Commun (2012) 1.32

Management of dislocated intraocular lenses. Ophthalmology (2008) 1.29

Gata-3 negatively regulates the tumor-initiating capacity of mammary luminal progenitor cells and targets the putative tumor suppressor caspase-14. Mol Cell Biol (2011) 1.29

AAV-mediated cone rescue in a naturally occurring mouse model of CNGA3-achromatopsia. PLoS One (2012) 1.28

Willingness to be circumcised for preventing HIV among Chinese men who have sex with men. AIDS Patient Care STDS (2009) 1.28

Magnetic nanoparticles for the manipulation of proteins and cells. Chem Soc Rev (2012) 1.28

TGFβ signaling plays a critical role in promoting alternative macrophage activation. BMC Immunol (2012) 1.27

HP1-beta is required for development of the cerebral neocortex and neuromuscular junctions. J Cell Biol (2008) 1.27

Disulfiram/copper complex inhibiting NFkappaB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines. Cancer Lett (2009) 1.27

Hydrophobic interaction and hydrogen bonding cooperatively confer a vancomycin hydrogel: a potential candidate for biomaterials. J Am Chem Soc (2002) 1.27

Using a kinase/phosphatase switch to regulate a supramolecular hydrogel and forming the supramolecular hydrogel in vivo. J Am Chem Soc (2006) 1.25

D-amino acids boost the selectivity and confer supramolecular hydrogels of a nonsteroidal anti-inflammatory drug (NSAID). J Am Chem Soc (2012) 1.25

Pericellular hydrogel/nanonets inhibit cancer cells. Angew Chem Int Ed Engl (2014) 1.24

Maternal safety of trivalent inactivated influenza vaccine in pregnant women. Obstet Gynecol (2013) 1.24

Productive replication of Ebola virus is regulated by the c-Abl1 tyrosine kinase. Sci Transl Med (2012) 1.24

Negative regulation of MAVS-mediated innate immune response by PSMA7. J Immunol (2009) 1.24

Practice preferences for glaucoma surgery: a survey of the American Glaucoma Society in 2008. Ophthalmic Surg Lasers Imaging (2011) 1.24

Intracellular hydrogelation of small molecules inhibits bacterial growth. Angew Chem Int Ed Engl (2007) 1.23

Lanthanide(III)-cobalt(II) heterometallic coordination polymers with radical adsorption properties. Inorg Chem (2007) 1.22

Spectrum of different types of hypophysitis: a clinicopathologic study of hypophysitis in 31 cases. Endocr Pathol (2002) 1.22

Lung alveolar integrity is compromised by telomere shortening in telomerase-null mice. Am J Physiol Lung Cell Mol Physiol (2008) 1.22

The BTB-ZF transcription factor Zbtb20 is driven by Irf4 to promote plasma cell differentiation and longevity. J Exp Med (2014) 1.21

Growth factor signaling in lung morphogenetic centers: automaticity, stereotypy and symmetry. Respir Res (2003) 1.20

All-trans retinoic acid promotes TGF-β-induced Tregs via histone modification but not DNA demethylation on Foxp3 gene locus. PLoS One (2011) 1.20

Single-molecule force spectroscopy and imaging of the vancomycin/D-Ala-D-Ala interaction. Nano Lett (2007) 1.20

Anthocyanins from Chinese bayberry extract protect β cells from oxidative stress-mediated injury via HO-1 upregulation. J Agric Food Chem (2010) 1.20