Published in Nature on November 28, 2012
A cornucopia of human polyomaviruses. Nat Rev Microbiol (2013) 2.08
The architecture of a eukaryotic replisome. Nat Struct Mol Biol (2015) 1.15
Repair of a DNA-protein crosslink by replication-coupled proteolysis. Cell (2014) 1.12
Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate. Nat Commun (2016) 1.04
What is the DNA repair defect underlying Fanconi anemia? Curr Opin Cell Biol (2015) 1.03
Switch on the engine: how the eukaryotic replicative helicase MCM2-7 becomes activated. Chromosoma (2014) 1.03
ATM and ATR activities maintain replication fork integrity during SV40 chromatin replication. PLoS Pathog (2013) 1.02
The E1 proteins. Virology (2013) 1.02
Dynamic look at DNA unwinding by a replicative helicase. Proc Natl Acad Sci U S A (2014) 0.96
Single-molecule imaging of FtsK translocation reveals mechanistic features of protein-protein collisions on DNA. Mol Cell (2014) 0.95
Mechanisms of mutagenesis: DNA replication in the presence of DNA damage. Mutat Res Rev Mutat Res (2016) 0.84
Mechanical operation and intersubunit coordination of ring-shaped molecular motors: insights from single-molecule studies. Biophys J (2014) 0.84
Loading strategies of ring-shaped nucleic acid translocases and helicases. Curr Opin Struct Biol (2013) 0.84
Mcm10 regulates DNA replication elongation by stimulating the CMG replicative helicase. Genes Dev (2017) 0.84
High-throughput single-molecule studies of protein-DNA interactions. FEBS Lett (2014) 0.83
The miRNA world of polyomaviruses. Virol J (2013) 0.82
Switching from single-stranded to double-stranded DNA limits the unwinding processivity of ring-shaped T7 DNA helicase. Nucleic Acids Res (2013) 0.81
Structural basis for DNA strand separation by a hexameric replicative helicase. Nucleic Acids Res (2015) 0.80
p97 Promotes a Conserved Mechanism of Helicase Unloading during DNA Cross-Link Repair. Mol Cell Biol (2016) 0.78
Analysis of the costructure of the simian virus 40 T-antigen origin binding domain with site I reveals a correlation between GAGGC spacing and spiral assembly. J Virol (2012) 0.78
Structural Mechanisms of Hexameric Helicase Loading, Assembly, and Unwinding. F1000Res (2016) 0.78
The structure of SV40 large T hexameric helicase in complex with AT-rich origin DNA. Elife (2016) 0.78
Biochemistry: Molecular hurdles cleared with ease. Nature (2012) 0.76
Homologous DNA strand exchange activity of the human mitochondrial DNA helicase TWINKLE. Nucleic Acids Res (2016) 0.76
Merkel cell polyomavirus and Merkel cell carcinoma. Philos Trans R Soc Lond B Biol Sci (2017) 0.76
Efficient modification of λ-DNA substrates for single-molecule studies. Sci Rep (2017) 0.75
Cryo-EM of dynamic protein complexes in eukaryotic DNA replication. Protein Sci (2016) 0.75
The Causes and Consequences of Topological Stress during DNA Replication. Genes (Basel) (2016) 0.75
Cohesin acetylation and Wapl-Pds5 oppositely regulate translocation of cohesin along DNA. EMBO J (2016) 0.75
Protein Displacement by Herpes Helicase-Primase and the Key Role of UL42 during Helicase-Coupled DNA Synthesis by the Herpes Polymerase. Biochemistry (2017) 0.75
Mechanisms of DNA replication termination. Nat Rev Mol Cell Biol (2017) 0.75
Bidirectional eukaryotic DNA replication is established by quasi-symmetrical helicase loading. Science (2017) 0.75
Replication and supercoiling of simian virus 40 DNA in cell extracts from human cells. Mol Cell Biol (1985) 5.83
In vitro replication of duplex circular DNA containing the simian virus 40 DNA origin site. Proc Natl Acad Sci U S A (1985) 5.16
Mechanism of DNA translocation in a replicative hexameric helicase. Nature (2006) 4.91
Structure and function of hexameric helicases. Annu Rev Biochem (2000) 4.30
Initiation of simian virus 40 DNA replication in vitro: large-tumor-antigen- and origin-dependent unwinding of the template. Proc Natl Acad Sci U S A (1987) 4.23
Mechanisms of conformational change for a replicative hexameric helicase of SV40 large tumor antigen. Cell (2004) 4.14
Complete enzymatic synthesis of DNA containing the SV40 origin of replication. J Biol Chem (1988) 3.61
Coupling of a replicative polymerase and helicase: a tau-DnaB interaction mediates rapid replication fork movement. Cell (1996) 2.96
Simian virus 40 T-antigen DNA helicase is a hexamer which forms a binary complex during bidirectional unwinding from the viral origin of DNA replication. J Virol (1992) 2.96
Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen. Nature (2003) 2.87
The unwinding of duplex regions in DNA by the simian virus 40 large tumor antigen-associated DNA helicase activity. J Biol Chem (1988) 2.80
Direct identification of the active-site nucleophile in a DNA (cytosine-5)-methyltransferase. Biochemistry (1991) 2.77
Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase. Cell (2011) 2.54
Pumps, paradoxes and ploughshares: mechanism of the MCM2-7 DNA helicase. Trends Biochem Sci (2005) 2.53
ATP stimulates the binding of simian virus 40 (SV40) large tumor antigen to the SV40 origin of replication. Proc Natl Acad Sci U S A (1988) 2.51
On helicases and other motor proteins. Curr Opin Struct Biol (2008) 2.43
Bacteriophage T7 helicase/primase proteins form rings around single-stranded DNA that suggest a general structure for hexameric helicases. Proc Natl Acad Sci U S A (1995) 2.41
Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex. J Biol Chem (2003) 2.15
DNA synthesis provides the driving force to accelerate DNA unwinding by a helicase. Nature (2005) 1.91
DNA-protein crosslinks: their induction, repair, and biological consequences. Mutat Res (2005) 1.87
Lysis timing and bacteriophage fitness. Genetics (2005) 1.79
Uncoupling of sister replisomes during eukaryotic DNA replication. Mol Cell (2010) 1.73
Initiation of simian virus 40 DNA synthesis in vitro. Mol Cell Biol (1991) 1.48
Strand-specific recognition of a synthetic DNA replication fork by the SV40 large tumor antigen. Science (1992) 1.39
Dimerization of simian virus 40 T-antigen hexamers activates T-antigen DNA helicase activity. J Virol (1997) 1.36
Simultaneous single-molecule measurements of phage T7 replisome composition and function reveal the mechanism of polymerase exchange. Proc Natl Acad Sci U S A (2011) 1.33
Twin DNA pumps of a hexameric helicase provide power to simultaneously melt two duplexes. Mol Cell (2004) 1.32
Large T antigen on the simian virus 40 origin of replication: a 3D snapshot prior to DNA replication. EMBO J (2003) 1.30
Functional interactions between SV40 T antigen and other replication proteins at the replication fork. J Biol Chem (1993) 1.28
SV40 DNA replication: from the A gene to a nanomachine. Virology (2008) 1.25
The replication of DNA containing the simian virus 40 origin by the monopolymerase and dipolymerase systems. J Biol Chem (1992) 1.23
Two heads are better than one: regulation of DNA replication by hexameric helicases. Genes Dev (2004) 1.23
Overcoming natural replication barriers: differential helicase requirements. Nucleic Acids Res (2011) 1.14
Role of single-stranded DNA binding activity of T antigen in simian virus 40 DNA replication. J Virol (2001) 1.13
Characterization of simian virus 40 T-antigen double hexamers bound to a replication fork. The active form of the helicase. J Biol Chem (2002) 1.09
Conformational rearrangements of SV40 large T antigen during early replication events. J Mol Biol (2010) 1.05
Labeling of unique sequences in double-stranded DNA at sites of vicinal nicks generated by nicking endonucleases. Nucleic Acids Res (2008) 1.02
Bidirectional DNA unwinding by a ternary complex of T antigen, nucleolin and topoisomerase I. EMBO Rep (2003) 0.98
Phosphorylation of simian virus 40 T antigen on Thr 124 selectively promotes double-hexamer formation on subfragments of the viral core origin. J Virol (2000) 0.98
Single-molecule analysis of DNA replication in Xenopus egg extracts. Methods (2012) 0.87
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev (2005) 5.53
A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Mol Cell (2006) 5.51
The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair. Science (2009) 4.85
A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA. Proc Natl Acad Sci U S A (2006) 4.60
Mechanism of replication-coupled DNA interstrand crosslink repair. Cell (2008) 4.53
Coupled, circumferential motions of the cell wall synthesis machinery and MreB filaments in B. subtilis. Science (2011) 4.26
Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited. Nat Chem Biol (2005) 4.24
Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells. Genes Dev (2007) 4.11
Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication. Mol Cell (2006) 3.77
DNA primase acts as a molecular brake in DNA replication. Nature (2006) 3.66
The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly. Cell (2006) 3.46
The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA. Science (2006) 3.46
RacA, a bacterial protein that anchors chromosomes to the cell poles. Science (2002) 3.44
Self-assembling protein microarrays. Science (2004) 3.37
The program of gene transcription for a single differentiating cell type during sporulation in Bacillus subtilis. PLoS Biol (2004) 3.33
PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication. Nat Cell Biol (2005) 3.18
A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication. EMBO J (2004) 3.02
Sequence-independent DNA binding and replication initiation by the human origin recognition complex. Genes Dev (2003) 3.01
MCM2-7 complexes bind chromatin in a distributed pattern surrounding the origin recognition complex in Xenopus egg extracts. J Biol Chem (2002) 3.00
PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination. J Biol Chem (2006) 2.96
Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro. Proc Natl Acad Sci U S A (2003) 2.80
Recruitment of SMC by ParB-parS organizes the origin region and promotes efficient chromosome segregation. Cell (2009) 2.56
Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45. Mol Cell (2002) 2.55
Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase. Cell (2011) 2.54
Pumps, paradoxes and ploughshares: mechanism of the MCM2-7 DNA helicase. Trends Biochem Sci (2005) 2.53
Imaging peptidoglycan biosynthesis in Bacillus subtilis with fluorescent antibiotics. Proc Natl Acad Sci U S A (2006) 2.53
A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase. Mol Cell Biol (2002) 2.51
Recruitment of Xenopus Scc2 and cohesin to chromatin requires the pre-replication complex. Nat Cell Biol (2004) 2.45
Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage. Mol Cell (2010) 2.39
Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts. Genes Dev (2004) 2.36
Single-particle kinetics of influenza virus membrane fusion. Proc Natl Acad Sci U S A (2008) 2.32
CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase. Mol Cell (2010) 2.29
An open letter to Elias Zerhouni. Science (2005) 2.19
Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA. Mol Cell Biol (2002) 2.15
Dynamics of DNA replication loops reveal temporal control of lagging-strand synthesis. Nature (2008) 2.09
Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen. Proc Natl Acad Sci U S A (2006) 2.06
Mechanism of RAD51-dependent DNA interstrand cross-link repair. Science (2011) 2.04
The ATPase SpoIIIE transports DNA across fused septal membranes during sporulation in Bacillus subtilis. Cell (2007) 2.03
Single-molecule studies of fork dynamics in Escherichia coli DNA replication. Nat Struct Mol Biol (2008) 2.03
mKikGR, a monomeric photoswitchable fluorescent protein. PLoS One (2008) 2.00
The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication. J Cell Biol (2002) 2.00
Docking of a specialized PIP Box onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt2. Mol Cell (2009) 1.97
Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase. Genes Dev (2011) 1.95
Dynamic DNA helicase-DNA polymerase interactions assure processive replication fork movement. Mol Cell (2007) 1.95
Subcellular localization of a sporulation membrane protein is achieved through a network of interactions along and across the septum. Mol Microbiol (2005) 1.94
A singular enzymatic megacomplex from Bacillus subtilis. Proc Natl Acad Sci U S A (2006) 1.89
Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins. Proc Natl Acad Sci U S A (2009) 1.88
Organization and segregation of bacterial chromosomes. Nat Rev Genet (2013) 1.76
Uncoupling of sister replisomes during eukaryotic DNA replication. Mol Cell (2010) 1.73
Tumor suppressor p53 slides on DNA with low friction and high stability. Biophys J (2008) 1.70
Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination. Proc Natl Acad Sci U S A (2008) 1.66
Escherichia coli and its chromosome. Trends Microbiol (2008) 1.63
The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA. Proc Natl Acad Sci U S A (2003) 1.62
FisB mediates membrane fission during sporulation in Bacillus subtilis. Genes Dev (2013) 1.59
Ribonucleotide reductase activity is coupled to DNA synthesis via proliferating cell nuclear antigen. Curr Biol (2012) 1.53
Proliferating cell nuclear antigen uses two distinct modes to move along DNA. J Biol Chem (2009) 1.53
Roles of PCNA-binding and ubiquitin-binding domains in human DNA polymerase eta in translesion DNA synthesis. Proc Natl Acad Sci U S A (2008) 1.47
The Cdc23 (Mcm10) protein is required for the phosphorylation of minichromosome maintenance complex by the Dfp1-Hsk1 kinase. Proc Natl Acad Sci U S A (2003) 1.47
Substrate requirements for duplex DNA translocation by the eukaryal and archaeal minichromosome maintenance helicases. J Biol Chem (2003) 1.46
Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis. Proc Natl Acad Sci U S A (2012) 1.44
A single-molecule characterization of p53 search on DNA. Proc Natl Acad Sci U S A (2010) 1.43
Isolation of human Dna2 endonuclease and characterization of its enzymatic properties. Nucleic Acids Res (2006) 1.42
A genome-wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction. Mol Cell (2011) 1.41
Fission yeast CENP-B homologs nucleate centromeric heterochromatin by promoting heterochromatin-specific histone tail modifications. Genes Dev (2002) 1.40
Primer utilization by DNA polymerase alpha-primase is influenced by its interaction with Mcm10p. J Biol Chem (2004) 1.37
Crystal structure of the GINS complex and functional insights into its role in DNA replication. Proc Natl Acad Sci U S A (2007) 1.36
Eukaryotic origins of DNA replication: could you please be more specific? Semin Cell Dev Biol (2005) 1.34
CDC7 kinase phosphorylates serine residues adjacent to acidic amino acids in the minichromosome maintenance 2 protein. Proc Natl Acad Sci U S A (2006) 1.34
A highly coordinated cell wall degradation machine governs spore morphogenesis in Bacillus subtilis. Genes Dev (2010) 1.34
Cdc7-Drf1 kinase links chromosome cohesion to the initiation of DNA replication in Xenopus egg extracts. Genes Dev (2008) 1.34
Simultaneous single-molecule measurements of phage T7 replisome composition and function reveal the mechanism of polymerase exchange. Proc Natl Acad Sci U S A (2011) 1.33
Novel secretion apparatus maintains spore integrity and developmental gene expression in Bacillus subtilis. PLoS Genet (2009) 1.32
Cdc7-Drf1 is a developmentally regulated protein kinase required for the initiation of vertebrate DNA replication. Genes Dev (2005) 1.32
SpoIIIE strips proteins off the DNA during chromosome translocation. Genes Dev (2008) 1.31
Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates. Elife (2013) 1.31
Dancing on DNA: kinetic aspects of search processes on DNA. Chemphyschem (2011) 1.30
Real-time single-molecule observation of rolling-circle DNA replication. Nucleic Acids Res (2009) 1.30
Defining a centromere-like element in Bacillus subtilis by Identifying the binding sites for the chromosome-anchoring protein RacA. Mol Cell (2005) 1.29
L3MBTL1 polycomb protein, a candidate tumor suppressor in del(20q12) myeloid disorders, is essential for genome stability. Proc Natl Acad Sci U S A (2010) 1.27
Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1. J Biol Chem (2008) 1.24
DNA replication in nucleus-free Xenopus egg extracts. Methods Mol Biol (2009) 1.24
Hopping of a processivity factor on DNA revealed by single-molecule assays of diffusion. Proc Natl Acad Sci U S A (2008) 1.21
Studies on human DNA polymerase epsilon and GINS complex and their role in DNA replication. J Biol Chem (2011) 1.21
Proximity-induced activation of human Cdc34 through heterologous dimerization. Proc Natl Acad Sci U S A (2005) 1.19
A novel DNA nuclease is stimulated by association with the GINS complex. Nucleic Acids Res (2011) 1.19
Domain architecture and biochemical characterization of vertebrate Mcm10. J Biol Chem (2007) 1.19
Unsynchronised subunit motion in single trimeric sodium-coupled aspartate transporters. Nature (2013) 1.17
Centrosomal protein of 192 kDa (Cep192) promotes centrosome-driven spindle assembly by engaging in organelle-specific Aurora A activation. Proc Natl Acad Sci U S A (2010) 1.17
SirA enforces diploidy by inhibiting the replication initiator DnaA during spore formation in Bacillus subtilis. Mol Microbiol (2009) 1.16
A branched pathway governing the activation of a developmental transcription factor by regulated intramembrane proteolysis. Mol Cell (2006) 1.15