Published in J Biol Chem on May 03, 2009
Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase. Cell (2011) 2.54
Nonspecifically bound proteins spin while diffusing along DNA. Nat Struct Mol Biol (2009) 2.43
ATP alters the diffusion mechanics of MutS on mismatched DNA. Structure (2012) 2.01
Conformational analysis of processivity clamps in solution demonstrates that tertiary structure does not correlate with protein dynamics. Structure (2014) 1.49
Simultaneous single-molecule measurements of phage T7 replisome composition and function reveal the mechanism of polymerase exchange. Proc Natl Acad Sci U S A (2011) 1.33
Continued primer synthesis at stalled replication forks contributes to checkpoint activation. J Cell Biol (2010) 1.27
Herpes simplex viruses: mechanisms of DNA replication. Cold Spring Harb Perspect Biol (2012) 1.21
BRCA1 promotes unloading of the CMG helicase from a stalled DNA replication fork. Mol Cell (2014) 1.14
Hopping enables a DNA repair glycosylase to search both strands and bypass a bound protein. ACS Chem Biol (2010) 1.13
Analysis of a single-stranded DNA-scanning process in which activation-induced deoxycytidine deaminase (AID) deaminates C to U haphazardly and inefficiently to ensure mutational diversity. J Biol Chem (2011) 1.05
Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: IV. viral proteinase slides along DNA to locate and process its substrates. J Biol Chem (2012) 1.03
PCNA structure and function: insights from structures of PCNA complexes and post-translationally modified PCNA. Subcell Biochem (2012) 1.01
Thioredoxin suppresses microscopic hopping of T7 DNA polymerase on duplex DNA. Proc Natl Acad Sci U S A (2010) 1.01
Direct role for proliferating cell nuclear antigen in substrate recognition by the E3 ubiquitin ligase CRL4Cdt2. J Biol Chem (2012) 0.97
Double-strand DNA end-binding and sliding of the toroidal CRISPR-associated protein Csn2. Nucleic Acids Res (2013) 0.95
Binding kinetics of human ISWI chromatin-remodelers to DNA repair sites elucidate their target location mechanism. Nucleus (2011) 0.94
Regulation of the Rev1-pol ζ complex during bypass of a DNA interstrand cross-link. EMBO J (2015) 0.93
Dynamics of lesion processing by bacterial nucleotide excision repair proteins. Prog Mol Biol Transl Sci (2012) 0.93
CRL2(Lrr1) promotes unloading of the vertebrate replisome from chromatin during replication termination. Genes Dev (2017) 0.91
TRF1 and TRF2 use different mechanisms to find telomeric DNA but share a novel mechanism to search for protein partners at telomeres. Nucleic Acids Res (2013) 0.89
Structural insights into the adaptation of proliferating cell nuclear antigen (PCNA) from Haloferax volcanii to a high-salt environment. Acta Crystallogr D Biol Crystallogr (2009) 0.85
Multistep assembly of DNA condensation clusters by SMC. Nat Commun (2016) 0.84
The rotation-coupled sliding of EcoRV. Nucleic Acids Res (2012) 0.83
Recruitment and positioning determine the specific role of the XPF-ERCC1 endonuclease in interstrand crosslink repair. EMBO J (2017) 0.82
Stability of the human polymerase δ holoenzyme and its implications in lagging strand DNA synthesis. Proc Natl Acad Sci U S A (2016) 0.82
High-Throughput Universal DNA Curtain Arrays for Single-Molecule Fluorescence Imaging. Langmuir (2015) 0.82
The diffusion constant of a labeled protein sliding along DNA. Eur Phys J E Soft Matter (2011) 0.81
Rapid movement and transcriptional re-localization of human cohesin on DNA. EMBO J (2016) 0.81
Stability versus exchange: a paradox in DNA replication. Nucleic Acids Res (2016) 0.80
The Many Roles of PCNA in Eukaryotic DNA Replication. Enzymes (2016) 0.79
The effect of esculentoside A on lupus nephritis-prone BXSB mice. Arch Med Sci (2012) 0.79
PCNA appears in two populations of slow and fast diffusion with a constant ratio throughout S-phase in replicating mammalian cells. Sci Rep (2016) 0.78
Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA. Nat Commun (2016) 0.78
Mechanism of membrane fusion induced by vesicular stomatitis virus G protein. Proc Natl Acad Sci U S A (2016) 0.77
Loading dynamics of a sliding DNA clamp. Angew Chem Int Ed Engl (2014) 0.77
Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions. Nat Commun (2016) 0.76
Translesion Synthesis: Insights into the Selection and Switching of DNA Polymerases. Genes (Basel) (2017) 0.75
Efficient modification of λ-DNA substrates for single-molecule studies. Sci Rep (2017) 0.75
Replication Protein A Prohibits Diffusion of the PCNA Sliding Clamp along Single-Stranded DNA. Biochemistry (2017) 0.75
Structural basis of human PCNA sliding on DNA. Nat Commun (2017) 0.75
Precise nanometer localization analysis for individual fluorescent probes. Biophys J (2002) 22.24
Myosin V walks hand-over-hand: single fluorophore imaging with 1.5-nm localization. Science (2003) 20.21
PCNA, the maestro of the replication fork. Cell (2007) 10.43
Diffusion-driven mechanisms of protein translocation on nucleic acids. 1. Models and theory. Biochemistry (1981) 9.05
Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA. Cell (1994) 6.54
Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA. Cell (1996) 5.38
Initiation and re-initiation of DNA unwinding by the Escherichia coli Rep helicase. Nature (2002) 5.13
A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA. Proc Natl Acad Sci U S A (2006) 4.60
Replication factors required for SV40 DNA replication in vitro. I. DNA structure-specific recognition of a primer-template junction by eukaryotic DNA polymerases and their accessory proteins. J Biol Chem (1991) 4.32
DNA primase acts as a molecular brake in DNA replication. Nature (2006) 3.66
DNA polymerases that propagate the eukaryotic DNA replication fork. Crit Rev Biochem Mol Biol (2005) 3.46
Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA. PLoS Biol (2003) 3.29
Regulated chromosomal DNA replication in the absence of a nucleus. Mol Cell (1998) 3.11
Single-molecule imaging of RNA polymerase-DNA interactions in real time. Biophys J (1999) 3.03
Dynamic basis for one-dimensional DNA scanning by the mismatch repair complex Msh2-Msh6. Mol Cell (2007) 2.78
Identification of replication factor C from Saccharomyces cerevisiae: a component of the leading-strand DNA replication complex. Mol Cell Biol (1992) 2.77
Visualization of single molecules of RNA polymerase sliding along DNA. Science (1993) 2.63
Visualizing one-dimensional diffusion of proteins along DNA. Nat Struct Mol Biol (2008) 2.51
Long-distance lateral diffusion of human Rad51 on double-stranded DNA. Proc Natl Acad Sci U S A (2006) 2.20
DNA synthesis in a cell-free system from Xenopus eggs: priming and elongation on single-stranded DNA in vitro. Cell (1982) 2.15
Clamp loading, unloading and intrinsic stability of the PCNA, beta and gp45 sliding clamps of human, E. coli and T4 replicases. Genes Cells (1996) 2.09
The crystal structure of an unusual processivity factor, herpes simplex virus UL42, bound to the C terminus of its cognate polymerase. Mol Cell (2000) 2.09
Structure-function relationship of the eukaryotic DNA replication factor, proliferating cell nuclear antigen. J Biol Chem (1995) 1.99
The one-dimensional diffusion coefficient of proteins absorbed on DNA. Hydrodynamic considerations. Biophys Chem (1979) 1.78
ATP-independent loading of the proliferating cell nuclear antigen requires DNA ends. J Biol Chem (1993) 1.77
Tumor suppressor p53 slides on DNA with low friction and high stability. Biophys J (2008) 1.70
ATP utilization by yeast replication factor C. I. ATP-mediated interaction with DNA and with proliferating cell nuclear antigen. J Biol Chem (2001) 1.68
ATP utilization by yeast replication factor C. II. Multiple stepwise ATP binding events are required to load proliferating cell nuclear antigen onto primed DNA. J Biol Chem (2001) 1.60
Deletion analysis of the large subunit p140 in human replication factor C reveals regions required for complex formation and replication activities. J Biol Chem (1997) 1.55
Single-molecule analysis of 1D diffusion and transcription elongation of T7 RNA polymerase along individual stretched DNA molecules. Nucleic Acids Res (2007) 1.54
Mammalian DNA polymerase auxiliary proteins: analysis of replication factor C-catalyzed proliferating cell nuclear antigen loading onto circular double-stranded DNA. Mol Cell Biol (1995) 1.44
Proliferating cell nuclear antigen loaded onto double-stranded DNA: dynamics, minor groove interactions and functional implications. Nucleic Acids Res (2006) 1.37
Detecting the ability of viral, bacterial and eukaryotic replication proteins to track along DNA. EMBO J (1994) 1.33
Diffusion constant of a nonspecifically bound protein undergoing curvilinear motion along DNA. J Phys Chem B (2008) 1.33
Monoubiquitination of proliferating cell nuclear antigen induced by stalled replication requires uncoupling of DNA polymerase and mini-chromosome maintenance helicase activities. J Biol Chem (2006) 1.33
Reconstitution of human replication factor C from its five subunits in baculovirus-infected insect cells. Proc Natl Acad Sci U S A (1996) 1.23
Hopping of a processivity factor on DNA revealed by single-molecule assays of diffusion. Proc Natl Acad Sci U S A (2008) 1.21
The herpes simplex virus processivity factor, UL42, binds DNA as a monomer. J Mol Biol (2004) 1.20
Replication factor C disengages from proliferating cell nuclear antigen (PCNA) upon sliding clamp formation, and PCNA itself tethers DNA polymerase delta to DNA. J Biol Chem (1998) 1.19
Motion of a DNA sliding clamp observed by single molecule fluorescence spectroscopy. J Biol Chem (2008) 1.14
Microscopic viscosity and rotational diffusion of proteins in a macromolecular environment. Biophys J (1999) 1.14
The solution structure of functionally active human proliferating cell nuclear antigen determined by small-angle neutron scattering. J Mol Biol (1998) 1.12
DNA polymerase delta holoenzyme: action on single-stranded DNA and on double-stranded DNA in the presence of replicative DNA helicases. Biochemistry (1995) 1.06
Proteins as micro viscosimeters: Brownian motion revisited. Eur Biophys J (2006) 1.03
Interaction of DNA polymerase delta, proliferating cell nuclear antigen, and synthetic oligonucleotide template-primers. Analysis by polyacrylamide gel electrophoresis-band mobility shift assay. J Biol Chem (1993) 0.96
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev (2005) 5.53
A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Mol Cell (2006) 5.51
The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair. Science (2009) 4.85
A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA. Proc Natl Acad Sci U S A (2006) 4.60
Mechanism of replication-coupled DNA interstrand crosslink repair. Cell (2008) 4.53
Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited. Nat Chem Biol (2005) 4.24
A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Mol Cell (2009) 4.17
Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells. Genes Dev (2007) 4.11
Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication. Mol Cell (2006) 3.77
DNA primase acts as a molecular brake in DNA replication. Nature (2006) 3.66
The structural determinants of checkpoint activation. Genes Dev (2007) 3.53
The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly. Cell (2006) 3.46
The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA. Science (2006) 3.46
Self-assembling protein microarrays. Science (2004) 3.37
PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication. Nat Cell Biol (2005) 3.18
A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication. EMBO J (2004) 3.02
Sequence-independent DNA binding and replication initiation by the human origin recognition complex. Genes Dev (2003) 3.01
MCM2-7 complexes bind chromatin in a distributed pattern surrounding the origin recognition complex in Xenopus egg extracts. J Biol Chem (2002) 3.00
PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination. J Biol Chem (2006) 2.96
An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol Cell (2003) 2.96
The ATR pathway: fine-tuning the fork. DNA Repair (Amst) (2007) 2.72
Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45. Mol Cell (2002) 2.55
Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase. Cell (2011) 2.54
Pumps, paradoxes and ploughshares: mechanism of the MCM2-7 DNA helicase. Trends Biochem Sci (2005) 2.53
Recruitment of Xenopus Scc2 and cohesin to chromatin requires the pre-replication complex. Nat Cell Biol (2004) 2.45
Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts. Genes Dev (2004) 2.36
Single-particle kinetics of influenza virus membrane fusion. Proc Natl Acad Sci U S A (2008) 2.32
CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase. Mol Cell (2010) 2.29
SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repair and prevent mutagenesis. Mol Cell (2011) 2.13
A requirement for replication in activation of the ATR-dependent DNA damage checkpoint. Genes Dev (2002) 2.09
Dynamics of DNA replication loops reveal temporal control of lagging-strand synthesis. Nature (2008) 2.09
Mechanism of RAD51-dependent DNA interstrand cross-link repair. Science (2011) 2.04
DNA damage tolerance: when it's OK to make mistakes. Nat Chem Biol (2009) 2.04
Single-molecule studies of fork dynamics in Escherichia coli DNA replication. Nat Struct Mol Biol (2008) 2.03
A two-dimensional ERK-AKT signaling code for an NGF-triggered cell-fate decision. Mol Cell (2011) 2.02
mKikGR, a monomeric photoswitchable fluorescent protein. PLoS One (2008) 2.00
The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication. J Cell Biol (2002) 2.00
NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathies. Mol Cell (2013) 1.97
Docking of a specialized PIP Box onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt2. Mol Cell (2009) 1.97
Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase. Genes Dev (2011) 1.95
Dynamic DNA helicase-DNA polymerase interactions assure processive replication fork movement. Mol Cell (2007) 1.95
Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaks. Mol Cell Biol (2006) 1.82
Local hydrogen bonding dynamics and collective reorganization in water: ultrafast infrared spectroscopy of HOD/D(2)O. J Chem Phys (2005) 1.78
Uncoupling of sister replisomes during eukaryotic DNA replication. Mol Cell (2010) 1.73
ATR phosphorylates SMARCAL1 to prevent replication fork collapse. Genes Dev (2013) 1.70
Tumor suppressor p53 slides on DNA with low friction and high stability. Biophys J (2008) 1.70
Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling. EMBO J (2006) 1.65
DNA replication stress underlies renal phenotypes in CEP290-associated Joubert syndrome. J Clin Invest (2015) 1.55
ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation. Curr Biol (2003) 1.55
Ribonucleotide reductase activity is coupled to DNA synthesis via proliferating cell nuclear antigen. Curr Biol (2012) 1.53
A single-molecule characterization of p53 search on DNA. Proc Natl Acad Sci U S A (2010) 1.43
A genome-wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction. Mol Cell (2011) 1.41
Eukaryotic origins of DNA replication: could you please be more specific? Semin Cell Dev Biol (2005) 1.34
Cdc7-Drf1 kinase links chromosome cohesion to the initiation of DNA replication in Xenopus egg extracts. Genes Dev (2008) 1.34
Monoubiquitination of proliferating cell nuclear antigen induced by stalled replication requires uncoupling of DNA polymerase and mini-chromosome maintenance helicase activities. J Biol Chem (2006) 1.33
Simultaneous single-molecule measurements of phage T7 replisome composition and function reveal the mechanism of polymerase exchange. Proc Natl Acad Sci U S A (2011) 1.33
Cdc7-Drf1 is a developmentally regulated protein kinase required for the initiation of vertebrate DNA replication. Genes Dev (2005) 1.32
Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates. Elife (2013) 1.31
A role for the MRN complex in ATR activation via TOPBP1 recruitment. Mol Cell (2013) 1.31
Dancing on DNA: kinetic aspects of search processes on DNA. Chemphyschem (2011) 1.30
Real-time single-molecule observation of rolling-circle DNA replication. Nucleic Acids Res (2009) 1.30
G2 damage checkpoints: what is the turn-on? J Cell Sci (2005) 1.29
Continued primer synthesis at stalled replication forks contributes to checkpoint activation. J Cell Biol (2010) 1.27
Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus. Mol Biol Cell (2006) 1.27
DNA replication in nucleus-free Xenopus egg extracts. Methods Mol Biol (2009) 1.24
A novel protein activity mediates DNA binding of an ATR-ATRIP complex. J Biol Chem (2004) 1.23
Hopping of a processivity factor on DNA revealed by single-molecule assays of diffusion. Proc Natl Acad Sci U S A (2008) 1.21
HARPing on about the DNA damage response during replication. Genes Dev (2009) 1.21
Domain architecture and biochemical characterization of vertebrate Mcm10. J Biol Chem (2007) 1.19
Unsynchronised subunit motion in single trimeric sodium-coupled aspartate transporters. Nature (2013) 1.17
Centrosomal protein of 192 kDa (Cep192) promotes centrosome-driven spindle assembly by engaging in organelle-specific Aurora A activation. Proc Natl Acad Sci U S A (2010) 1.17
Bypass of a protein barrier by a replicative DNA helicase. Nature (2012) 1.16
Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint. Mol Cell Biol (2006) 1.15
Sequence-dependent sliding kinetics of p53. Proc Natl Acad Sci U S A (2012) 1.13
DNA replication of mitotic chromatin in Xenopus egg extracts. Proc Natl Acad Sci U S A (2003) 1.07
Analysis of kinetic intermediates in single-particle dwell-time distributions. Biophys J (2010) 1.06
Single-molecule observation of prokaryotic DNA replication. Methods Mol Biol (2009) 1.06
Chromosomal DNA replication in a soluble cell-free system derived from Xenopus eggs. Methods Mol Biol (2006) 1.05
E. coli DNA replication in the absence of free β clamps. EMBO J (2011) 1.04
A general approach to break the concentration barrier in single-molecule imaging. Nat Methods (2012) 1.04
New Myc-anisms for DNA replication and tumorigenesis? Cancer Cell (2007) 1.02
A cell-permeable, activity-based probe for protein and lipid kinases. J Biol Chem (2005) 1.02
Single-molecule spectroscopy selectively probes donor and acceptor chromophores in the phycobiliprotein allophycocyanin. Biophys J (2004) 1.01
A direct proofreader-clamp interaction stabilizes the Pol III replicase in the polymerization mode. EMBO J (2013) 1.01
Thioredoxin suppresses microscopic hopping of T7 DNA polymerase on duplex DNA. Proc Natl Acad Sci U S A (2010) 1.01
Whole-exome sequencing reveals TopBP1 as a novel gene in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med (2014) 0.99
Analyzing the ATR-mediated checkpoint using Xenopus egg extracts. Methods (2007) 0.99
Ultrafast excited-state dynamics of the photoswitchable protein Dronpa. J Am Chem Soc (2007) 0.99
Timing, coordination, and rhythm: acrobatics at the DNA replication fork. J Biol Chem (2010) 0.98
The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination. Mol Cell Biol (2013) 0.98
Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. J Med Chem (2005) 0.98