Published in Proc Natl Acad Sci U S A on November 19, 2010
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Aurora A kinase (AURKA) in normal and pathological cell division. Cell Mol Life Sci (2012) 1.84
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Issues in interpreting the in vivo activity of Aurora-A. Expert Opin Ther Targets (2014) 0.80
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The nucleoporin ALADIN regulates Aurora A localization to ensure robust mitotic spindle formation. Mol Biol Cell (2015) 0.77
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Centrosomes at M phase act as a scaffold for the accumulation of intracellular ubiquitinated proteins. Cell Cycle (2014) 0.76
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Aurora A inhibition by MNL8054 promotes centriole elongation during Drosophila male meiosis. Cell Cycle (2015) 0.75
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Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell (2003) 5.68
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Structural basis of Aurora-A activation by TPX2 at the mitotic spindle. Mol Cell (2003) 4.51
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Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells. Nat Cell Biol (2002) 3.01
A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly. Nat Cell Biol (2003) 2.86
A novel mechanism for activation of the protein kinase Aurora A. Curr Biol (2003) 2.68
Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins. Curr Opin Cell Biol (2009) 2.61
Centrosome maturation and duplication in C. elegans require the coiled-coil protein SPD-2. Dev Cell (2004) 2.60
Rational design of potent antagonists to the human growth hormone receptor. Science (1992) 2.45
The Caenorhabditis elegans centrosomal protein SPD-2 is required for both pericentriolar material recruitment and centriole duplication. Curr Biol (2004) 2.44
Chromosomal enrichment and activation of the aurora B pathway are coupled to spatially regulate spindle assembly. Dev Cell (2007) 2.25
The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A. Mol Cell (2005) 2.11
Ran-GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly. Nat Cell Biol (2001) 1.95
Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition. J Cell Sci (2004) 1.93
Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A. J Cell Biol (2008) 1.92
The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis. Curr Biol (2008) 1.88
A microtubule-independent role for centrosomes and aurora a in nuclear envelope breakdown. Dev Cell (2007) 1.81
Human Cep192 is required for mitotic centrosome and spindle assembly. Curr Biol (2007) 1.81
Identification of phosphorylated residues that affect the activity of the mitotic kinase Aurora-A. Proc Natl Acad Sci U S A (2002) 1.80
Investigating mitotic spindle assembly and function in vitro using Xenopus laevis egg extracts. Nat Protoc (2006) 1.80
Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development. Proc Natl Acad Sci U S A (2001) 1.67
Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A. J Cell Biol (2010) 1.60
Dissecting the role of Aurora A during spindle assembly. EMBO J (2008) 1.53
Aurora A kinase-coated beads function as microtubule-organizing centers and enhance RanGTP-induced spindle assembly. Curr Biol (2005) 1.52
Protein-protein interactions in the allosteric regulation of protein kinases. Curr Opin Struct Biol (2006) 1.49
A novel domain suggests a ciliary function for ASPM, a brain size determining gene. Bioinformatics (2006) 1.39
An essential function of the C. elegans ortholog of TPX2 is to localize activated aurora A kinase to mitotic spindles. Dev Cell (2005) 1.27
Long-range communication between chromatin and microtubules in Xenopus egg extracts. Curr Biol (2003) 1.08
Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev (2005) 12.15
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature (2009) 11.46
A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. Science (2002) 7.33
Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2. Mol Cell (2006) 7.33
X chromosomal abnormalities in basal-like human breast cancer. Cancer Cell (2006) 7.17
RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. Science (2007) 6.70
Aberrant T cell differentiation in the absence of Dicer. J Exp Med (2005) 6.58
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev (2005) 5.53
A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Mol Cell (2006) 5.51
Efficacy of neoadjuvant Cisplatin in triple-negative breast cancer. J Clin Oncol (2010) 5.50
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc Natl Acad Sci U S A (2002) 5.07
Fanconi anemia is associated with a defect in the BRCA2 partner PALB2. Nat Genet (2006) 4.98
The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair. Science (2009) 4.85
Network modeling links breast cancer susceptibility and centrosome dysfunction. Nat Genet (2007) 4.69
A recurrent mutation in PALB2 in Finnish cancer families. Nature (2007) 4.64
Mechanism of replication-coupled DNA interstrand crosslink repair. Cell (2008) 4.53
Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes. Genes Dev (2006) 4.18
Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells. Genes Dev (2007) 4.11
Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication. Mol Cell (2006) 3.77
The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly. Cell (2006) 3.46
The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA. Science (2006) 3.46
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell (2004) 3.43
Self-assembling protein microarrays. Science (2004) 3.37
Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha. Proc Natl Acad Sci U S A (2002) 3.28
MYC recruits the TIP60 histone acetyltransferase complex to chromatin. EMBO Rep (2003) 3.24
Polyubiquitination of p53 by a ubiquitin ligase activity of p300. Science (2003) 3.21
PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication. Nat Cell Biol (2005) 3.18
A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication. EMBO J (2004) 3.02
Sequence-independent DNA binding and replication initiation by the human origin recognition complex. Genes Dev (2003) 3.01
MCM2-7 complexes bind chromatin in a distributed pattern surrounding the origin recognition complex in Xenopus egg extracts. J Biol Chem (2002) 3.00
PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination. J Biol Chem (2006) 2.96
An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells. Cancer Cell (2010) 2.85
A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Nature (2011) 2.82
Identification of BRCA1-IRIS, a BRCA1 locus product. Nat Cell Biol (2004) 2.65
Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45. Mol Cell (2002) 2.55
Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase. Cell (2011) 2.54
Pumps, paradoxes and ploughshares: mechanism of the MCM2-7 DNA helicase. Trends Biochem Sci (2005) 2.53
BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair. Carcinogenesis (2010) 2.46
Recruitment of Xenopus Scc2 and cohesin to chromatin requires the pre-replication complex. Nat Cell Biol (2004) 2.45
The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations. Proc Natl Acad Sci U S A (2004) 2.41
Analysis of PALB2/FANCN-associated breast cancer families. Proc Natl Acad Sci U S A (2007) 2.41
Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts. Genes Dev (2004) 2.36
CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase. Mol Cell (2010) 2.29
Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure. Genes Dev (2002) 2.26
BRCA1 supports XIST RNA concentration on the inactive X chromosome. Cell (2002) 2.24
p21 transcription is regulated by differential localization of histone H2A.Z. Genes Dev (2007) 2.21
Mechanism of RAD51-dependent DNA interstrand cross-link repair. Science (2011) 2.04
RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci. Genes Dev (2011) 2.00
The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication. J Cell Biol (2002) 2.00
Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal. Proc Natl Acad Sci U S A (2002) 1.99
Docking of a specialized PIP Box onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt2. Mol Cell (2009) 1.97
Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase. Genes Dev (2011) 1.95
DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors. JAMA (2011) 1.85
E2F-dependent histone acetylation and recruitment of the Tip60 acetyltransferase complex to chromatin in late G1. Mol Cell Biol (2004) 1.85
Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress. Mol Cell (2012) 1.79
Uncoupling of sister replisomes during eukaryotic DNA replication. Mol Cell (2010) 1.73
The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway. Genes Dev (2005) 1.70
Penetrance analysis of the PALB2 c.1592delT founder mutation. Clin Cancer Res (2008) 1.65
Active localization of the retinoblastoma protein in chromatin and its response to S phase DNA damage. Mol Cell (2003) 1.55
Ribonucleotide reductase activity is coupled to DNA synthesis via proliferating cell nuclear antigen. Curr Biol (2012) 1.53
Proliferating cell nuclear antigen uses two distinct modes to move along DNA. J Biol Chem (2009) 1.53
Genomic rearrangements account for more than one-third of the BRCA1 mutations in northern Italian breast/ovarian cancer families. Hum Mol Genet (2003) 1.49
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BRCA1 is required for postreplication repair after UV-induced DNA damage. Mol Cell (2011) 1.48
Homeotic transformations of the axial skeleton that accompany a targeted deletion of E2f6. EMBO Rep (2002) 1.43
A genome-wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction. Mol Cell (2011) 1.41
X chromosome inactivation in the absence of Dicer. Proc Natl Acad Sci U S A (2009) 1.38
Eukaryotic origins of DNA replication: could you please be more specific? Semin Cell Dev Biol (2005) 1.34
Cdc7-Drf1 kinase links chromosome cohesion to the initiation of DNA replication in Xenopus egg extracts. Genes Dev (2008) 1.34
Cdc7-Drf1 is a developmentally regulated protein kinase required for the initiation of vertebrate DNA replication. Genes Dev (2005) 1.32
Mechanisms of BRCA1 tumor suppression. Cancer Discov (2012) 1.32
The disappearing Barr body in breast and ovarian cancers. Nat Rev Cancer (2007) 1.24
DNA replication in nucleus-free Xenopus egg extracts. Methods Mol Biol (2009) 1.24
p400 is required for E1A to promote apoptosis. J Biol Chem (2005) 1.19
Domain architecture and biochemical characterization of vertebrate Mcm10. J Biol Chem (2007) 1.19
Bypass of a protein barrier by a replicative DNA helicase. Nature (2012) 1.16
Further evidence for BRCA1 communication with the inactive X chromosome. Cell (2007) 1.15
Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint. Mol Cell Biol (2006) 1.15
DNA replication of mitotic chromatin in Xenopus egg extracts. Proc Natl Acad Sci U S A (2003) 1.07
Chromosomal DNA replication in a soluble cell-free system derived from Xenopus eggs. Methods Mol Biol (2006) 1.05
A general approach to break the concentration barrier in single-molecule imaging. Nat Methods (2012) 1.04
New Myc-anisms for DNA replication and tumorigenesis? Cancer Cell (2007) 1.02
The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination. Mol Cell Biol (2013) 0.98
Direct role for proliferating cell nuclear antigen in substrate recognition by the E3 ubiquitin ligase CRL4Cdt2. J Biol Chem (2012) 0.97
DNA is a co-factor for its own replication in Xenopus egg extracts. Nucleic Acids Res (2010) 0.95
Initiation of DNA replication in Xenopus egg extracts. Front Biosci (2004) 0.93
Novel consensus DNA-binding sequence for BRCA1 protein complexes. Mol Carcinog (2003) 0.92
Getting a grip on licensing: mechanism of stable Mcm2-7 loading onto replication origins. Mol Cell (2006) 0.92
Tumor suppression by a severely truncated species of retinoblastoma protein. Mol Cell Biol (2002) 0.91
Construction of plasmids containing site-specific DNA interstrand cross-links for biochemical and cell biological studies. Methods Mol Biol (2012) 0.90
Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer. Proc Natl Acad Sci U S A (2013) 0.89
Physiological modulation of endogenous BRCA1 p220 abundance suppresses DNA damage during the cell cycle. Genes Dev (2013) 0.88
Single-molecule analysis of DNA replication in Xenopus egg extracts. Methods (2012) 0.87
Identification of BRCA1 and BRCA2 carriers by allele-specific gene expression (AGE) analysis. Int J Cancer (2002) 0.86
Replication-coupled DNA interstrand cross-link repair in Xenopus egg extracts. Methods Mol Biol (2012) 0.86
Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis. Blood (2011) 0.86
Protein phosphatase 2A regulates binding of Cdc45 to the prereplication complex. J Biol Chem (2002) 0.85