Published in J Invest Dermatol on December 06, 2012
DMBA/TPA treatment is necessary for BCC formation from patched deficient epidermal cells in Ptch(flox/flox)CD4Cre(+/-) mice. J Invest Dermatol (2014) 1.41
Cellular reprogramming in skin cancer. Semin Cancer Biol (2014) 0.80
Discovery of a Novel Immune Gene Signature with Profound Prognostic Value in Colorectal Cancer: A Model of Cooperativity Disorientation Created in the Process from Development to Cancer. PLoS One (2015) 0.78
Developmental genes significantly afflicted by aberrant promoter methylation and somatic mutation predict overall survival of late-stage colorectal cancer. Sci Rep (2015) 0.76
"Patch"ing up our tumor signaling knowledge. J Invest Dermatol (2013) 0.75
Identification of genomic aberrations in hemangioblastoma by droplet digital PCR and SNP microarray highlights novel candidate genes and pathways for pathogenesis. BMC Genomics (2016) 0.75
Transcriptomic comparison of primary bovine horn core carcinoma culture and parental tissue at early stage. Vet World (2017) 0.75
A network-based method for identifying prognostic gene modules in lung squamous carcinoma. Oncotarget (2016) 0.75
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 120.51
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature (1996) 11.46
Altered neural cell fates and medulloblastoma in mouse patched mutants. Science (1997) 11.44
Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science (1996) 8.06
Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell (1996) 7.86
Specification of motoneurons from human embryonic stem cells. Nat Biotechnol (2005) 7.74
Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature (1986) 6.14
Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling. Nature (2008) 4.60
Biochemical evidence that patched is the Hedgehog receptor. Nature (1996) 4.53
Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas. Nature (1984) 4.28
Dual roles for patched in sequestering and transducing Hedgehog. Cell (1996) 4.10
Basal cell carcinomas in mice overexpressing sonic hedgehog. Science (1997) 3.84
Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. Dev Biol (2001) 3.82
Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome. Nat Med (1998) 3.75
Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours. Nature (1997) 3.64
Programming gene expression in developing epidermis. Development (1994) 3.60
Metastasis is driven by sequential elevation of H-ras and Smad2 levels. Nat Cell Biol (2002) 3.52
Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling. Proc Natl Acad Sci U S A (2007) 3.16
Emerging properties of animal gene regulatory networks. Nature (2010) 2.89
Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell (2001) 2.65
Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice. Nat Med (1999) 2.39
Role of the Drosophila patched gene in positional signalling. Nature (1991) 2.03
Genome-wide promoter analysis of the SOX4 transcriptional network in prostate cancer cells. Cancer Res (2009) 1.97
Genetic architecture of mouse skin inflammation and tumour susceptibility. Nature (2009) 1.89
A new look into an old problem: keratins as tools to investigate determination, morphogenesis, and differentiation in skin. Genes Dev (1989) 1.62
Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice. Nature (2007) 1.54
Patched1 interacts with cyclin B1 to regulate cell cycle progression. EMBO J (2001) 1.52
Loss of heterozygosity and mutational alterations of the p53 gene in skin tumours of interspecific hybrid mice. Oncogene (1991) 1.32
Allele-specific Hras mutations and genetic alterations at tumor susceptibility loci in skin carcinomas from interspecific hybrid mice. Cancer Res (2003) 1.27
Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog. J Clin Invest (2007) 1.22
Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite. Proc Natl Acad Sci U S A (2001) 1.22
Transdifferentiation of the ventral retinal pigmented epithelium to neural retina in the growth arrest specific gene 1 mutant. Dev Biol (2001) 1.09
Understanding human cancer using Drosophila: Tid47, a cytosolic product of the DnaJ-like tumor suppressor gene l2Tid, is a novel molecular partner of patched related to skin cancer. J Biol Chem (2003) 0.87
Natural variation in human gene expression assessed in lymphoblastoid cells. Nat Genet (2003) 11.63
A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis. Cell (2009) 6.03
Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature (2004) 4.35
FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression. Science (2008) 3.78
Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia. Proc Natl Acad Sci U S A (2008) 3.71
Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nat Genet (2003) 3.70
Metastasis is driven by sequential elevation of H-ras and Smad2 levels. Nat Cell Biol (2002) 3.52
Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer. Clin Cancer Res (2007) 2.94
Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3. Nat Genet (2005) 2.51
RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings. Cell Res (2012) 2.41
Stem-cell hierarchy in skin cancer. Nat Rev Cancer (2003) 2.36
Dissociation of epithelial and neuroendocrine carcinoma lineages in the transgenic adenocarcinoma of mouse prostate model of prostate cancer. Am J Pathol (2007) 2.23
Kras regulatory elements and exon 4A determine mutation specificity in lung cancer. Nat Genet (2008) 2.05
Genome-wide detection of chromosomal imbalances in tumors using BAC microarrays. Nat Biotechnol (2002) 2.04
Genomic segmental polymorphisms in inbred mouse strains. Nat Genet (2004) 1.93
Genetic architecture of mouse skin inflammation and tumour susceptibility. Nature (2009) 1.89
Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior. Cancer Res (2007) 1.79
A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2LA2 mice. Nat Genet (2006) 1.79
Mapping segmental and sequence variations among laboratory mice using BAC array CGH. Genome Res (2005) 1.71
Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types. Carcinogenesis (2005) 1.61
Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice. Cancer Cell (2007) 1.59
HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis. Proc Natl Acad Sci U S A (2007) 1.58
Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation. Mol Cell Biol (2002) 1.56
Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice. Nature (2007) 1.54
Structural and functional studies of LRP6 ectodomain reveal a platform for Wnt signaling. Dev Cell (2011) 1.50
CUL4A induces epithelial-mesenchymal transition and promotes cancer metastasis by regulating ZEB1 expression. Cancer Res (2013) 1.48
Mutations in a new scaffold protein Sans cause deafness in Jackson shaker mice. Hum Mol Genet (2003) 1.45
A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors. Cancer Res (2004) 1.44
From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia. Blood (2011) 1.41
Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back. Am J Med Genet A (2010) 1.36
Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer. Nat Cell Biol (2013) 1.36
The prostate cancer-up-regulated long noncoding RNA PlncRNA-1 modulates apoptosis and proliferation through reciprocal regulation of androgen receptor. Urol Oncol (2012) 1.33
A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia. Proc Natl Acad Sci U S A (2009) 1.32
Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression. Genes Dev (2004) 1.31
Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects. J Allergy Clin Immunol (2013) 1.30
SRC-induced disassembly of adherens junctions requires localized phosphorylation and degradation of the rac activator tiam1. Mol Cell (2009) 1.30
The expression level of HJURP has an independent prognostic impact and predicts the sensitivity to radiotherapy in breast cancer. Breast Cancer Res (2010) 1.29
Genetic interactions between Pten and p53 in radiation-induced lymphoma development. Oncogene (2003) 1.28
Allele-specific Hras mutations and genetic alterations at tumor susceptibility loci in skin carcinomas from interspecific hybrid mice. Cancer Res (2003) 1.27
Radiation acts on the microenvironment to affect breast carcinogenesis by distinct mechanisms that decrease cancer latency and affect tumor type. Cancer Cell (2011) 1.25
Cul4A is an oncogene in malignant pleural mesothelioma. J Cell Mol Med (2011) 1.21
Environmental factors and genetic susceptibility promote urinary bladder cancer. Toxicol Lett (2010) 1.20
Keratin 16 regulates innate immunity in response to epidermal barrier breach. Proc Natl Acad Sci U S A (2013) 1.16
Cancer evolution and individual susceptibility. Integr Biol (Camb) (2011) 1.15
Oncogenic CUL4A determines the response to thalidomide treatment in prostate cancer. J Mol Med (Berl) (2012) 1.12
Henoch-Schönlein purpura nephritis in children: incidence, pathogenesis and management. World J Pediatr (2014) 1.12
Characterizing the protective component of the alphabeta T cell response to transplantable squamous cell carcinoma. J Invest Dermatol (2004) 1.11
Deletion of the PER3 gene on chromosome 1p36 in recurrent ER-positive breast cancer. J Clin Oncol (2010) 1.10
The role of ATF-2 in oncogenesis. Bioessays (2008) 1.08
Genomic approaches to identification of tumour-susceptibility genes using mouse models. Curr Opin Genet Dev (2003) 1.08
Network analysis of skin tumor progression identifies a rewired genetic architecture affecting inflammation and tumor susceptibility. Genome Biol (2011) 1.08
p53 activates ICAM-1 (CD54) expression in an NF-kappaB-independent manner. EMBO J (2003) 1.06
Systems genetics analysis of cancer susceptibility: from mouse models to humans. Nat Rev Genet (2009) 1.06
CUL4A overexpression enhances lung tumor growth and sensitizes lung cancer cells to erlotinib via transcriptional regulation of EGFR. Mol Cancer (2014) 1.06
Irradiation of juvenile, but not adult, mammary gland increases stem cell self-renewal and estrogen receptor negative tumors. Stem Cells (2014) 1.05
Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development. Mol Cancer Res (2012) 1.05
A gain of function TGFB1 polymorphism may be associated with late stage prostate cancer. Cancer Epidemiol Biomarkers Prev (2004) 1.04
p63 and p73 do not contribute to p53-mediated lymphoma suppressor activity in vivo. Oncogene (2005) 1.04
Genetic differences in transcript responses to low-dose ionizing radiation identify tissue functions associated with breast cancer susceptibility. PLoS One (2012) 1.00
Control of genomic instability and epithelial tumor development by the p53-Fbxw7/Cdc4 pathway. Cancer Res (2005) 1.00
Inhibition of CK2α down-regulates Hedgehog/Gli signaling leading to a reduction of a stem-like side population in human lung cancer cells. PLoS One (2012) 0.99
A tumor-protective role for human kallikrein-related peptidase 6 in breast cancer mediated by inhibition of epithelial-to-mesenchymal transition. Cancer Res (2009) 0.99
Synergistic effects of STK15 gene polymorphisms and endogenous estrogen exposure in the risk of breast cancer. Cancer Epidemiol Biomarkers Prev (2004) 0.98
C2ORF40 suppresses breast cancer cell proliferation and invasion through modulating expression of M phase cell cycle genes. Epigenetics (2013) 0.98
Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. Genes Dev (2011) 0.98
Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility. Proc Natl Acad Sci U S A (2006) 0.97
Developing novel oncolytic adenoviruses through bioselection. J Virol (2003) 0.97
Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas. Am J Pathol (2009) 0.97
Progressive genomic instability in the FVB/Kras(LA2) mouse model of lung cancer. Mol Cancer Res (2011) 0.96
Gene transcriptional networks integrate microenvironmental signals in human breast cancer. Integr Biol (Camb) (2010) 0.96
FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7. Oncotarget (2013) 0.96
Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas. Nat Commun (2013) 0.95
Genomic instability in radiation-induced mouse lymphoma from p53 heterozygous mice. Oncogene (2005) 0.95
Rapamycin inhibits FBXW7 loss-induced epithelial-mesenchymal transition and cancer stem cell-like characteristics in colorectal cancer cells. Biochem Biophys Res Commun (2013) 0.95
Pauci-immune glomerulonephritis in individuals with disease associated with levamisole-adulterated cocaine: a series of 4 cases. Medicine (Baltimore) (2014) 0.94