Published in Genes Dev on January 01, 1989
Molecular dissection of mesenchymal-epithelial interactions in the hair follicle. PLoS Biol (2005) 4.27
Modeling tissue-specific signaling and organ function in three dimensions. J Cell Sci (2003) 3.52
Onset of keratin 17 expression coincides with the definition of major epithelial lineages during skin development. J Cell Biol (1998) 2.91
Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice. J Virol (1994) 2.73
Onset of re-epithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: defining a potential role for keratin 16. J Cell Biol (1996) 2.49
Structure and functions of keratin proteins in simple, stratified, keratinized and cornified epithelia. J Anat (2009) 2.21
Epidermolysis bullosa simplex: a paradigm for disorders of tissue fragility. J Clin Invest (2009) 2.06
Cloning and characterization of a cluster of genes encoding polypeptides present in the insoluble fraction of the spore coat of Bacillus subtilis. J Bacteriol (1993) 1.82
A function for keratins and a common thread among different types of epidermolysis bullosa simplex diseases. J Cell Biol (1991) 1.80
Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice. EMBO J (1993) 1.70
Expression of keratin K14 in the epidermis and hair follicle: insights into complex programs of differentiation. J Cell Biol (1989) 1.64
Probing keratinocyte and differentiation specificity of the human K5 promoter in vitro and in transgenic mice. Mol Cell Biol (1993) 1.59
Isolation, sequence, and expression of a human keratin K5 gene: transcriptional regulation of keratins and insights into pairwise control. Mol Cell Biol (1989) 1.56
Segregation of keratinocyte colony-forming cells in the bulge of the rat vibrissa. Proc Natl Acad Sci U S A (1993) 1.46
Mouse notch: expression in hair follicles correlates with cell fate determination. J Cell Biol (1993) 1.46
Transgenic mice expressing a mutant keratin 10 gene reveal the likely genetic basis for epidermolytic hyperkeratosis. Proc Natl Acad Sci U S A (1992) 1.46
WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis. Nature (2014) 1.40
The role of the hairless (hr) gene in the regulation of hair follicle catagen transformation. Am J Pathol (1999) 1.38
Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin. J Cell Biol (1994) 1.27
The conversion of mouse skin squamous cell carcinomas to spindle cell carcinomas is a recessive event. J Cell Biol (1993) 1.18
Oct-6: a regulator of keratinocyte gene expression in stratified squamous epithelia. Mol Cell Biol (1994) 1.17
Defining keratin protein function in skin epithelia: epidermolysis bullosa simplex and its aftermath. J Invest Dermatol (2012) 1.16
The differentiation-specific factor CDP/Cut represses transcription and replication of human papillomaviruses through a conserved silencing element. J Virol (2000) 1.15
Ptch1 overexpression drives skin carcinogenesis and developmental defects in K14Ptch(FVB) mice. J Invest Dermatol (2012) 0.86
The cDNA-deduced amino acid sequence for trichohyalin, a differentiation marker in the hair follicle, contains a 23 amino acid repeat. J Cell Biol (1990) 0.83
Pancreatic cancer organotypics: High throughput, preclinical models for pharmacological agent evaluation. World J Gastroenterol (2014) 0.80
Wharton's jelly stem cells: a novel cell source for oral mucosa and skin epithelia regeneration. Stem Cells Transl Med (2013) 0.77
Transcription Factor PAX6 (Paired Box 6) Controls Limbal Stem Cell Lineage in Development and Disease. J Biol Chem (2015) 0.77
Hair-specific expression of chloramphenicol acetyltransferase in transgenic mice under the control of an ultra-high-sulfur keratin promoter. Proc Natl Acad Sci U S A (1990) 0.76
LGN plays distinct roles in oral epithelial stratification, filiform papilla morphogenesis and hair follicle development. Development (2016) 0.76
Keratin gene mutations in human skin disease. Postgrad Med J (1994) 0.75
Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. Development (1999) 9.82
Directed actin polymerization is the driving force for epithelial cell-cell adhesion. Cell (2000) 8.13
De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell (1998) 7.95
The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. Proc Natl Acad Sci U S A (1999) 7.67
Mefloquine compared with other malaria chemoprophylactic regimens in tourists visiting east Africa. Lancet (1993) 5.99
Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat Genet (1999) 5.91
Changes in keratin gene expression during terminal differentiation of the keratinocyte. Cell (1980) 5.83
Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin. Cell (2001) 5.01
Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin. Genes Dev (2001) 4.62
Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. J Neurosci (1997) 4.00
A common human skin tumour is caused by activating mutations in beta-catenin. Nat Genet (1999) 3.93
Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet (2000) 3.92
Human papillomavirus type 16 alters human epithelial cell differentiation in vitro. Proc Natl Acad Sci U S A (1988) 3.73
Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival. J Cell Biol (1996) 3.68
Regulation of terminal differentiation of cultured human keratinocytes by vitamin A. Cell (1981) 3.61
Programming gene expression in developing epidermis. Development (1994) 3.60
Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice. Proc Natl Acad Sci U S A (1989) 3.55
Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. Proc Natl Acad Sci U S A (1998) 3.53
Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: genetic and functional analyses. Cell (1991) 3.49
Conditional ablation of beta1 integrin in skin. Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination. J Cell Biol (2000) 3.38
Desmoplakin is essential in epidermal sheet formation. Nat Cell Biol (2001) 3.31
The cDNA sequence of a human epidermal keratin: divergence of sequence but conservation of structure among intermediate filament proteins. Cell (1982) 3.08
Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine. Proc Natl Acad Sci U S A (2001) 3.01
Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate. Genes Dev (1995) 2.99
Mutant keratin expression in transgenic mice causes marked abnormalities resembling a human genetic skin disease. Cell (1991) 2.98
The cDNA sequence of a Type II cytoskeletal keratin reveals constant and variable structural domains among keratins. Cell (1983) 2.92
Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation. J Cell Biol (1988) 2.88
Initiation of DNA-dependent RNA synthesis and the effect of heparin on RNA polymerase. Eur J Biochem (1967) 2.87
The expression of keratin genes in epidermis and cultured epidermal cells. Cell (1978) 2.87
Keratinocyte growth factor is required for hair development but not for wound healing. Genes Dev (1996) 2.82
The initiation of translation in E. coli: apparent base pairing between the 16srRNA and downstream sequences of the mRNA. Nucleic Acids Res (1990) 2.81
Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation. Genes Dev (1991) 2.78
Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration. Cell (1995) 2.75
Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews. J Neurosci (1996) 2.73
Retinoids as important regulators of terminal differentiation: examining keratin expression in individual epidermal cells at various stages of keratinization. J Cell Biol (1987) 2.62
The expression of mutant epidermal keratin cDNAs transfected in simple epithelial and squamous cell carcinoma lines. J Cell Biol (1987) 2.61
A randomized controlled trial of a reduced daily dose of zidovudine in patients with the acquired immunodeficiency syndrome. The AIDS Clinical Trials Group. N Engl J Med (1990) 2.50
Hippocampal neurogenesis in adult Old World primates. Proc Natl Acad Sci U S A (1999) 2.37
Stress revisited: a critical evaluation of the stress concept. Neurosci Biobehav Rev (2011) 2.37
Complementary DNA sequence of a human cytoplasmic actin. Interspecies divergence of 3' non-coding regions. J Mol Biol (1983) 2.25
An Epstein-Barr virus transforming protein associates with vimentin in lymphocytes. Mol Cell Biol (1987) 2.22
Multiple keratins of cultured human epidermal cells are translated from different mRNA molecules. Cell (1979) 2.18
Actin dynamics and cell-cell adhesion in epithelia. Curr Opin Cell Biol (2001) 2.15
Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage. J Cell Biol (1998) 2.14
An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments. Cell (1996) 2.09
Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor. Nature (1995) 2.09
CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes. Immunity (1996) 2.09
Remarkable conservation of structure among intermediate filament genes. Cell (1984) 2.07
The basal keratin network of stratified squamous epithelia: defining K15 function in the absence of K14. J Cell Biol (1995) 2.06
Evidence for posttranscriptional regulation of the keratins expressed during hyperproliferation and malignant transformation in human epidermis. J Cell Biol (1986) 1.89
Expression of mutant keratin cDNAs in epithelial cells reveals possible mechanisms for initiation and assembly of intermediate filaments. J Cell Biol (1989) 1.89
Making a connection: direct binding between keratin intermediate filaments and desmosomal proteins. J Cell Biol (1994) 1.87
Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action. Eur Neuropsychopharmacol (2010) 1.85
A function for keratins and a common thread among different types of epidermolysis bullosa simplex diseases. J Cell Biol (1991) 1.80
Elucidating the early stages of keratin filament assembly. J Cell Biol (1990) 1.80
FGF-7 modulates ureteric bud growth and nephron number in the developing kidney. Development (1999) 1.79
Complete sequence of a gene encoding a human type I keratin: sequences homologous to enhancer elements in the regulatory region of the gene. Proc Natl Acad Sci U S A (1985) 1.78
The ovo gene required for cuticle formation and oogenesis in flies is involved in hair formation and spermatogenesis in mice. Genes Dev (1998) 1.78
Defining the interactions between intermediate filaments and desmosomes. J Cell Biol (1998) 1.78
Genetic and clinical mosaicism in a type of epidermal nevus. N Engl J Med (1994) 1.72
Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice. EMBO J (1993) 1.70
The downstream box: an efficient and independent translation initiation signal in Escherichia coli. EMBO J (1996) 1.70
Transcription factor AP2 and its role in epidermal-specific gene expression. Proc Natl Acad Sci U S A (1991) 1.70
Transgenic studies with a keratin promoter-driven growth hormone transgene: prospects for gene therapy. Proc Natl Acad Sci U S A (1997) 1.68
Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice. Genes Dev (1992) 1.68
Unraveling the structure of the intermediate filaments. Cell (1983) 1.67
A human keratin 14 "knockout": the absence of K14 leads to severe epidermolysis bullosa simplex and a function for an intermediate filament protein. Genes Dev (1994) 1.65
Expression of keratin K14 in the epidermis and hair follicle: insights into complex programs of differentiation. J Cell Biol (1989) 1.64
Type I and type II keratins have evolved from lower eukaryotes to form the epidermal intermediate filaments in mammalian skin. Proc Natl Acad Sci U S A (1983) 1.61
A dysfunctional desmin mutation in a patient with severe generalized myopathy. Proc Natl Acad Sci U S A (1998) 1.61
An epidermal plakin that integrates actin and microtubule networks at cellular junctions. J Cell Biol (2000) 1.60
Rescuing desmoplakin function in extra-embryonic ectoderm reveals the importance of this protein in embryonic heart, neuroepithelium, skin and vasculature. Development (2001) 1.60
Expression of vascular endothelial growth factor and its receptors in human renal ontogenesis and in adult kidney. Am J Physiol (1995) 1.60
Probing keratinocyte and differentiation specificity of the human K5 promoter in vitro and in transgenic mice. Mol Cell Biol (1993) 1.59
Integrators of the cytoskeleton that stabilize microtubules. Cell (1999) 1.56
Isolation, sequence, and expression of a human keratin K5 gene: transcriptional regulation of keratins and insights into pairwise control. Mol Cell Biol (1989) 1.56
Mice expressing a mutant desmosomal cadherin exhibit abnormalities in desmosomes, proliferation, and epidermal differentiation. J Cell Biol (1996) 1.55
High-titer protamine-specific IgG antibody associated with anaphylaxis: report of a case and quantitative analysis of antibody in vasectomized men. Anesthesiology (1993) 1.54
The sequence of a type II keratin gene expressed in human skin: conservation of structure among all intermediate filament genes. Proc Natl Acad Sci U S A (1985) 1.52
The genetic basis of epidermolytic hyperkeratosis: a disorder of differentiation-specific epidermal keratin genes. Cell (1992) 1.51
Deletions in epidermal keratins leading to alterations in filament organization in vivo and in intermediate filament assembly in vitro. J Cell Biol (1990) 1.49
PDGF essentially links TGF-beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression. Oncogene (2006) 1.48
The transfection of epidermal keratin genes into fibroblasts and simple epithelial cells: evidence for inducing a type I keratin by a type II gene. Cell (1987) 1.47
Two signal model of lymphocyte activation. Immunol Today (1992) 1.46
Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty-acid synthase. Biol Chem Hoppe Seyler (1986) 1.45
Regulation of a human epidermal keratin gene: sequences and nuclear factors involved in keratinocyte-specific transcription. Genes Dev (1990) 1.42
Expandable esophageal stents: initial experience with a new nitinol stent. Gastrointest Endosc (1995) 1.42
Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development. Proc Natl Acad Sci U S A (1994) 1.42
Disease severity correlates with position of keratin point mutations in patients with epidermolysis bullosa simplex. Proc Natl Acad Sci U S A (1993) 1.41
The molecular biology of intermediate filament proteins. Int Rev Cytol (1992) 1.40
The importance of intramolecular ion pairing in intermediate filaments. Proc Natl Acad Sci U S A (1995) 1.40
Interleukin 6: insights to its function in skin by overexpression in transgenic mice. Proc Natl Acad Sci U S A (1992) 1.37
Isolation and characterization of the DNA replication complex from Escherichia coli. J Mol Biol (1970) 1.34
Three tightly linked genes encoding human type I keratins: conservation of sequence in the 5'-untranslated leader and 5'-upstream regions of coexpressed keratin genes. Mol Cell Biol (1986) 1.33
Differences in keratin synthesis between normal epithelial cells and squamous cell carcinomas are mediated by vitamin A. Proc Natl Acad Sci U S A (1984) 1.32
MicroRNA-mediated control in the skin. Cell Death Differ (2009) 1.30
The roles of K5 and K14 head, tail, and R/K L L E G E domains in keratin filament assembly in vitro. J Cell Biol (1992) 1.28
TGF-beta and retinoic acid: regulators of growth and modifiers of differentiation in human epidermal cells. Cell Regul (1990) 1.28
A group of type I keratin genes on human chromosome 17: characterization and expression. Mol Cell Biol (1988) 1.27