Published in J Biol Chem on December 13, 2012
Pore-forming toxins: ancient, but never really out of fashion. Nat Rev Microbiol (2015) 1.08
Toxin plasmids of Clostridium perfringens. Microbiol Mol Biol Rev (2013) 1.07
Towards an understanding of the role of Clostridium perfringens toxins in human and animal disease. Future Microbiol (2014) 1.07
Structural and functional analysis of the pore-forming toxin NetB from Clostridium perfringens. MBio (2013) 0.95
Protection against avian necrotic enteritis after immunisation with NetB genetic or formaldehyde toxoids. Vaccine (2013) 0.91
Cryo-EM structure of lysenin pore elucidates membrane insertion by an aerolysin family protein. Nat Commun (2016) 0.83
A novel pore-forming toxin in type A Clostridium perfringens is associated with both fatal canine hemorrhagic gastroenteritis and fatal foal necrotizing enterocolitis. PLoS One (2015) 0.83
Life at the border: adaptation of proteins to anisotropic membrane environment. Protein Sci (2014) 0.81
Structural Insights into Clostridium perfringens Delta Toxin Pore Formation. PLoS One (2013) 0.79
Clostridium perfringens type A-E toxin plasmids. Res Microbiol (2014) 0.78
Clostridium perfringens Delta-Toxin Induces Rapid Cell Necrosis. PLoS One (2016) 0.77
Identification of a key residue for oligomerisation and pore-formation of Clostridium perfringens NetB. Toxins (Basel) (2014) 0.77
Characteristics of hemolytic activity induced by skin secretions of the frog Kaloula pulchra hainana. J Venom Anim Toxins Incl Trop Dis (2013) 0.75
Identification and characterization of Clostridium perfringens beta toxin variants with differing trypsin sensitivity and in vitro cytotoxicity activity. Infect Immun (2015) 0.75
Variable protection against experimental broiler necrotic enteritis after immunization with the C-terminal fragment of Clostridium perfringens alpha-toxin and a non-toxic NetB variant. Avian Pathol (2016) 0.75
The Relationship between Glycan Binding and Direct Membrane Interactions in Vibrio cholerae Cytolysin, a Channel-forming Toxin. J Biol Chem (2015) 0.75
Quantification of Bacillus thuringiensis Vip3Aa16 Entomopathogenic Toxin Using Its Hemolytic Activity. Curr Microbiol (2017) 0.75
PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr (2010) 108.52
Phaser crystallographic software. J Appl Crystallogr (2007) 108.34
Features and development of Coot. Acta Crystallogr D Biol Crystallogr (2010) 89.46
NIH Image to ImageJ: 25 years of image analysis. Nat Methods (2012) 84.41
Overview of the CCP4 suite and current developments. Acta Crystallogr D Biol Crystallogr (2011) 67.55
Scaling and assessment of data quality. Acta Crystallogr D Biol Crystallogr (2005) 61.38
MolProbity: all-atom contacts and structure validation for proteins and nucleic acids. Nucleic Acids Res (2007) 37.31
iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLM. Acta Crystallogr D Biol Crystallogr (2011) 18.13
Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore. Science (1996) 16.69
Continuous base identification for single-molecule nanopore DNA sequencing. Nat Nanotechnol (2009) 8.09
Structure of the outer membrane protein A transmembrane domain. Nat Struct Biol (1998) 4.06
Staphylococcal alpha-toxin: oligomerization of hydrophilic monomers to form amphiphilic hexamers induced through contact with deoxycholate detergent micelles. Proc Natl Acad Sci U S A (1981) 2.38
NetB, a new toxin that is associated with avian necrotic enteritis caused by Clostridium perfringens. PLoS Pathog (2008) 2.23
Crystal structure of staphylococcal LukF delineates conformational changes accompanying formation of a transmembrane channel. Nat Struct Biol (1999) 1.99
Ion permeation through the alpha-hemolysin channel: theoretical studies based on Brownian dynamics and Poisson-Nernst-Plank electrodiffusion theory. Biophys J (2004) 1.91
Reversal of charge selectivity in transmembrane protein pores by using noncovalent molecular adapters. Proc Natl Acad Sci U S A (2000) 1.79
Key residues for membrane binding, oligomerization, and pore forming activity of staphylococcal alpha-hemolysin identified by cysteine scanning mutagenesis and targeted chemical modification. J Biol Chem (1995) 1.73
Crystal structure of the octameric pore of staphylococcal γ-hemolysin reveals the β-barrel pore formation mechanism by two components. Proc Natl Acad Sci U S A (2011) 1.43
Use of antimicrobial agents in veterinary medicine and food animal production. Int J Antimicrob Agents (2001) 1.40
Evidence that clustered phosphocholine head groups serve as sites for binding and assembly of an oligomeric protein pore. J Biol Chem (2006) 1.31
Crystal structure of the Vibrio cholerae cytolysin heptamer reveals common features among disparate pore-forming toxins. Proc Natl Acad Sci U S A (2011) 1.30
High resolution crystallographic studies of alpha-hemolysin-phospholipid complexes define heptamer-lipid head group interactions: implication for understanding protein-lipid interactions. Protein Sci (2004) 1.15
Staphylococcal alpha-toxin increases the permeability of lipid vesicles by cholesterol- and pH-dependent assembly of oligomeric channels. Eur J Biochem (1989) 1.13
Molecular and phenotypical characterization of Clostridium perfringens isolates from poultry flocks with different disease status. Vet Microbiol (2005) 1.13
Electrostatic influence on ion transport through the alphaHL channel. J Membr Biol (2003) 1.12
Site-directed mutagenesis of Clostridium perfringens beta-toxin: expression of wild-type and mutant toxins in Bacillus subtilis. FEMS Microbiol Lett (1998) 1.08
Lipids favoring inverted phase enhance the ability of aerolysin to permeabilize liposome bilayers. Biochemistry (2000) 1.04
Barley inclusion and avoparcin supplementation in broiler diets. 2. Clinical, pathological, and bacteriological findings in a mild form of necrotic enteritis. Poult Sci (1992) 1.01
Influence of membrane fluidity on the assembly of Staphylococcus aureus alpha-toxin, a channel-forming protein, in liposome membrane. J Biol Chem (1992) 1.00
2-Methyl-2,4-pentanediol induces spontaneous assembly of staphylococcal α-hemolysin into heptameric pore structure. Protein Sci (2011) 0.97
Oligomerization of Clostridium perfringens epsilon-toxin is dependent upon membrane fluidity in liposomes. Biochemistry (2006) 0.96
Protein engineering modulates the transport properties and ion selectivity of the pores formed by staphylococcal gamma-haemolysins in lipid membranes. Mol Microbiol (2002) 0.92
Efficacy of narasin in the prevention of necrotic enteritis in broiler chickens. Avian Dis (2001) 0.92
The influence of membrane lipids in Staphylococcus aureus gamma-hemolysins pore formation. J Membr Biol (2008) 0.92
Efficacy of in-feed tylosin phosphate for the treatment of necrotic enteritis in broiler chickens. Poult Sci (2001) 0.91
Factors affecting the incidence of necrotic enteritis, caecal carriage of Clostridium perfringens and bird performance in broiler chicks. Acta Vet Scand (1992) 0.90
Essential residues, W177 and R198, of LukF for phosphatidylcholine-binding and pore-formation by staphylococcal gamma-hemolysin on human erythrocyte membranes. J Biochem (2004) 0.86
Reduced incidence of Clostridium perfringens-associated lesions and improved performance in broiler chickens treated with normal intestinal bacteria from adult fowl. Avian Dis (2001) 0.83
Tularemia. Clin Microbiol Rev (2002) 8.51
Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei. Proc Natl Acad Sci U S A (2004) 7.30
The complete genome sequence of Francisella tularensis, the causative agent of tularemia. Nat Genet (2005) 6.22
Tularaemia: bioterrorism defence renews interest in Francisella tularensis. Nat Rev Microbiol (2004) 5.38
Genome-wide DNA microarray analysis of Francisella tularensis strains demonstrates extensive genetic conservation within the species but identifies regions that are unique to the highly virulent F. tularensis subsp. tularensis. J Clin Microbiol (2003) 3.08
Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens. Genome Res (2006) 2.84
Absence of Yersinia pestis-specific DNA in human teeth from five European excavations of putative plague victims. Microbiology (2004) 2.75
Application of DNA microarrays to study the evolutionary genomics of Yersinia pestis and Yersinia pseudotuberculosis. Genome Res (2003) 2.51
Attenuated virulence and protective efficacy of a Burkholderia pseudomallei bsa type III secretion mutant in murine models of melioidosis. Microbiology (2004) 2.28
Conjugative transfer of clostridial shuttle vectors from Escherichia coli to Clostridium difficile through circumvention of the restriction barrier. Mol Microbiol (2002) 2.19
ATP-binding cassette transporters are targets for the development of antibacterial vaccines and therapies. Infect Immun (2004) 2.15
A Burkholderia pseudomallei protein microarray reveals serodiagnostic and cross-reactive antigens. Proc Natl Acad Sci U S A (2009) 2.10
Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing. Nat Commun (2012) 2.01
Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number. Hum Mol Genet (2004) 2.00
Evaluation of lipopolysaccharide and capsular polysaccharide as subunit vaccines against experimental melioidosis. J Med Microbiol (2004) 1.82
From protein microarrays to diagnostic antigen discovery: a study of the pathogen Francisella tularensis. Bioinformatics (2007) 1.68
A genomic survey of positive selection in Burkholderia pseudomallei provides insights into the evolution of accidental virulence. PLoS Pathog (2010) 1.65
Direct repeat-mediated deletion of a type IV pilin gene results in major virulence attenuation of Francisella tularensis. Mol Microbiol (2006) 1.65
A recombinant carboxy-terminal domain of the protective antigen of Bacillus anthracis protects mice against anthrax infection. Infect Immun (2002) 1.60
Role of T cells in innate and adaptive immunity against murine Burkholderia pseudomallei infection. J Infect Dis (2005) 1.56
Clostridium perfringens epsilon-toxin shows structural similarity to the pore-forming toxin aerolysin. Nat Struct Mol Biol (2004) 1.55
Characterization of the O antigen gene cluster and structural analysis of the O antigen of Francisella tularensis subsp. tularensis. J Med Microbiol (2003) 1.48
Benchmarking pK(a) prediction. BMC Biochem (2006) 1.47
Exploiting the Burkholderia pseudomallei acute phase antigen BPSL2765 for structure-based epitope discovery/design in structural vaccinology. Chem Biol (2013) 1.45
The immunologically distinct O antigens from Francisella tularensis subspecies tularensis and Francisella novicida are both virulence determinants and protective antigens. Infect Immun (2006) 1.42
Rethinking our understanding of the pathogenesis of necrotic enteritis in chickens. Trends Microbiol (2008) 1.39
Discrimination of human pathogenic subspecies of Francisella tularensis by using restriction fragment length polymorphism. J Clin Microbiol (2003) 1.38
Characterisation of an acapsular mutant of Burkholderia pseudomallei identified by signature tagged mutagenesis. J Med Microbiol (2002) 1.37
A type IV pilin, PilA, Contributes To Adherence of Burkholderia pseudomallei and virulence in vivo. Infect Immun (2005) 1.34
Genotyping and phenotyping of beta2-toxigenic Clostridium perfringens fecal isolates associated with gastrointestinal diseases in piglets. J Clin Microbiol (2003) 1.32
Melioidosis vaccines: a systematic review and appraisal of the potential to exploit biodefense vaccines for public health purposes. PLoS Negl Trop Dis (2012) 1.28
A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A. Science (2011) 1.27
Galleria mellonella as an alternative infection model for Yersinia pseudotuberculosis. Microbiology (2009) 1.23
Synergistic protection of mice against plague with monoclonal antibodies specific for the F1 and V antigens of Yersinia pestis. Infect Immun (2003) 1.23
Salmonella vaccines for use in humans: present and future perspectives. FEMS Microbiol Rev (2002) 1.22
Francisella tularensis vaccines. FEMS Immunol Med Microbiol (2007) 1.19
ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization. Brief Bioinform (2009) 1.19
Role of the C-terminal domain in the structure and function of tetrameric sodium channels. Nat Commun (2013) 1.19
Macrophage and Galleria mellonella infection models reflect the virulence of naturally occurring isolates of B. pseudomallei, B. thailandensis and B. oklahomensis. BMC Microbiol (2011) 1.19
ImmunoGrid: towards agent-based simulations of the human immune system at a natural scale. Philos Trans A Math Phys Eng Sci (2010) 1.16
Structural characterization of lipo-oligosaccharide (LOS) from Yersinia pestis: regulation of LOS structure by the PhoPQ system. Mol Microbiol (2002) 1.15
Identification of a LolC homologue in Burkholderia pseudomallei, a novel protective antigen for melioidosis. Infect Immun (2007) 1.15
Vaccination strategies for Francisella tularensis. Adv Drug Deliv Rev (2005) 1.15
The ABC transporter protein OppA provides protection against experimental Yersinia pestis infection. Infect Immun (2006) 1.14
Efficacy of the live attenuated Francisella tularensis vaccine (LVS) in a murine model of disease. Vaccine (2005) 1.14
Insect infection model for Campylobacter jejuni reveals that O-methyl phosphoramidate has insecticidal activity. J Infect Dis (2010) 1.13
Characterization and deposition of respirable large- and small-particle bioaerosols. Appl Environ Microbiol (2008) 1.13
Interactions of the type III secretion pathway proteins LcrV and LcrG from Yersinia pestis are mediated by coiled-coil domains. J Biol Chem (2002) 1.12
Global map of growth-regulated gene expression in Burkholderia pseudomallei, the causative agent of melioidosis. J Bacteriol (2006) 1.11
Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia mice. Blood (2004) 1.10
Development of vaccines against burkholderia pseudomallei. Front Microbiol (2011) 1.10
Genome sequencing shows that European isolates of Francisella tularensis subspecies tularensis are almost identical to US laboratory strain Schu S4. PLoS One (2007) 1.09
Oral administration of a Salmonella enterica-based vaccine expressing Bacillus anthracis protective antigen confers protection against aerosolized B. anthracis. Infect Immun (2006) 1.08
Oral immunization with a dam mutant of Yersinia pseudotuberculosis protects against plague. Microbiology (2005) 1.08
Experimental aerogenic Burkholderia mallei (glanders) infection in the BALB/c mouse. J Med Microbiol (2003) 1.07
Characterization of the Burkholderia pseudomallei K96243 capsular polysaccharide I coding region. Infect Immun (2012) 1.07
Immunization with the C-Domain of alpha -Toxin prevents lethal infection, localizes tissue injury, and promotes host response to challenge with Clostridium perfringens. J Infect Dis (2004) 1.06
A Salmonella enterica serovar Typhi vaccine expressing Yersinia pestis F1 antigen on its surface provides protection against plague in mice. Vaccine (2004) 1.06
Oral immunisation with live aroA attenuated Salmonella enterica serovar Typhimurium expressing the Yersinia pestis V antigen protects mice against plague. Vaccine (2003) 1.05
Phenotypic and functional characterization of human memory T cell responses to Burkholderia pseudomallei. PLoS Negl Trop Dis (2009) 1.05
Clostridium absonum alpha-toxin: new insights into clostridial phospholipase C substrate binding and specificity. J Mol Biol (2003) 1.05
Recombinant Bacillus subtilis expressing the Clostridium perfringens alpha toxoid is a candidate orally delivered vaccine against necrotic enteritis. Infect Immun (2008) 1.05
Low-dose exposure of C57BL/6 mice to burkholderia pseudomallei mimics chronic human melioidosis. Am J Pathol (2011) 1.05
DNA vaccines: improving expression of antigens. Genet Vaccines Ther (2003) 1.04
Galleria mellonella as an infection model for Campylobacter jejuni virulence. J Med Microbiol (2011) 1.04
Molecular basis of toxicity of Clostridium perfringens epsilon toxin. FEBS J (2011) 1.02
CpG-DNA protects against a lethal orthopoxvirus infection in a murine model. Antiviral Res (2005) 1.02
The identification of surface proteins of Burkholderia pseudomallei. Vaccine (2006) 1.02
Administration of antibody to the lung protects mice against pneumonic plague. Infect Immun (2006) 1.02
Protective efficacy of heat-inactivated B. thailandensis, B. mallei or B. pseudomallei against experimental melioidosis and glanders. Vaccine (2009) 1.02
Structure of the food-poisoning Clostridium perfringens enterotoxin reveals similarity to the aerolysin-like pore-forming toxins. J Mol Biol (2011) 1.02
Lipopolysaccharide from Burkholderia thailandensis E264 provides protection in a murine model of melioidosis. Vaccine (2010) 1.01
A bacterial process for selenium nanosphere assembly. Proc Natl Acad Sci U S A (2011) 1.01
Progress toward development of vaccines against melioidosis: A review. Clin Ther (2010) 1.01
Structural relationships and cellular tropism of staphylococcal superantigen-like proteins. Infect Immun (2004) 1.01
The use of live attenuated bacteria as a delivery system for heterologous antigens. J Drug Target (2003) 1.01
Analysis of the human hephaestin gene and protein: comparative modelling of the N-terminus ecto-domain based upon ceruloplasmin. Protein Eng (2002) 1.00
Immunization against anthrax using Bacillus subtilis spores expressing the anthrax protective antigen. Vaccine (2006) 1.00
A dam mutant of Yersinia pestis is attenuated and induces protection against plague. FEMS Microbiol Lett (2005) 1.00
ATP-binding cassette systems in Burkholderia pseudomallei and Burkholderia mallei. BMC Genomics (2007) 1.00
Neutrophils are important in early control of lung infection by Yersinia pestis. Microbes Infect (2010) 0.99
Salmonella enterica serovar typhimurium expressing a chromosomally integrated copy of the Bacillus anthracis protective antigen gene protects mice against an anthrax spore challenge. Infect Immun (2003) 0.98
Age influences resistance of Caenorhabditis elegans to killing by pathogenic bacteria. FEMS Microbiol Lett (2004) 0.97
Structural analysis of human FANCL, the E3 ligase in the Fanconi anemia pathway. J Biol Chem (2011) 0.97
A 55 kDa hypothetical membrane protein is an iron-regulated virulence factor of Francisella tularensis subsp. novicida U112. J Med Microbiol (2007) 0.97
Structures of OppA and PstS from Yersinia pestis indicate variability of interactions with transmembrane domains. Acta Crystallogr D Biol Crystallogr (2007) 0.96