Published in Am J Hum Genet on August 12, 2011
Sequence kernel association tests for the combined effect of rare and common variants. Am J Hum Genet (2013) 2.41
SNP set association analysis for familial data. Genet Epidemiol (2012) 2.08
Family-based association tests for sequence data, and comparisons with population-based association tests. Eur J Hum Genet (2013) 1.55
Challenges and opportunities in genome-wide environmental interaction (GWEI) studies. Hum Genet (2012) 1.37
Multivariate phenotype association analysis by marker-set kernel machine regression. Genet Epidemiol (2012) 1.29
Gene-based testing of interactions in association studies of quantitative traits. PLoS Genet (2013) 1.23
Scan-statistic approach identifies clusters of rare disease variants in LRP2, a gene linked and associated with autism spectrum disorders, in three datasets. Am J Hum Genet (2012) 1.23
Quantitative trait analysis in sequencing studies under trait-dependent sampling. Proc Natl Acad Sci U S A (2013) 1.21
Test for interactions between a genetic marker set and environment in generalized linear models. Biostatistics (2013) 1.20
GEE-based SNP set association test for continuous and discrete traits in family-based association studies. Genet Epidemiol (2013) 1.14
Haplotype-based methods for detecting uncommon causal variants with common SNPs. Genet Epidemiol (2012) 1.04
SBERIA: set-based gene-environment interaction test for rare and common variants in complex diseases. Genet Epidemiol (2013) 0.99
Beyond the fourth wave of genome-wide obesity association studies. Nutr Diabetes (2012) 0.98
Gene-environment interactions in genome-wide association studies: current approaches and new directions. J Child Psychol Psychiatry (2013) 0.93
A Powerful Pathway-Based Adaptive Test for Genetic Association with Common or Rare Variants. Am J Hum Genet (2015) 0.90
Powerful and Adaptive Testing for Multi-trait and Multi-SNP Associations with GWAS and Sequencing Data. Genetics (2016) 0.90
A generalized genetic random field method for the genetic association analysis of sequencing data. Genet Epidemiol (2014) 0.88
Correcting systematic inflation in genetic association tests that consider interaction effects: application to a genome-wide association study of posttraumatic stress disorder. JAMA Psychiatry (2014) 0.88
Using Hamming Distance as Information for SNP-Sets Clustering and Testing in Disease Association Studies. PLoS One (2015) 0.88
On the Aggregation of Multimarker Information for Marker-Set and Sequencing Data Analysis: Genotype Collapsing vs. Similarity Collapsing. Front Genet (2012) 0.86
Comparison of statistical tests for association between rare variants and binary traits. PLoS One (2012) 0.86
The value of statistical or bioinformatics annotation for rare variant association with quantitative trait. Genet Epidemiol (2013) 0.84
FVGWAS: Fast voxelwise genome wide association analysis of large-scale imaging genetic data. Neuroimage (2015) 0.83
U-statistics in genetic association studies. Hum Genet (2012) 0.82
Complete effect-profile assessment in association studies with multiple genetic and multiple environmental factors. Genet Epidemiol (2014) 0.82
Multiple SNP Set Analysis for Genome-Wide Association Studies Through Bayesian Latent Variable Selection. Genet Epidemiol (2015) 0.80
Analysis of gene-gene interactions using gene-trait similarity regression. Hum Hered (2014) 0.80
Powerful Set-Based Gene-Environment Interaction Testing Framework for Complex Diseases. Genet Epidemiol (2015) 0.79
Assessing gene-environment interactions for common and rare variants with binary traits using gene-trait similarity regression. Genetics (2015) 0.79
Similarity-based multimarker association tests for continuous traits. Ann Hum Genet (2012) 0.79
Rare Variants Association Analysis in Large-Scale Sequencing Studies at the Single Locus Level. PLoS Comput Biol (2016) 0.78
Incorporating gene-environment interaction in testing for association with rare genetic variants. Hum Hered (2014) 0.78
A New Method for Detecting Associations with Rare Copy-Number Variants. PLoS Genet (2015) 0.78
Approximate score-based testing with application to multivariate trait association analysis. Genet Epidemiol (2015) 0.77
Module-based association analysis for omics data with network structure. PLoS One (2015) 0.77
GENE-LEVEL PHARMACOGENETIC ANALYSIS ON SURVIVAL OUTCOMES USING GENE-TRAIT SIMILARITY REGRESSION. Ann Appl Stat (2014) 0.76
A Fast Multiple-Kernel Method With Applications to Detect Gene-Environment Interaction. Genet Epidemiol (2015) 0.76
Kernel Approach for Modeling Interaction Effects in Genetic Association Studies of Complex Quantitative Traits. Genet Epidemiol (2015) 0.75
A unified powerful set-based test for sequencing data analysis of GxE interactions. Biostatistics (2016) 0.75
Some surprising twists on the road to discovering the contribution of rare variants to complex diseases. Hum Hered (2013) 0.75
Joint genetic analysis using variant sets reveals polygenic gene-context interactions. PLoS Genet (2017) 0.75
Powerful Genetic Association Analysis for Common or Rare Variants with High Dimensional Structured Traits. Genetics (2017) 0.75
Genome-wide association studies for common diseases and complex traits. Nat Rev Genet (2005) 33.96
Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data. Am J Hum Genet (2008) 26.79
Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet (2001) 22.07
A groupwise association test for rare mutations using a weighted sum statistic. PLoS Genet (2009) 19.64
Pooled association tests for rare variants in exon-resequencing studies. Am J Hum Genet (2010) 13.18
A global test for groups of genes: testing association with a clinical outcome. Bioinformatics (2004) 10.82
Testing for an unusual distribution of rare variants. PLoS Genet (2011) 9.28
Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humans. Hum Mol Genet (2002) 9.18
A strategy to discover genes that carry multi-allelic or mono-allelic risk for common diseases: a cohort allelic sums test (CAST). Mutat Res (2006) 7.89
Haplotype sharing analysis using mantel statistics. Hum Hered (2005) 6.76
Powerful SNP-set analysis for case-control genome-wide association studies. Am J Hum Genet (2010) 6.60
Gene--environment-wide association studies: emerging approaches. Nat Rev Genet (2010) 6.10
Exploiting gene-environment interaction to detect genetic associations. Hum Hered (2007) 5.63
Estimation and tests of haplotype-environment interaction when linkage phase is ambiguous. Hum Hered (2003) 5.06
A powerful and flexible multilocus association test for quantitative traits. Am J Hum Genet (2008) 4.96
Testing association between disease and multiple SNPs in a candidate gene. Genet Epidemiol (2007) 4.50
Powerful multilocus tests of genetic association in the presence of gene-gene and gene-environment interactions. Am J Hum Genet (2006) 4.40
Generalized genomic distance-based regression methodology for multilocus association analysis. Am J Hum Genet (2006) 3.79
Hypothesis testing in semiparametric additive mixed models. Biostatistics (2003) 3.63
Improved power by use of a weighted score test for linkage disequilibrium mapping. Am J Hum Genet (2006) 3.36
On multiple-testing correction in genome-wide association studies. Genet Epidemiol (2008) 3.19
On the identification of disease mutations by the analysis of haplotype similarity and goodness of fit. Am J Hum Genet (2003) 3.16
Haplotype-based association analysis via variance-components score test. Am J Hum Genet (2007) 2.93
A principal components regression approach to multilocus genetic association studies. Genet Epidemiol (2008) 2.89
Nonparametric tests of association of multiple genes with human disease. Am J Hum Genet (2005) 2.87
Analysis of multiple SNPs in a candidate gene or region. Genet Epidemiol (2008) 2.40
Association tests using kernel-based measures of multi-locus genotype similarity between individuals. Genet Epidemiol (2010) 2.39
The design of case-control studies: the influence of confounding and interaction effects. Int J Epidemiol (1984) 2.35
Genomic similarity and kernel methods I: advancements by building on mathematical and statistical foundations. Hum Hered (2010) 2.01
Methods for investigating gene-environment interactions in candidate pathway and genome-wide association studies. Annu Rev Public Health (2010) 1.88
Gene-environment interactions for complex traits: definitions, methodological requirements and challenges. Eur J Hum Genet (2008) 1.82
Self-contained gene-set analysis of expression data: an evaluation of existing and novel methods. PLoS One (2010) 1.67
Genomic similarity and kernel methods II: methods for genomic information. Hum Hered (2010) 1.58
U-statistics-based tests for multiple genes in genetic association studies. Ann Hum Genet (2008) 1.53
Comparisons of multi-marker association methods to detect association between a candidate region and disease. Genet Epidemiol (2010) 1.50
An entropy-based statistic for genomewide association studies. Am J Hum Genet (2005) 1.47
ATOM: a powerful gene-based association test by combining optimally weighted markers. Bioinformatics (2008) 1.44
Gene-trait similarity regression for multimarker-based association analysis. Biometrics (2009) 1.44
Genome scan of complex traits by haplotype sharing correlation. Genet Epidemiol (2001) 1.39
Gene, region and pathway level analyses in whole-genome studies. Genet Epidemiol (2010) 1.36
The impact of gene-environment dependence and misclassification in genetic association studies incorporating gene-environment interactions. Hum Hered (2009) 1.27
Group additive regression models for genomic data analysis. Biostatistics (2007) 1.13
Transcobalamin 2 variant associated with poststroke homocysteine modifies recurrent stroke risk. Neurology (2011) 0.94
A 31 bp VNTR in the cystathionine beta-synthase (CBS) gene is associated with reduced CBS activity and elevated post-load homocysteine levels. Eur J Hum Genet (2001) 0.94
Relation between plasma homocysteine concentration, the 844ins68 variant of the cystathionine beta-synthase gene, and pyridoxal-5'-phosphate concentration. Mol Genet Metab (1999) 0.90
Association of a 31 bp VNTR in the CBS gene with postload homocysteine concentrations in the Framingham Offspring Study. Eur J Hum Genet (2006) 0.80
Finding the missing heritability of complex diseases. Nature (2009) 67.95
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature (2009) 33.26
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (2007) 32.97
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Cumulative association of five genetic variants with prostate cancer. N Engl J Med (2008) 15.34
New models of collaboration in genome-wide association studies: the Genetic Association Information Network. Nat Genet (2007) 13.76
Five years of GWAS discovery. Am J Hum Genet (2012) 12.97
Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet (2009) 12.96
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet (2008) 12.32
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet (2008) 12.07
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89
Transcriptome and genome sequencing uncovers functional variation in humans. Nature (2013) 8.89
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet (2009) 7.65
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet (2013) 7.44
Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One (2008) 7.16
Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat Genet (2012) 6.97
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N Engl J Med (2014) 6.89
A common variant of HMGA2 is associated with adult and childhood height in the general population. Nat Genet (2007) 6.87
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet (2010) 6.49
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet (2009) 6.39
A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry (2012) 6.34
The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet (2012) 6.15
Microduplications of 16p11.2 are associated with schizophrenia. Nat Genet (2009) 6.13
Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med (2014) 6.12
The architecture of gene regulatory variation across multiple human tissues: the MuTHER study. PLoS Genet (2011) 5.95
Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular Health Study. Circulation (2007) 5.87
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. Nat Genet (2012) 5.78
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet (2011) 5.56
Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat Genet (2012) 5.55
eVOC: a controlled vocabulary for unifying gene expression data. Genome Res (2003) 5.41
Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA (2009) 5.32
Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc Natl Acad Sci U S A (2006) 5.19
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet (2009) 4.97
Assessment of cumulative evidence on genetic associations: interim guidelines. Int J Epidemiol (2007) 4.96
Genomic inflation factors under polygenic inheritance. Eur J Hum Genet (2011) 4.89
A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet (2008) 4.75
Genomewide association studies: history, rationale, and prospects for psychiatric disorders. Am J Psychiatry (2009) 4.74
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
Early-onset stroke and vasculopathy associated with mutations in ADA2. N Engl J Med (2014) 4.70
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet (2009) 4.61
Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes (2008) 4.57
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet (2011) 4.50
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet (2010) 4.42
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Modeling and E-M estimation of haplotype-specific relative risks from genotype data for a case-control study of unrelated individuals. Hum Hered (2003) 4.34
Association between two unlinked loci at 8q24 and prostate cancer risk among European Americans. J Natl Cancer Inst (2007) 4.24
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Exome sequencing and the genetic basis of complex traits. Nat Genet (2012) 4.11
Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat Genet (2012) 4.08
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population. PLoS Genet (2012) 4.05
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Lancet Neurol (2012) 3.93
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med (2016) 3.88
Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet (2013) 3.87
Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes. Diabetes (2007) 3.84
Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk. Diabetes (2006) 3.79
Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes (2008) 3.76
Combining information from common type 2 diabetes risk polymorphisms improves disease prediction. PLoS Med (2006) 3.75
Genetic loci influencing kidney function and chronic kidney disease. Nat Genet (2010) 3.75
Common variants in WFS1 confer risk of type 2 diabetes. Nat Genet (2007) 3.58
No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians. Diabetes (2006) 3.58
The Swedish Twin Registry in the third millennium: an update. Twin Res Hum Genet (2006) 3.58
Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate. Diabetes (2006) 3.51
Discovery and statistical genotyping of copy-number variation from whole-exome sequencing depth. Am J Hum Genet (2012) 3.50
Regulation of Fto/Ftm gene expression in mice and humans. Am J Physiol Regul Integr Comp Physiol (2008) 3.49
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat Genet (2011) 3.46
What makes a good genetic association study? Lancet (2005) 3.46
Optimal two-stage genotyping designs for genome-wide association scans. Genet Epidemiol (2006) 3.41
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. Nat Genet (2012) 3.40
Betting odds and genetic associations. J Natl Cancer Inst (2004) 3.39
Type 2 diabetes: new genes, new understanding. Trends Genet (2008) 3.35
Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21. Hum Mol Genet (2010) 3.34
Bayesian refinement of association signals for 14 loci in 3 common diseases. Nat Genet (2012) 3.31
Variation of breast cancer risk among BRCA1/2 carriers. JAMA (2008) 3.30
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. PLoS Genet (2010) 3.21
Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes. Nat Genet (2011) 3.20