Published in Development on December 01, 2002
Planar cell polarity signaling: from fly development to human disease. Annu Rev Genet (2008) 3.43
PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature. Genes Dev (2005) 3.29
The Wnt signaling pathway and its role in tumor development. J Cancer Res Clin Oncol (2003) 3.06
Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development (2006) 2.96
DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. Cancer Cell (2008) 2.46
Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure. Development (2007) 2.45
Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway. Nat Genet (2005) 2.36
Can we safely target the WNT pathway? Nat Rev Drug Discov (2014) 2.31
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. PLoS Genet (2008) 2.29
Gene targeting reveals a widespread role for the high-mobility-group transcription factor Sox11 in tissue remodeling. Mol Cell Biol (2004) 2.23
Model systems for the study of heart development and disease. Cardiac neural crest and conotruncal malformations. Semin Cell Dev Biol (2006) 2.03
Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia. Genes Dev (2011) 1.94
Genetic interaction between members of the Vangl family causes neural tube defects in mice. Proc Natl Acad Sci U S A (2008) 1.90
The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development. Nat Cell Biol (2009) 1.90
Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction. J Cell Biol (2008) 1.89
Planar polarization of node cells determines the rotational axis of node cilia. Nat Cell Biol (2010) 1.83
Aberrant regulation of planar cell polarity in polycystic kidney disease. J Am Soc Nephrol (2010) 1.81
Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure. Nat Cell Biol (2009) 1.80
The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex. PLoS Genet (2008) 1.80
Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation. J Clin Invest (2008) 1.76
Neural tube defects. Annu Rev Neurosci (2014) 1.69
Regulation of convergence and extension movements during vertebrate gastrulation by the Wnt/PCP pathway. Semin Cell Dev Biol (2009) 1.68
Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3. Cell Signal (2007) 1.55
Wnt signaling in development and disease. Neurobiol Dis (2009) 1.51
Morphogenesis of the node and notochord: the cellular basis for the establishment and maintenance of left-right asymmetry in the mouse. Dev Dyn (2008) 1.50
Protein kinase CK2 in health and disease: CK2 and its role in Wnt and NF-kappaB signaling: linking development and cancer. Cell Mol Life Sci (2009) 1.50
Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and Xenopus embryogenesis. PLoS One (2010) 1.49
Epicardial-myocardial signaling directing coronary vasculogenesis. Circ Res (2010) 1.46
Cilia in the nervous system: linking cilia function and neurodevelopmental disorders. Curr Opin Neurol (2011) 1.43
Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development. Dev Cell (2010) 1.33
Dynamic imaging of mammalian neural tube closure. Dev Biol (2010) 1.29
Non-canonical Wnt signaling through Wnt5a/b and a novel Wnt11 gene, Wnt11b, regulates cell migration during avian gastrulation. Dev Biol (2008) 1.28
Epidermal wound repair is regulated by the planar cell polarity signaling pathway. Dev Cell (2010) 1.25
Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis. Development (2011) 1.24
Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6. Proc Natl Acad Sci U S A (2005) 1.23
The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo. Mol Biol Cell (2008) 1.23
Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways. Hum Mol Genet (2009) 1.22
Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo. Mol Cell Biol (2005) 1.21
A role for planar cell polarity signaling in angiogenesis. Angiogenesis (2008) 1.18
Wnt signaling mediates pathological vascular growth in proliferative retinopathy. Circulation (2011) 1.18
Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled activity and leads to posterior malformation in mice. J Biol Chem (2010) 1.17
Functional interactions between Fat family cadherins in tissue morphogenesis and planar polarity. Development (2012) 1.17
Functional studies of signaling pathways in peri-implantation development of the mouse embryo by RNAi. BMC Dev Biol (2005) 1.16
The relationship between sonic Hedgehog signaling, cilia, and neural tube defects. Birth Defects Res A Clin Mol Teratol (2010) 1.16
Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin. PLoS Genet (2009) 1.16
Non-canonical Wnt signaling regulates cell polarity in female reproductive tract development via van gogh-like 2. Development (2009) 1.14
Mechanistic insights into folate supplementation from Crooked tail and other NTD-prone mutant mice. Birth Defects Res A Clin Mol Teratol (2009) 1.14
Gene targeting of CK2 catalytic subunits. Mol Cell Biochem (2008) 1.12
Distinct apical and basolateral mechanisms drive planar cell polarity-dependent convergent extension of the mouse neural plate. Dev Cell (2014) 1.12
Shaping the nervous system: role of the core planar cell polarity genes. Nat Rev Neurosci (2013) 1.11
Planar cell polarity signaling: coordination of cellular orientation across tissues. Wiley Interdiscip Rev Dev Biol (2013) 1.11
Alternative Wnt pathways and receptors. Cold Spring Harb Perspect Biol (2012) 1.09
Importance of myocyte-nonmyocyte interactions in cardiac development and disease. Circ Res (2012) 1.07
Dvl2 promotes intestinal length and neoplasia in the ApcMin mouse model for colorectal cancer. Cancer Res (2010) 1.07
The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear. BMC Dev Biol (2010) 1.06
Abelson family kinases regulate Frizzled planar cell polarity signaling via Dsh phosphorylation. Genes Dev (2010) 1.06
Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies. Hum Mol Genet (2012) 1.00
The mouse Wnt/PCP protein Vangl2 is necessary for migration of facial branchiomotor neurons, and functions independently of Dishevelled. Dev Biol (2012) 1.00
Wnt signaling in vertebrate neural development and function. J Neuroimmune Pharmacol (2012) 1.00
Wnt to build a tube: contributions of Wnt signaling to epithelial tubulogenesis. Dev Dyn (2010) 1.00
Loss of Dishevelleds disrupts planar polarity in ependymal motile cilia and results in hydrocephalus. Neuron (2014) 0.99
A 3.7 Mb deletion encompassing ZEB2 causes a novel polled and multisystemic syndrome in the progeny of a somatic mosaic bull. PLoS One (2012) 0.98
Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance. Genes Dis (2016) 0.97
Disheveled mediated planar cell polarity signaling is required in the second heart field lineage for outflow tract morphogenesis. Dev Biol (2012) 0.96
Metastasis-associated kinase modulates Wnt signaling to regulate brain patterning and morphogenesis. Development (2006) 0.96
Wnt-dependent assembly of supermolecular Dishevelled-3-based complexes. J Cell Sci (2010) 0.96
The PCP effector Fuzzy controls cilial assembly and signaling by recruiting Rab8 and Dishevelled to the primary cilium. Mol Biol Cell (2013) 0.95
A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice. Bone Res (2013) 0.94
Prenatal β-catenin/Brn2/Tbr2 transcriptional cascade regulates adult social and stereotypic behaviors. Mol Psychiatry (2016) 0.94
A genome-wide screen reveals a role for microRNA-1 in modulating cardiac cell polarity. Dev Cell (2011) 0.93
Mouse models for dissecting vertebrate planar cell polarity signaling in the inner ear. Brain Res (2009) 0.92
Current perspectives on the genetic causes of neural tube defects. Neurogenetics (2006) 0.92
Expression of canonical WNT/β-CATENIN signaling components in the developing human lung. BMC Dev Biol (2012) 0.92
Diversification of the expression patterns and developmental functions of the dishevelled gene family during chordate evolution. Dev Dyn (2009) 0.92
Planar cell polarity signaling in collective cell movements during morphogenesis and disease. Curr Genomics (2012) 0.91
Dosage changes of a segment at 17p13.1 lead to intellectual disability and microcephaly as a result of complex genetic interaction of multiple genes. Am J Hum Genet (2014) 0.90
Superoxide Dismutase 1 In Vivo Ameliorates Maternal Diabetes Mellitus-Induced Apoptosis and Heart Defects Through Restoration of Impaired Wnt Signaling. Circ Cardiovasc Genet (2015) 0.90
Planar polarity: A new player in both lung development and disease. Organogenesis (2011) 0.90
IQGAP1 functions as a modulator of dishevelled nuclear localization in Wnt signaling. PLoS One (2013) 0.89
Roles of planar cell polarity pathways in the development of neural [correction of neutral] tube defects. J Biomed Sci (2011) 0.88
Genetic interactions between planar cell polarity genes cause diverse neural tube defects in mice. Dis Model Mech (2014) 0.88
The importance of Wnt signaling in cardiovascular development. Pediatr Cardiol (2009) 0.88
Vangl-dependent planar cell polarity signalling is not required for neural crest migration in mammals. Development (2014) 0.87
β-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation. Development (2013) 0.87
The mouse notches up another success: understanding the causes of human vertebral malformation. Mamm Genome (2011) 0.86
Genetic analysis of disheveled 2 and disheveled 3 in human neural tube defects. J Mol Neurosci (2012) 0.86
Modulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1. PLoS One (2009) 0.85
LRP6 exerts non-canonical effects on Wnt signaling during neural tube closure. Hum Mol Genet (2013) 0.84
Copy number variation analysis implicates the cell polarity gene glypican 5 as a human spina bifida candidate gene. Hum Mol Genet (2012) 0.84
Vangl2-regulated polarisation of second heart field-derived cells is required for outflow tract lengthening during cardiac development. PLoS Genet (2014) 0.84
Planar cell polarity pathway genes and risk for spina bifida. Am J Med Genet A (2010) 0.83
Origin and evolution of dishevelled. G3 (Bethesda) (2013) 0.83
Loss of Wnt5a disrupts second heart field cell deployment and may contribute to OFT malformations in DiGeorge syndrome. Hum Mol Genet (2014) 0.83
Mutations in DVL1 cause an osteosclerotic form of Robinow syndrome. Am J Hum Genet (2015) 0.82
Testin interacts with vangl2 genetically to regulate inner ear sensory cell orientation and the normal development of the female reproductive tract in mice. Dev Dyn (2013) 0.82
Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia. Cell Death Differ (2012) 0.81
The cellular story of dishevelleds. Croat Med J (2014) 0.81
Planar cell polarity signaling pathway in congenital heart diseases. J Biomed Biotechnol (2011) 0.80
Null and hypomorph Prickle1 alleles in mice phenocopy human Robinow syndrome and disrupt signaling downstream of Wnt5a. Biol Open (2014) 0.80
The involvement of PCP proteins in radial cell intercalations during Xenopus embryonic development. Dev Biol (2015) 0.80
IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med (2005) 12.07
MicroRNA-133 controls cardiac hypertrophy. Nat Med (2007) 11.68
Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature (2005) 9.44
Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell (2006) 7.21
Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature (2008) 7.03
Marked differences in differentiation propensity among human embryonic stem cell lines. Nat Biotechnol (2008) 6.19
JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab (2007) 5.38
The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell (2002) 4.72
Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages. Nature (2009) 4.68
Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature (2006) 4.35
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol (2003) 4.25
An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene. Nature (2003) 3.90
An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell (2007) 3.74
Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511. Nat Biotechnol (2010) 3.70
Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat Med (2004) 3.63
Fibulin-5/DANCE is essential for elastogenesis in vivo. Nature (2002) 3.60
The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell (2007) 3.54
Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development. Cell (2002) 3.37
ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med (2002) 3.36
Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions. Development (2007) 3.28
Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation. Proc Natl Acad Sci U S A (2005) 3.13
Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice. Proc Natl Acad Sci U S A (2002) 3.13
Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2. EMBO J (2003) 3.02
Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration. J Cell Biol (2004) 3.01
LRP4 serves as a coreceptor of agrin. Neuron (2008) 2.98
The neuregulin-1 receptor erbB4 controls glutamatergic synapse maturation and plasticity. Neuron (2007) 2.96
Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development (2006) 2.96
Neuregulin-1 enhances depolarization-induced GABA release. Neuron (2007) 2.89
Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development. Nat Neurosci (2004) 2.81
Lives of a heart cell: tracing the origins of cardiac progenitors. Cell Stem Cell (2008) 2.68
Neuroepithelial stem cell proliferation requires LIS1 for precise spindle orientation and symmetric division. Cell (2008) 2.68
To build a synapse: signaling pathways in neuromuscular junction assembly. Development (2010) 2.65
Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins. Proc Natl Acad Sci U S A (2007) 2.65
Generation of functional ventricular heart muscle from mouse ventricular progenitor cells. Science (2009) 2.60
Origins and fates of cardiovascular progenitor cells. Cell (2008) 2.55
BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development (2004) 2.50
Life is a journey: a genetic look at neocortical development. Nat Rev Genet (2002) 2.46
Identification of cardiac-specific myosin light chain kinase. Circ Res (2008) 2.45
Islet1 cardiovascular progenitors: a single source for heart lineages? Development (2008) 2.39
Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery. Nat Med (2002) 2.37
Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway. Nat Genet (2005) 2.36
Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy. Proc Natl Acad Sci U S A (2002) 2.32
A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts. Biotechniques (2009) 2.30
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. PLoS Genet (2008) 2.29
14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. Nat Genet (2003) 2.27
Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. Mol Cell Biol (2004) 2.12
Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nat Biotechnol (2013) 2.11
Retrograde regulation of motoneuron differentiation by muscle beta-catenin. Nat Neurosci (2008) 2.07
The in vivo degradation, absorption and excretion of PCL-based implant. Biomaterials (2005) 2.01
Focal adhesion kinase in netrin-1 signaling. Nat Neurosci (2004) 1.99
Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons. Proc Natl Acad Sci U S A (2009) 1.98
Neogenin regulation of BMP-induced canonical Smad signaling and endochondral bone formation. Dev Cell (2010) 1.97
Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1. Neuron (2002) 1.96
p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload. Mol Cell Biol (2004) 1.95
Doublecortin is required in mice for lamination of the hippocampus but not the neocortex. J Neurosci (2002) 1.94
Regeneration next: toward heart stem cell therapeutics. Cell Stem Cell (2009) 1.92
N-glycolylneuraminic acid deficiency in mice: implications for human biology and evolution. Mol Cell Biol (2007) 1.87
Mouse PeP: a novel peroxisomal protein linked to myoblast differentiation and development. Dev Dyn (2002) 1.87
Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4. J Biol Chem (2001) 1.87
Immunoglobulin class switch recombination is impaired in Atm-deficient mice. J Exp Med (2004) 1.87
Cardiac muscle regeneration: lessons from development. Genes Dev (2011) 1.86
Planar polarization of node cells determines the rotational axis of node cilia. Nat Cell Biol (2010) 1.83
Multiple dose-dependent effects of Lis1 on cerebral cortical development. J Neurosci (2003) 1.81
Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy. J Am Coll Cardiol (2004) 1.79
Stem cells: lost in translation. Nature (2004) 1.79
Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis. J Clin Invest (2004) 1.79
Towards regenerative therapy for cardiac disease. Lancet (2012) 1.75
Phosphatidylinositol transfer protein-alpha in netrin-1-induced PLC signalling and neurite outgrowth. Nat Cell Biol (2005) 1.74
Reversal of behavioral deficits and synaptic dysfunction in mice overexpressing neuregulin 1. Neuron (2013) 1.73
Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice. Nat Immunol (2002) 1.73
Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene. J Mol Cell Cardiol (2009) 1.72
Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons. J Neurosci (2011) 1.72
Epicardium-derived progenitor cells require beta-catenin for coronary artery formation. Proc Natl Acad Sci U S A (2007) 1.72
LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein. EMBO J (2008) 1.72
Complete loss of Ndel1 results in neuronal migration defects and early embryonic lethality. Mol Cell Biol (2005) 1.71
Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies. Biochem Biophys Res Commun (2004) 1.69
NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment. Mol Cell Biol (2006) 1.69
Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor. J Biol Chem (2003) 1.68
The effect of bioengineered acellular collagen patch on cardiac remodeling and ventricular function post myocardial infarction. Biomaterials (2013) 1.68
Regulated subset of G1 growth-control genes in response to derepression by the Wnt pathway. Proc Natl Acad Sci U S A (2003) 1.68
T-cadherin is critical for adiponectin-mediated cardioprotection in mice. J Clin Invest (2010) 1.66
Targeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities of mesoendodermal derivatives prior to early embryonic lethality. Mol Cell Biol (2002) 1.66
Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis. Blood (2010) 1.63
APJ acts as a dual receptor in cardiac hypertrophy. Nature (2012) 1.62
Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3. Am J Hum Genet (2003) 1.61
Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos. Nat Neurosci (2004) 1.61
Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo. J Cell Biol (2007) 1.60
ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation. Proc Natl Acad Sci U S A (2010) 1.59