Published in Proc Natl Acad Sci U S A on April 01, 1990
gamma-Glutamyl transpeptidase. What does the organization and expression of a multipromoter gene tell us about its functions? Am J Pathol (1995) 1.25
The hepoxilins and some analogues: a review of their biology. Br J Pharmacol (2009) 0.89
Mammalian soluble epoxide hydrolase is identical to liver hepoxilin hydrolase. J Lipid Res (2011) 0.87
Hepoxilin A3-specific binding in human neutrophils. Biochem J (1996) 0.84
Hepoxilin A3 is the endogenous lipid mediator opposing hypotonic swelling of intact human platelets. Proc Natl Acad Sci U S A (1993) 0.82
The Lipoxygenases: Their Regulation and Implication in Alzheimer's Disease. Neurochem Res (2015) 0.75
Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells. Nature (1987) 2.32
IDENTIFICATION OF A SMOOTH MUSCLE-STIMULATING FACTOR IN BOVINE BRAIN. PROSTAGLANDINS AND RELATED FACTORS 25. Biochim Biophys Acta (1964) 1.98
Eicosanoids: prostaglandins, thromboxanes, leukotrienes, and other derivatives of carbon-20 unsaturated fatty acids. J Neurochem (1982) 1.49
Arachidonic acid epoxides. Isolation and structure of two hydroxy epoxide intermediates in the formation of 8,11,12- and 10,11,12-trihydroxyeicosatrienoic acids. J Biol Chem (1983) 1.19
Leukotrienes in the rat central nervous system. Proc Natl Acad Sci U S A (1984) 1.10
Metabolites of arachidonic acid in the nervous system of Aplysia: possible mediators of synaptic modulation. J Neurosci (1987) 1.06
Hepoxilin A3 induces changes in cytosolic calcium, intracellular pH and membrane potential in human neutrophils. Biochem J (1990) 1.05
Arachidonic acid epoxides. Demonstration through [18O]oxygen studies of an intramolecular transfer of the terminal hydroxyl group of (12S)-hydroperoxyeicosa-5,8,10,14-tetraenoic acid to form hydroxyepoxides. J Biol Chem (1984) 1.04
Formation and action of 8-hydroxy-11,12-epoxy-5,9,14-icosatrienoic acid in Aplysia: a possible second messenger in neurons. Proc Natl Acad Sci U S A (1989) 1.03
Hepoxilin, a new family of insulin secretagogues formed by intact rat pancreatic islets. Prostaglandins Leukot Med (1984) 1.02
Transformation of leukotriene A4 methyl ester to leukotriene C4 monomethyl ester by cytosolic rat glutathione transferases. FEBS Lett (1984) 0.98
Purification of hepoxilin epoxide hydrolase from rat liver. J Biol Chem (1989) 0.96
Actions of arachidonic acid and hepoxilin A3 on mammalian hippocampal CA1 neurons. Brain Res (1989) 0.95
A mass fragmentographic procedure for the simultaneous determination of HETE and PGF2alpha in the central nervous system. Prostaglandins (1978) 0.94
Hemoglobin- and hemin-catalyzed transformation of 12L-hydroperoxy-5,8,10,14-eicosatetraenoic acid. Biochim Biophys Acta (1984) 0.94
Prostaglandin formation in the hypothalamus in vivo: effect of pyrogens. Am J Physiol (1989) 0.91
Isozyme specificity of rat liver glutathione S-transferases in the formation of PGF2 alpha and PGE2 from PGH2. Arch Biochem Biophys (1987) 0.88
Formation and metabolism of hepoxilin A3 by the rat brain. Biochem Biophys Res Commun (1988) 0.87
Hepoxilin A, hydroxyepoxide metabolite of arachidonic acid, stimulates transport of 45Ca across the guinea pig visceral yolk sac. Can J Physiol Pharmacol (1984) 0.86
PGF2 alpha, thromboxane B2 and HETE levels in gerbil brain cortex after ligation of common carotid arteries and decapitation. Prostaglandins (1979) 0.85
Specificity of the glutathione S-transferases in the conversion of leukotriene A4 to leukotriene C4. Arch Biochem Biophys (1987) 0.85
New products in the hepoxilin pathway: isolation of 11-glutathionyl hepoxilin A3 through reaction of hepoxilin A3 with glutathione S-transferase. Biochem Biophys Res Commun (1989) 0.81
Prostaglandin D2: a neuromodulator. Adv Prostaglandin Thromboxane Leukot Res (1983) 0.78
Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science (1995) 8.58
The Ikaros gene is required for the development of all lymphoid lineages. Cell (1994) 5.90
Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. Proc Natl Acad Sci U S A (1999) 5.08
Heat-inducible degron: a method for constructing temperature-sensitive mutants. Science (1994) 4.42
A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma. Cell (1995) 4.02
Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. N Engl J Med (1985) 4.00
Mapping point mutations in the Drosophila rosy locus using denaturing gradient gel blots. Genetics (1991) 3.66
Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. Biochem J (1998) 3.36
Local effects of synthetic leukotrienes (LTC4, LTD4, LTE4, and LTB4) in human skin. J Invest Dermatol (1983) 3.18
Slow reacting substances of anaphylaxis: identification of leukotrienes C-1 and D from human and rat sources. Proc Natl Acad Sci U S A (1980) 3.18
Rheology of the upper mantle: a synthesis. Science (1993) 3.00
Interleukin (IL)-10 inhibits nuclear factor kappa B (NF kappa B) activation in human monocytes. IL-10 and IL-4 suppress cytokine synthesis by different mechanisms. J Biol Chem (1995) 2.95
Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro. Proc Natl Acad Sci U S A (1980) 2.94
Preliminary epidemiological assessment of MERS-CoV outbreak in South Korea, May to June 2015. Euro Surveill (2015) 2.77
Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J (1997) 2.71
Identification of the C(6)-S-conjugate of leukotriene A with cysteine as a naturally occurring slow reacting substance of anaphylaxis (SRS-A). Importance of the 11-cis-geometry for biological activity. Biochem Biophys Res Commun (1980) 2.49
Nobel laureates' letter to President Bush. Washington Post (2001) 2.43
Structure of leukotriene C. Identification of the amino acid part. Biochem Biophys Res Commun (1979) 2.30
Efficacy and safety of statin treatment for cardiovascular disease: a network meta-analysis of 170,255 patients from 76 randomized trials. QJM (2010) 2.27
Proteasome inhibitors block development of Plasmodium spp. Antimicrob Agents Chemother (1998) 2.07
Leukotriene B4 action on endothelium mediates augmented neutrophil/endothelial adhesion. Proc Natl Acad Sci U S A (1984) 2.06
Reconstitution of mitogen-activated protein kinase phosphorylation cascades in bacteria. Efficient synthesis of active protein kinases. J Biol Chem (1997) 2.03
Nop2p is required for pre-rRNA processing and 60S ribosome subunit synthesis in yeast. Mol Cell Biol (1997) 2.02
Generation and metabolism of 5-lipoxygenase pathway leukotrienes by human eosinophils: predominant production of leukotriene C4. Proc Natl Acad Sci U S A (1983) 1.91
Bronchoconstrictor effects of leukotriene C in humans. Science (1982) 1.91
Triflimide activation of a chiral oxazaborolidine leads to a more general catalytic system for enantioselective Diels-Alder addition. J Am Chem Soc (2003) 1.89
Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin. J Biol Chem (1994) 1.78
Components of a Stat recognition code: evidence for two layers of molecular selectivity. Immunity (1995) 1.77
Novel acetoxylation and C-C coupling reactions at unactivated positions in alpha-amino acid derivatives. Org Lett (2006) 1.74
GLQ223: an inhibitor of human immunodeficiency virus replication in acutely and chronically infected cells of lymphocyte and mononuclear phagocyte lineage. Proc Natl Acad Sci U S A (1989) 1.73
Reversible cerebral atrophy in recently abstinent chronic alcoholics measured by computed tomography scans. Science (1978) 1.72
Effects of leukotriene D on the airways in asthma. N Engl J Med (1983) 1.69
Human infection with avian influenza A(H7N9) virus re-emerges in China in winter 2013. Euro Surveill (2013) 1.68
A soluble 2,3-oxidosqualene sterol cyclase. J Biol Chem (1967) 1.68
Docosahexaenoic acid is a strong inhibitor of prostaglandin but not leukotriene biosynthesis. Proc Natl Acad Sci U S A (1983) 1.67
IL-10 inhibits transcription of cytokine genes in human peripheral blood mononuclear cells. J Immunol (1994) 1.66
Movement disorders in alcoholism: a review. Neurology (1990) 1.65
Effects of exogenous arachidonic, eicosapentaenoic, and docosahexaenoic acids on the generation of 5-lipoxygenase pathway products by ionophore-activated human neutrophils. J Clin Invest (1984) 1.65
Synthesis and biological properties of a 9,11-azo-prostanoid: highly active biochemical mimic of prostaglandin endoperoxides. Proc Natl Acad Sci U S A (1975) 1.64
Requirements for interleukin-4-induced gene expression and functional characterization of Stat6. Mol Cell Biol (1996) 1.64
Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons. J Neurosci (1993) 1.63
Maternal smoking during pregnancy and smoking by adolescent daughters. Am J Public Health (1994) 1.62
Leukotriene A: stereochemistry and enzymatic conversion to leukotriene B. Biochem Biophys Res Commun (1980) 1.62
Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation. J Biol Chem (1998) 1.57
Characterization and biologic properties of 5,12-dihydroxy derivatives of eicosapentaenoic acid, including leukotriene B5 and the double lipoxygenase product. J Biol Chem (1984) 1.56
The complete unique long sequence and the overall genomic organization of the GA strain of Marek's disease virus. Proc Natl Acad Sci U S A (2000) 1.55
Gap junctions, synchrony and seizures. Trends Neurosci (2000) 1.54
Dihydrolipoamide dehydrogenase-binding protein of the human pyruvate dehydrogenase complex. DNA-derived amino acid sequence, expression, and reconstitution of the pyruvate dehydrogenase complex. J Biol Chem (1997) 1.52
The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse. J Immunol (1996) 1.51
A short synthetic route to (+)-austamide, (+)-deoxyisoaustamide, and (+)-hydratoaustamide from a common precursor by a novel palladium-mediated indole --> dihydroindoloazocine cyclization. J Am Chem Soc (2002) 1.51
Thyroid hormone regulates TRH biosynthesis in the paraventricular nucleus of the rat hypothalamus. Science (1987) 1.50
Modulation of gap junctional mechanisms during calcium-free induced field burst activity: a possible role for electrotonic coupling in epileptogenesis. J Neurosci (1994) 1.49
Computer-assisted design of complex organic syntheses. Science (1969) 1.48
Do cerebral potentials to magnetic stimulation of paraspinal muscles reflect changes in palpable muscle spasm, low back pain, and activity scores? J Manipulative Physiol Ther (2000) 1.46
Radioimmunoassay of the leukotrienes of slow reacting substance of anaphylaxis. Proc Natl Acad Sci U S A (1981) 1.45
The role of altered tissue osmolality on the characteristics and propagation of seizure activity in the intact isolated mouse hippocampus. Clin Neurophysiol (2009) 1.44
A beta-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line. Proc Natl Acad Sci U S A (1994) 1.39
Adrenal autotransplantation with attached blood vessels for treatment of Cushing's disease. J Urol (1989) 1.38
Chlamydia pneumoniae--a new causative agent of reactive arthritis and undifferentiated oligoarthritis. Ann Rheum Dis (1994) 1.37
Functional characterization of synthetic leukotriene B and its stereochemical isomers. J Exp Med (1981) 1.37
Treatment of primary peritoneal mesothelioma by continuous hyperthermic peritoneal perfusion (CHPP). Ann Surg Oncol (1999) 1.34
Selective, covalent modification of beta-tubulin residue Cys-239 by T138067, an antitumor agent with in vivo efficacy against multidrug-resistant tumors. Proc Natl Acad Sci U S A (1999) 1.33
Adeno-associated viral transfer of opioid receptor gene to primary sensory neurons: a strategy to increase opioid antinociception. Proc Natl Acad Sci U S A (2003) 1.32
Leukotriene E4-induced airway hyperresponsiveness of guinea pig tracheal smooth muscle to histamine and evidence for three separate sulfidopeptide leukotriene receptors. Proc Natl Acad Sci U S A (1984) 1.32
Biological laser printing: a novel technique for creating heterogeneous 3-dimensional cell patterns. Biomed Microdevices (2004) 1.31
Concise total syntheses of palominol, dolabellatrienone, beta-araneosene, and isoedunol via an enantioselective Diels-Alder macrobicyclization. J Am Chem Soc (2006) 1.30
Generation of leukotriene C4 from a subclass of mast cells differentiated in vitro from mouse bone marrow. Proc Natl Acad Sci U S A (1982) 1.30
Leukotriene A. Isolation from human polymorphonuclear leukocytes. J Biol Chem (1980) 1.28
Phantom limbs and related phenomena in recent traumatic amputations. Neurology (1978) 1.27
Crucial role of interleukin-10/interleukin-12 balance in the regulation of the type 2 T helper cytokine response in reactive arthritis. Arthritis Rheum (1997) 1.27
Leukotrienes C4, D4 and E4: effects on human and guinea-pig cardiac preparations in vitro. J Pharmacol Exp Ther (1982) 1.26
Total synthesis of (+/-)-pentacycloanammoxic acid. J Am Chem Soc (2004) 1.26
Glycylcyclines bind to the high-affinity tetracycline ribosomal binding site and evade Tet(M)- and Tet(O)-mediated ribosomal protection. Antimicrob Agents Chemother (1996) 1.25
A two-step total synthesis of the natural pentacycle trichodimerol, a novel inhibitor of TNF-alpha production. Org Lett (1999) 1.25
A new chiral Rh(II) catalyst for enantioselective [2 + 1]-cycloaddition. mechanistic implications and applications. J Am Chem Soc (2004) 1.25
Human skeletal muscle PDH kinase activity and isoform expression during a 3-day high-fat/low-carbohydrate diet. Am J Physiol Endocrinol Metab (2001) 1.25
A total synthesis of ( )-fumagillin. J Am Chem Soc (1972) 1.25
Phosphodiesterase 4B2 is the predominant phosphodiesterase species and undergoes differential regulation of gene expression in human monocytes and neutrophils. Mol Pharmacol (1999) 1.24
Stereocontrolled synthesis of dafachronic acid A, the ligand for the DAF-12 nuclear receptor of Caenorhabditis elegans. J Am Chem Soc (2007) 1.23
T cell cytokine pattern in the joints of patients with Lyme arthritis and its regulation by cytokines and anticytokines. Arthritis Rheum (1997) 1.23
A tetradentate ligand for the enantioselective Ti(IV)-promoted oxidation of sulfides to sulfoxides: origin of enantioselectivity. J Am Chem Soc (2012) 1.22
Interleukin-10 inhibits interleukin-8 production in human neutrophils. Blood (1994) 1.22
Oxidative inactivation of leukotriene C4 by stimulated human polymorphonuclear leukocytes. Proc Natl Acad Sci U S A (1982) 1.22
Bronchoconstrictor effects of leukotriene E4 in normal and asthmatic subjects. Am Rev Respir Dis (1987) 1.22
Mapping QTLs and candidate genes for rice root traits under different water-supply conditions and comparative analysis across three populations. Theor Appl Genet (2003) 1.21
Airway constriction in normal humans produced by inhalation of leukotriene D. Potency, time course, and effect of aspirin therapy. JAMA (1983) 1.21
Patch-clamp study of postnatal development of CA1 neurons in rat hippocampal slices: membrane excitability and K+ currents. J Neurophysiol (1992) 1.21
Cerebral atrophy and functional deficits in alcoholics without clinically apparent liver disease. Neurology (1981) 1.21
Immunologic and ionophore-induced generation of leukotriene B4 from mouse bone marrow-derived mast cells. J Immunol (1983) 1.21
Thyrotropin-releasing hormone precursor: characterization in rat brain. Science (1986) 1.20
Conversion of leukotriene D4 to leukotriene E4 by a dipeptidase released from the specific granule of human polymorphonuclear leucocytes. Immunology (1983) 1.20
Stereo-controlled synthesis of prostaglandins F-2a and E-2 (dl). J Am Chem Soc (1969) 1.19
Effects of leukotrienes C4 and D4 on glycoprotein and lysozyme secretion by human bronchial mucosa. Prostaglandins (1983) 1.19
Development of GABA-mediated, chloride-dependent inhibition in CA1 pyramidal neurones of immature rat hippocampal slices. J Physiol (1991) 1.19
Coupling potentials in CA1 neurons during calcium-free-induced field burst activity. J Neurosci (1995) 1.19
Surreptitious hepatitis C virus (HCV) infection detected in the majority of patients with cryptogenic chronic hepatitis and negative HCV antibody tests. J Infect Dis (1997) 1.19
Oxidative stress is involved in seizure-induced neurodegeneration in the kindling model of epilepsy. Neuroscience (2000) 1.19
An outbreak of scabies in a teaching hospital: lessons learned. Infect Control Hosp Epidemiol (2001) 1.19
A mild, catalytic, and highly selective method for the oxidation of alpha,beta-enones to 1,4-enediones. J Am Chem Soc (2003) 1.18
The mechanism of vascular leakage induced by leukotriene E4. Endothelial contraction. Am J Pathol (1987) 1.18