Nix is a selective autophagy receptor for mitochondrial clearance.

PubWeight™: 5.52‹?› | Rank: Top 1%

🔗 View Article (PMC 2816619)

Published in EMBO Rep on December 11, 2009

Authors

Ivana Novak1, Vladimir Kirkin, David G McEwan, Ji Zhang, Philipp Wild, Alexis Rozenknop, Vladimir Rogov, Frank Löhr, Doris Popovic, Angelo Occhipinti, Andreas S Reichert, Janos Terzic, Volker Dötsch, Paul A Ney, Ivan Dikic

Author Affiliations

1: Mediterranean Institute for Life Sciences, Mestrovicevo setaliste bb, HR-21000 Split, Croatia.

Articles citing this

(truncated to the top 100)

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Network organization of the human autophagy system. Nature (2010) 11.38

Autophagy and the integrated stress response. Mol Cell (2010) 11.21

Mechanisms of mitophagy. Nat Rev Mol Cell Biol (2011) 10.66

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy (2016) 7.05

Selective autophagy mediated by autophagic adapter proteins. Autophagy (2011) 6.88

Autophagy in mammalian development and differentiation. Nat Cell Biol (2010) 5.99

Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Science (2011) 5.46

Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res (2011) 5.40

Selective autophagy: ubiquitin-mediated recognition and beyond. Nat Cell Biol (2010) 3.74

Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science (2011) 3.74

LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis. EMBO J (2010) 3.68

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy (2010) 3.68

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem J (2012) 3.37

The machinery of macroautophagy. Cell Res (2013) 3.13

The autophagosome: origins unknown, biogenesis complex. Nat Rev Mol Cell Biol (2013) 3.04

Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming. J Biol Chem (2010) 2.93

Mitochondrial fission and remodelling contributes to muscle atrophy. EMBO J (2010) 2.74

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat Cell Biol (2012) 2.56

The pathways of mitophagy for quality control and clearance of mitochondria. Cell Death Differ (2012) 2.45

LC3C, bound selectively by a noncanonical LIR motif in NDP52, is required for antibacterial autophagy. Mol Cell (2012) 2.41

Cellular and molecular mechanisms of muscle atrophy. Dis Model Mech (2013) 2.40

Mitochondria and mitophagy: the yin and yang of cell death control. Circ Res (2012) 2.38

The Cvt pathway as a model for selective autophagy. FEBS Lett (2010) 2.26

Pex3-anchored Atg36 tags peroxisomes for degradation in Saccharomyces cerevisiae. EMBO J (2012) 2.23

Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease. Annu Rev Pathol (2012) 2.20

The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. Mol Cell (2010) 2.12

Ubiquitination and selective autophagy. Cell Death Differ (2012) 2.12

Mitochondrial dynamics and inheritance during cell division, development and disease. Nat Rev Mol Cell Biol (2014) 2.07

Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites. Nature (2013) 2.07

Atg8: an autophagy-related ubiquitin-like protein family. Genome Biol (2011) 2.04

Mitochondria removal by autophagy. Autophagy (2011) 2.04

Oxidative stress and autophagy: the clash between damage and metabolic needs. Cell Death Differ (2014) 2.00

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells. Nat Cell Biol (2013) 2.00

Parkin protein deficiency exacerbates cardiac injury and reduces survival following myocardial infarction. J Biol Chem (2012) 1.98

Mitophagy: mechanisms, pathophysiological roles, and analysis. Biol Chem (2012) 1.95

Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy. J Biol Chem (2012) 1.83

p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways. J Biol Chem (2011) 1.82

Selective degradation of p62 by autophagy. Semin Immunopathol (2010) 1.80

Protein breakdown in muscle wasting: role of autophagy-lysosome and ubiquitin-proteasome. Int J Biochem Cell Biol (2013) 1.73

Autophagy in health and disease. 5. Mitophagy as a way of life. Am J Physiol Cell Physiol (2010) 1.72

Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat Chem Biol (2013) 1.71

The multiple roles of autophagy in cancer. Carcinogenesis (2011) 1.63

Mitochondrial shape changes: orchestrating cell pathophysiology. EMBO Rep (2010) 1.61

ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs. J Biol Chem (2012) 1.59

When autophagy meets cancer through p62/SQSTM1. Am J Cancer Res (2012) 1.58

Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy. Proc Natl Acad Sci U S A (2010) 1.54

Contribution of impaired mitochondrial autophagy to cardiac aging: mechanisms and therapeutic opportunities. Circ Res (2012) 1.53

Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover. Cell Death Differ (2010) 1.53

Mitochondria and cell signalling. J Cell Sci (2012) 1.52

Aggrephagy: selective disposal of protein aggregates by macroautophagy. Int J Cell Biol (2012) 1.52

ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy. EMBO Rep (2014) 1.49

Receptor protein complexes are in control of autophagy. Autophagy (2012) 1.49

Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. Mol Cell Biol (2012) 1.48

Role of autophagy in cancer prevention. Cancer Prev Res (Phila) (2011) 1.43

The Three Musketeers of Autophagy: phosphorylation, ubiquitylation and acetylation. Trends Cell Biol (2011) 1.43

Bnip3-mediated mitochondrial autophagy is independent of the mitochondrial permeability transition pore. Autophagy (2010) 1.42

A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease. Hum Mol Genet (2010) 1.41

Plant NBR1 is a selective autophagy substrate and a functional hybrid of the mammalian autophagic adapters NBR1 and p62/SQSTM1. Autophagy (2011) 1.39

Self and nonself: how autophagy targets mitochondria and bacteria. Cell Host Microbe (2014) 1.36

Identification of an autophagy defect in smokers' alveolar macrophages. J Immunol (2010) 1.36

Functions of autophagy in hepatic and pancreatic physiology and disease. Gastroenterology (2011) 1.35

The complex interplay between autophagy, apoptosis, and necrotic signals promotes T-cell homeostasis. Immunol Rev (2010) 1.35

Mitophagy and Parkinson's disease: the PINK1-parkin link. Biochim Biophys Acta (2010) 1.34

Eating the strangers within: host control of intracellular bacteria via xenophagy. Cell Microbiol (2011) 1.34

Mitochondrial pruning by Nix and BNip3: an essential function for cardiac-expressed death factors. J Cardiovasc Transl Res (2010) 1.33

Dynamic regulation of macroautophagy by distinctive ubiquitin-like proteins. Nat Struct Mol Biol (2014) 1.31

Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates. J Cell Sci (2012) 1.30

Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis. J Biol Chem (2012) 1.29

Autophagy: regulation and role in development. Autophagy (2013) 1.28

Regulation and function of autophagy during cell survival and cell death. Cold Spring Harb Perspect Biol (2012) 1.25

Organellophagy: eliminating cellular building blocks via selective autophagy. J Cell Biol (2014) 1.25

Regulation of lipid droplets by autophagy. Trends Endocrinol Metab (2011) 1.23

Mitochondrial turnover in the heart. Biochim Biophys Acta (2010) 1.23

Mitochondria get a Parkin' ticket. Nat Cell Biol (2010) 1.22

NBR1-mediated selective autophagy targets insoluble ubiquitinated protein aggregates in plant stress responses. PLoS Genet (2013) 1.21

Autophagy-related protein 8 (Atg8) family interacting motif in Atg3 mediates the Atg3-Atg8 interaction and is crucial for the cytoplasm-to-vacuole targeting pathway. J Biol Chem (2010) 1.20

The mitochondrial dynamism-mitophagy-cell death interactome: multiple roles performed by members of a mitochondrial molecular ensemble. Circ Res (2014) 1.18

Lewy body-like α-synuclein aggregates resist degradation and impair macroautophagy. J Biol Chem (2013) 1.18

After the banquet: mitochondrial biogenesis, mitophagy, and cell survival. Autophagy (2013) 1.17

Parkin- and PINK1-Dependent Mitophagy in Neurons: Will the Real Pathway Please Stand Up? Front Neurol (2013) 1.17

Autophagy in cellular metabolism and cancer. J Clin Invest (2015) 1.17

The interplay between autophagy and ROS in tumorigenesis. Front Oncol (2012) 1.17

Normal and disordered reticulocyte maturation. Curr Opin Hematol (2011) 1.16

Autophagy: more than a nonselective pathway. Int J Cell Biol (2012) 1.13

Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death. Autophagy (2012) 1.13

A new type of compartment, defined by plant-specific Atg8-interacting proteins, is induced upon exposure of Arabidopsis plants to carbon starvation. Plant Cell (2012) 1.12

Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated Abeta in AD models. Hum Mol Genet (2011) 1.12

Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy. Proc Natl Acad Sci U S A (2013) 1.12

Exercise training-induced regulation of mitochondrial quality. Exerc Sport Sci Rev (2012) 1.11

Mitochondria autophagy in yeast. Antioxid Redox Signal (2011) 1.10

Mitochondrial dynamics and mitochondrial quality control. Redox Biol (2014) 1.09

Autophagy-related protein 32 acts as autophagic degron and directly initiates mitophagy. J Biol Chem (2012) 1.09

Starch-binding domain-containing protein 1 (Stbd1) and glycogen metabolism: Identification of the Atg8 family interacting motif (AIM) in Stbd1 required for interaction with GABARAPL1. Biochem Biophys Res Commun (2011) 1.08

Receptor-mediated mitophagy in yeast and mammalian systems. Cell Res (2014) 1.07

Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis. EMBO Rep (2015) 1.07

Molecular mechanisms of mitochondrial autophagy/mitophagy in the heart. Circ Res (2015) 1.06

Bnip3 as a dual regulator of mitochondrial turnover and cell death in the myocardium. Pediatr Cardiol (2011) 1.04

Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy. Redox Biol (2014) 1.04

Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy. Cell Mol Life Sci (2015) 1.03

Articles cited by this

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem (2007) 21.73

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol (2008) 17.81

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell (2007) 14.63

Autophagosome formation: core machinery and adaptations. Nat Cell Biol (2007) 13.59

Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat Rev Mol Cell Biol (2009) 9.32

A role for ubiquitin in selective autophagy. Mol Cell (2009) 8.43

Selective degradation of mitochondria by mitophagy. Arch Biochem Biophys (2007) 8.24

A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol Cell (2009) 6.88

Discovery of Atg5/Atg7-independent alternative macroautophagy. Nature (2009) 6.74

Essential role for Nix in autophagic maturation of erythroid cells. Nature (2008) 6.49

Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy. Dev Cell (2009) 5.85

Atg32 is a mitochondrial protein that confers selectivity during mitophagy. Dev Cell (2009) 5.77

Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation. Blood (2008) 5.43

NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc Natl Acad Sci U S A (2007) 5.14

The mitochondrial permeability transition initiates autophagy in rat hepatocytes. FASEB J (2001) 4.99

Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol Cell Biol (2009) 4.95

Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J Biol Chem (2009) 4.90

Structural basis for sorting mechanism of p62 in selective autophagy. J Biol Chem (2008) 4.20

The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division. J Cell Biol (2007) 3.83

Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling. PLoS One (2008) 3.59

Structural basis of target recognition by Atg8/LC3 during selective autophagy. Genes Cells (2008) 3.23

Role of BNIP3 and NIX in cell death, autophagy, and mitophagy. Cell Death Differ (2009) 2.93

Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species. J Cell Sci (2007) 2.84

Impairing the bioenergetic status and the biogenesis of mitochondria triggers mitophagy in yeast. Cell Death Differ (2005) 2.73

Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation. Blood (2009) 2.39

Role of ubiquitin- and Ubl-binding proteins in cell signaling. Curr Opin Cell Biol (2007) 2.30

Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis. J Cell Sci (2009) 1.92

Nix directly binds to GABARAP: a possible crosstalk between apoptosis and autophagy. Autophagy (2009) 1.90

A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration. Proc Natl Acad Sci U S A (2009) 1.74

Organelle degradation during the lens and erythroid differentiation is independent of autophagy. Biochem Biophys Res Commun (2005) 1.73

Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability. Oncogene (1999) 1.70

Unique dimeric structure of BNip3 transmembrane domain suggests membrane permeabilization as a cell death trigger. J Biol Chem (2007) 1.56

Accentuated response to phenylhydrazine and erythropoietin in mice genetically impaired for their GATA-1 expression (GATA-1(low) mice). Blood (2001) 1.51

Sequence dependence of BNIP3 transmembrane domain dimerization implicates side-chain hydrogen bonding and a tandem GxxxG motif in specific helix-helix interactions. J Mol Biol (2006) 1.27

Mitophagy in mammalian cells: the reticulocyte model. Methods Enzymol (2009) 1.06

Articles by these authors

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10

IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell (2009) 11.52

A role for ubiquitin in selective autophagy. Mol Cell (2009) 8.43

Genetics and beyond--the transcriptome of human monocytes and disease susceptibility. PLoS One (2010) 7.48

A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol Cell (2009) 6.88

Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series. EMBO Rep (2008) 6.21

Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation. Cell (2009) 5.76

Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Science (2005) 5.75

Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. J Neurosci (2007) 5.68

Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Science (2011) 5.46

Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation. Blood (2008) 5.43

Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation. Nat Cell Biol (2003) 5.43

NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc Natl Acad Sci U S A (2007) 5.14

New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet (2009) 5.12

Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature (2008) 4.76

Ubiquitylation and cell signaling. EMBO J (2005) 4.65

Reading protein modifications with interaction domains. Nat Rev Mol Cell Biol (2006) 4.55

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature (2011) 4.14

Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors. Nature (2002) 3.99

Specification of SUMO1- and SUMO2-interacting motifs. J Biol Chem (2006) 3.59

Statins alleviate experimental nerve injury-induced neuropathic pain. Pain (2011) 3.50

Distinct monoubiquitin signals in receptor endocytosis. Trends Biochem Sci (2003) 3.37

Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology. J Biol Chem (2006) 3.36

Targeting the ubiquitin system in cancer therapy. Nature (2009) 3.27

The Cbl interactome and its functions. Nat Rev Mol Cell Biol (2005) 3.27

Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors. Proc Natl Acad Sci U S A (2007) 3.20

Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction. Nature (2008) 3.11

Regulation of ubiquitin-binding proteins by monoubiquitination. Nat Cell Biol (2006) 2.99

Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs. Nat Neurosci (2002) 2.92

Ubiquitin and ubiquitin-like proteins in cancer pathogenesis. Nat Rev Cancer (2006) 2.90

E3-independent monoubiquitination of ubiquitin-binding proteins. Mol Cell (2007) 2.77

Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA. J Biol Chem (2003) 2.75

Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. J Biol Chem (2009) 2.64

Serial changes in highly sensitive troponin I assay and early diagnosis of myocardial infarction. JAMA (2011) 2.61

Ubiquitin-binding proteins: decoders of ubiquitin-mediated cellular functions. Annu Rev Biochem (2012) 2.53

A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature (2002) 2.50

Clinical, experimental, and genomic differences between intermediately pathogenic, highly pathogenic, and epidemic Streptococcus suis. J Infect Dis (2009) 2.49

Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation. Blood (2009) 2.39

Alternative topogenesis of Mgm1 and mitochondrial morphology depend on ATP and a functional import motor. J Cell Biol (2004) 2.36

Role of ubiquitin- and Ubl-binding proteins in cell signaling. Curr Opin Cell Biol (2007) 2.30

Post-translational modifications in signal integration. Nat Struct Mol Biol (2010) 2.23

GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein. Proc Natl Acad Sci U S A (2008) 2.17

The spatial and temporal organization of ubiquitin networks. Nat Rev Mol Cell Biol (2011) 2.15

NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets. Cell Cycle (2009) 2.12

Streptococcus suis sequence type 7 outbreak, Sichuan, China. Emerg Infect Dis (2006) 2.07

Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling. Nat Cell Biol (2011) 2.07

The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts. Nucleic Acids Res (2007) 2.07

Spatial organization of transmembrane receptor signalling. EMBO J (2010) 2.03

Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage. Mol Cell Biol (2006) 2.02

Flt3-dependent transformation by inactivating c-Cbl mutations in AML. Blood (2007) 1.99

Dynamic subcompartmentalization of the mitochondrial inner membrane. J Cell Biol (2006) 1.98

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proc Natl Acad Sci U S A (2012) 1.97

Fluorescence-based sensors to monitor localization and functions of linear and K63-linked ubiquitin chains in cells. Mol Cell (2012) 1.94

Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex. Cell Host Microbe (2012) 1.93

Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy. Mol Cell (2011) 1.91

Improvement of aspirin-intolerant asthma by montelukast, a leukotriene antagonist: a randomized, double-blind, placebo-controlled trial. Am J Respir Crit Care Med (2002) 1.90

Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing. Nat Methods (2013) 1.88

Low-conductivity buffers for high-sensitivity NMR measurements. J Am Chem Soc (2002) 1.88

OPA1 processing reconstituted in yeast depends on the subunit composition of the m-AAA protease in mitochondria. Mol Biol Cell (2007) 1.87

Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation. EMBO J (2008) 1.87

What determines the specificity and outcomes of ubiquitin signaling? Cell (2010) 1.84

Cristae formation-linking ultrastructure and function of mitochondria. Biochim Biophys Acta (2008) 1.84

Regulation of translesion synthesis DNA polymerase eta by monoubiquitination. Mol Cell (2010) 1.84

Selective autophagy in cancer development and therapy. Cancer Res (2010) 1.79

New confidence bounds for QT studies. Stat Med (2007) 1.78

PML/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia. Cancer Cell (2010) 1.75

The role of ubiquitylation in receptor endocytosis and endosomal sorting. J Cell Sci (2012) 1.73

A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism. Mol Cell Biol (2002) 1.73

Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration. PLoS One (2009) 1.71

Caspase-8 is involved in neovascularization-promoting progenitor cell functions. Arterioscler Thromb Vasc Biol (2009) 1.70

Structural basis for tail-anchored membrane protein biogenesis by the Get3-receptor complex. Science (2011) 1.68

Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex. Mol Cell Biol (2004) 1.67

Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A (2005) 1.67

Generation and physiological roles of linear ubiquitin chains. BMC Biol (2012) 1.66

Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g. J Cell Biol (2009) 1.66

Structural basis for the selectivity of the external thioesterase of the surfactin synthetase. Nature (2008) 1.66

Actin binding to the central domain of WASP/Scar proteins plays a critical role in the activation of the Arp2/3 complex. J Biol Chem (2005) 1.64

Conformational switches modulate protein interactions in peptide antibiotic synthetases. Science (2006) 1.61