Published in PLoS One on December 21, 2012
Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline. EMBO J (2013) 1.22
Small RNAs derived from tRNAs and rRNAs are highly enriched in exosomes from both old and new world Leishmania providing evidence for conserved exosomal RNA Packaging. BMC Genomics (2015) 0.92
The Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite. Evol Bioinform Online (2014) 0.83
Piwil 2 expression is correlated with disease-specific and progression-free survival of chemotherapy-treated bladder cancer patients. Mol Med (2015) 0.78
Histone-derived piRNA biogenesis depends on the ping-pong partners Piwi5 and Ago3 in Aedes aegypti. Nucleic Acids Res (2017) 0.75
Differential evolution of duplicated medakafish mitf genes. Int J Biol Sci (2013) 0.75
DDX3 DEAD-box RNA helicase plays a central role in mitochondrial protein quality control in Leishmania. Cell Death Dis (2016) 0.75
The Gene Ontology (GO) database and informatics resource. Nucleic Acids Res (2004) 54.37
Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell (2007) 18.35
Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev (2006) 15.20
A distinct small RNA pathway silences selfish genetic elements in the germline. Science (2006) 11.63
The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race. Science (2007) 9.36
Argonaute proteins: key players in RNA silencing. Nat Rev Mol Cell Biol (2008) 8.96
The genome of the kinetoplastid parasite, Leishmania major. Science (2005) 8.64
MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. Dev Cell (2007) 7.66
A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol Cell (2008) 6.35
A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish. Cell (2007) 6.31
miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis. Dev Cell (2002) 5.85
Analysis of a piwi-related gene implicates small RNAs in genome rearrangement in tetrahymena. Cell (2002) 5.78
Mili, a mammalian member of piwi family gene, is essential for spermatogenesis. Development (2004) 5.47
Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis. Cell (2005) 5.43
Endogenous RNA interference provides a somatic defense against Drosophila transposons. Curr Biol (2008) 5.22
An epigenetic role for maternally inherited piRNAs in transposon silencing. Science (2008) 5.05
Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain. Nature (2003) 4.92
Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J Exp Med (1995) 4.88
Comparative genomic analysis of three Leishmania species that cause diverse human disease. Nat Genet (2007) 4.58
piwi encodes a nucleoplasmic factor whose activity modulates the number and division rate of germline stem cells. Development (2000) 4.54
Slicer and the argonautes. Nat Chem Biol (2007) 3.99
An epigenetic activation role of Piwi and a Piwi-associated piRNA in Drosophila melanogaster. Nature (2007) 3.86
Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity. EMBO J (2004) 3.57
Drosophila PIWI associates with chromatin and interacts directly with HP1a. Genes Dev (2007) 3.46
Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo. Nature (2010) 3.44
The biogenesis and function of PIWI proteins and piRNAs: progress and prospect. Annu Rev Cell Dev Biol (2009) 3.21
Function, targets, and evolution of Caenorhabditis elegans piRNAs. Science (2012) 3.11
The Argonaute protein family. Genome Biol (2008) 2.83
MIWI associates with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis. Proc Natl Acad Sci U S A (2006) 2.80
Conserved themes in small-RNA-mediated transposon control. Trends Cell Biol (2008) 2.67
Improvements in transfection efficiency and tests of RNA interference (RNAi) approaches in the protozoan parasite Leishmania. Mol Biochem Parasitol (2003) 2.45
Argonaute: A scaffold for the function of short regulatory RNAs. Trends Biochem Sci (2006) 2.28
Fellowship of the rings: the replication of kinetoplast DNA. Trends Parasitol (2005) 2.21
Stem-cell protein Piwil2 is widely expressed in tumors and inhibits apoptosis through activation of Stat3/Bcl-XL pathway. Hum Mol Genet (2005) 2.17
Cytoplasmic compartmentalization of the fetal piRNA pathway in mice. PLoS Genet (2009) 2.11
Developmental regulation of gene expression in trypanosomatid parasitic protozoa. Curr Opin Microbiol (2007) 1.80
Retention and loss of RNA interference pathways in trypanosomatid protozoans. PLoS Pathog (2010) 1.69
Prefractionation by digitonin extraction increases representation of the cytosolic and intracellular proteome of Leishmania infantum. J Proteome Res (2006) 1.65
Miltefosine induces apoptosis-like death in Leishmania donovani promastigotes. Antimicrob Agents Chemother (2004) 1.63
Members of a large retroposon family are determinants of post-transcriptional gene expression in Leishmania. PLoS Pathog (2007) 1.59
Prokaryotic homologs of Argonaute proteins are predicted to function as key components of a novel system of defense against mobile genetic elements. Biol Direct (2009) 1.58
Hydrogen peroxide induces apoptosis-like death in Leishmania donovani promastigotes. J Cell Sci (2001) 1.54
RNA editing in kinetoplastid mitochondria. FASEB J (1993) 1.48
Genome-wide gene expression profiling analysis of Leishmania major and Leishmania infantum developmental stages reveals substantial differences between the two species. BMC Genomics (2008) 1.47
piRNAs mediate posttranscriptional retroelement silencing and localization to pi-bodies in the Drosophila germline. J Cell Biol (2009) 1.46
RNA interference in protozoan parasites: achievements and challenges. Eukaryot Cell (2011) 1.42
Tests of cytoplasmic RNA interference (RNAi) and construction of a tetracycline-inducible T7 promoter system in Trypanosoma cruzi. Mol Biochem Parasitol (2004) 1.40
DNA transformation of Leishmania infantum axenic amastigotes and their use in drug screening. Antimicrob Agents Chemother (2001) 1.39
Antimonial-mediated DNA fragmentation in Leishmania infantum amastigotes. Antimicrob Agents Chemother (2001) 1.34
Whole-genome comparative RNA expression profiling of axenic and intracellular amastigote forms of Leishmania infantum. Mol Biochem Parasitol (2009) 1.28
Autonomous replication of bacterial DNA plasmid oligomers in Leishmania. Mol Biochem Parasitol (1994) 1.28
Distinct 3'-untranslated region elements regulate stage-specific mRNA accumulation and translation in Leishmania. J Biol Chem (2005) 1.24
Selection against the dihydrofolate reductase-thymidylate synthase (DHFR-TS) locus as a probe of genetic alterations in Leishmania major. Mol Cell Biol (1996) 1.08
L-arginine and cationic amino acid transporter 2B regulate growth and survival of Leishmania amazonensis amastigotes in macrophages. Infect Immun (2007) 1.08
Leishmania virulence factors: focus on the metalloprotease GP63. Microbes Infect (2012) 1.06
Structure and regulation of histone H2B mRNAs from Leishmania enriettii. Mol Cell Biol (1991) 1.01
Phenotypic characterization of a glucose transporter null mutant in Leishmania mexicana. Mol Biochem Parasitol (2007) 1.01
Arginine homeostasis and transport in the human pathogen Leishmania donovani. J Biol Chem (2009) 1.00
Intracellular localization and routing of miRNA and RNAi pathway components. Curr Top Med Chem (2012) 0.99
A novel class of developmentally regulated noncoding RNAs in Leishmania. Eukaryot Cell (2006) 0.98
Structural evolution and functional diversification analyses of argonaute protein. J Cell Biochem (2012) 0.97
Metabolic changes in glucose transporter-deficient Leishmania mexicana and parasite virulence. J Biol Chem (2006) 0.97
Internal frameshifts within the mitochondrial genes for cytochrome oxidase subunit II and maxicircle unidentified reading frame 3 of Leishmania tarentolae are corrected by RNA editing: evidence for translation of the edited cytochrome oxidase subunit II mRNA. Proc Natl Acad Sci U S A (1989) 0.93
Molecular cloning and analysis of expression of the Leishmania infantum histone H4 genes. Mol Biochem Parasitol (1997) 0.92
Histone H1 expression varies during the Leishmania major life cycle. Mol Biochem Parasitol (1997) 0.91
Rapid decay of unstable Leishmania mRNAs bearing a conserved retroposon signature 3'-UTR motif is initiated by a site-specific endonucleolytic cleavage without prior deadenylation. Nucleic Acids Res (2010) 0.89
Cloning, characterization and subcellular localization of a Trypanosoma cruzi argonaute protein defining a new subfamily distinctive of trypanosomatids. Gene (2010) 0.87
Developmental functions of piRNAs and transposable elements: a Drosophila point-of-view. RNA Biol (2011) 0.85
Leishmania infantum possesses a complex family of histone H2A genes: structural characterization and analysis of expression. Parasitology (2003) 0.84
Organization, transcription and regulation of the Leishmania infantum histone H3 genes. Biochem J (1996) 0.83
Apoptosis-like programmed cell death induces antisense ribosomal RNA (rRNA) fragmentation and rRNA degradation in Leishmania. Cell Death Differ (2012) 0.80
Distinct mitochondrial HSP70 homologues conserved in various Leishmania species suggest novel biological functions. Mol Biochem Parasitol (2008) 0.79
Argonaute proteins: key players in RNA silencing. Nat Rev Mol Cell Biol (2008) 8.96
Sequence-specific inhibition of small RNA function. PLoS Biol (2004) 7.98
Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi. Cell (2006) 7.14
Human let-7a miRNA blocks protein production on actively translating polyribosomes. Nat Struct Mol Biol (2006) 4.67
Role for miR-204 in human pulmonary arterial hypertension. J Exp Med (2011) 2.60
Leishmaniasis: drugs in the clinic, resistance and new developments. Drug Resist Updat (2004) 1.96
Developmental regulation of gene expression in trypanosomatid parasitic protozoa. Curr Opin Microbiol (2007) 1.80
Prefractionation by digitonin extraction increases representation of the cytosolic and intracellular proteome of Leishmania infantum. J Proteome Res (2006) 1.65
A member of the polymerase beta nucleotidyltransferase superfamily is required for RNA interference in C. elegans. Curr Biol (2005) 1.61
Members of a large retroposon family are determinants of post-transcriptional gene expression in Leishmania. PLoS Pathog (2007) 1.59
A common mechanism of stage-regulated gene expression in Leishmania mediated by a conserved 3'-untranslated region element. J Biol Chem (2002) 1.48
Genome-wide gene expression profiling analysis of Leishmania major and Leishmania infantum developmental stages reveals substantial differences between the two species. BMC Genomics (2008) 1.47
Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy. Genome Biol (2008) 1.38
Measuring social participation: reliability of the LIFE-H in older adults with disabilities. Disabil Rehabil (2004) 1.31
Characterization and developmental gene regulation of a large gene family encoding amastin surface proteins in Leishmania spp. Mol Biochem Parasitol (2005) 1.30
Whole-genome comparative RNA expression profiling of axenic and intracellular amastigote forms of Leishmania infantum. Mol Biochem Parasitol (2009) 1.28
A combined proteomic and transcriptomic approach to the study of stage differentiation in Leishmania infantum. Proteomics (2006) 1.24
Distinct 3'-untranslated region elements regulate stage-specific mRNA accumulation and translation in Leishmania. J Biol Chem (2005) 1.24
Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway. Sci Signal (2011) 1.24
Role of the ABC transporter MRPA (PGPA) in antimony resistance in Leishmania infantum axenic and intracellular amastigotes. Antimicrob Agents Chemother (2005) 1.24
Genome sequencing of the lizard parasite Leishmania tarentolae reveals loss of genes associated to the intracellular stage of human pathogenic species. Nucleic Acids Res (2011) 1.23
Two molecular features contribute to the Argonaute specificity for the microRNA and RNAi pathways in C. elegans. RNA (2008) 1.22
Coordinated gene expression by post-transcriptional regulons in African trypanosomes. J Biol (2009) 1.17
Modulation of gene expression in Leishmania drug resistant mutants as determined by targeted DNA microarrays. Nucleic Acids Res (2003) 1.16
Antileishmanial activity mediated by apoptosis and structure-based target study of peganine hydrochloride dihydrate: an approach for rational drug design. J Antimicrob Chemother (2008) 1.14
The decapping scavenger enzyme DCS-1 controls microRNA levels in Caenorhabditis elegans. Mol Cell (2013) 1.13
Live nonpathogenic parasitic vector as a candidate vaccine against visceral leishmaniasis. Infect Immun (2005) 1.11
Formation of linear inverted repeat amplicons following targeting of an essential gene in Leishmania. Nucleic Acids Res (2005) 1.11
Predictors of long-term participation after stroke. Disabil Rehabil (2006) 1.09
Modulation of Leishmania ABC protein gene expression through life stages and among drug-resistant parasites. Eukaryot Cell (2006) 1.09
The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans. EMBO Rep (2011) 1.07
Promastigote to amastigote differentiation of Leishmania is markedly delayed in the absence of PERK eIF2alpha kinase-dependent eIF2alpha phosphorylation. Cell Microbiol (2011) 1.06
Organization and evolution of two SIDER retroposon subfamilies and their impact on the Leishmania genome. BMC Genomics (2009) 1.04
Reduced infectivity of a Leishmania donovani biopterin transporter genetic mutant and its use as an attenuated strain for vaccination. Infect Immun (2002) 1.00
Annexin-1-mediated endothelial cell migration and angiogenesis are regulated by vascular endothelial growth factor (VEGF)-induced inhibition of miR-196a expression. J Biol Chem (2012) 0.99
A novel class of developmentally regulated noncoding RNAs in Leishmania. Eukaryot Cell (2006) 0.98
Effects of different adjuvants in the context of intramuscular and intranasal routes on humoral and cellular immune responses induced by detergent-split A/H3N2 influenza vaccines in mice. Clin Vaccine Immunol (2011) 0.98
A proteomic analysis of penicillin resistance in Streptococcus pneumoniae reveals a novel role for PstS, a subunit of the phosphate ABC transporter. Mol Microbiol (2005) 0.97
Developmental characterization of the microRNA-specific C. elegans Argonautes alg-1 and alg-2. PLoS One (2012) 0.96
Leishmania infantum enhances human immunodeficiency virus type-1 replication in primary human macrophages through a complex cytokine network. Clin Immunol (2004) 0.95
Role of transposable elements in trypanosomatids. Microbes Infect (2008) 0.93
Comparison of changes in upper and lower extremity impairments and disabilities after stroke. Int J Rehabil Res (2003) 0.93
Recombinant Leishmania tarentolae expressing the A2 virulence gene as a novel candidate vaccine against visceral leishmaniasis. Vaccine (2009) 0.93
Deadenylation-independent stage-specific mRNA degradation in Leishmania. Nucleic Acids Res (2008) 0.92
Recombinant Leishmania major secreting biologically active granulocyte-macrophage colony-stimulating factor survives poorly in macrophages in vitro and delays disease development in mice. Infect Immun (2003) 0.92
Validity of the Assessment of Life Habits in older adults. J Rehabil Med (2004) 0.92
Synergizing expectation and execution for stroke communities of practice innovations. Implement Sci (2010) 0.92
The slicing activity of miRNA-specific Argonautes is essential for the miRNA pathway in C. elegans. Nucleic Acids Res (2012) 0.91
Analysis of stage-specific expression of basic proteins in Leishmania infantum. J Proteome Res (2010) 0.91
The microRNA pathway controls germ cell proliferation and differentiation in C. elegans. Cell Res (2012) 0.91
Translational control through eIF2alpha phosphorylation during the Leishmania differentiation process. PLoS One (2012) 0.90
Comparison of two functional independence scales with a participation measure in post-stroke rehabilitation. Arch Gerontol Geriatr (2003) 0.90
Photodynamic vaccination of hamsters with inducible suicidal mutants of Leishmania amazonensis elicits immunity against visceral leishmaniasis. Eur J Immunol (2009) 0.90
Leishmania infantum promotes replication of HIV type 1 in human lymphoid tissue cultured ex vivo by inducing secretion of the proinflammatory cytokines TNF-alpha and IL-1 alpha. J Immunol (2004) 0.89
Development and validation of a scale for rating motor compensations used for reaching in patients with hemiparesis: the reaching performance scale. Phys Ther (2004) 0.89
Development of novel prime-boost strategies based on a tri-gene fusion recombinant L. tarentolae vaccine against experimental murine visceral leishmaniasis. PLoS Negl Trop Dis (2013) 0.89
Rapid decay of unstable Leishmania mRNAs bearing a conserved retroposon signature 3'-UTR motif is initiated by a site-specific endonucleolytic cleavage without prior deadenylation. Nucleic Acids Res (2010) 0.89
Impact of wheelchair acquisition on social participation. Disabil Rehabil Assist Technol (2009) 0.88
Participation after stroke compared to normal aging. J Rehabil Med (2005) 0.88
Th1-stimulatory polyproteins of soluble Leishmania donovani promastigotes ranging from 89.9 to 97.1 kDa offers long-lasting protection against experimental visceral leishmaniasis. Vaccine (2008) 0.88
Amastin peptide-binding antibodies as biomarkers of active human visceral leishmaniasis. Clin Vaccine Immunol (2006) 0.88
The ribosomal RNA gene promoter and adjacent cis-acting DNA sequences govern plasmid DNA partitioning and stable inheritance in the parasitic protozoan Leishmania. Nucleic Acids Res (2004) 0.88
Effect of a home leisure education program after stroke: a randomized controlled trial. Arch Phys Med Rehabil (2007) 0.88
A proteomic approach to identify developmentally regulated proteins in Leishmania infantum. Proteomics (2002) 0.86
Clinicians' expectations of Web 2.0 as a mechanism for knowledge transfer of stroke best practices. J Med Internet Res (2012) 0.86
Falling through the cracks: a literature review to understand the reality of mild stroke survivors. Top Stroke Rehabil (2010) 0.86
In primary human monocyte-derived macrophages exposed to Human immunodeficiency virus type 1, does the increased intracellular growth of Leishmania infantum rely on its enhanced uptake? J Gen Virol (2006) 0.85
Evaluation of antileishmanial potential of Tinospora sinensis against experimental visceral leishmaniasis. Parasitol Res (2007) 0.85
Social participation of older adults in Quebec. Aging Clin Exp Res (2004) 0.85
Improving the prediction of mRNA extremities in the parasitic protozoan Leishmania. BMC Bioinformatics (2008) 0.85
RIP-chip-SRM--a new combinatorial large-scale approach identifies a set of translationally regulated bantam/miR-58 targets in C. elegans. Genome Res (2012) 0.85
A national survey of occupational therapists' practices related to participation post-stroke. J Rehabil Med (2008) 0.85
RNA polymerase I-mediated transcription of a reporter gene integrated into different loci of Leishmania. Mol Biochem Parasitol (2002) 0.84
DC-SIGN-mediated transfer of HIV-1 is compromised by the ability of Leishmania infantum to exploit DC-SIGN as a ligand. J Infect Dis (2005) 0.84
Arm and leg impairments and disabilities after stroke rehabilitation: relation to handicap. Clin Rehabil (2003) 0.84
miR-20a represses endothelial cell migration by targeting MKK3 and inhibiting p38 MAP kinase activation in response to VEGF. Angiogenesis (2012) 0.84
Structural biology: Tracing Argonaute binding. Nature (2009) 0.83
Treatment of Leishmania donovani-infected hamsters with miltefosine: analysis of cytokine mRNA expression by real-time PCR, lymphoproliferation, nitrite production and antibody responses. J Antimicrob Chemother (2011) 0.83
Argonaute pull-down and RISC analysis using 2'-O-methylated oligonucleotides affinity matrices. Methods Mol Biol (2011) 0.83
A protein of the leucine-rich repeats (LRRs) superfamily is implicated in antimony resistance in Leishmania infantum amastigotes. Mol Biochem Parasitol (2007) 0.83
Social participation of relatives post-stroke: the role of rehabilitation and related ethical issues. Disabil Rehabil (2010) 0.83
Selective inactivation of SIDER2 retroposon-mediated mRNA decay contributes to stage- and species-specific gene expression in Leishmania. Mol Microbiol (2010) 0.83
Impacts of wheelchair acquisition on children from a person-occupation-environment interactional perspective. Disabil Rehabil Assist Technol (2012) 0.83
Characterization of hibernating ribosomes in mammalian cells. Cell Cycle (2011) 0.82
Validation of a new lower-extremity motor coordination test. Arch Phys Med Rehabil (2005) 0.82
Next-generation biobanking of metastases to enable multidimensional molecular profiling in personalized medicine. Mod Pathol (2013) 0.82
Age-influenced population kinetics and immunological responses of Leishmania donovani in hamsters. Parasitol Res (2007) 0.82