Published in Dev Cell on June 01, 2002
Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes. Nature (2008) 10.71
A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol Cell (2008) 6.35
A novel class of small RNAs in mouse spermatogenic cells. Genes Dev (2006) 5.85
Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes. Genes Dev (2006) 4.97
The biology of infertility: research advances and clinical challenges. Nat Med (2008) 4.62
PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans. Mol Cell (2008) 4.48
Piwi and piRNAs act upstream of an endogenous siRNA pathway to suppress Tc3 transposon mobility in the Caenorhabditis elegans germline. Mol Cell (2008) 3.37
The biogenesis and function of PIWI proteins and piRNAs: progress and prospect. Annu Rev Cell Dev Biol (2009) 3.21
Mighty Piwis defend the germline against genome intruders. Cell (2007) 3.06
Endogenous small interfering RNAs in animals. Nat Rev Mol Cell Biol (2008) 3.00
Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members. Genes Dev (2009) 2.95
The Argonaute protein family. Genome Biol (2008) 2.83
MicroRNA biogenesis is required for mouse primordial germ cell development and spermatogenesis. PLoS One (2008) 2.82
MIWI associates with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis. Proc Natl Acad Sci U S A (2006) 2.80
The chromatoid body of male germ cells: similarity with processing bodies and presence of Dicer and microRNA pathway components. Proc Natl Acad Sci U S A (2006) 2.75
Conserved themes in small-RNA-mediated transposon control. Trends Cell Biol (2008) 2.67
Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profile. Nat Struct Mol Biol (2009) 2.64
The mammalian ovary from genesis to revelation. Endocr Rev (2009) 2.31
A C. elegans Piwi, PRG-1, regulates 21U-RNAs during spermatogenesis. Curr Biol (2008) 2.25
An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes. Mol Cell (2013) 2.23
Mili interacts with tudor domain-containing protein 1 in regulating spermatogenesis. Curr Biol (2009) 2.13
Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing. Nature (2011) 2.11
Cytoplasmic compartmentalization of the fetal piRNA pathway in mice. PLoS Genet (2009) 2.11
Uniting germline and stem cells: the function of Piwi proteins and the piRNA pathway in diverse organisms. Annu Rev Genet (2011) 2.07
MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline. Dev Cell (2011) 1.94
MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation. J Biol Chem (2008) 1.93
PIWI-interacting RNAs: from generation to transgenerational epigenetics. Nat Rev Genet (2013) 1.92
The piRNA pathway: a fly's perspective on the guardian of the genome. Trends Genet (2010) 1.91
The PIWI proteins SMEDWI-2 and SMEDWI-3 are required for stem cell function and piRNA expression in planarians. RNA (2008) 1.87
Zili is required for germ cell differentiation and meiosis in zebrafish. EMBO J (2008) 1.87
MVH in piRNA processing and gene silencing of retrotransposons. Genes Dev (2010) 1.84
GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline. PLoS Genet (2009) 1.83
Tdrd6 is required for spermiogenesis, chromatoid body architecture, and regulation of miRNA expression. Curr Biol (2009) 1.81
RNA granules in germ cells. Cold Spring Harb Perspect Biol (2011) 1.80
2'-O-methylation stabilizes Piwi-associated small RNAs and ensures DNA elimination in Tetrahymena. RNA (2009) 1.76
Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi. Proc Natl Acad Sci U S A (2009) 1.73
How does the royal family of Tudor rule the PIWI-interacting RNA pathway? Genes Dev (2010) 1.71
Mili and Miwi target RNA repertoire reveals piRNA biogenesis and function of Miwi in spermiogenesis. Nat Struct Mol Biol (2012) 1.70
Deciphering arginine methylation: Tudor tells the tale. Nat Rev Mol Cell Biol (2011) 1.69
MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs. Proc Natl Acad Sci U S A (2010) 1.66
Male infertility caused by spermiogenic defects: lessons from gene knockouts. Mol Cell Endocrinol (2009) 1.64
Epigenetic disruption of the PIWI pathway in human spermatogenic disorders. PLoS One (2012) 1.64
RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis. Development (2005) 1.58
Argonautes promote male fertility and provide a paternal memory of germline gene expression in C. elegans. Cell (2013) 1.54
Hen1 is required for oocyte development and piRNA stability in zebrafish. EMBO J (2010) 1.53
Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization. RNA (2009) 1.53
PIWI proteins and PIWI-interacting RNAs in the soma. Nature (2014) 1.53
Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway. Proc Natl Acad Sci U S A (2010) 1.52
Establishment of a normal medakafish spermatogonial cell line capable of sperm production in vitro. Proc Natl Acad Sci U S A (2004) 1.51
HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse. PLoS Genet (2015) 1.49
Novel function of PIWIL1 in neuronal polarization and migration via regulation of microtubule-associated proteins. Mol Brain (2015) 1.44
Deficiency of pantothenate kinase 2 (Pank2) in mice leads to retinal degeneration and azoospermia. Hum Mol Genet (2004) 1.44
A conserved germline multipotency program. Development (2010) 1.42
Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain. Proc Natl Acad Sci U S A (2010) 1.40
Direct differentiation of human pluripotent stem cells into haploid spermatogenic cells. Cell Rep (2012) 1.40
SOHLH1 and SOHLH2 coordinate spermatogonial differentiation. Dev Biol (2011) 1.39
Identification of piRNAs in the central nervous system. RNA (2011) 1.39
Jmjd1a demethylase-regulated histone modification is essential for cAMP-response element modulator-regulated gene expression and spermatogenesis. J Biol Chem (2009) 1.38
Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis. Cell Res (2014) 1.37
The stem cell-associated Hiwi gene in human adenocarcinoma of the pancreas: expression and risk of tumour-related death. Br J Cancer (2008) 1.36
Computational analysis of mouse piRNA sequence and biogenesis. PLoS Comput Biol (2007) 1.36
Small RNAs in early mammalian development: from gametes to gastrulation. Development (2011) 1.33
MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing. Mol Hum Reprod (2010) 1.31
Inactivation of CUG-BP1/CELF1 causes growth, viability, and spermatogenesis defects in mice. Mol Cell Biol (2006) 1.30
Requirement for Sun1 in the expression of meiotic reproductive genes and piRNA. Development (2009) 1.30
The Yb body, a major site for Piwi-associated RNA biogenesis and a gateway for Piwi expression and transport to the nucleus in somatic cells. J Biol Chem (2010) 1.30
Male germ cell apoptosis: regulation and biology. Philos Trans R Soc Lond B Biol Sci (2010) 1.27
Small RNA class transition from siRNA/piRNA to miRNA during pre-implantation mouse development. Nucleic Acids Res (2010) 1.27
Immortalization of mouse germ line stem cells. Stem Cells (2005) 1.25
Systematic and single cell analysis of Xenopus Piwi-interacting RNAs and Xiwi. EMBO J (2009) 1.25
Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline. EMBO J (2013) 1.22
Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. Proc Natl Acad Sci U S A (2011) 1.21
TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice. J Cell Biol (2011) 1.20
Argonautes confront new small RNAs. Curr Opin Chem Biol (2007) 1.20
A novel epigenetic mechanism in Drosophila somatic cells mediated by Piwi and piRNAs. Cold Spring Harb Symp Quant Biol (2009) 1.20
miRNA and piRNA localization in the male mammalian meiotic nucleus. Chromosome Res (2008) 1.19
The sperm nucleus: chromatin, RNA, and the nuclear matrix. Reproduction (2010) 1.18
Identification of Piwil2-like (PL2L) proteins that promote tumorigenesis. PLoS One (2010) 1.17
Novel insights into DNA methylation features in spermatozoa: stability and peculiarities. PLoS One (2012) 1.16
Cancer/testis (CT) antigens, carcinogenesis and spermatogenesis. Spermatogenesis (2011) 1.16
Beyond transposons: the epigenetic and somatic functions of the Piwi-piRNA mechanism. Curr Opin Cell Biol (2013) 1.16
piRNA biogenesis during adult spermatogenesis in mice is independent of the ping-pong mechanism. Cell Res (2012) 1.15
Long non-coding RNA expression profiling of mouse testis during postnatal development. PLoS One (2013) 1.15
MIWI and piRNA-mediated cleavage of messenger RNAs in mouse testes. Cell Res (2015) 1.13
Interaction between NANOS2 and the CCR4-NOT deadenylation complex is essential for male germ cell development in mouse. PLoS One (2012) 1.13
Novel dimensions of piRNAs in cancer. Cancer Lett (2013) 1.13
PIWI Expression and Function in Cancer. Front Genet (2012) 1.12
Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression. Development (2005) 1.12
The de novo cytosine methyltransferase DRM2 requires intact UBA domains and a catalytically mutated paralog DRM3 during RNA-directed DNA methylation in Arabidopsis thaliana. PLoS Genet (2010) 1.12
The kinesin KIF17b and RNA-binding protein TB-RBP transport specific cAMP-responsive element modulator-regulated mRNAs in male germ cells. Proc Natl Acad Sci U S A (2003) 1.10
The nuclear RNA-binding protein Sam68 translocates to the cytoplasm and associates with the polysomes in mouse spermatocytes. Mol Biol Cell (2005) 1.09
The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation. Mol Cell Biol (2013) 1.08
piRNA clusters and open chromatin structure. Mob DNA (2014) 1.08
Retrotransposons and pseudogenes regulate mRNAs and lncRNAs via the piRNA pathway in the germline. Genome Res (2014) 1.07
A novel requirement in mammalian spermatid differentiation for the DAZ-family protein Boule. Hum Mol Genet (2010) 1.06
Two Piwi proteins, Xiwi and Xili, are expressed in the Xenopus female germline. RNA (2009) 1.05
Piwil2 suppresses p53 by inducing phosphorylation of signal transducer and activator of transcription 3 in tumor cells. PLoS One (2012) 1.04
Small RNAs in the animal gonad: guarding genomes and guiding development. Int J Biochem Cell Biol (2010) 1.03
Reduced pachytene piRNAs and translation underlie spermiogenic arrest in Maelstrom mutant mice. EMBO J (2014) 1.00
Blockade of pachytene piRNA biogenesis reveals a novel requirement for maintaining post-meiotic germline genome integrity. PLoS Genet (2012) 1.00
A novel class of small RNAs in mouse spermatogenic cells. Genes Dev (2006) 5.85
Mili, a mammalian member of piwi family gene, is essential for spermatogenesis. Development (2004) 5.47
MicroRNAs: key regulators of stem cells. Nat Rev Mol Cell Biol (2009) 4.26
An epigenetic activation role of Piwi and a Piwi-associated piRNA in Drosophila melanogaster. Nature (2007) 3.86
Drosophila PIWI associates with chromatin and interacts directly with HP1a. Genes Dev (2007) 3.46
Dynamic transcriptomes during neural differentiation of human embryonic stem cells revealed by short, long, and paired-end sequencing. Proc Natl Acad Sci U S A (2010) 3.28
The biogenesis and function of PIWI proteins and piRNAs: progress and prospect. Annu Rev Cell Dev Biol (2009) 3.21
The role of PIWI and the miRNA machinery in Drosophila germline determination. Curr Biol (2006) 3.06
MIWI associates with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis. Proc Natl Acad Sci U S A (2006) 2.80
Role for piRNAs and noncoding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus. Science (2011) 2.17
Mili interacts with tudor domain-containing protein 1 in regulating spermatogenesis. Curr Biol (2009) 2.13
Uniting germline and stem cells: the function of Piwi proteins and the piRNA pathway in diverse organisms. Annu Rev Genet (2011) 2.07
Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas. Oncogene (2002) 2.03
MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline. Dev Cell (2011) 1.94
MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation. J Biol Chem (2008) 1.93
Genome-wide studies reveal that Lin28 enhances the translation of genes important for growth and survival of human embryonic stem cells. Stem Cells (2011) 1.90
A major epigenetic programming mechanism guided by piRNAs. Dev Cell (2013) 1.89
Regulatory relationship among piwi, pumilio, and bag-of-marbles in Drosophila germline stem cell self-renewal and differentiation. Curr Biol (2005) 1.88
Nanos maintains germline stem cell self-renewal by preventing differentiation. Science (2004) 1.74
Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation. Nat Genet (2010) 1.62
Interplay of PIWI/Argonaute protein MIWI and kinesin KIF17b in chromatoid bodies of male germ cells. J Cell Sci (2006) 1.52
Precancerous stem cells have the potential for both benign and malignant differentiation. PLoS One (2007) 1.36
Pumilio 1 suppresses multiple activators of p53 to safeguard spermatogenesis. Curr Biol (2012) 1.34
Piecing together the mosaic of early mammalian development through microRNAs. J Biol Chem (2008) 1.32
The Yb body, a major site for Piwi-associated RNA biogenesis and a gateway for Piwi expression and transport to the nucleus in somatic cells. J Biol Chem (2010) 1.30
A high-resolution whole-genome map of key chromatin modifications in the adult Drosophila melanogaster. PLoS Genet (2011) 1.27
The Yb protein defines a novel organelle and regulates male germline stem cell self-renewal in Drosophila melanogaster. J Cell Biol (2009) 1.26
Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline. EMBO J (2013) 1.22
Identification of Piwil2-like (PL2L) proteins that promote tumorigenesis. PLoS One (2010) 1.17
Beyond transposons: the epigenetic and somatic functions of the Piwi-piRNA mechanism. Curr Opin Cell Biol (2013) 1.16
piRNA biogenesis during adult spermatogenesis in mice is independent of the ping-pong mechanism. Cell Res (2012) 1.15
PAPI, a novel TUDOR-domain protein, complexes with AGO3, ME31B and TRAL in the nuage to silence transposition. Development (2011) 1.12
Germline stem cells in the Drosophila ovary descend from pole cells in the anterior region of the embryonic gonad. Development (2004) 1.01
Function of Piwi, a nuclear Piwi/Argonaute protein, is independent of its slicer activity. Proc Natl Acad Sci U S A (2013) 1.00
PIWI proteins and PIWI-interacting RNAs function in Hydra somatic stem cells. Proc Natl Acad Sci U S A (2013) 0.98
High-efficiency siRNA-based gene knockdown in human embryonic stem cells. RNA (2010) 0.98
The division of Drosophila germline stem cells and their precursors requires a specific cyclin. Curr Biol (2005) 0.95
Small noncoding RNAs in the germline. Cold Spring Harb Perspect Biol (2011) 0.94
Screens for piwi suppressors in Drosophila identify dosage-dependent regulators of germline stem cell division. Genetics (2003) 0.92
Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse. Dev Biol (2011) 0.91
Stem cells: to be and not to be. Nature (2003) 0.89
A Drosophila chromatin factor interacts with the Piwi-interacting RNA mechanism in niche cells to regulate germline stem cell self-renewal. Genetics (2010) 0.86
Repressing the repressor: a lincRNA as a MicroRNA sponge in embryonic stem cell self-renewal. Dev Cell (2013) 0.85
Piwi genes are dispensable for normal hematopoiesis in mice. PLoS One (2013) 0.84
The miRNA Regulation of Stem Cells. Wiley Interdiscip Rev Membr Transp Signal (2011) 0.84
Essential roles of the chromatin remodeling factor BRG1 in spermatogenesis in mice. Biol Reprod (2012) 0.84
Sex-lethal is a target of Bruno-mediated translational repression in promoting the differentiation of stem cell progeny during Drosophila oogenesis. Dev Biol (2006) 0.79
High-efficiency transfection and siRNA-mediated gene knockdown in human pluripotent stem cells. Curr Protoc Stem Cell Biol (2012) 0.77
The microRNA regulation of stem cells. Wiley Interdiscip Rev Dev Biol (2011) 0.76
Poreless eggshells. J Clin Invest (2015) 0.75
Chromatin immunoprecipitation assay of Piwi in Drosophila. Methods Mol Biol (2014) 0.75
Dr. Haifan Lin. Interviewed by Han Lee and Rachel Rosenstein. Yale J Biol Med (2006) 0.75
Stem cells in 2009. Cell Stem Cell (2009) 0.75