Published in Proc Natl Acad Sci U S A on January 08, 2013
Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms. Elife (2014) 1.20
Variable cooperativity in SNARE-mediated membrane fusion. Proc Natl Acad Sci U S A (2014) 1.15
Interaction of the complexin accessory helix with the C-terminus of the SNARE complex: molecular-dynamics model of the fusion clamp. Biophys J (2013) 0.95
Complexin-1 enhances the on-rate of vesicle docking via simultaneous SNARE and membrane interactions. J Am Chem Soc (2013) 0.94
Studying protein-reconstituted proteoliposome fusion with content indicators in vitro. Bioessays (2013) 0.91
Towards reconstitution of membrane fusion mediated by SNAREs and other synaptic proteins. Crit Rev Biochem Mol Biol (2015) 0.88
Nonaggregated α-synuclein influences SNARE-dependent vesicle docking via membrane binding. Biochemistry (2014) 0.87
The synaptotagmin 1 linker may function as an electrostatic zipper that opens for docking but closes for fusion pore opening. Biochem J (2013) 0.87
Modulation of neurotransmission by GPCRs is dependent upon the microarchitecture of the primed vesicle complex. J Neurosci (2014) 0.85
Synaptotagmin-7 links fusion-activated Ca²⁺ entry and fusion pore dilation. J Cell Sci (2014) 0.84
Exocytotic fusion pores are composed of both lipids and proteins. Nat Struct Mol Biol (2015) 0.84
Synaptotagmin-1 is an antagonist for Munc18-1 in SNARE zippering. J Biol Chem (2015) 0.84
Cholesterol Increases the Openness of SNARE-Mediated Flickering Fusion Pores. Biophys J (2016) 0.84
Synaptotagmin's role in neurotransmitter release likely involves Ca(2+)-induced conformational transition. Biophys J (2014) 0.84
Reconstituting SNARE-mediated membrane fusion at the single liposome level. Methods Cell Biol (2015) 0.83
Molecular origins of synaptotagmin 1 activities on vesicle docking and fusion pore opening. Sci Rep (2015) 0.79
A cascade of multiple proteins and lipids catalyzes membrane fusion. Mol Biol Cell (2017) 0.78
Two gigs of Munc18 in membrane fusion. Proc Natl Acad Sci U S A (2013) 0.78
Synaptotagmin 1 and Ca2+ drive trans SNARE zippering. Sci Rep (2014) 0.78
Lipid molecules influence early stages of yeast SNARE-mediated membrane fusion. Phys Biol (2015) 0.78
Amyloid-β Oligomers May Impair SNARE-Mediated Exocytosis by Direct Binding to Syntaxin 1a. Cell Rep (2015) 0.78
Fusion pores and their control of neurotransmitter and hormone release. J Gen Physiol (2017) 0.78
Preincubation of t-SNAREs with Complexin I Increases Content-Mixing Efficiency. Biochemistry (2016) 0.76
Local electrostatic interactions determine the diameter of fusion pores. Channels (Austin) (2015) 0.75
High Transmembrane Voltage Raised by Close Contact Initiates Fusion Pore. Front Mol Neurosci (2016) 0.75
Copper binding affinity of the C2B domain of synaptotagmin-1 and its potential role in the nonclassical secretion of acidic fibroblast growth factor. Biochim Biophys Acta (2014) 0.75
Functional redundancy between trans-Golgi network SNARE family members in Arabidopsis thaliana. BMC Biochem (2013) 0.75
Exocytosis, Endocytosis, and Their Coupling in Excitable Cells. Front Mol Neurosci (2017) 0.75
The Rab3A-22A Chimera Prevents Sperm Exocytosis by Stabilizing Open Fusion Pores. J Biol Chem (2016) 0.75
PC12 cells that lack synaptotagmin I exhibit loss of a subpool of small dense core vesicles. Biophys J (2014) 0.75
Dilation of fusion pores by crowding of SNARE proteins. Elife (2017) 0.75
A novel assay for detecting fusion pore formation: implications for the fusion mechanism. Biochemistry (2013) 0.75
How do you recognize and reconstitute a synaptic vesicle after fusion? F1000Res (2017) 0.75
Vesicle Fusion Mediated by Solanesol-Anchored DNA. Biophys J (2017) 0.75
Membrane Fusion Involved in Neurotransmission: Glimpse from Electron Microscope and Molecular Simulation. Front Mol Neurosci (2017) 0.75
VMD: visual molecular dynamics. J Mol Graph (1996) 117.02
Scalable molecular dynamics with NAMD. J Comput Chem (2005) 59.49
Extending the treatment of backbone energetics in protein force fields: limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations. J Comput Chem (2004) 17.97
Membrane fusion. Cell (2003) 7.68
Lipid-anchored influenza hemagglutinin promotes hemifusion, not complete fusion. Cell (1994) 5.65
Protein-lipid interplay in fusion and fission of biological membranes. Annu Rev Biochem (2003) 4.77
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis. Cell (2006) 4.36
Synaptic vesicle fusion. Nat Struct Mol Biol (2008) 4.22
A clamping mechanism involved in SNARE-dependent exocytosis. Science (2006) 3.74
The dynamic control of kiss-and-run and vesicular reuse probed with single nanoparticles. Science (2009) 3.34
Hemifusion in SNARE-mediated membrane fusion. Nat Struct Mol Biol (2005) 3.33
Complexin controls the force transfer from SNARE complexes to membranes in fusion. Science (2009) 3.30
Hemifusion arrest by complexin is relieved by Ca2+-synaptotagmin I. Nat Struct Mol Biol (2006) 3.07
Multiple intermediates in SNARE-induced membrane fusion. Proc Natl Acad Sci U S A (2006) 2.65
Distinct domains of complexin I differentially regulate neurotransmitter release. Nat Struct Mol Biol (2007) 2.63
In vitro system capable of differentiating fast Ca2+-triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter release. Proc Natl Acad Sci U S A (2011) 2.27
Complexin and Ca2+ stimulate SNARE-mediated membrane fusion. Nat Struct Mol Biol (2008) 2.25
Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+. Nat Struct Mol Biol (2008) 2.11
Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion. Elife (2012) 2.04
Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis. Neuron (2002) 2.01
3D-DART: a DNA structure modelling server. Nucleic Acids Res (2009) 1.99
Dynamic Ca2+-dependent stimulation of vesicle fusion by membrane-anchored synaptotagmin 1. Science (2010) 1.77
Membrane fusion intermediates via directional and full assembly of the SNARE complex. Science (2012) 1.71
The fusion pores of Ca2+ -triggered exocytosis. Nat Struct Mol Biol (2008) 1.57
A single vesicle-vesicle fusion assay for in vitro studies of SNAREs and accessory proteins. Nat Protoc (2012) 1.28
A single-vesicle content mixing assay for SNARE-mediated membrane fusion. Nat Commun (2010) 1.20
Solution single-vesicle assay reveals PIP2-mediated sequential actions of synaptotagmin-1 on SNAREs. EMBO J (2012) 1.16
Single-Vesicle Fusion Assay Reveals Munc18-1 Binding to the SNARE Core Is Sufficient for Stimulating Membrane Fusion. ACS Chem Neurosci (2010) 1.16
Multiple Ca2+ sensors in secretion: teammates, competitors or autocrats? Trends Neurosci (2011) 1.06
The importance of an asymmetric distribution of acidic lipids for synaptotagmin 1 function as a Ca2+ sensor. Biochem J (2012) 0.92
Single-molecule FRET study of SNARE-mediated membrane fusion. Biosci Rep (2011) 0.84
Scalable molecular dynamics with NAMD. J Comput Chem (2005) 59.49
Myosin V walks hand-over-hand: single fluorophore imaging with 1.5-nm localization. Science (2003) 20.21
A practical guide to single-molecule FRET. Nat Methods (2008) 8.62
Single-molecule high-resolution imaging with photobleaching. Proc Natl Acad Sci U S A (2004) 6.36
Nonblinking and long-lasting single-molecule fluorescence imaging. Nat Methods (2006) 6.25
Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics. Nature (2010) 6.25
Flexible fitting of atomic structures into electron microscopy maps using molecular dynamics. Structure (2008) 5.97
Control of the selectivity of the aquaporin water channel family by global orientational tuning. Science (2002) 5.78
Analysis of single-molecule FRET trajectories using hidden Markov modeling. Biophys J (2006) 5.52
Accelerating molecular modeling applications with graphics processors. J Comput Chem (2007) 4.83
Imaging alpha-hemolysin with molecular dynamics: ionic conductance, osmotic permeability, and the electrostatic potential map. Biophys J (2005) 4.45
Advances in single-molecule fluorescence methods for molecular biology. Annu Rev Biochem (2008) 4.40
Single-molecule experiments in vitro and in silico. Science (2007) 4.22
Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA. Science (2009) 4.00
Structural dynamics of individual Holliday junctions. Nat Struct Biol (2003) 4.00
Probing cellular protein complexes using single-molecule pull-down. Nature (2011) 3.92
Microscopic Kinetics of DNA Translocation through synthetic nanopores. Biophys J (2004) 3.83
Repetitive shuttling of a motor protein on DNA. Nature (2005) 3.82
Calculating potentials of mean force from steered molecular dynamics simulations. J Chem Phys (2004) 3.81
Ten-microsecond molecular dynamics simulation of a fast-folding WW domain. Biophys J (2008) 3.81
Spontaneous intersubunit rotation in single ribosomes. Mol Cell (2008) 3.77
Spring-loaded mechanism of DNA unwinding by hepatitis C virus NS3 helicase. Science (2007) 3.70
Probing single-stranded DNA conformational flexibility using fluorescence spectroscopy. Biophys J (2004) 3.69
Energetics of glycerol conduction through aquaglyceroporin GlpF. Proc Natl Acad Sci U S A (2002) 3.60
Real-time observation of RecA filament dynamics with single monomer resolution. Cell (2006) 3.44
In search of the hair-cell gating spring elastic properties of ankyrin and cadherin repeats. Structure (2005) 3.36
Molecular biomimetics: nanotechnology through biology. Nat Mater (2003) 3.34
Hemifusion in SNARE-mediated membrane fusion. Nat Struct Mol Biol (2005) 3.33
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med (2005) 3.26
Near-complete suppression of quantum dot blinking in ambient conditions. J Am Chem Soc (2004) 3.14
Hemifusion arrest by complexin is relieved by Ca2+-synaptotagmin I. Nat Struct Mol Biol (2006) 3.07
Orientation discrimination of single-stranded DNA inside the alpha-hemolysin membrane channel. Proc Natl Acad Sci U S A (2005) 3.06
Structure of monomeric yeast and mammalian Sec61 complexes interacting with the translating ribosome. Science (2009) 3.00
Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics. Nature (2013) 2.98
Sizing DNA using a nanometer-diameter pore. Biophys J (2004) 2.95
Gating of MscL studied by steered molecular dynamics. Biophys J (2003) 2.91
Structural insight into nascent polypeptide chain-mediated translational stalling. Science (2009) 2.89
Structural basis for cooperative DNA binding by CAP and lac repressor. Structure (2004) 2.85
Pressure-induced water transport in membrane channels studied by molecular dynamics. Biophys J (2002) 2.78
Molecular dynamics simulations of the complete satellite tobacco mosaic virus. Structure (2006) 2.71
Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis. Proc Natl Acad Sci U S A (2009) 2.69
A four-way junction accelerates hairpin ribozyme folding via a discrete intermediate. Proc Natl Acad Sci U S A (2003) 2.65
Multiple intermediates in SNARE-induced membrane fusion. Proc Natl Acad Sci U S A (2006) 2.65
Extreme conformational diversity in human telomeric DNA. Proc Natl Acad Sci U S A (2005) 2.63
Regulation of neuronal SNARE assembly by the membrane. Nat Struct Biol (2003) 2.63
Theory and simulation of water permeation in aquaporin-1. Biophys J (2004) 2.63
Computational studies of membrane channels. Structure (2004) 2.61
Structural dynamics of the lac repressor-DNA complex revealed by a multiscale simulation. Proc Natl Acad Sci U S A (2005) 2.61
Single-molecule three-color FRET. Biophys J (2004) 2.59
Collective diffusion model for water permeation through microscopic channels. Phys Rev Lett (2004) 2.53
Fluorescence-force spectroscopy maps two-dimensional reaction landscape of the holliday junction. Science (2007) 2.49
BRAF(L597) mutations in melanoma are associated with sensitivity to MEK inhibitors. Cancer Discov (2012) 2.48
Mg2+-dependent conformational change of RNA studied by fluorescence correlation and FRET on immobilized single molecules. Proc Natl Acad Sci U S A (2002) 2.47
Defining single molecular forces required to activate integrin and notch signaling. Science (2013) 2.44
Extreme bendability of DNA less than 100 base pairs long revealed by single-molecule cyclization. Science (2012) 2.42
DNA-binding orientation and domain conformation of the E. coli rep helicase monomer bound to a partial duplex junction: single-molecule studies of fluorescently labeled enzymes. J Mol Biol (2004) 2.40
Following movement of the L1 stalk between three functional states in single ribosomes. Proc Natl Acad Sci U S A (2009) 2.40
Molecular dynamics flexible fitting: a practical guide to combine cryo-electron microscopy and X-ray crystallography. Methods (2009) 2.39
Vesicle encapsulation studies reveal that single molecule ribozyme heterogeneities are intrinsic. Biophys J (2004) 2.37
SSB protein diffusion on single-stranded DNA stimulates RecA filament formation. Nature (2009) 2.33
Insights into the molecular mechanism of rotation in the Fo sector of ATP synthase. Biophys J (2004) 2.33
Electrostatic tuning of permeation and selectivity in aquaporin water channels. Biophys J (2003) 2.31
Lipid bilayer pressure profiles and mechanosensitive channel gating. Biophys J (2004) 2.30
In vitro system capable of differentiating fast Ca2+-triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter release. Proc Natl Acad Sci U S A (2011) 2.27
Defocused orientation and position imaging (DOPI) of myosin V. Proc Natl Acad Sci U S A (2006) 2.27
Cryo-EM structure of the ribosome-SecYE complex in the membrane environment. Nat Struct Mol Biol (2011) 2.25
Complexin and Ca2+ stimulate SNARE-mediated membrane fusion. Nat Struct Mol Biol (2008) 2.25
Mechanisms of selectivity in channels and enzymes studied with interactive molecular dynamics. Biophys J (2003) 2.24
Orientation dependence in fluorescent energy transfer between Cy3 and Cy5 terminally attached to double-stranded nucleic acids. Proc Natl Acad Sci U S A (2008) 2.24
A structural mechanism for MscS gating in lipid bilayers. Science (2008) 2.24
Binding dynamics of isolated nucleoporin repeat regions to importin-beta. Structure (2005) 2.22
Routine multiplex mutational profiling of melanomas enables enrollment in genotype-driven therapeutic trials. PLoS One (2012) 2.21
Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction. Proc Natl Acad Sci U S A (2008) 2.19
Coordinating DNA replication by means of priming loop and differential synthesis rate. Nature (2009) 2.16
Steered molecular dynamics studies of titin I1 domain unfolding. Biophys J (2002) 2.13
PcrA helicase dismantles RecA filaments by reeling in DNA in uniform steps. Cell (2010) 2.10
Early steps of supported bilayer formation probed by single vesicle fluorescence assays. Biophys J (2002) 2.09
Tuning the mechanical stability of fibronectin type III modules through sequence variations. Structure (2004) 2.08
Photosynthetic apparatus of purple bacteria. Q Rev Biophys (2002) 2.07
Structural insights into how the MIDAS ion stabilizes integrin binding to an RGD peptide under force. Structure (2004) 2.01
Four-scale description of membrane sculpting by BAR domains. Biophys J (2008) 2.00
Molecular dynamics study of gating in the mechanosensitive channel of small conductance MscS. Biophys J (2004) 2.00
Common structural transitions in explicit-solvent simulations of villin headpiece folding. Biophys J (2009) 1.96
Stability and dynamics of virus capsids described by coarse-grained modeling. Structure (2006) 1.91
Stretching DNA using the electric field in a synthetic nanopore. Nano Lett (2005) 1.88
Water and proton conduction through carbon nanotubes as models for biological channels. Biophys J (2003) 1.87
Calculation of the gating charge for the Kv1.2 voltage-activated potassium channel. Biophys J (2010) 1.87
Structure and functional significance of mechanically unfolded fibronectin type III1 intermediates. Proc Natl Acad Sci U S A (2003) 1.86
Coarse grained protein-lipid model with application to lipoprotein particles. J Phys Chem B (2006) 1.81
What makes an aquaporin a glycerol channel? A comparative study of AqpZ and GlpF. Structure (2005) 1.80
Quantitative fluorescence labeling of aldehyde-tagged proteins for single-molecule imaging. Nat Methods (2012) 1.80
Ion conduction through MscS as determined by electrophysiology and simulation. Biophys J (2006) 1.80
Imaging the migration pathways for O2, CO, NO, and Xe inside myoglobin. Biophys J (2006) 1.80