Published in Science on June 22, 2006
Membrane fusion: grappling with SNARE and SM proteins. Science (2009) 8.98
Synaptic vesicle fusion. Nat Struct Mol Biol (2008) 4.22
Complexin controls the force transfer from SNARE complexes to membranes in fusion. Science (2009) 3.30
Neurotransmitter release: the last millisecond in the life of a synaptic vesicle. Neuron (2013) 2.94
Multiple intermediates in SNARE-induced membrane fusion. Proc Natl Acad Sci U S A (2006) 2.65
Distinct domains of complexin I differentially regulate neurotransmitter release. Nat Struct Mol Biol (2007) 2.63
Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helix. Neuron (2010) 2.52
Alternative zippering as an on-off switch for SNARE-mediated fusion. Science (2009) 2.30
Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis. Neuron (2009) 2.26
Complexin and Ca2+ stimulate SNARE-mediated membrane fusion. Nat Struct Mol Biol (2008) 2.25
Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+. Nat Struct Mol Biol (2008) 2.11
Membranes of the world unite! J Cell Biol (2006) 2.06
Complexin cross-links prefusion SNAREs into a zigzag array. Nat Struct Mol Biol (2011) 1.81
The Janus-faced nature of the C(2)B domain is fundamental for synaptotagmin-1 function. Nat Struct Mol Biol (2008) 1.76
Postsynaptic complexin controls AMPA receptor exocytosis during LTP. Neuron (2012) 1.74
A quaternary SNARE-synaptotagmin-Ca2+-phospholipid complex in neurotransmitter release. J Mol Biol (2007) 1.73
A fast, single-vesicle fusion assay mimics physiological SNARE requirements. Proc Natl Acad Sci U S A (2010) 1.68
Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system. Proc Natl Acad Sci U S A (2008) 1.68
Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice. Proc Natl Acad Sci U S A (2008) 1.68
Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity. Nat Struct Mol Biol (2010) 1.63
Distinct domains of complexins bind SNARE complexes and clamp fusion in vitro. J Biol Chem (2008) 1.59
Minimal membrane docking requirements revealed by reconstitution of Rab GTPase-dependent membrane fusion from purified components. Proc Natl Acad Sci U S A (2009) 1.55
The carboxy-terminal domain of complexin I stimulates liposome fusion. Proc Natl Acad Sci U S A (2009) 1.51
Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex. Proc Natl Acad Sci U S A (2010) 1.51
Complexin has opposite effects on two modes of synaptic vesicle fusion. Curr Biol (2011) 1.47
Trans-SNARE complex assembly and yeast vacuole membrane fusion. Proc Natl Acad Sci U S A (2007) 1.46
Complexin maintains vesicles in the primed state in C. elegans. Curr Biol (2011) 1.44
SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion. J Cell Biol (2010) 1.43
Synaptobrevin N-terminally bound to syntaxin-SNAP-25 defines the primed vesicle state in regulated exocytosis. J Cell Biol (2010) 1.43
Molecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter release. Annu Rev Physiol (2013) 1.41
A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion. Nat Struct Mol Biol (2011) 1.37
Complexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activity. J Neurosci (2012) 1.36
LTP requires a unique postsynaptic SNARE fusion machinery. Neuron (2013) 1.33
Synaptotagmin C2A loop 2 mediates Ca2+-dependent SNARE interactions essential for Ca2+-triggered vesicle exocytosis. Mol Biol Cell (2007) 1.32
Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release. EMBO J (2012) 1.31
Filamentous actin regulates insulin exocytosis through direct interaction with Syntaxin 4. J Biol Chem (2008) 1.30
A role of complexin-lipid interactions in membrane fusion. FEBS Lett (2009) 1.30
Loss of AP-3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses. Proc Natl Acad Sci U S A (2006) 1.28
Complexin II plays a positive role in Ca2+-triggered exocytosis by facilitating vesicle priming. Proc Natl Acad Sci U S A (2008) 1.28
Fusion pore formation and expansion induced by Ca2+ and synaptotagmin 1. Proc Natl Acad Sci U S A (2013) 1.27
Comparative analysis of Drosophila and mammalian complexins as fusion clamps and facilitators of neurotransmitter release. Mol Cell Neurosci (2010) 1.27
Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state. Nat Struct Mol Biol (2011) 1.26
Snapin facilitates the synchronization of synaptic vesicle fusion. Neuron (2009) 1.24
C-terminal complexin sequence is selectively required for clamping and priming but not for Ca2+ triggering of synaptic exocytosis. J Neurosci (2012) 1.22
VAMP8/endobrevin as a general vesicular SNARE for regulated exocytosis of the exocrine system. Mol Biol Cell (2007) 1.22
Differential dependence of phasic transmitter release on synaptotagmin 1 at GABAergic and glutamatergic hippocampal synapses. Proc Natl Acad Sci U S A (2008) 1.21
Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms. Elife (2014) 1.20
Kinetics of complexin binding to the SNARE complex: correcting single molecule FRET measurements for hidden events. Biophys J (2007) 1.20
Modelling vesicular release at hippocampal synapses. PLoS Comput Biol (2010) 1.10
Deconstructing complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypes. Proc Natl Acad Sci U S A (2013) 1.10
Concurrent binding of complexin and synaptotagmin to liposome-embedded SNARE complexes. Biochemistry (2009) 1.09
Re-examining how complexin inhibits neurotransmitter release. Elife (2014) 1.07
An ancient duplication of exon 5 in the Snap25 gene is required for complex neuronal development/function. PLoS Genet (2008) 1.05
Accessory alpha-helix of complexin I can displace VAMP2 locally in the complexin-SNARE quaternary complex. J Mol Biol (2009) 1.05
Nitric oxide regulation of protein trafficking in the cardiovascular system. Cardiovasc Res (2007) 1.04
Should I stop or should I go? The role of complexin in neurotransmitter release. Nat Rev Neurosci (2016) 1.02
Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution. Nat Struct Mol Biol (2015) 1.01
A half-zippered SNARE complex represents a functional intermediate in membrane fusion. J Am Chem Soc (2014) 1.00
Dual roles of Munc18-1 rely on distinct binding modes of the central cavity with Stx1A and SNARE complex. Mol Biol Cell (2011) 0.97
Rapid fusion of synaptic vesicles with reconstituted target SNARE membranes. Biophys J (2013) 0.96
Regulation of synaptic vesicle docking by different classes of macromolecules in active zone material. PLoS One (2012) 0.96
Complexin activates exocytosis of distinct secretory vesicles controlled by different synaptotagmins. J Neurosci (2013) 0.96
Differential regulation of evoked and spontaneous neurotransmitter release by C-terminal modifications of complexin. Mol Cell Neurosci (2012) 0.95
Interaction of the complexin accessory helix with the C-terminus of the SNARE complex: molecular-dynamics model of the fusion clamp. Biophys J (2013) 0.95
Membrane curvature sensing by the C-terminal domain of complexin. Nat Commun (2014) 0.95
SNAP-23 and syntaxin-2 localize to the extracellular surface of the platelet plasma membrane. Blood (2007) 0.94
Genetic analysis of the Complexin trans-clamping model for cross-linking SNARE complexes in vivo. Proc Natl Acad Sci U S A (2014) 0.94
Subtle Interplay between synaptotagmin and complexin binding to the SNARE complex. J Mol Biol (2013) 0.94
Real-time visualization of complexin during single exocytic events. Nat Neurosci (2010) 0.93
Complexin facilitates exocytosis and synchronizes vesicle release in two secretory model systems. J Physiol (2013) 0.93
The importance of an asymmetric distribution of acidic lipids for synaptotagmin 1 function as a Ca2+ sensor. Biochem J (2012) 0.92
Secretion machinery at the cell plasma membrane. Curr Opin Struct Biol (2007) 0.92
Calcium sensitive ring-like oligomers formed by synaptotagmin. Proc Natl Acad Sci U S A (2014) 0.92
The SNARE complex in neuronal and sensory cells. Mol Cell Neurosci (2012) 0.92
α-SNAP prevents docking of the acrosome during sperm exocytosis because it sequesters monomeric syntaxin. PLoS One (2011) 0.91
VAMP-1, VAMP-2, and syntaxin-4 regulate ANP release from cardiac myocytes. J Mol Cell Cardiol (2010) 0.91
Prevalent mechanism of membrane bridging by synaptotagmin-1. Proc Natl Acad Sci U S A (2013) 0.90
Complexin synchronizes primed vesicle exocytosis and regulates fusion pore dynamics. J Cell Biol (2014) 0.89
PTP1B dephosphorylates N-ethylmaleimide-sensitive factor and elicits SNARE complex disassembly during human sperm exocytosis. J Biol Chem (2009) 0.89
Conformational dynamics of calcium-triggered activation of fusion by synaptotagmin. Biophys J (2013) 0.89
Transmission, Development, and Plasticity of Synapses. Genetics (2015) 0.89
Re-visiting the trans insertion model for complexin clamping. Elife (2015) 0.87
Complexin I is required for mammalian sperm acrosomal exocytosis. Dev Biol (2007) 0.86
The trans-SNARE-regulating function of Munc18-1 is essential to synaptic exocytosis. Nat Commun (2015) 0.85
Molecular underpinnings of synaptic vesicle pool heterogeneity. Traffic (2015) 0.85
Synip arrests soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-dependent membrane fusion as a selective target membrane SNARE-binding inhibitor. J Biol Chem (2013) 0.84
Tag team action at the synapse. EMBO Rep (2007) 0.84
Structural disorder provides increased adaptability for vesicle trafficking pathways. PLoS Comput Biol (2013) 0.83
A role for soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex dimerization during neurosecretion. Mol Biol Cell (2008) 0.83
SNARE zippering. Biosci Rep (2016) 0.83
Reconstituting SNARE-mediated membrane fusion at the single liposome level. Methods Cell Biol (2015) 0.83
Complexin 2 modulates vesicle-associated membrane protein (VAMP) 2-regulated zymogen granule exocytosis in pancreatic acini. J Biol Chem (2010) 0.83
Complexins: small but capable. Cell Mol Life Sci (2015) 0.82
Secretory granules in inositol 1,4,5-trisphosphate-dependent Ca2+ signaling in the cytoplasm of neuroendocrine cells. FASEB J (2009) 0.82
A sequential vesicle pool model with a single release sensor and a Ca(2+)-dependent priming catalyst effectively explains Ca(2+)-dependent properties of neurosecretion. PLoS Comput Biol (2013) 0.82
Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complex. Elife (2016) 0.82
Retinoic Acid and LTP Recruit Postsynaptic AMPA Receptors Using Distinct SNARE-Dependent Mechanisms. Neuron (2015) 0.81
Extracellular localization of epimorphin/syntaxin-2. Blood (2007) 0.80
Phosphorylation of Complexin by PKA Regulates Activity-Dependent Spontaneous Neurotransmitter Release and Structural Synaptic Plasticity. Neuron (2015) 0.80
The dendritic SNARE fusion machinery involved in AMPARs insertion during long-term potentiation. Front Cell Neurosci (2014) 0.80
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Membrane fusion: grappling with SNARE and SM proteins. Science (2009) 8.98
Selective activation of cognate SNAREpins by Sec1/Munc18 proteins. Cell (2007) 4.26
Energetics and dynamics of SNAREpin folding across lipid bilayers. Nat Struct Mol Biol (2007) 3.39
SNARE proteins are required for macroautophagy. Cell (2011) 2.99
Single reconstituted neuronal SNARE complexes zipper in three distinct stages. Science (2012) 2.98
Fusion of cells by flipped SNAREs. Science (2003) 2.60
Acetylation targets mutant huntingtin to autophagosomes for degradation. Cell (2009) 2.57
Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway. J Cell Biol (2006) 2.45
Journeys through the Golgi--taking stock in a new era. J Cell Biol (2009) 2.30
Alternative zippering as an on-off switch for SNARE-mediated fusion. Science (2009) 2.30
Regulation of membrane fusion by the membrane-proximal coil of the t-SNARE during zippering of SNAREpins. J Cell Biol (2002) 2.13
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. Mol Cell (2010) 2.12
Distinct SNARE complexes mediating membrane fusion in Golgi transport based on combinatorial specificity. Proc Natl Acad Sci U S A (2002) 2.07
A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy (2011) 2.02
Imaging single membrane fusion events mediated by SNARE proteins. Proc Natl Acad Sci U S A (2004) 1.99
SNARE proteins: one to fuse and three to keep the nascent fusion pore open. Science (2012) 1.89
Molecular imaging using fluorescent lectins permits rapid endoscopic identification of dysplasia in Barrett's esophagus. Nat Med (2012) 1.83
The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation. Science (2012) 1.82
Complexin cross-links prefusion SNAREs into a zigzag array. Nat Struct Mol Biol (2011) 1.81
SNAREs can promote complete fusion and hemifusion as alternative outcomes. J Cell Biol (2005) 1.78
A fast, single-vesicle fusion assay mimics physiological SNARE requirements. Proc Natl Acad Sci U S A (2010) 1.68
Sequence characteristics of functional siRNAs. RNA (2005) 1.59
Distinct domains of complexins bind SNARE complexes and clamp fusion in vitro. J Biol Chem (2008) 1.59
Liposome fusion assay to monitor intracellular membrane fusion machines. Methods Enzymol (2003) 1.49
SNAREpin/Munc18 promotes adhesion and fusion of large vesicles to giant membranes. Proc Natl Acad Sci U S A (2008) 1.48
Stapled Golgi cisternae remain in place as cargo passes through the stack. Elife (2013) 1.47
SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion. J Cell Biol (2010) 1.43
Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT. Nat Neurosci (2011) 1.41
Countercurrent distribution of two distinct SNARE complexes mediating transport within the Golgi stack. Mol Biol Cell (2004) 1.39
A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion. Nat Struct Mol Biol (2011) 1.37
A SNARE required for retrograde transport to the endoplasmic reticulum. Proc Natl Acad Sci U S A (2003) 1.31
Localization and activity of the SNARE Ykt6 determined by its regulatory domain and palmitoylation. Proc Natl Acad Sci U S A (2004) 1.28
Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state. Nat Struct Mol Biol (2011) 1.26
The specificity of SNARE-dependent fusion is encoded in the SNARE motif. Proc Natl Acad Sci U S A (2004) 1.23
Two-color STED microscopy in living cells. Biomed Opt Express (2011) 1.19
Identification of a conserved glycan signature for microvesicles. J Proteome Res (2011) 1.14
A resident Golgi protein is excluded from peri-Golgi vesicles in NRK cells. Proc Natl Acad Sci U S A (2002) 1.14
i-SNAREs: inhibitory SNAREs that fine-tune the specificity of membrane fusion. J Cell Biol (2003) 1.14
Differential use of endoplasmic reticulum membrane for phagocytosis in J774 macrophages. Proc Natl Acad Sci U S A (2005) 1.12
Intracellular bacteria encode inhibitory SNARE-like proteins. PLoS One (2009) 1.10
COPI buds 60-nm lipid droplets from reconstituted water-phospholipid-triacylglyceride interfaces, suggesting a tension clamp function. Proc Natl Acad Sci U S A (2013) 1.08
Lipidic antagonists to SNARE-mediated fusion. J Biol Chem (2006) 1.05
Protein determinants of SNARE-mediated lipid mixing. Biophys J (2010) 1.05
Induction of cortical endoplasmic reticulum by dimerization of a coatomer-binding peptide anchored to endoplasmic reticulum membranes. Proc Natl Acad Sci U S A (2010) 1.04
A half-zippered SNARE complex represents a functional intermediate in membrane fusion. J Am Chem Soc (2014) 1.00
Dual roles of Munc18-1 rely on distinct binding modes of the central cavity with Stx1A and SNARE complex. Mol Biol Cell (2011) 0.97
Mapping posttranscriptional regulation of the human glycome uncovers microRNA defining the glycocode. Proc Natl Acad Sci U S A (2014) 0.95
Fusion of single proteoliposomes with planar, cushioned bilayers in microfluidic flow cells. Nat Protoc (2012) 0.92
Preparation and characterization of SNARE-containing nanodiscs and direct study of cargo release through fusion pores. Nat Protoc (2013) 0.90
Conformational dynamics of calcium-triggered activation of fusion by synaptotagmin. Biophys J (2013) 0.89
Functional mapping of disease susceptibility loci using cell biology. Proc Natl Acad Sci U S A (2006) 0.89
Dynamic transport of SNARE proteins in the Golgi apparatus. Proc Natl Acad Sci U S A (2005) 0.89
Inter-Golgi transport mediated by COPI-containing vesicles carrying small cargoes. Elife (2013) 0.88
Concerted auto-regulation in yeast endosomal t-SNAREs. J Biol Chem (2005) 0.87
How a G protein binds a membrane. J Biol Chem (2004) 0.87
Approaches to the study of Atg8-mediated membrane dynamics in vitro. Methods Cell Biol (2012) 0.86
Membrane adhesion dictates Golgi stacking and cisternal morphology. Proc Natl Acad Sci U S A (2014) 0.86
Using light to see and control membrane traffic. Curr Opin Chem Biol (2011) 0.82
A Programmable DNA Origami Platform to Organize SNAREs for Membrane Fusion. J Am Chem Soc (2016) 0.81
Modulating macroautophagy: a neuronal perspective. Future Med Chem (2012) 0.81
Cell-based assays using primary endothelial cells to study multiple steps in inflammation. Methods Enzymol (2006) 0.79
Correction: Re-visiting the trans insertion model for complexin clamping. Elife (2017) 0.75
Correction to Formation of Giant Unilamellar Proteo-Liposomes by Osmotic Shock. Langmuir (2015) 0.75