Dysregulated A to I RNA editing and non-coding RNAs in neurodegeneration.

Basic biology and therapeutic implications of lncRNA. Adv Drug Deliv Rev (2015) 0.88

Invited review: decoding the pathophysiological mechanisms that underlie RNA dysregulation in neurodegenerative disorders: a review of the current state of the art. Neuropathol Appl Neurobiol (2015) 0.85

Epigenetic regulation in Parkinson's disease. Acta Neuropathol (2016) 0.83

RNA-mediated pathogenic mechanisms in polyglutamine diseases and amyotrophic lateral sclerosis. Front Cell Neurosci (2014) 0.82

Selectively Constrained RNA Editing Regulation Crosstalks with piRNA Biogenesis in Primates. Mol Biol Evol (2015) 0.80

Chronic glutamate treatment selectively modulates AMPA RNA editing and ADAR expression and activity in primary cortical neurons. RNA Biol (2015) 0.77

Pigmy MicroRNA: surveillance cops in Therapies kingdom. Mol Med (2016) 0.75

MicroRNAs: genomics, biogenesis, mechanism, and function. Cell (2004) 198.59

Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15

Origins and Mechanisms of miRNAs and siRNAs. Cell (2009) 20.77

RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science (2007) 18.59

Small silencing RNAs: an expanding universe. Nat Rev Genet (2009) 13.88

Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3' end of a transcript encoding a protein kinase family member. Cell (1992) 12.74

Non-coding RNA. Hum Mol Genet (2006) 10.57

RNA editing by adenosine deaminases that act on RNA. Annu Rev Biochem (2001) 9.66

Myotonic dystrophy mutation: an unstable CTG repeat in the 3' untranslated region of the gene. Science (1992) 9.32

An unstable triplet repeat in a gene related to myotonic muscular dystrophy. Science (1992) 8.20

Sequence variants in SLITRK1 are associated with Tourette's syndrome. Science (2005) 8.20

Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc Natl Acad Sci U S A (2003) 7.95

Regulation of serotonin-2C receptor G-protein coupling by RNA editing. Nature (1997) 7.92

Systematic identification of abundant A-to-I editing sites in the human transcriptome. Nat Biotechnol (2004) 7.61

Modulation of microRNA processing and expression through RNA editing by ADAR deaminases. Nat Struct Mol Biol (2005) 7.49

Widespread A-to-I RNA editing of Alu-containing mRNAs in the human transcriptome. PLoS Biol (2004) 6.67

Numerous microRNPs in neuronal cells containing novel microRNAs. RNA (2003) 6.28

Protein networks in disease. Genome Res (2008) 5.65

Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase. Nat Med (2008) 5.62

Regulating gene expression through RNA nuclear retention. Cell (2005) 5.58

Transcriptional silencing and promoter methylation triggered by double-stranded RNA. EMBO J (2000) 5.41

Widespread RNA editing of embedded alu elements in the human transcriptome. Genome Res (2004) 5.14

Rapid evolution of noncoding RNAs: lack of conservation does not mean lack of function. Trends Genet (2005) 5.07

Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration. Nature (2006) 5.07

Regulation of alternative splicing by RNA editing. Nature (1999) 5.00

RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila. Mol Cell (2002) 4.90

The power of the 3' UTR: translational control and development. Nat Rev Genet (2003) 4.84

Epigenetics in alternative pre-mRNA splicing. Cell (2011) 4.74

Diseases of unstable repeat expansion: mechanisms and common principles. Nat Rev Genet (2005) 4.66

Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization. Proc Natl Acad Sci U S A (2000) 4.54

RNA editing of a miRNA precursor. RNA (2004) 4.43

RNA editing of human microRNAs. Genome Biol (2006) 4.16

An untranslated CTG expansion causes a novel form of spinocerebellar ataxia (SCA8) Nat Genet (1999) 4.15

Small regulatory RNAs in mammals. Hum Mol Genet (2005) 4.15

Promoter-associated RNA is required for RNA-directed transcriptional gene silencing in human cells. Proc Natl Acad Sci U S A (2007) 3.99

Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene. J Biol Chem (2003) 3.93

A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity. Cell (2000) 3.86

Differentiating protein-coding and noncoding RNA: challenges and ambiguities. PLoS Comput Biol (2008) 3.66

RNAi-mediated allelic trans-interaction at the imprinted Rtl1/Peg11 locus. Curr Biol (2005) 3.65

Challenging the dogma: the hidden layer of non-protein-coding RNAs in complex organisms. Bioessays (2003) 3.59

RNA hairpins in noncoding regions of human brain and Caenorhabditis elegans mRNA are edited by adenosine deaminases that act on RNA. Proc Natl Acad Sci U S A (2002) 3.41

RNA editing of the microRNA-151 precursor blocks cleavage by the Dicer-TRBP complex. EMBO Rep (2007) 3.40

Editor meets silencer: crosstalk between RNA editing and RNA interference. Nat Rev Mol Cell Biol (2006) 3.31

Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein. Am J Hum Genet (2008) 3.27

Inosine exists in mRNA at tissue-specific levels and is most abundant in brain mRNA. EMBO J (1998) 3.23

Alu element-mediated gene silencing. EMBO J (2008) 3.22

Myotonic dystrophy type 1 is associated with nuclear foci of mutant RNA, sequestration of muscleblind proteins and deregulated alternative splicing in neurons. Hum Mol Genet (2004) 3.21

Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims. Neuron (2002) 3.06

A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains. RNA (2000) 3.06

Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing. Science (2005) 2.94

The many facets of H/ACA ribonucleoproteins. Chromosoma (2005) 2.89

Targets of RNA-directed DNA methylation. Curr Opin Plant Biol (2007) 2.81

The evolution of controlled multitasked gene networks: the role of introns and other noncoding RNAs in the development of complex organisms. Mol Biol Evol (2001) 2.67

RED2, a brain-specific member of the RNA-specific adenosine deaminase family. J Biol Chem (1996) 2.64

Large expansion of the ATTCT pentanucleotide repeat in spinocerebellar ataxia type 10. Nat Genet (2000) 2.60

Identification of tandemly-repeated C/D snoRNA genes at the imprinted human 14q32 domain reminiscent of those at the Prader-Willi/Angelman syndrome region. Hum Mol Genet (2002) 2.55

Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease. Nat Rev Neurosci (2012) 2.52

Paramutation: from maize to mice. Cell (2007) 2.38

Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation. BMC Neurosci (2010) 2.34

Is abundant A-to-I RNA editing primate-specific? Trends Genet (2005) 2.32

Non-coding RNAs: new players in eukaryotic biology. Gene (2005) 2.29

Understanding microRNAs in neurodegeneration. Nat Rev Neurosci (2009) 2.22

The Muscleblind family of proteins: an emerging class of regulators of developmentally programmed alternative splicing. Differentiation (2006) 2.16

RNA editing by ADARs is important for normal behavior in Caenorhabditis elegans. EMBO J (2002) 2.14

Dynamic association of RNA-editing enzymes with the nucleolus. J Cell Sci (2003) 2.14

Mitochondrial DNA and disease. Ann Med (2005) 2.13

RNA editing of the human serotonin 5-hydroxytryptamine 2C receptor silences constitutive activity. J Biol Chem (1999) 2.10

How imprinting centres work. Cytogenet Genome Res (2006) 2.06

Clusters of internally primed transcripts reveal novel long noncoding RNAs. PLoS Genet (2006) 1.95

Requirement of dimerization for RNA editing activity of adenosine deaminases acting on RNA. J Biol Chem (2003) 1.93

RNAi is antagonized by A-->I hyper-editing. EMBO Rep (2001) 1.86

Human box H/ACA pseudouridylation guide RNA machinery. Mol Cell Biol (2004) 1.85

miRNA malfunction causes spinal motor neuron disease. Proc Natl Acad Sci U S A (2010) 1.83

The snoRNA MBII-52 (SNORD 115) is processed into smaller RNAs and regulates alternative splicing. Hum Mol Genet (2010) 1.83

Noncoding RNAs and RNA editing in brain development, functional diversification, and neurological disease. Physiol Rev (2007) 1.79

ADAR gene family and A-to-I RNA editing: diverse roles in posttranscriptional gene regulation. Prog Nucleic Acid Res Mol Biol (2005) 1.78

ADAR2-mediated editing of RNA substrates in the nucleolus is inhibited by C/D small nucleolar RNAs. J Cell Biol (2005) 1.78

Global profiling of DNA methylation erasure in mouse primordial germ cells. Genome Res (2012) 1.78

SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacology (1997) 1.76

Editing independent effects of ADARs on the miRNA/siRNA pathways. EMBO J (2009) 1.76

RNA editing level in the mouse is determined by the genomic repeat repertoire. RNA (2006) 1.75

Expansion of a novel CAG trinucleotide repeat in the 5' region of PPP2R2B is associated with SCA12. Nat Genet (1999) 1.74

Modulation of RNA editing by functional nucleolar sequestration of ADAR2. Proc Natl Acad Sci U S A (2003) 1.73

Expression of interferon-inducible RNA adenosine deaminase ADAR1 during pathogen infection and mouse embryo development involves tissue-selective promoter utilization and alternative splicing. J Biol Chem (2005) 1.72

The RNA world meets behavior: A-->I pre-mRNA editing in animals. Trends Genet (2001) 1.72

Noncoding RNAs and intranuclear positioning in monoallelic gene expression. Cell (2007) 1.71

RNA editing, DNA recoding and the evolution of human cognition. Trends Neurosci (2008) 1.70

The uniqueness of the imprinting mechanism. Curr Opin Genet Dev (2000) 1.65

Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron. J Biol Chem (2005) 1.61

Imprinted gene expression in the brain. Neurosci Biobehav Rev (2005) 1.59

How stress and fluoxetine modulate serotonin 2C receptor pre-mRNA editing. J Neurosci (2005) 1.57

A Cajal body-specific pseudouridylation guide RNA is composed of two box H/ACA snoRNA-like domains. Nucleic Acids Res (2002) 1.56

Epigenetic principles and mechanisms underlying nervous system functions in health and disease. Prog Neurobiol (2008) 1.53

Action at a distance: epigenetic silencing of large chromosomal regions in carcinogenesis. Hum Mol Genet (2007) 1.52

Genetic mapping of a second myotonic dystrophy locus. Nat Genet (1998) 1.52

Long non-coding RNAs in Huntington's disease neurodegeneration. Neurobiol Dis (2011) 1.51

The spinocerebellar ataxia 8 noncoding RNA causes neurodegeneration and associates with staufen in Drosophila. Curr Biol (2004) 1.51

Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader-Willi syndrome. Neurobiol Dis (2010) 1.46

The influence of non-coding RNAs on allele-specific gene expression in mammals. Hum Mol Genet (2005) 1.46

RNA editing of the 5-HT(2C) receptor is reduced in schizophrenia. Mol Psychiatry (2001) 1.45