Published in Nat Genet on January 07, 2007
Tackling the widespread and critical impact of batch effects in high-throughput data. Nat Rev Genet (2010) 11.82
High-resolution mapping of expression-QTLs yields insight into human gene regulation. PLoS Genet (2008) 9.68
Mapping complex disease traits with global gene expression. Nat Rev Genet (2009) 7.44
SCAN: SNP and copy number annotation. Bioinformatics (2009) 5.96
Patterns of cis regulatory variation in diverse human populations. PLoS Genet (2012) 5.28
Genetics of human gene expression: mapping DNA variants that influence gene expression. Nat Rev Genet (2009) 4.05
Evaluation of genetic variation contributing to differences in gene expression between populations. Am J Hum Genet (2008) 4.01
Accurate discovery of expression quantitative trait loci under confounding from spurious and genuine regulatory hotspots. Genetics (2008) 3.66
RNA interference in the clinic: challenges and future directions. Nat Rev Cancer (2010) 3.43
A Bayesian framework to account for complex non-genetic factors in gene expression levels greatly increases power in eQTL studies. PLoS Comput Biol (2010) 3.23
ReCount: a multi-experiment resource of analysis-ready RNA-seq gene count datasets. BMC Bioinformatics (2011) 3.12
On the design and analysis of gene expression studies in human populations. Nat Genet (2007) 3.07
Single-nucleotide polymorphisms inside microRNA target sites influence tumor susceptibility. Cancer Res (2010) 2.82
Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue. PLoS Genet (2011) 2.68
Adaptive evolution of UGT2B17 copy-number variation. Am J Hum Genet (2008) 2.58
Extreme clonality in lymphoblastoid cell lines with implications for allele specific expression analyses. PLoS One (2008) 2.28
A genome-wide gene expression signature of environmental geography in leukocytes of Moroccan Amazighs. PLoS Genet (2008) 2.19
Effects of cis and trans genetic ancestry on gene expression in African Americans. PLoS Genet (2008) 2.09
Classification of human chromosome 21 gene-expression variations in Down syndrome: impact on disease phenotypes. Am J Hum Genet (2007) 2.06
Population-specificity of human DNA methylation. Genome Biol (2012) 2.04
Heritability and genomics of gene expression in peripheral blood. Nat Genet (2014) 2.00
Allele-specific DNA methylation: beyond imprinting. Hum Mol Genet (2010) 1.98
Pharmacogenomic discovery using cell-based models. Pharmacol Rev (2009) 1.96
Identification of common genetic variants that account for transcript isoform variation between human populations. Hum Genet (2008) 1.96
Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes. Hum Mol Genet (2010) 1.89
Natural gene-expression variation in Down syndrome modulates the outcome of gene-dosage imbalance. Am J Hum Genet (2007) 1.86
Coexpression network based on natural variation in human gene expression reveals gene interactions and functions. Genome Res (2009) 1.74
The HapMap Resource is Providing New Insights into Ourselves and its Application to Pharmacogenomics. Bioinform Biol Insights (2008) 1.73
seeQTL: a searchable database for human eQTLs. Bioinformatics (2011) 1.72
Intrinsic variability of gene expression encoded in nucleosome positioning sequences. Nat Genet (2009) 1.71
Human MHC architecture and evolution: implications for disease association studies. Int J Immunogenet (2008) 1.70
Extensive relationship between antisense transcription and alternative splicing in the human genome. Genome Res (2011) 1.69
Identification of cis- and trans-regulatory variation modulating microRNA expression levels in human fibroblasts. Genome Res (2010) 1.67
Heritable and non-genetic factors as variables of pharmacologic phenotypes in lymphoblastoid cell lines. Pharmacogenomics J (2010) 1.66
Patrocles: a database of polymorphic miRNA-mediated gene regulation in vertebrates. Nucleic Acids Res (2009) 1.60
Molecular discrimination of responders and nonresponders to anti-TNF alpha therapy in rheumatoid arthritis by etanercept. Arthritis Res Ther (2008) 1.59
Genetic control of gene expression in whole blood and lymphoblastoid cell lines is largely independent. Genome Res (2011) 1.58
Expression quantitative trait loci detected in cell lines are often present in primary tissues. Hum Mol Genet (2009) 1.57
A genome-wide approach to identifying novel-imprinted genes. Hum Genet (2007) 1.55
Quantitative genetics of CTCF binding reveal local sequence effects and different modes of X-chromosome association. PLoS Genet (2014) 1.55
Cooperativity and rapid evolution of cobound transcription factors in closely related mammals. Cell (2013) 1.52
Race and socioeconomic status influence outcomes of unrelated donor hematopoietic cell transplantation. Biol Blood Marrow Transplant (2009) 1.52
Impact of microRNA regulation on variation in human gene expression. Genome Res (2012) 1.49
The Brisbane Systems Genetics Study: genetical genomics meets complex trait genetics. PLoS One (2012) 1.49
The general population cohort in rural south-western Uganda: a platform for communicable and non-communicable disease studies. Int J Epidemiol (2013) 1.48
Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene. Neuropsychopharmacology (2007) 1.48
Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse. Nat Genet (2013) 1.45
Modifier effects between regulatory and protein-coding variation. PLoS Genet (2008) 1.42
Pharmacogenomics: candidate gene identification, functional validation and mechanisms. Hum Mol Genet (2008) 1.41
Gene expression variability within and between human populations and implications toward disease susceptibility. PLoS Comput Biol (2010) 1.39
Analytical methods for inferring functional effects of single base pair substitutions in human cancers. Hum Genet (2009) 1.39
Consistency of genome-wide associations across major ancestral groups. Hum Genet (2011) 1.35
From human genetics and genomics to pharmacogenetics and pharmacogenomics: past lessons, future directions. Drug Metab Rev (2008) 1.35
Evolving gene expression: from G to E to GxE. Trends Ecol Evol (2009) 1.34
Population differences in microRNA expression and biological implications. RNA Biol (2011) 1.33
Exprtarget: an integrative approach to predicting human microRNA targets. PLoS One (2010) 1.31
Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. PLoS Genet (2009) 1.30
Large-scale East-Asian eQTL mapping reveals novel candidate genes for LD mapping and the genomic landscape of transcriptional effects of sequence variants. PLoS One (2014) 1.27
Estimation of alternative splicing variability in human populations. Genome Res (2011) 1.27
Gene expression profiling in sepsis: timing, tissue, and translational considerations. Trends Mol Med (2014) 1.25
A genome-wide survey for SNPs altering microRNA seed sites identifies functional candidates in GWAS. BMC Genomics (2011) 1.25
Gene expression variation in African and European populations of Drosophila melanogaster. Genome Biol (2008) 1.22
Genomic characterization of esophageal squamous cell carcinoma from a high-risk population in China. Cancer Res (2009) 1.20
Expression quantitative trait loci: present and future. Philos Trans R Soc Lond B Biol Sci (2013) 1.20
Validating discovered Cis-acting regulatory genetic variants: application of an allele specific expression approach to HapMap populations. PLoS One (2008) 1.20
Beyond the HapMap Genotypic Data: Prospects of Deep Resequencing Projects. Curr Bioinform (2008) 1.19
Plasticity of the systemic inflammatory response to acute infection during critical illness: development of the riboleukogram. PLoS One (2008) 1.19
Gene expression profiles of sporadic canine hemangiosarcoma are uniquely associated with breed. PLoS One (2009) 1.19
A genome-wide in vitro bacterial-infection screen reveals human variation in the host response associated with inflammatory disease. Am J Hum Genet (2009) 1.18
Effectively identifying eQTLs from multiple tissues by combining mixed model and meta-analytic approaches. PLoS Genet (2013) 1.18
Integrating Epigenomics into Pharmacogenomic Studies. Pharmgenomics Pers Med (2008) 1.18
A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder. Arch Gen Psychiatry (2009) 1.16
Batch effects and pathway analysis: two potential perils in cancer studies involving DNA methylation array analysis. Cancer Epidemiol Biomarkers Prev (2013) 1.16
Extent of differential allelic expression of candidate breast cancer genes is similar in blood and breast. Breast Cancer Res (2009) 1.16
Impact of the 1000 genomes project on the next wave of pharmacogenomic discovery. Pharmacogenomics (2010) 1.12
The human Major Histocompatibility Complex as a paradigm in genomics research. Brief Funct Genomic Proteomic (2009) 1.11
Identification of candidate regulatory SNPs by combination of transcription-factor-binding site prediction, SNP genotyping and haploChIP. Nucleic Acids Res (2009) 1.11
Interactions among genes, tumor biology and the environment in cancer health disparities: examining the evidence on a national and global scale. Carcinogenesis (2011) 1.10
Integrating microRNAs into a system biology approach to acute lung injury. Transl Res (2011) 1.10
Current genetic methodologies in the identification of disaster victims and in forensic analysis. J Appl Genet (2011) 1.07
Identification of genetic variants and gene expression relationships associated with pharmacogenes in humans. Pharmacogenet Genomics (2008) 1.06
Whole genome survey of coding SNPs reveals a reproducible pathway determinant of Parkinson disease. Hum Mutat (2009) 1.06
Peripheral blood gene expression as a novel genomic biomarker in complicated sarcoidosis. PLoS One (2012) 1.05
Gene expression variation in Down's syndrome mice allows prioritization of candidate genes. Genome Biol (2007) 1.04
GSTP1 and TNF Gene variants and associations between air pollution and incident childhood asthma: the traffic, asthma and genetics (TAG) study. Environ Health Perspect (2014) 1.02
Association of IRF5 polymorphisms with activation of the interferon alpha pathway. Ann Rheum Dis (2009) 1.02
Variability in small airway epithelial gene expression among normal smokers. Chest (2008) 1.02
Trans-ethnic genome-wide association studies: advantages and challenges of mapping in diverse populations. Genome Med (2014) 1.02
Removing batch effects for prediction problems with frozen surrogate variable analysis. PeerJ (2014) 1.01
Systematic reviews of animal models: methodology versus epistemology. Int J Med Sci (2013) 1.01
Disparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and non-Hispanic whites. BMC Genet (2009) 1.01
Population differences in the rate of proliferation of international HapMap cell lines. Am J Hum Genet (2010) 1.00
Genome-wide analysis of natural selection on human cis-elements. PLoS One (2008) 1.00
Systematic review of genome-wide expression studies in multiple sclerosis. BMJ Open (2011) 1.00
Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion. PLoS One (2009) 0.99
Animal models and conserved processes. Theor Biol Med Model (2012) 0.99
Identifying genetic variants that contribute to chemotherapy-induced cytotoxicity. Pharmacogenomics (2007) 0.99
Allele-specific expression in the germline of patients with familial pancreatic cancer: an unbiased approach to cancer gene discovery. Cancer Biol Ther (2007) 0.98
Pharmacogenomics: a systems approach. Wiley Interdiscip Rev Syst Biol Med (2010) 0.97
Genetic and genomic analysis modeling of germline c-MYC overexpression and cancer susceptibility. BMC Genomics (2008) 0.97
Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci U S A (1998) 192.97
A haplotype map of the human genome. Nature (2005) 105.70
Genetic analysis of genome-wide variation in human gene expression. Nature (2004) 27.28
Genetics of gene expression surveyed in maize, mouse and man. Nature (2003) 22.17
Whole-genome patterns of common DNA variation in three human populations. Science (2005) 21.22
Genome-wide associations of gene expression variation in humans. PLoS Genet (2005) 17.27
Mapping determinants of human gene expression by regional and genome-wide association. Nature (2005) 17.24
Common deletion polymorphisms in the human genome. Nat Genet (2006) 15.66
SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans. Science (2005) 12.02
Natural variation in human gene expression assessed in lymphoblastoid cells. Nat Genet (2003) 11.63
Allelic variation in human gene expression. Science (2002) 11.42
Genetic inheritance of gene expression in human cell lines. Am J Hum Genet (2004) 8.97
A survey of genetic and epigenetic variation affecting human gene expression. Physiol Genomics (2004) 4.99
Regulatory polymorphisms underlying complex disease traits. J Mol Med (Berl) (2004) 3.22
Characterization of a common deletion polymorphism of the UGT2B17 gene linked to UGT2B15. Genomics (2004) 2.59
Mutations and sequence variations detected in the cystic fibrosis transmembrane conductance regulator (CFTR) gene: a report from the Cystic Fibrosis Genetic Analysis Consortium. Hum Mutat (1992) 2.12
Frequency of three Hex A mutant alleles among Jewish and non-Jewish carriers identified in a Tay-Sachs screening program. Am J Hum Genet (1990) 1.94
The genetic architecture of normal variation in human pigmentation: an evolutionary perspective and model. Hum Mol Genet (2006) 1.90
Genomic inferences of the cis-regulatory nucleotide polymorphisms underlying gene expression differences between Drosophila melanogaster mating races. Mol Biol Evol (2006) 1.55
Genetic analysis of genome-wide variation in human gene expression. Nature (2004) 27.28
Mapping determinants of human gene expression by regional and genome-wide association. Nature (2005) 17.24
Natural variation in human gene expression assessed in lymphoblastoid cells. Nat Genet (2003) 11.63
Widespread RNA and DNA sequence differences in the human transcriptome. Science (2011) 11.45
In silico method for inferring genotypes in pedigrees. Nat Genet (2006) 7.08
Polymorphic cis- and trans-regulation of human gene expression. PLoS Biol (2010) 2.42
Genetic analysis of radiation-induced changes in human gene expression. Nature (2009) 2.30
Genetic analysis of variation in human meiotic recombination. PLoS Genet (2009) 2.11
Effects of cis and trans genetic ancestry on gene expression in African Americans. PLoS Genet (2008) 2.09
RNA-sequence analysis of human B-cells. Genome Res (2011) 2.02
A randomised controlled trial to test the feasibility of a collaborative care model for the management of depression in older people. Br J Gen Pract (2007) 1.98
Toxicity testing in the 21st century: a vision and a strategy. J Toxicol Environ Health B Crit Rev (2010) 1.81
Identification of polymorphic antioxidant response elements in the human genome. Hum Mol Genet (2007) 1.79
Transcriptional response of lymphoblastoid cells to ionizing radiation. Genome Res (2003) 1.77
Coexpression network based on natural variation in human gene expression reveals gene interactions and functions. Genome Res (2009) 1.74
Polymorphic variation in human meiotic recombination. Am J Hum Genet (2007) 1.49
Adjustment for local ancestry in genetic association analysis of admixed populations. Bioinformatics (2010) 1.44
The relationship between gender role stereotypes and requisite managerial characteristics: the case of nursing and midwifery professionals. J Nurs Manag (2012) 1.40
Genetic variation in radiation-induced expression phenotypes. Am J Hum Genet (2004) 1.37
Identification of novel p53 target genes in ionizing radiation response. Cancer Res (2005) 1.28
Monozygotic twins reveal germline contribution to allelic expression differences. Am J Hum Genet (2008) 1.23
ATM gene mutations result in both recessive and dominant expression phenotypes of genes and microRNAs. Am J Hum Genet (2008) 1.21
A flexible two-stage procedure for identifying gene sets that are differentially expressed. Bioinformatics (2009) 1.20
ADAR regulates RNA editing, transcript stability, and gene expression. Cell Rep (2013) 1.19
Gene expression phenotype in heterozygous carriers of ataxia telangiectasia. Am J Hum Genet (2002) 1.18
Genetic risk assessment in carrier testing for spinal muscular atrophy. Am J Med Genet (2002) 1.15
On estimating P values by the Monte Carlo method. Am J Hum Genet (2003) 1.07
Gene expression and genetic variation in response to endoplasmic reticulum stress in human cells. Am J Hum Genet (2010) 1.07
Genetic variation in radiation-induced cell death. Genome Res (2011) 0.94
A quantitative model of normal Caenorhabditis elegans embryogenesis and its disruption after stress. Dev Biol (2012) 0.94
The TDT is a statistically valid test: comments on Wittkowski and Liu. Hum Hered (2004) 0.89
Method for manufacturing whole-genome microarrays by rolling circle amplification. Genes Chromosomes Cancer (2004) 0.86
Stability of alginate microbead properties in vitro. J Mater Sci Mater Med (2012) 0.86
Heterozygous carriers of Nijmegen Breakage Syndrome have a distinct gene expression phenotype. Genome Res (2006) 0.85
Genetic heterogeneity and trans regulators of gene expression. BMC Proc (2007) 0.84
Rapid assessment of avoidable blindness in Bhutan. Ophthalmic Epidemiol (2013) 0.83
Stress-induced changes in gene interactions in human cells. Nucleic Acids Res (2013) 0.81
Natural variation in the histone demethylase, KDM4C, influences expression levels of specific genes including those that affect cell growth. Genome Res (2013) 0.79
DNA reassociation using oscillating phenol emulsions. Genomics (2005) 0.78
Direct IBD mapping: identical-by-descent mapping without genotyping. Genomics (2004) 0.76
Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function. J Clin Invest (2017) 0.75
There's plenty of time for evolution. Proc Natl Acad Sci U S A (2010) 0.75
Nerve block. J Am Dent Assoc (2012) 0.75
Vitalizing physician-scientists: it's time to overcome our imagination fatigue. J Clin Invest (2017) 0.75
HGV2011: personalized genomic medicine meets the incidentalome. Hum Mutat (2012) 0.75
Polymorphic landscape of the human genome. Eur J Hum Genet (2005) 0.75
Corrigendum: Divergence of a conserved elongation factor and transcription regulation in budding and fission yeast. Genome Res (2016) 0.75