Published in Arch Pharm Res on February 10, 2013
Neddylation plays an important role in the regulation of murine and human dendritic cell function. Blood (2013) 1.69
Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance. Biochim Biophys Acta (2013) 1.60
Transcription factors STAT6 and KLF4 implement macrophage polarization via the dual catalytic powers of MCPIP. J Immunol (2015) 1.01
The regulatory role of activating transcription factor 2 in inflammation. Mediators Inflamm (2014) 0.96
Functional roles of Syk in macrophage-mediated inflammatory responses. Mediators Inflamm (2014) 0.95
Uncoupling lipid metabolism from inflammation through fatty acid binding protein-dependent expression of UCP2. Mol Cell Biol (2015) 0.91
Adipocyte-derived PAMM suppresses macrophage inflammation by inhibiting MAPK signalling. Biochem J (2015) 0.80
Effects of a community-based weight loss intervention on adipose tissue circulating factors. Diabetes Metab Syndr (2014) 0.79
Association of a Large Panel of Cytokine Gene Polymorphisms with Complications and Comorbidities in Type 2 Diabetes Patients. J Diabetes Res (2015) 0.78
High-density lipoprotein increases the uptake of oxidized low density lipoprotein via PPARγ/CD36 pathway in inflammatory adipocytes. Int J Biol Sci (2015) 0.78
RLIP76 protein knockdown attenuates obesity due to a high-fat diet. J Biol Chem (2013) 0.77
High intensity interval training improves liver and adipose tissue insulin sensitivity. Mol Metab (2015) 0.77
Gut microbiome in chronic kidney disease: challenges and opportunities. Transl Res (2016) 0.76
Maternal obesity drives functional alterations in uterine NK cells. JCI Insight (2016) 0.76
Quantitative analysis of rat adipose tissue cell recovery, and non-fat cell volume, in primary cell cultures. PeerJ (2016) 0.75
CXCL14-Like Immunoreactivity Exists in Somatostatin-Containing Cells of Mouse Pancreas. Acta Histochem Cytochem (2015) 0.75
The role of obesity in the immune response during sepsis. Nutr Diabetes (2014) 0.75
A Mouse Model of Diet-Induced Obesity Resembling Most Features of Human Metabolic Syndrome. Nutr Metab Insights (2016) 0.75
Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22
Inflammation and metabolic disorders. Nature (2006) 33.33
Banting lecture 1988. Role of insulin resistance in human disease. Diabetes (1988) 33.22
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest (2003) 32.01
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science (1993) 25.54
Monocyte and macrophage heterogeneity. Nat Rev Immunol (2005) 24.36
Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity (2003) 21.56
Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest (2007) 20.19
Inflammation and insulin resistance. J Clin Invest (2006) 18.76
TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest (2006) 17.49
A central role for JNK in obesity and insulin resistance. Nature (2002) 17.27
C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA (2001) 15.85
NF-kappa B: ten years after. Cell (1996) 12.80
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest (2006) 12.32
IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med (2005) 12.07
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res (2005) 11.88
Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol (2010) 11.80
Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature (2007) 11.59
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science (2001) 11.56
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med (2007) 11.51
A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature (1997) 11.31
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med (2009) 11.28
Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol (2008) 11.02
Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med (2005) 10.88
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature (2010) 10.60
Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature (1997) 10.53
Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science (2009) 10.47
CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest (2005) 10.44
Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol (2006) 10.05
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med (2009) 9.71
Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. J Clin Invest (2007) 9.09
CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science (2005) 8.97
Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol (2010) 8.87
GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell (2010) 8.69
Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. J Clin Invest (2007) 8.65
Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation. Science (2011) 8.53
Type 2 diabetes as an inflammatory disease. Nat Rev Immunol (2011) 8.30
Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med (2009) 8.15
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med (2011) 8.00
Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation (2000) 7.37
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nat Immunol (2012) 7.32
Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol (2004) 6.78
A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem (2007) 6.58
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol (2011) 6.53
IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. Cell (2004) 6.25
Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes (2007) 6.08
Macrophage receptors and immune recognition. Annu Rev Immunol (2005) 5.83
The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu Rev Immunol (2011) 5.73
Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes (2005) 5.68
Retracted Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes (2007) 5.67
The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med (2012) 5.63
Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J Biol Chem (2006) 5.57
Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab (2008) 5.53
The CD14+ CD16+ blood monocytes: their role in infection and inflammation. J Leukoc Biol (2006) 5.50
Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study. Diabetes (2003) 5.43
B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat Med (2011) 5.16
Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab (2008) 5.10
AP-1 subunits: quarrel and harmony among siblings. J Cell Sci (2004) 5.08
Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. J Clin Invest (2002) 4.96
Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis (2000) 4.88
Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care (2004) 4.88
Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest (2007) 4.86
Prevention of fat-induced insulin resistance by salicylate. J Clin Invest (2001) 4.74
Macrophage-mediated inflammation in metabolic disease. Nat Rev Immunol (2011) 4.68
From mice to men: insights into the insulin resistance syndromes. Annu Rev Physiol (2006) 4.58
Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. J Clin Invest (2010) 4.56
Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo. Diabetes (2004) 4.37
Transcription factors in myeloid development: balancing differentiation with transformation. Nat Rev Immunol (2007) 4.27
Deciphering the transcriptional network of the dendritic cell lineage. Nat Immunol (2012) 4.17
Phagocyte partnership during the onset and resolution of inflammation. Nat Rev Immunol (2010) 4.07
Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study. Lancet (1999) 4.07
Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med (2009) 3.97
Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities. EMBO J (2003) 3.93
Neutrophil function: from mechanisms to disease. Annu Rev Immunol (2012) 3.63
C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study. Diabetes (2002) 3.59
The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial. Ann Intern Med (2010) 3.56
Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation. Nature (2009) 3.21
From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes. Diabetes (2004) 3.13
Inflamed fat: what starts the fire? J Clin Invest (2006) 3.11
Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. Cell Metab (2009) 3.10
Krüppel-like factor 4 regulates macrophage polarization. J Clin Invest (2011) 3.08
Retracted Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice. PLoS Biol (2011) 3.02
Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects. Diabetes (2003) 3.00
Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive pro-inflammatory mediator production. Int J Obes (Lond) (2007) 2.92
Inflammasome is a central player in the induction of obesity and insulin resistance. Proc Natl Acad Sci U S A (2011) 2.92
Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance. Int J Obes Relat Metab Disord (2003) 2.89
Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. J Clin Invest (2007) 2.73
Diabetes and cardiovascular disease. The "common soil" hypothesis. Diabetes (1995) 2.71
Heterogeneity of human peripheral blood monocyte subsets. J Leukoc Biol (2001) 2.56
Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes. Clin Transl Sci (2008) 2.54
The relation of markers of inflammation to the development of glucose disorders in the elderly: the Cardiovascular Health Study. Diabetes (2001) 2.47
Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance. Diabetes (2009) 2.42
Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice. Diabetes (2003) 2.40
Remodeling phenotype of human subcutaneous adipose tissue macrophages. Circulation (2008) 2.38
Adiposity elevates plasma MCP-1 levels leading to the increased CD11b-positive monocytes in mice. J Biol Chem (2003) 2.36
High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes. Diabetes (2002) 2.36
Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization. Immunity (2004) 2.27