The PARP3- and ATM-dependent phosphorylation of APLF facilitates DNA double-strand break repair.

PubWeight™: 0.89‹?›

🔗 View Article (PMC 3627606)

Published in Nucleic Acids Res on February 28, 2013

Authors

Amanda L Fenton1, Purnata Shirodkar, Chloe J Macrae, Li Meng, C Anne Koch

Author Affiliations

1: Division of Signalling Biology, Ontario Cancer Institute (University Health Network), 610 University Avenue, Toronto, Ontario M5G 2M9, Canada.

Articles citing this

Non-homologous end joining often uses microhomology: implications for alternative end joining. DNA Repair (Amst) (2014) 1.24

Non-homologous end joining: emerging themes and unanswered questions. DNA Repair (Amst) (2014) 1.05

Poly(ADP-ribosyl)ation in regulation of chromatin structure and the DNA damage response. Chromosoma (2013) 0.98

PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways. Nucleic Acids Res (2014) 0.93

An Intrinsically Disordered APLF Links Ku, DNA-PKcs and XRCC4-DNA Ligase IV in an Extended Flexible Non-Homologous End Joining Complex. J Biol Chem (2016) 0.78

Identification and Functional Characterizations of N-Terminal α-N-Methylation and Phosphorylation of Serine 461 in Human Poly(ADP-ribose) Polymerase 3. J Proteome Res (2015) 0.77

Parp3 negatively regulates immunoglobulin class switch recombination. PLoS Genet (2015) 0.76

Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model. Cell Death Dis (2016) 0.76

PARP3 controls TGFβ and ROS driven epithelial-to-mesenchymal transition and stemness by stimulating a TG2-Snail-E-cadherin axis. Oncotarget (2016) 0.76

PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA. Nat Commun (2017) 0.75

ADP-ribosyltransferases and poly ADP-ribosylation. Curr Protein Pept Sci (2015) 0.75

Histone chaperone APLF regulates induction of pluripotency in murine fibroblasts. J Cell Sci (2016) 0.75

Site-specific ADP-ribosylation of histone H2B in response to DNA double strand breaks. Sci Rep (2017) 0.75

PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes. Genes Dev (2017) 0.75

Articles cited by this

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature (2003) 20.13

Clonogenic assay of cells in vitro. Nat Protoc (2006) 11.85

Poly(ADP-ribose): novel functions for an old molecule. Nat Rev Mol Cell Biol (2006) 9.58

ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J Biol Chem (2001) 8.78

PARP inhibition: PARP1 and beyond. Nat Rev Cancer (2010) 6.70

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J Cell Biol (2006) 6.52

Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition. Cancer Res (2006) 6.28

Regulation of DNA double-strand break repair pathway choice. Cell Res (2008) 6.19

XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Cell (2006) 5.62

DNA double-strand break repair: from mechanistic understanding to cancer treatment. DNA Repair (Amst) (2007) 3.69

Endogenous DNA double-strand breaks: production, fidelity of repair, and induction of cancer. Proc Natl Acad Sci U S A (2003) 3.26

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme? Curr Opin Cell Biol (2001) 2.93

DNA damage-induced activation of ATM and ATM-dependent signaling pathways. DNA Repair (Amst) (2004) 2.86

Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks. Trends Biochem Sci (1995) 2.85

PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites. J Biol Chem (2007) 2.62

Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4. EMBO J (2010) 2.25

Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV. EMBO J (2004) 2.24

The world according to PARP. Trends Biochem Sci (2001) 2.18

Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression. Proc Natl Acad Sci U S A (2011) 2.10

DNA-damage repair; the good, the bad, and the ugly. EMBO J (2008) 1.89

Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair. Nucleic Acids Res (2006) 1.88

Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents. J Biol Chem (2007) 1.80

PARP-3 and APLF function together to accelerate nonhomologous end-joining. Mol Cell (2011) 1.77

Purification and characterization of the double-stranded DNA-activated protein kinase, DNA-PK, from human placenta. Biochem Cell Biol (1996) 1.75

APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks. Mol Cell Biol (2007) 1.71

A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses. EMBO J (2007) 1.65

APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation. DNA Repair (Amst) (2008) 1.44

APLF (C2orf13) is a novel component of poly(ADP-ribose) signaling in mammalian cells. Mol Cell Biol (2008) 1.41

The role of ATM in DNA damage responses and cancer. Oncogene (1998) 1.38

Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks. J Biol Chem (2007) 1.38

PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA. J Biol Chem (2010) 1.32

Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK. EMBO J (2009) 1.32

PARP-3 associates with polycomb group bodies and with components of the DNA damage repair machinery. J Cell Biochem (2007) 1.28

Poly(ADP-ribose) polymerase-1 modulates DNA repair capacity and prevents formation of DNA double strand breaks. DNA Repair (Amst) (2008) 1.23

PARP-1 and PARP-2: New players in tumour development. Am J Cancer Res (2011) 1.23

DNA repair factor APLF is a histone chaperone. Mol Cell (2011) 1.17

Structure and identification of ADP-ribose recognition motifs of APLF and role in the DNA damage response. Proc Natl Acad Sci U S A (2010) 1.14

ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair. EMBO Rep (2011) 1.12

Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage. Nucleic Acids Res (2011) 0.99

ATM mediated phosphorylation of CHD4 contributes to genome maintenance. Genome Integr (2011) 0.90

Twists and turns in the function of DNA damage signaling and repair proteins by post-translational modifications. DNA Repair (Amst) (2007) 0.90

Articles by these authors

Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes. Proc Natl Acad Sci U S A (2008) 2.33

The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase. Mol Cell (2005) 2.09

Enhanced proatherogenic responses in macrophages and vascular smooth muscle cells derived from diabetic db/db mice. Diabetes (2006) 1.49

APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation. DNA Repair (Amst) (2008) 1.44

Overexpression of vimentin contributes to prostate cancer invasion and metastasis via src regulation. Anticancer Res (2008) 1.21

Ezrin silencing by small hairpin RNA reverses metastatic behaviors of human breast cancer cells. Cancer Lett (2007) 1.20

Structure and identification of ADP-ribose recognition motifs of APLF and role in the DNA damage response. Proc Natl Acad Sci U S A (2010) 1.14

Asperolides A-C, tetranorlabdane diterpenoids from the marine alga-derived endophytic fungus Aspergillus wentii EN-48. J Nat Prod (2012) 1.14

Cooperation of SRC-1 and p300 with NF-kappaB and CREB in angiotensin II-induced IL-6 expression in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2007) 1.07

Peripheral electrical stimulation reversed the cell size reduction and increased BDNF level in the ventral tegmental area in chronic morphine-treated rats. Brain Res (2007) 1.04

Nigerapyrones A-H, α-pyrone derivatives from the marine mangrove-derived endophytic fungus Aspergillus niger MA-132. J Nat Prod (2011) 1.04

Interactions of the apolipoprotein C-III 3238C>G polymorphism and alcohol consumption on serum triglyceride levels. Lipids Health Dis (2010) 1.02

RNA interference against HPV16 E7 oncogene leads to viral E6 and E7 suppression in cervical cancer cells and apoptosis via upregulation of Rb and p53. Apoptosis (2008) 1.01

Activation of fibronectin/PI-3K/Akt2 leads to chemoresistance to docetaxel by regulating survivin protein expression in ovarian and breast cancer cells. Cancer Lett (2008) 1.00

Implication of the Akt2/survivin pathway as a critical target in paclitaxel treatment in human ovarian cancer cells. Cancer Lett (2008) 0.98

Synthesis and evaluation of febrifugine analogues as potential antimalarial agents. Bioorg Med Chem Lett (2006) 0.98

Enhanced in vitro invasiveness of ovarian cancer cells through up-regulation of VEGF and induction of MMP-2. Oncol Rep (2006) 0.97

Antisense targeting human papillomavirus type 16 E6 and E7 genes contributes to apoptosis and senescence in SiHa cervical carcinoma cells. Gynecol Oncol (2007) 0.96

Hypoxia induced paclitaxel resistance in human ovarian cancers via hypoxia-inducible factor 1alpha. J Cancer Res Clin Oncol (2009) 0.95

Correlation of volume transfer coefficient Ktrans with histopathologic grades of gliomas. J Magn Reson Imaging (2012) 0.95

TMTP1, a novel tumor-homing peptide specifically targeting metastasis. Clin Cancer Res (2008) 0.95

The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways. Bioorg Med Chem Lett (2011) 0.94

Adjuvant adenovirus-mediated delivery of herpes simplex virus thymidine kinase administration improves outcome of liver transplantation in patients with advanced hepatocellular carcinoma. Clin Cancer Res (2007) 0.94

A comparison of four screening methods for cervical neoplasia. Int J Gynaecol Obstet (2005) 0.94

T-cell epitopes in severe acute respiratory syndrome (SARS) coronavirus spike protein elicit a specific T-cell immune response in patients who recover from SARS. J Virol (2004) 0.94

The relationship between c-FLIP expression and human papillomavirus E2 gene disruption in cervical carcinogenesis. Gynecol Oncol (2007) 0.93

Diet, alcohol consumption, and serum lipid levels of the middle-aged and elderly in the Guangxi Bai Ku Yao and Han populations. Alcohol (2008) 0.92

Rigorous thermal control during intracytoplasmic sperm injection stabilizes the meiotic spindle and improves fertilization and pregnancy rates. Fertil Steril (2002) 0.91

Heat shock proteins and p53 play a critical role in K+ channel-mediated tumor cell proliferation and apoptosis. Apoptosis (2007) 0.90

Process optimization for the preparation of oligomycin-loaded folate-conjugated chitosan nanoparticles as a tumor-targeted drug delivery system using a two-level factorial design method. Int J Nanomedicine (2011) 0.88

Reversing chemoresistance in cisplatin-resistant human ovarian cancer cells: a role of c-Jun NH2-terminal kinase 1. Biochem Biophys Res Commun (2005) 0.88

Cytoplasmic p21 is a potential predictor for cisplatin sensitivity in ovarian cancer. BMC Cancer (2011) 0.88

A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization. Apoptosis (2008) 0.87

7-Nor-ergosterolide, a pentalactone-containing norsteroid and related steroids from the marine-derived endophytic Aspergillus ochraceus EN-31. J Nat Prod (2010) 0.87

Apolipoprotein C-III gene polymorphism and several environmental factors with serum lipid levels in the Guangxi Hei Yi Zhuang and Han populations. J Investig Med (2010) 0.87

miR-222 is upregulated in epithelial ovarian cancer and promotes cell proliferation by downregulating P27(kip1.) Oncol Lett (2013) 0.87

The universal overexpression of a cancer testis antigen hiwi is associated with cancer angiogenesis. Oncol Rep (2010) 0.86

Identification and functional characterization of a Ku-binding motif in aprataxin polynucleotide kinase/phosphatase-like factor (APLF). J Biol Chem (2013) 0.86

The associations between OPRM 1 and COMT genotypes and postoperative pain, opioid use, and opioid-induced sedation. Biol Res Nurs (2012) 0.86

Pulmonary responses to printer toner particles in mice after intratracheal instillation. Toxicol Lett (2010) 0.86

Differential regulation of mitogen- and stress-activated protein kinase-1 and -2 (MSK1 and MSK2) by CK2 following UV radiation. J Biol Chem (2009) 0.85

Regulation of DNA methylation on the expression of the FHIT gene contributes to cervical carcinoma cell tumorigenesis. Oncol Rep (2006) 0.85

Isolation and functional analysis of a homolog of flavonoid 3',5'-hydroxylase gene from Pericallis × hybrida. Physiol Plant (2013) 0.84

Essential role of c-Jun-NH2-terminal kinase on synergy induction of apoptosis by TRAIL plus ADM in ADM resistant MCF-7/ADM cells. Apoptosis (2006) 0.83

Anti-tumor effects of the peptide TMTP1-GG-D(KLAKLAK)(2) on highly metastatic cancers. PLoS One (2012) 0.83

A novel oncolytic adenovirus selectively silences the expression of tumor-associated STAT3 and exhibits potent antitumoral activity. Carcinogenesis (2009) 0.83

Direct autologous bone marrow-derived stem cell transplantation for ischemic heart disease: a meta-analysis. Expert Opin Biol Ther (2011) 0.83

Characterization of gold nanorods in vivo by integrated analytical techniques: their uptake, retention, and chemical forms. Anal Bioanal Chem (2009) 0.83

Composite tumor of metanephric adenoma and Wilms' tumor of the kidney: A case report and review of the literature. Oncol Lett (2013) 0.82

Selective targeting of HPV-16 E6/E7 in cervical cancer cells with a potent oncolytic adenovirus and its enhanced effect with radiotherapy in vitro and vivo. Cancer Lett (2009) 0.82

Reversal of the malignant phenotype of ovarian cancer A2780 cells through transfection with wild-type PTEN gene. Cancer Lett (2008) 0.82

Role of hTERT in apoptosis of cervical cancer induced by histone deacetylase inhibitor. Biochem Biophys Res Commun (2005) 0.82

Acute pulmonary and moderate cardiovascular responses of spontaneously hypertensive rats after exposure to single-wall carbon nanotubes. Nanotoxicology (2011) 0.82

Establishment and preliminery use of hepatitis B virus preS1/2 antigen assay. World J Gastroenterol (1999) 0.82

Inhibition of proliferative and invasive capacities of breast cancer cells by arginine-glycine-aspartic acid peptide in vitro. Oncol Rep (2006) 0.81

Arsenic disulfide synergizes with the phosphoinositide 3-kinase inhibitor PI-103 to eradicate acute myeloid leukemia stem cells by inducing differentiation. Carcinogenesis (2011) 0.81

Antisense-Snail transfer inhibits tumor metastasis by inducing E-cadherin expression. Anticancer Res (2008) 0.81

Synergistic killing effect between vorinostat and target of CD146 in malignant cells. Clin Cancer Res (2010) 0.81

Triggering of death receptor apoptotic signaling by human papillomavirus 16 E2 protein in cervical cancer cell lines is mediated by interaction with c-FLIP. Apoptosis (2011) 0.81

Relationship between urinary podocytes and kidney diseases. Ren Fail (2012) 0.81

Fibronectin-mediated activation of Akt2 protects human ovarian and breast cancer cells from docetaxel-induced apoptosis via inhibition of the p38 pathway. Apoptosis (2008) 0.81

The association of CYP2D6 genotype and postoperative nausea and vomiting in orthopedic trauma patients. Biol Res Nurs (2012) 0.81

Identification of LIV1, a putative zinc transporter gene responsible for HDACi-induced apoptosis, using a functional gene screen approach. Mol Cancer Ther (2009) 0.80

Monozygotic pregnancies from transfers of zona-free blastocysts. Fertil Steril (2004) 0.80

[Multicentral randomized controlled clinical trials about treatment of perimenopausal syndrome with electroacupuncture of sanyinjiao (SP 6)]. Zhen Ci Yan Jiu (2008) 0.80

Non-NMDAR neuronal Ca(2+)-permeable channels in delayed neuronal death and as potential therapeutic targets for ischemic brain damage. Expert Opin Ther Targets (2015) 0.80

Reduced expression of Snail decreases breast cancer cell motility by downregulating the expression and inhibiting the activity of RhoA GTPase. Oncol Lett (2013) 0.80

Production and verification of human papillomavirus type 18 vaccine in vitro. Oncol Rep (2008) 0.80

Long-term efficacy of autologous haematopoietic stem cell transplantation in multiple sclerosis at a single institution in China. Neurol Sci (2011) 0.79

Preparation of 10-hydroxycamptothecin-loaded glycyrrhizic acid-conjugated bovine serum albumin nanoparticles for hepatocellular carcinoma-targeted drug delivery. Int J Nanomedicine (2013) 0.79

Soluble B and T lymphocyte attenuator possesses antitumor effects and facilitates heat shock protein 70 vaccine-triggered antitumor immunity against a murine TC-1 cervical cancer model in vivo. J Immunol (2009) 0.79

Hypoxia-inducible factor-1α enhances the malignant phenotype of multicellular spheroid HeLa cells in vitro. Oncol Lett (2010) 0.79

Dose- and time-dependent, context-induced elevation of dopamine and its metabolites in the nucleus accumbens of morphine-induced CPP rats. Behav Brain Res (2009) 0.79

Bilateral masculine mastoplasia associated with imatinib mesylate: a case report and literature review. J Huazhong Univ Sci Technolog Med Sci (2011) 0.79

Human papillomavirus 16/18 E5 promotes cervical cancer cell proliferation, migration and invasion in vitro and accelerates tumor growth in vivo. Oncol Rep (2012) 0.78

Development and characterization of a novel method for the analysis of gene expression patterns in lymphatic endothelial cells derived from primary breast tissues. J Cancer Res Clin Oncol (2009) 0.78

[Effects of electroacupuncture of Sanyinjiao (SP 6) on genito-endocrine in patients with perimenopausal syndrome]. Zhen Ci Yan Jiu (2007) 0.78

Reversal of the malignant phenotype of cervical cancer CaSki cells through adeno-associated virus-mediated delivery of HPV16 E7 antisense RNA. Clin Cancer Res (2006) 0.78

Enhanced targeted anticancer effects and inhibition of tumor metastasis by the TMTP1 compound peptide TMTP1-TAT-NBD. J Control Release (2012) 0.78

Serum paraoxonase, arylesterase activity, and oxidative status in patients with nasal polyp. Eur Arch Otorhinolaryngol (2012) 0.78

Association between Nm23-H1 gene expression and metastasis of ovarian carcinoma. Ai Zheng (2004) 0.77

Synergistic efficacy in human ovarian cancer cells by histone deacetylase inhibitor TSA and proteasome inhibitor PS-341. Cancer Invest (2011) 0.77

Autologous bone marrow cell therapy for patients with peripheral arterial disease: a meta-analysis of randomized controlled trials. Expert Opin Biol Ther (2011) 0.77

HPV16/18 E5, a promising candidate for cervical cancer vaccines, affects SCPs, cell proliferation and cell cycle, and forms a potential network with E6 and E7. Int J Mol Med (2012) 0.77

The dose-dependent toxicological effects and potential perturbation on the neurotransmitter secretion in brain following intranasal instillation of copper nanoparticles. Nanotoxicology (2011) 0.77

Suppression of EphB4 improves the inhibitory effect of mTOR shRNA on the biological behaviors of ovarian cancer cells by down-regulating Akt phosphorylation. J Huazhong Univ Sci Technolog Med Sci (2012) 0.77

Inhibition of Akt signaling by SN-38 induces apoptosis in cervical cancer. Cancer Lett (2008) 0.77

Febrifugine analogue compounds: synthesis and antimalarial evaluation. Bioorg Med Chem (2011) 0.77

Four genetic variants interact to confer susceptibility to atopic dermatitis in Chinese Han population. Mol Genet Genomics (2015) 0.77

Isolation and characterization of lymphatic endothelial cells from human glossal lymphangioma. Oncol Rep (2010) 0.76

The preparation of human papillomavirus type 58 vaccine and exploring its biological activity and immunogenicity in vitro. Int J Gynecol Cancer (2011) 0.76

HSP27 Knockdown Increases Cytoplasmic p21 and Cisplatin Sensitivity in Ovarian Carcinoma Cells. Oncol Res (2016) 0.76

Antisense Ki-67 cDNA transfection reverses the tumorigenicity and induces apoptosis in human breast cancer cells. Cancer Invest (2008) 0.76

The effect of rhG-CSF on the conformation of LFA-1 on CD4+ T cells in hemopoietic stem cell transplantation. Immunopharmacol Immunotoxicol (2009) 0.76

Polymorphisms of progesterone receptor and ovarian cancer risk: a systemic review and meta-analysis. J Obstet Gynaecol Res (2014) 0.75

Suppression of amino acid transporter LAT3 expression on proliferation of K562 cells. J Huazhong Univ Sci Technolog Med Sci (2013) 0.75