Published in DNA Repair (Amst) on February 26, 2014
An XRCC4 splice mutation associated with severe short stature, gonadal failure, and early-onset metabolic syndrome. J Clin Endocrinol Metab (2015) 0.99
The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis. Prog Biophys Mol Biol (2014) 0.96
FBXW7 Facilitates Nonhomologous End-Joining via K63-Linked Polyubiquitylation of XRCC4. Mol Cell (2016) 0.82
Two-Stage Synapsis of DNA Ends during Non-homologous End Joining. Mol Cell (2016) 0.81
Characterization of DNA binding and pairing activities associated with the native SFPQ·NONO DNA repair protein complex. Biochem Biophys Res Commun (2015) 0.80
Systemic DNA damage responses in aging and diseases. Semin Cancer Biol (2016) 0.79
The Role of the Core Non-Homologous End Joining Factors in Carcinogenesis and Cancer. Cancers (Basel) (2017) 0.78
Risky business: Microhomology-mediated end joining. Mutat Res (2016) 0.78
Non-homologous end joining repair in Xenopus egg extract. Sci Rep (2016) 0.77
Choreographing the Double Strand Break Response: Ubiquitin and SUMO Control of Nuclear Architecture. Front Genet (2016) 0.77
Structure-Based Virtual Ligand Screening on the XRCC4/DNA Ligase IV Interface. Sci Rep (2016) 0.76
Cell cycle-dependent resolution of DNA double-strand breaks. Oncotarget (2016) 0.76
Molecular basis for DNA strand displacement by NHEJ repair polymerases. Nucleic Acids Res (2015) 0.76
Homeodomain-Interacting Protein Kinase-2: A Critical Regulator of the DNA Damage Response and the Epigenome. Int J Mol Sci (2016) 0.76
Noncoding RNA joins Ku and DNA-PKcs for DNA-break resistance in breast cancer. Nat Struct Mol Biol (2016) 0.75
Probing Enhanced Double-Strand Break Formation at Abasic Sites within Clustered Lesions in Nucleosome Core Particles. Biochemistry (2016) 0.75
DNA Repair in Drosophila: Mutagens, Models, and Missing Genes. Genetics (2017) 0.75
DNA double-strand break repair is impaired in presenescent Syrian hamster fibroblasts. BMC Mol Biol (2015) 0.75
Characterization of a novel large deletion caused by double-stranded breaks in 6-bp microhomologous sequences of intron 11 and 12 of the F13A1 gene. Hum Genome Var (2016) 0.75
The human DNA ends proteome uncovers an unexpected entanglement of functional pathways. Nucleic Acids Res (2016) 0.75
Controlling DNA-End Resection: An Emerging Task for Ubiquitin and SUMO. Front Genet (2016) 0.75
DNA requirements for interaction of the C-terminal region of Ku80 with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). DNA Repair (Amst) (2017) 0.75
Structural and functional characterization of the PNKP-XRCC4-LigIV DNA repair complex. Nucleic Acids Res (2017) 0.75
What Combined Measurements From Structures and Imaging Tell Us About DNA Damage Responses. Methods Enzymol (2017) 0.75
Differential expression profile analysis of DNA damage repair genes in CD133(+)/CD133(-) colorectal cancer cells. Oncol Lett (2017) 0.75
Synergy between Prkdc and Trp53 regulates stem cell proliferation and GI-ARS after irradiation. Cell Death Differ (2017) 0.75
Hallmarks of cancer: the next generation. Cell (2011) 140.01
ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol (2008) 11.86
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem (2010) 9.80
Mechanism of eukaryotic homologous recombination. Annu Rev Biochem (2008) 8.86
The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell (1993) 7.17
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer. Nat Rev Mol Cell Biol (2008) 6.62
ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. Mol Cell (2008) 6.60
Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol Cell Biol (2003) 6.36
Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell (2002) 6.34
Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature (2001) 6.29
XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Cell (2006) 5.62
Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell (1995) 5.58
Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly. Cell (2006) 5.33
Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature (1997) 5.08
Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science (1994) 4.99
Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency. Cell (2001) 4.79
DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect. Science (1995) 4.54
The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. Cell (1995) 4.35
Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line. Science (1995) 4.19
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochem J (2009) 3.89
BRCA1 and BRCA2: different roles in a common pathway of genome protection. Nat Rev Cancer (2011) 3.85
Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Genes Dev (2002) 3.83
Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins. Nature (2008) 3.67
Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV. Curr Biol (1997) 3.67
XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair. Cell (2001) 3.66
Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II. Proc Natl Acad Sci U S A (1992) 3.58
A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Mol Cell (2013) 3.55
Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation. Cell (2008) 3.42
Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen. Mol Cell Biol (1990) 3.30
Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks. J Biol Chem (2005) 3.19
A means to a DNA end: the many roles of Ku. Nat Rev Mol Cell Biol (2004) 3.07
RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection. Mol Cell (2013) 3.05
The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxin. Nat Genet (2001) 3.01
A DNA-activated protein kinase from HeLa cell nuclei. Mol Cell Biol (1990) 2.95
Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks. J Cell Biol (2007) 2.92
Double-strand break repair: 53BP1 comes into focus. Nat Rev Mol Cell Biol (2013) 2.90
The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature (2006) 2.86
Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining. Mol Cell Biol (1999) 2.86
Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair. Mol Cell Biol (2003) 2.74
Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4. Proc Natl Acad Sci U S A (2006) 2.71
Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break. J Biol Chem (2006) 2.66
Repair of DNA double strand breaks by non-homologous end joining. Biochimie (2003) 2.65
Factors determining DNA double-strand break repair pathway choice in G2 phase. EMBO J (2011) 2.46
Induction and repair of DNA double strand breaks: the increasing spectrum of non-homologous end joining pathways. Mutat Res (2011) 2.37
Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice. Mol Cell Biol (2005) 2.37
Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair. Mol Cell Biol (2002) 2.25
Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV. EMBO J (2004) 2.24
The DNA-dependent protein kinase: the director at the end. Immunol Rev (2004) 2.20
Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase. Biochem J (2002) 2.18
DNA-PK: the means to justify the ends? Adv Immunol (2008) 2.14
End-joining, translocations and cancer. Nat Rev Cancer (2013) 2.13
Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends. Proc Natl Acad Sci U S A (2007) 2.09
Purification and characterization of a template-associated protein kinase that phosphorylates RNA polymerase II. J Biol Chem (1993) 2.08
Crystal structure of an Xrcc4-DNA ligase IV complex. Nat Struct Biol (2001) 2.07
Ku recruits XLF to DNA double-strand breaks. EMBO Rep (2007) 2.00
DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell (2013) 1.93
Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex. J Biol Chem (2009) 1.91
The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4. DNA Repair (Amst) (2004) 1.86
RIF1 counteracts BRCA1-mediated end resection during DNA repair. J Biol Chem (2013) 1.86
The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps. DNA Repair (Amst) (2005) 1.81
PARP-3 and APLF function together to accelerate nonhomologous end-joining. Mol Cell (2011) 1.77
53BP1: pro choice in DNA repair. Trends Cell Biol (2013) 1.75
Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends. Nature (2010) 1.74
APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks. Mol Cell Biol (2007) 1.71
A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation. DNA Repair (Amst) (2010) 1.71
Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination. Nucleic Acids Res (2000) 1.65
A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses. EMBO J (2007) 1.65
The response to and repair of RAG-mediated DNA double-strand breaks. Annu Rev Immunol (2012) 1.64
Ku80 removal from DNA through double strand break-induced ubiquitylation. J Cell Biol (2008) 1.64
ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks. Nature (2010) 1.64
The DNA-dependent protein kinase catalytic subunit is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain. Mol Cell Biol (2006) 1.64
The E3 ligase RNF8 regulates KU80 removal and NHEJ repair. Nat Struct Mol Biol (2012) 1.64
Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response. Mol Cell Biol (2004) 1.63
Repair of double-strand breaks by end joining. Cold Spring Harb Perspect Biol (2013) 1.58
Detection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joining. Int J Radiat Oncol Biol Phys (2013) 1.57
XRCC4 protein interactions with XRCC4-like factor (XLF) create an extended grooved scaffold for DNA ligation and double strand break repair. J Biol Chem (2011) 1.48
Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair. Trends Biochem Sci (2011) 1.47
APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation. DNA Repair (Amst) (2008) 1.44
XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation. Nucleic Acids Res (2008) 1.44
Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4. Mol Cell Biol (2009) 1.43
Cellular radiosensitivity: how much better do we understand it? Int J Radiat Biol (2009) 1.40
Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks. J Biol Chem (2007) 1.38
Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair. J Cell Biol (2011) 1.36
Analysis of DNA ligase IV mutations found in LIG4 syndrome patients: the impact of two linked polymorphisms. Hum Mol Genet (2004) 1.33
Inhibition of homologous recombination by DNA-dependent protein kinase requires kinase activity, is titratable, and is modulated by autophosphorylation. Mol Cell Biol (2011) 1.32
DNA DSB repair pathway choice: an orchestrated handover mechanism. Br J Radiol (2014) 1.31
DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks. DNA Repair (Amst) (2008) 1.29
A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair. J Cell Biol (2013) 1.29
Stable down-regulation of human polynucleotide kinase enhances spontaneous mutation frequency and sensitizes cells to genotoxic agents. Proc Natl Acad Sci U S A (2004) 1.27
Live cell imaging of XLF and XRCC4 reveals a novel view of protein assembly in the non-homologous end-joining pathway. Cell Cycle (2008) 1.19
Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining. Proc Natl Acad Sci U S A (2011) 1.18
Choosing the right path: does DNA-PK help make the decision? Mutat Res (2011) 1.18
DNA repair factor APLF is a histone chaperone. Mol Cell (2011) 1.17
Phosphorylation of Artemis following irradiation-induced DNA damage. Eur J Immunol (2004) 1.16
A human XRCC4-XLF complex bridges DNA. Nucleic Acids Res (2012) 1.15
ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair. EMBO Rep (2011) 1.12
Functional significance of the interaction with Ku in DNA double-strand break recognition of XLF. FEBS Lett (2011) 1.11
Induction and repair of clustered DNA lesions: what do we know so far? Radiat Res (2013) 1.10
DNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice. Nucleic Acids Res (2013) 1.09
APLF promotes the assembly and activity of non-homologous end joining protein complexes. EMBO J (2012) 1.09