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The Secret Role of microRNAs in Cancer Stem Cell Development and Potential Therapy: A Notch-Pathway Approach. Front Oncol (2015) 0.80

Inhibition of Phosphatidylcholine-Specific Phospholipase C Interferes with Proliferation and Survival of Tumor Initiating Cells in Squamous Cell Carcinoma. PLoS One (2015) 0.78

Investigations on agglomeration and haemocompatibility of vitamin E TPGS surface modified berberine chloride nanoparticles. Biomed Res Int (2014) 0.77

Multifunctional nanoparticles for prostate cancer therapy. AAPS PharmSciTech (2014) 0.75

Adult neurogenesis and glial oncogenesis: when the process fails. Biomed Res Int (2014) 0.75

Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 59.17

Stem cells, cancer, and cancer stem cells. Nature (2001) 50.27

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med (1997) 32.63

Wnt/beta-catenin signaling in development and disease. Cell (2006) 30.09

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature (2006) 27.91

Identification and expansion of human colon-cancer-initiating cells. Nature (2006) 24.44

ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell (2007) 22.89

In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev (2003) 20.77

Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer (2008) 18.08

Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer (2002) 15.72

Tumour stem cells and drug resistance. Nat Rev Cancer (2005) 15.21

Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell (2007) 14.87

Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res (2005) 13.89

Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A (2007) 13.58

Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med (2000) 12.34

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell (2002) 10.34

Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol Cancer (2006) 8.50

Identification and expansion of the tumorigenic lung cancer stem cell population. Cell Death Differ (2007) 8.08

Cancer stem cells: models and concepts. Annu Rev Med (2007) 8.06

Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res (2006) 7.91

A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Res (2005) 7.86

Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell (2009) 7.09

A distinct "side population" of cells with high drug efflux capacity in human tumor cells. Proc Natl Acad Sci U S A (2004) 6.84

Significance of CD90+ cancer stem cells in human liver cancer. Cancer Cell (2008) 6.48

A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. Cell (2010) 6.47

Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res (2009) 6.43

Notch signaling: from the outside in. Dev Biol (2000) 6.06

Therapeutic nanoparticles for drug delivery in cancer. Clin Cancer Res (2008) 5.67

Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nat Biotechnol (2007) 5.21

HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr Biol (2006) 5.17

Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proc Natl Acad Sci U S A (2003) 4.69

Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res (2008) 4.64

WNT signaling pathway and stem cell signaling network. Clin Cancer Res (2007) 4.24

The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors. Blood (2002) 4.02

Pharmacokinetics and biodistribution of nanoparticles. Mol Pharm (2008) 3.92

Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis. J Clin Oncol (2008) 3.84

Stem and progenitor-like cells contribute to the aggressive behavior of human epithelial ovarian cancer. Cancer Res (2005) 3.79

Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling. PLoS Biol (2009) 3.67

Molecular phenotyping of human ovarian cancer stem cells unravels the mechanisms for repair and chemoresistance. Cell Cycle (2009) 3.60

TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma. Cancer Cell (2009) 3.38

Genomic and personalized medicine: foundations and applications. Transl Res (2009) 3.24

Breast cancer, stem/progenitor cells and the estrogen receptor. Trends Endocrinol Metab (2004) 3.10

Mammary stem cells, self-renewal pathways, and carcinogenesis. Breast Cancer Res (2005) 3.05

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The multidrug resistance transporter ABCG2 (breast cancer resistance protein 1) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells. Clin Cancer Res (2002) 2.75

Functional and molecular characterisation of mammary side population cells. Breast Cancer Res (2002) 2.63

The Notch signaling pathway: transcriptional regulation at Notch target genes. Cell Mol Life Sci (2009) 2.51

Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model. Proc Natl Acad Sci U S A (2009) 2.41

Targeting aldehyde dehydrogenase cancer stem cells in ovarian cancer. Mol Cancer Ther (2010) 2.27

Cancer stem cells from colorectal cancer-derived cell lines. Proc Natl Acad Sci U S A (2010) 2.22

Induction of cyclophosphamide-resistance by aldehyde-dehydrogenase gene transfer. Blood (1996) 2.17

Wnt/beta-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells. Cancer Res (2008) 1.98

Side population cells and Bcrp1 expression in lung. Am J Physiol Lung Cell Mol Physiol (2003) 1.90

NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer. Cancer Res (2010) 1.85

The role of the PTEN/AKT Pathway in NOTCH1-induced leukemia. Cell Cycle (2008) 1.83

Cancer stem cells in breast: current opinion and future challenges. Pathobiology (2008) 1.77

Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma. Clin Exp Metastasis (2009) 1.71

Drug discovery approaches to target Wnt signaling in cancer stem cells. Oncotarget (2010) 1.71

Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporter. Biochem Biophys Res Commun (2002) 1.67

Wnt/beta-catenin signaling regulates cancer stem cells in lung cancer A549 cells. Biochem Biophys Res Commun (2010) 1.67

Nanomedicine for drug delivery and imaging: a promising avenue for cancer therapy and diagnosis using targeted functional nanoparticles. Int J Cancer (2007) 1.65

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Expression of beta-catenin by acute myeloid leukemia cells predicts enhanced clonogenic capacities and poor prognosis. Leukemia (2006) 1.58

Fluorescent cell labeling for in vivo and in vitro cell tracking. Methods Cell Biol (1990) 1.55

Self-renewal of hematopoietic and leukemic stem cells: a central role for the Polycomb-group gene Bmi-1. Trends Immunol (2003) 1.55

Nuclear factor-kappaB contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancer. Cancer Res (2006) 1.52

Nanomedicine for targeted cancer therapy: towards the overcoming of drug resistance. Drug Resist Updat (2011) 1.51

Identification of human pancreatic cancer stem cells. Methods Mol Biol (2009) 1.51

Hedgehog signaling drives cellular survival in human colon carcinoma cells. Cancer Res (2010) 1.50

A functional Notch-survivin gene signature in basal breast cancer. Breast Cancer Res (2008) 1.46

Cancer stem cells: a new paradigm for understanding tumor growth and progression and drug resistance. Curr Med Chem (2009) 1.41

Inhibition of Notch signaling reduces the stem-like population of breast cancer cells and prevents mammosphere formation. Anticancer Res (2010) 1.37

Self-assembled nanoparticles based on glycol chitosan bearing hydrophobic moieties as carriers for doxorubicin: in vivo biodistribution and anti-tumor activity. Biomaterials (2006) 1.32

DNA repair and cancer stem-like cells--potential partners in glioma drug resistance? Cancer Treat Rev (2008) 1.30

Glioma formation, cancer stem cells, and akt signaling. Stem Cell Rev (2008) 1.30

Reversal in multidrug resistance by magnetic nanoparticle of Fe3O4 loaded with adriamycin and tetrandrine in K562/A02 leukemic cells. Int J Nanomedicine (2008) 1.29

Chemotherapy and cancer stem cells. Cell Stem Cell (2007) 1.26

Hit 'em where they live: targeting the cancer stem cell niche. Cancer Cell (2007) 1.23

The telomerase inhibitor imetelstat depletes cancer stem cells in breast and pancreatic cancer cell lines. Cancer Res (2010) 1.23

Photothermolysis of glioblastoma stem-like cells targeted by carbon nanotubes conjugated with CD133 monoclonal antibody. Nanomedicine (2010) 1.22

Cancer: the root of the problem. Nature (2006) 1.19

Transcription factor Oct1 is a somatic and cancer stem cell determinant. PLoS Genet (2012) 1.15

The eradication of breast cancer and cancer stem cells using octreotide modified paclitaxel active targeting micelles and salinomycin passive targeting micelles. Biomaterials (2011) 1.11

Mesoporous silica nanoparticles as drug delivery systems for targeted inhibition of Notch signaling in cancer. Mol Ther (2011) 1.05

Targeting signal transduction pathways to eliminate chemotherapeutic drug resistance and cancer stem cells. Adv Enzyme Regul (2009) 1.03

Isolation and characterization of spheroid cells from the HT29 colon cancer cell line. Int J Colorectal Dis (2011) 1.03

ALDH-positive lung cancer stem cells confer resistance to epidermal growth factor receptor tyrosine kinase inhibitors. Cancer Lett (2012) 1.02

Side population cells derived from adult human liver generate hepatocyte-like cells in vitro. Dig Dis Sci (2005) 1.02

Galiellalactone inhibits stem cell-like ALDH-positive prostate cancer cells. PLoS One (2011) 1.02

Inhibition of hedgehog signaling depresses self-renewal of pancreatic cancer stem cells and reverses chemoresistance. Int J Oncol (2012) 1.01

Novel biodegradable lipid nano complex for siRNA delivery significantly improving the chemosensitivity of human colon cancer stem cells to paclitaxel. J Control Release (2009) 0.99

Cancer stem cell, niche and EGFR decide tumor development and treatment response: A bio-computational simulation study. J Theor Biol (2010) 0.98

The resistance of breast cancer stem cells to conventional hyperthermia and their sensitivity to nanoparticle-mediated photothermal therapy. Biomaterials (2012) 0.97

Selective inhibitory effect of HPMA copolymer-cyclopamine conjugate on prostate cancer stem cells. Biomaterials (2011) 0.93

Selective enrichment of hepatocellular cancer stem cells by chemotherapy. J Int Med Res (2009) 0.89

Promotion of the self-renewal capacity of human acute leukemia cells by Wnt3A. Anticancer Res (2008) 0.88

Novel micelle formulation of curcumin for enhancing antitumor activity and inhibiting colorectal cancer stem cells. Int J Nanomedicine (2012) 0.87

Oxaliplatin-incorporated micelles eliminate both cancer stem-like and bulk cell populations in colorectal cancer. Int J Nanomedicine (2011) 0.87

In vitro and in vivo characterization of a novel Hedgehog signaling antagonist in human glioblastoma cell lines. Int J Cancer (2012) 0.86

Identification and characterization of label-retaining cells in mouse pancreas. Differentiation (2007) 0.86

Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. J Natl Cancer Inst (2008) 11.93

COORDINATE DESCENT ALGORITHMS FOR NONCONVEX PENALIZED REGRESSION, WITH APPLICATIONS TO BIOLOGICAL FEATURE SELECTION. Ann Appl Stat (2011) 4.18

Homozygosity mapping with SNP arrays identifies TRIM32, an E3 ubiquitin ligase, as a Bardet-Biedl syndrome gene (BBS11). Proc Natl Acad Sci U S A (2006) 4.16

Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell (2011) 3.27

Enterovirus 71 outbreak in the People's Republic of China in 2008. J Clin Microbiol (2009) 2.98

Loss of phosphatase and tensin homolog or phosphoinositol-3 kinase activation and response to trastuzumab or lapatinib in human epidermal growth factor receptor 2-overexpressing locally advanced breast cancers. J Clin Oncol (2010) 2.93

Regulation of gene expression in the mammalian eye and its relevance to eye disease. Proc Natl Acad Sci U S A (2006) 2.91

The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα. Cell (2013) 2.87

A renewable tissue resource of phenotypically stable, biologically and ethnically diverse, patient-derived human breast cancer xenograft models. Cancer Res (2013) 2.63

Distinct roles for the RSC and Swi/Snf ATP-dependent chromatin remodelers in DNA double-strand break repair. Genes Dev (2005) 2.47

DNA damage checkpoints in stem cells, ageing and cancer. Nat Rev Mol Cell Biol (2012) 2.39

Regularized ROC method for disease classification and biomarker selection with microarray data. Bioinformatics (2005) 2.38

MATS: a Bayesian framework for flexible detection of differential alternative splicing from RNA-Seq data. Nucleic Acids Res (2012) 2.09

Enterovirus 71 protease 2Apro targets MAVS to inhibit anti-viral type I interferon responses. PLoS Pathog (2013) 1.99

Supervised group Lasso with applications to microarray data analysis. BMC Bioinformatics (2007) 1.99

Soybean WRKY-type transcription factor genes, GmWRKY13, GmWRKY21, and GmWRKY54, confer differential tolerance to abiotic stresses in transgenic Arabidopsis plants. Plant Biotechnol J (2008) 1.98

Clustering threshold gradient descent regularization: with applications to microarray studies. Bioinformatics (2006) 1.97

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An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. Genome Biol (2014) 1.95

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Choriocapillaris vascular dropout related to density of drusen in human eyes with early age-related macular degeneration. Invest Ophthalmol Vis Sci (2011) 1.85

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Toll-like receptors in inflammation, infection and cancer. Int Immunopharmacol (2007) 1.76

T cell factor 1 is required for group 2 innate lymphoid cell generation. Immunity (2013) 1.72

Combining multiple markers for classification using ROC. Biometrics (2007) 1.72

MicroRNA-125b suppresses the development of bladder cancer by targeting E2F3. Int J Cancer (2011) 1.70

Chemical ablation of the Purkinje system causes early termination and activation rate slowing of long-duration ventricular fibrillation in dogs. Am J Physiol Heart Circ Physiol (2008) 1.66

The 3C protein of enterovirus 71 inhibits retinoid acid-inducible gene I-mediated interferon regulatory factor 3 activation and type I interferon responses. J Virol (2010) 1.66

Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease. Proc Natl Acad Sci U S A (2008) 1.65

Regularized gene selection in cancer microarray meta-analysis. BMC Bioinformatics (2009) 1.64

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Cleavage of the adaptor protein TRIF by enterovirus 71 3C inhibits antiviral responses mediated by Toll-like receptor 3. J Virol (2011) 1.61

Myosin light chain kinase and myosin phosphorylation effect frequency-dependent potentiation of skeletal muscle contraction. Proc Natl Acad Sci U S A (2005) 1.59

Definition of the landscape of promoter DNA hypomethylation in liver cancer. Cancer Res (2011) 1.58

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Coxsackievirus A21, enterovirus 68, and acute respiratory tract infection, China. Emerg Infect Dis (2012) 1.52

A copper-catalyzed C-N bond formation involving sp-hybridized carbons. A direct entry to chiral ynamides via N-alkynylation of amides. J Am Chem Soc (2003) 1.51

Penalized feature selection and classification in bioinformatics. Brief Bioinform (2008) 1.51

The yeast RSC chromatin-remodeling complex is required for kinetochore function in chromosome segregation. Mol Cell Biol (2003) 1.50

Neutralizing antibodies in patients with severe acute respiratory syndrome-associated coronavirus infection. J Infect Dis (2004) 1.50

Lanthanum enhances in vitro osteoblast differentiation via pertussis toxin-sensitive gi protein and ERK signaling pathway. J Cell Biochem (2008) 1.49

Identification of interleukin-6 promoter polymorphisms in the Chinese Han population and their functional significance. Crit Care Med (2008) 1.49

Characteristics and prognosis analysis of additional chromosome abnormalities in newly diagnosed acute promyelocytic leukemia treated with arsenic trioxide as the front-line therapy. Leuk Res (2013) 1.48

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Identification of sequence variants in genetic disease-causing genes using targeted next-generation sequencing. PLoS One (2011) 1.44

A role of RIP3-mediated macrophage necrosis in atherosclerosis development. Cell Rep (2013) 1.44

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Unbiased parallel detection of viral pathogens in clinical samples by use of a metagenomic approach. J Clin Microbiol (2011) 1.41

Additive risk survival model with microarray data. BMC Bioinformatics (2007) 1.40

Novel molecular and computational methods improve the accuracy of insertion site analysis in Sleeping Beauty-induced tumors. PLoS One (2011) 1.38

Cardiac myosin light chain kinase is necessary for myosin regulatory light chain phosphorylation and cardiac performance in vivo. J Biol Chem (2010) 1.37

Low-temperature processed electron collection layers of graphene/TiO2 nanocomposites in thin film perovskite solar cells. Nano Lett (2013) 1.36

A polymorphism in the complement component C1qA correlates with prolonged response following rituximab therapy of follicular lymphoma. Clin Cancer Res (2008) 1.36

lncRNA H19/miR-675 axis represses prostate cancer metastasis by targeting TGFBI. FEBS J (2014) 1.36

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CCAAT/enhancer binding protein alpha interacts with ZTA and mediates ZTA-induced p21(CIP-1) accumulation and G(1) cell cycle arrest during the Epstein-Barr virus lytic cycle. J Virol (2003) 1.33

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miRNA-27b targets vascular endothelial growth factor C to inhibit tumor progression and angiogenesis in colorectal cancer. PLoS One (2013) 1.31

Multi-stage analysis of gene expression and transcription regulation in C57/B6 mouse liver development. Genomics (2008) 1.31

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The soybean Dof-type transcription factor genes, GmDof4 and GmDof11, enhance lipid content in the seeds of transgenic Arabidopsis plants. Plant J (2007) 1.29

Gene expression analysis of photoreceptor cell loss in bbs4-knockout mice reveals an early stress gene response and photoreceptor cell damage. Invest Ophthalmol Vis Sci (2007) 1.28

Integrative analysis of multiple cancer prognosis studies with gene expression measurements. Stat Med (2011) 1.27

Reactive oxygen species-mediated endoplasmic reticulum stress and mitochondrial dysfunction contribute to cirsimaritin-induced apoptosis in human gallbladder carcinoma GBC-SD cells. Cancer Lett (2010) 1.26

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A critical role for the g protein-coupled receptor mFPR2 in airway inflammation and immune responses. J Immunol (2010) 1.26

Fiberglass needle electrodes for transmural cardiac mapping. IEEE Trans Biomed Eng (2002) 1.26

Soybean GmbZIP44, GmbZIP62 and GmbZIP78 genes function as negative regulator of ABA signaling and confer salt and freezing tolerance in transgenic Arabidopsis. Planta (2008) 1.25

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Mold damage in homes and wheezing in infants. Ann Allergy Asthma Immunol (2006) 1.24

The posterior probability of linkage allowing for linkage disequilibrium and a new estimate of disequilibrium between a trait and a marker. Hum Hered (2005) 1.24

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Preferential expression of very late antigen-4 on type 1 CTL cells plays a critical role in trafficking into central nervous system tumors. Cancer Res (2007) 1.22

Myosin light chain kinase activation and calcium sensitization in smooth muscle in vivo. Am J Physiol Cell Physiol (2008) 1.20

Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice. J Clin Invest (2011) 1.20

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Intramural foci during long duration fibrillation in the pig ventricle. Circ Res (2008) 1.20

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Crystal structure of human enterovirus 71 3C protease. J Mol Biol (2011) 1.20

Integrative analysis and variable selection with multiple high-dimensional data sets. Biostatistics (2011) 1.19

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linc-UBC1 physically associates with polycomb repressive complex 2 (PRC2) and acts as a negative prognostic factor for lymph node metastasis and survival in bladder cancer. Biochim Biophys Acta (2013) 1.19

Icariin, a natural flavonol glycoside, induces apoptosis in human hepatoma SMMC-7721 cells via a ROS/JNK-dependent mitochondrial pathway. Cancer Lett (2010) 1.18

Intratumoral delivery of dendritic cells engineered to secrete both interleukin (IL)-12 and IL-18 effectively treats local and distant disease in association with broadly reactive Tc1-type immunity. Cancer Res (2003) 1.18

Human rhinovirus C infections mirror those of human rhinovirus A in children with community-acquired pneumonia. J Clin Virol (2010) 1.16