Antigen-specific memory regulatory CD4+Foxp3+ T cells control memory responses to influenza virus infection.

PubWeight™: 1.16‹?› | Rank: Top 10%

🔗 View Article (PMC 3608733)

Published in J Immunol on March 06, 2013

Authors

Erik L Brincks1, Alan D Roberts, Tres Cookenham, Stewart Sell, Jacob E Kohlmeier, Marcia A Blackman, David L Woodland

Author Affiliations

1: Trudeau Institute, Saranac Lake, NY 12983, USA.

Articles citing this

A Distinct Function of Regulatory T Cells in Tissue Protection. Cell (2015) 2.78

Regulatory T cells in nonlymphoid tissues. Nat Immunol (2013) 1.69

Role of regulatory T cells during virus infection. Immunol Rev (2013) 1.28

Regulatory T cell memory. Nat Rev Immunol (2015) 0.96

Adipose tissue-resident regulatory T cells: phenotypic specialization, functions and therapeutic potential. Immunology (2014) 0.95

Late engagement of CD86 after influenza virus clearance promotes recovery in a FoxP3+ regulatory T cell dependent manner. PLoS Pathog (2014) 0.95

The cytokine storm of severe influenza and development of immunomodulatory therapy. Cell Mol Immunol (2015) 0.94

Diet-induced obese mice exhibit altered heterologous immunity during a secondary 2009 pandemic H1N1 infection. J Immunol (2013) 0.94

Multipronged CD4(+) T-cell effector and memory responses cooperate to provide potent immunity against respiratory virus. Immunol Rev (2013) 0.93

The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa. Elife (2015) 0.93

PC61 (anti-CD25) treatment inhibits influenza A virus-expanded regulatory T cells and severe lung pathology during a subsequent heterologous lymphocytic choriomeningitis virus infection. J Virol (2013) 0.87

Regulatory T cells as adjuvant target for enhancing the viral disease vaccine efficacy. Virusdisease (2013) 0.83

Perinatal Listeria monocytogenes susceptibility despite preconceptual priming and maintenance of pathogen-specific CD8(+) T cells during pregnancy. Cell Mol Immunol (2014) 0.82

CD4 T-cell memory generation and maintenance. Crit Rev Immunol (2014) 0.81

Alterations in antigen-specific naive CD4 T cell precursors after sepsis impairs their responsiveness to pathogen challenge. J Immunol (2015) 0.80

Expanded regulatory T cells in chronically friend retrovirus-infected mice suppress immunity to a murine cytomegalovirus superinfection. J Virol (2014) 0.80

Pregnancy-induced maternal regulatory T cells, bona fide memory or maintenance by antigenic reminder from fetal cell microchimerism? Chimerism (2014) 0.79

Why is coinfection with influenza virus and bacteria so difficult to control? Discov Med (2015) 0.79

Isolation of highly suppressive CD25+FoxP3+ T regulatory cells from G-CSF-mobilized donors with retention of cytotoxic anti-viral CTLs: application for multi-functional immunotherapy post stem cell transplantation. PLoS One (2014) 0.78

New Insights into the Generation of CD4 Memory May Shape Future Vaccine Strategies for Influenza. Front Immunol (2016) 0.78

Opposing effects of CTLA4 insufficiency on regulatory versus conventional T cells in autoimmunity converge on effector memory in target tissue. J Immunol (2014) 0.78

Regulatory T cells resist virus infection-induced apoptosis. J Virol (2014) 0.76

CD11b(+)Ly6C(++)Ly6G(-) Cells with Suppressive Activity Towards T Cells Accumulate in Lungs of Influenza a Virus-Infected Mice. Eur J Microbiol Immunol (Bp) (2015) 0.76

Tolerance to noninherited maternal antigens, reproductive microchimerism and regulatory T cell memory: 60 years after 'Evidence for actively acquired tolerance to Rh antigens'. Chimerism (2015) 0.75

Hyperexpansion of Functional Viral-Specific CD8+ T Cells in Lymphopenia-Associated MCMV Pneumonitis. Viral Immunol (2015) 0.75

Intraepithelial T-cell cytotoxicity, induced bronchus-associated lymphoid tissue, and proliferation of pneumocytes in experimental mouse models of influenza. Viral Immunol (2014) 0.75

The Immune Fulcrum: Regulatory T Cells Tip the Balance Between Pro- and Anti-inflammatory Outcomes upon Infection. Prog Mol Biol Transl Sci (2015) 0.75

A dual purpose universal influenza vaccine candidate confers protective immunity against anthrax. Immunology (2016) 0.75

Direct IL-6 Signals Maximize Protective Secondary CD4 T Cell Responses against Influenza. J Immunol (2016) 0.75

Cross-protective efficacy of dendritic cells targeting conserved influenza virus antigen expressed by Lactobacillus plantarum. Sci Rep (2016) 0.75

Regulatory T-cell heterogeneity and the cancer immune response. Clin Transl Immunology (2017) 0.75

Regulatory T Cell and Forkhead Box Protein 3 as Modulators of Immune Homeostasis. Front Immunol (2017) 0.75

Articles cited by this

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature (2002) 11.79

How regulatory T cells work. Nat Rev Immunol (2008) 11.66

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol (2005) 7.44

Natural regulatory T cells in infectious disease. Nat Immunol (2005) 6.49

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med (2007) 5.52

Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection. Immunity (2009) 4.85

CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses. J Exp Med (2003) 4.56

Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc Natl Acad Sci U S A (2004) 4.12

Tregs and rethinking cancer immunotherapy. J Clin Invest (2007) 3.77

Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases. Nat Rev Immunol (2010) 3.69

Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens. J Exp Med (2006) 3.22

CD4+CD25+ regulatory T cells control the severity of viral immunoinflammatory lesions. J Immunol (2004) 3.06

Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis. J Exp Med (2010) 2.35

Specific history of heterologous virus infections determines anti-viral immunity and immunopathology in the lung. Am J Pathol (2003) 2.05

Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infection. J Immunol (2010) 1.88

The pathogenesis and pathology of experimental air-borne influenza virus A infections in mice. J Infect Dis (1949) 1.82

CD4+FOXP3+ T regulatory cells in human autoimmunity: more than a numbers game. J Immunol (2011) 1.76

CD8 T cells utilize TRAIL to control influenza virus infection. J Immunol (2008) 1.75

CD25+ natural regulatory T cells are critical in limiting innate and adaptive immunity and resolving disease following respiratory syncytial virus infection. J Virol (2010) 1.51

A complex interplay among virus, dendritic cells, T cells, and cytokines in dengue virus infections. J Immunol (2008) 1.48

IFN-γ- and IL-10-expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis. J Exp Med (2011) 1.45

Inflammatory chemokine receptors regulate CD8(+) T cell contraction and memory generation following infection. J Exp Med (2011) 1.40

Bronchus-associated lymphoid tissue (BALT) is not present in the normal adult lung but in different diseases. Pathobiology (2000) 1.38

Regulatory conversation between antigen presenting cells and regulatory T cells enhance immune suppression. Cell Immunol (2008) 1.22

Regulatory T cells inhibit T cell proliferation and decrease demyelination in mice chronically infected with a coronavirus. J Immunol (2010) 1.17

Treg control of antimicrobial T cell responses. Curr Opin Immunol (2006) 1.12

Nonmalignant clonal expansions of memory CD8+ T cells that arise with age vary in their capacity to mount recall responses to infection. J Immunol (2010) 1.08

The plasticity of regulatory T cell function. J Immunol (2011) 1.03

The magnitude of the T cell response to a clinically significant dose of influenza virus is regulated by TRAIL. J Immunol (2011) 0.97

The influence of CD4+ CD25+ Foxp3+ regulatory T cells on the immune response to rotavirus infection. Vaccine (2008) 0.95

Tumor-specific T-cell memory: clearing the regulatory T-cell hurdle. Cancer Res (2008) 0.92

A Pathological Study of Mice Infected with the Virus of Swine Influenza. Am J Pathol (1945) 0.92

Influenza-induced expression of functional tumor necrosis factor-related apoptosis-inducing ligand on human peripheral blood mononuclear cells. Hum Immunol (2008) 0.87

B7-deficient autoreactive T cells are highly susceptible to suppression by CD4(+)CD25(+) regulatory T cells. J Immunol (2007) 0.86

Articles by these authors

Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity. Nat Med (2004) 5.22

Activated primary and memory CD8 T cells migrate to nonlymphoid tissues regardless of site of activation or tissue of origin. J Immunol (2004) 3.15

Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus. J Exp Med (2008) 3.15

Migration, maintenance and recall of memory T cells in peripheral tissues. Nat Rev Immunol (2009) 3.09

Activation phenotype, rather than central- or effector-memory phenotype, predicts the recall efficacy of memory CD8+ T cells. J Exp Med (2007) 3.09

IL-10 deficiency unleashes an influenza-specific Th17 response and enhances survival against high-dose challenge. J Immunol (2009) 2.74

Type I interferons regulate cytolytic activity of memory CD8(+) T cells in the lung airways during respiratory virus challenge. Immunity (2010) 2.52

Immunity to respiratory viruses. Annu Rev Immunol (2009) 2.50

Differential contributions of central and effector memory T cells to recall responses. J Exp Med (2005) 2.40

Gamma-herpesvirus latency is preferentially maintained in splenic germinal center and memory B cells. J Exp Med (2002) 2.20

Networks of intergenic long-range enhancers and snpRNAs drive castration-resistant phenotype of prostate cancer and contribute to pathogenesis of multiple common human disorders. Cell Cycle (2011) 2.19

Memory T cell populations in the lung airways are maintained by continual recruitment. J Immunol (2006) 2.17

The chemokine receptor CCR5 plays a key role in the early memory CD8+ T cell response to respiratory virus infections. Immunity (2008) 2.13

ESAT-6-specific CD4 T cell responses to aerosol Mycobacterium tuberculosis infection are initiated in the mediastinal lymph nodes. Proc Natl Acad Sci U S A (2008) 2.10

Differential antigen presentation regulates the changing patterns of CD8+ T cell immunodominance in primary and secondary influenza virus infections. J Exp Med (2003) 2.07

Nonspecific recruitment of memory CD8+ T cells to the lung airways during respiratory virus infections. J Immunol (2003) 2.01

Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo. J Immunol (2004) 2.00

T-cell memory and recall responses to respiratory virus infections. Immunol Rev (2006) 1.95

Cutting edge: effector memory CD8+ T cells play a prominent role in recall responses to secondary viral infection in the lung. J Immunol (2004) 1.90

Distinct functions of antigen-specific CD4 T cells during murine Mycobacterium tuberculosis infection. Proc Natl Acad Sci U S A (2010) 1.85

Persistence and turnover of antigen-specific CD4 T cells during chronic tuberculosis infection in the mouse. J Immunol (2003) 1.84

Priming with cold-adapted influenza A does not prevent infection but elicits long-lived protection against supralethal challenge with heterosubtypic virus. J Immunol (2007) 1.78

Live attenuated influenza vaccine (LAIV) impacts innate and adaptive immune responses. Vaccine (2011) 1.59

Antibody-mediated control of persistent gamma-herpesvirus infection. J Immunol (2002) 1.59

T-cell immunosenescence: lessons learned from mouse models of aging. Trends Immunol (2009) 1.55

CXCR3 directs antigen-specific effector CD4+ T cell migration to the lung during parainfluenza virus infection. J Immunol (2009) 1.53

Clonal expansions and loss of receptor diversity in the naive CD8 T cell repertoire of aged mice. J Immunol (2009) 1.53

Cutting edge: Antigen is not required for the activation and maintenance of virus-specific memory CD8+ T cells in the lung airways. J Immunol (2007) 1.46

IL-15 regulates both quantitative and qualitative features of the memory CD8 T cell pool. J Immunol (2009) 1.45

Immunity and retroviral superantigens in humans. Trends Immunol (2002) 1.44

Unexpected artifacts raise new caution in stem cell culture research. Hepatology (2004) 1.42

Long-term maintenance of virus-specific effector memory CD8+ T cells in the lung airways depends on proliferation. J Immunol (2002) 1.42

Inflammatory chemokine receptors regulate CD8(+) T cell contraction and memory generation following infection. J Exp Med (2011) 1.40

Early dysregulation of the memory CD8+ T cell repertoire leads to compromised immune responses to secondary viral infection in the aged. Immun Ageing (2012) 1.39

In a murine tuberculosis model, the absence of homeostatic chemokines delays granuloma formation and protective immunity. J Immunol (2009) 1.38

Cutting edge: T-bet and IL-27R are critical for in vivo IFN-gamma production by CD8 T cells during infection. J Immunol (2008) 1.36

Identification of protective and non-protective T cell epitopes in influenza. Vaccine (2005) 1.35

Cutting edge: effector memory CD8+ T cells in the lung airways retain the potential to mediate recall responses. J Immunol (2003) 1.34

Uneven distribution of MHC class II epitopes within the influenza virus. Vaccine (2005) 1.31

Differential gamma-herpesvirus distribution in distinct anatomical locations and cell subsets during persistent infection in mice. J Immunol (2003) 1.30

Lymphotoxin-alpha-deficient mice make delayed, but effective, T and B cell responses to influenza. J Immunol (2002) 1.29

Early T-cell responses in tuberculosis immunity. Immunol Rev (2008) 1.28

Cutting edge: virus-specific CD4+ memory T cells in nonlymphoid tissues express a highly activated phenotype. J Immunol (2002) 1.28

A mouse model for infectious mononucleosis. Immunol Res (2002) 1.24

The route of priming influences the ability of respiratory virus-specific memory CD8+ T cells to be activated by residual antigen. J Exp Med (2010) 1.24

The functional heterogeneity of type 1 effector T cells in response to infection is related to the potential for IFN-gamma production. J Immunol (2005) 1.23

Vaccination with an acidic polymerase epitope of influenza virus elicits a potent antiviral T cell response but delayed clearance of an influenza virus challenge. J Immunol (2005) 1.23

The majority of immunogenic epitopes generate CD4+ T cells that are dependent on MHC class II-bound peptide-flanking residues. J Immunol (2002) 1.22

gamma-Herpesvirus-induced protection against bacterial infection is transient. Viral Immunol (2009) 1.19

IgM production by bone marrow plasmablasts contributes to long-term protection against intracellular bacterial infection. J Immunol (2010) 1.18

Identification of intergenic trans-regulatory RNAs containing a disease-linked SNP sequence and targeting cell cycle progression/differentiation pathways in multiple common human disorders. Cell Cycle (2009) 1.16

Murid herpesvirus 4 strain 68 M2 protein is a B-cell-associated antigen important for latency but not lymphocytosis. J Virol (2003) 1.14

T cell responses to influenza virus infection: effector and memory cells. Viral Immunol (2004) 1.12

Antigen-specific CD8+ T cell clonal expansions develop from memory T cell pools established by acute respiratory virus infections. J Immunol (2007) 1.10