The role of pattern recognition receptors in intestinal inflammation.

PubWeight™: 1.00‹?› | Rank: Top 15%

🔗 View Article (PMC 3730813)

Published in Mucosal Immunol on March 20, 2013

Authors

M Fukata1, M Arditi

Author Affiliations

1: Division of Gastroenterology, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.

Articles citing this

The role of the local microbial ecosystem in respiratory health and disease. Philos Trans R Soc Lond B Biol Sci (2015) 0.99

Inflammatory bowel disease. Immunol Lett (2014) 0.98

Cooperativity among secretory IgA, the polymeric immunoglobulin receptor, and the gut microbiota promotes host-microbial mutualism. Immunol Lett (2014) 0.97

Ceramide-CD300f binding suppresses experimental colitis by inhibiting ATP-mediated mast cell activation. Gut (2015) 0.86

Contribution of TLR signaling to the pathogenesis of colitis-associated cancer in inflammatory bowel disease. World J Gastroenterol (2014) 0.83

The dual role of nod-like receptors in mucosal innate immunity and chronic intestinal inflammation. Front Immunol (2014) 0.83

Pattern Recognition Receptors in Cancer Progression and Metastasis. Cancer Growth Metastasis (2015) 0.82

TLR4 activation enhances the PD-L1-mediated tolerogenic capacity of colonic CD90+ stromal cells. J Immunol (2014) 0.82

Immune reaction and colorectal cancer: friends or foes? World J Gastroenterol (2014) 0.81

A method for high purity intestinal epithelial cell culture from adult human and murine tissues for the investigation of innate immune function. J Immunol Methods (2014) 0.80

Innate immunity in disease. Clin Gastroenterol Hepatol (2014) 0.79

Mucosal immunity and the microbiome. Ann Am Thorac Soc (2014) 0.78

Human intestinal epithelial cells express interleukin-10 through Toll-like receptor 4-mediated epithelial-macrophage crosstalk. J Innate Immun (2014) 0.78

Intestinal dysbiosis and probiotic applications in autoimmune diseases. Immunology (2017) 0.78

Neutralization of pro-inflammatory monocytes by targeting TLR2 dimerization ameliorates colitis. EMBO J (2016) 0.76

Functional defects in NOD2 signaling in experimental and human Crohn disease. Gut Microbes (2014) 0.76

Overexpression of HMGB1 A-box reduced lipopolysaccharide-induced intestinal inflammation via HMGB1/TLR4 signaling in vitro. World J Gastroenterol (2015) 0.76

Mend Your Fences: The Epithelial Barrier and its Relationship With Mucosal Immunity in Inflammatory Bowel Disease. Cell Mol Gastroenterol Hepatol (2017) 0.76

Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of Apc(Min/+) mice. Nat Commun (2017) 0.75

The development and role of microbial-host interactions in gut mucosal immune development. J Anim Sci Biotechnol (2017) 0.75

Transcriptional modulation of pattern recognition receptors in chronic colitis in mice is accompanied with Th1 and Th17 response. Biochem Biophys Rep (2017) 0.75

Downregulation of mucosal mast cell activation and immune response in diarrhoea-irritable bowel syndrome by oral disodium cromoglycate: A pilot study. United European Gastroenterol J (2017) 0.75

Intramembrane attenuation of the TLR4-TLR6 dimer impairs receptor assembly and reduces microglia mediated neurodegeneration. J Biol Chem (2017) 0.75

Articles cited by this

(truncated to the top 100)

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell (2004) 29.32

Interleukin-10-deficient mice develop chronic enterocolitis. Cell (1993) 22.57

Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell (2009) 20.29

The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol (2009) 13.87

IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell (2009) 11.52

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature (2008) 11.39

Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science (2005) 11.31

NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell (2011) 9.75

Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science (2004) 8.68

ATP drives lamina propria T(H)17 cell differentiation. Nature (2008) 8.02

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med (2009) 7.45

Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology (2004) 6.47

Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury. Proc Natl Acad Sci U S A (2004) 5.89

Dectin-1 mediates the biological effects of beta-glucans. J Exp Med (2003) 5.82

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc Natl Acad Sci U S A (2008) 5.78

Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science (2007) 5.54

A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nat Immunol (2009) 5.26

Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science (2005) 5.25

The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity (2010) 5.12

Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. Am J Physiol Gastrointest Liver Physiol (2004) 5.12

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity (2012) 5.08

Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL. Immunity (2007) 4.87

Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice. Gastroenterology (1994) 4.57

NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Gut (2004) 4.39

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. J Exp Med (2010) 4.37

Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis. Am J Physiol Gastrointest Liver Physiol (2005) 4.28

Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity. J Clin Invest (2005) 4.26

Deletion of TLR5 results in spontaneous colitis in mice. J Clin Invest (2007) 4.18

Intestinal inflammation and cancer. Gastroenterology (2011) 4.13

NLRs join TLRs as innate sensors of pathogens. Trends Immunol (2005) 4.12

Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria. Gastroenterology (2005) 4.10

Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors. Gastroenterology (2007) 3.99

Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity (2006) 3.98

Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. Immunity (2010) 3.96

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome. J Cell Biol (2009) 3.85

Nod2 is required for the regulation of commensal microbiota in the intestine. Proc Natl Acad Sci U S A (2009) 3.58

Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice. Clin Immunol (2004) 3.41

Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat Cell Biol (2006) 3.16

Mechanisms of cross hyporesponsiveness to Toll-like receptor bacterial ligands in intestinal epithelial cells. Gastroenterology (2004) 3.11

Critical role of IL-17 receptor signaling in acute TNBS-induced colitis. Inflamm Bowel Dis (2006) 3.09

Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. Gastroenterology (2007) 2.99

Human intestinal epithelial cells are broadly unresponsive to Toll-like receptor 2-dependent bacterial ligands: implications for host-microbial interactions in the gut. J Immunol (2003) 2.96

Inflammation: gearing the journey to cancer. Mutat Res (2008) 2.89

Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis. J Clin Invest (2008) 2.88

Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility. PLoS One (2009) 2.79

MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. J Exp Med (2010) 2.57

Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury. J Clin Invest (2007) 2.55

Rig-I-/- mice develop colitis associated with downregulation of G alpha i2. Cell Res (2007) 2.49

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome. Gut (2010) 2.42

Regulation of interferon-gamma production by IL-12 and IL-18. Curr Opin Immunol (1998) 2.42

Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways. Immunity (2010) 2.39

The intestinal mucus layer from patients with inflammatory bowel disease harbors high numbers of bacteria compared with controls. Gastroenterology (1999) 2.37

Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4. Proc Natl Acad Sci U S A (2010) 2.33

Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C. Gastroenterology (2004) 2.33

Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis. Gastroenterology (2002) 2.19

Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production. Am J Physiol Regul Integr Comp Physiol (2001) 2.16

Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury. Proc Natl Acad Sci U S A (2011) 2.12

Molecular links between tumor angiogenesis and inflammation: inflammatory stimuli of macrophages and cancer cells as targets for therapeutic strategy. Cancer Sci (2008) 2.12

IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells. J Exp Med (2012) 2.11

Flagellin treatment protects against chemicals, bacteria, viruses, and radiation. J Immunol (2008) 2.07

Beta-defensin-2 expression is regulated by TLR signaling in intestinal epithelial cells. J Immunol (2004) 2.05

Shift towards pro-inflammatory intestinal bacteria aggravates acute murine colitis via Toll-like receptors 2 and 4. PLoS One (2007) 2.05

Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine. J Exp Med (2012) 2.03

NOD2 transgenic mice exhibit enhanced MDP-mediated down-regulation of TLR2 responses and resistance to colitis induction. Gastroenterology (2007) 2.03

Pathogenic and protective roles of MyD88 in leukocytes and epithelial cells in mouse models of inflammatory bowel disease. Gastroenterology (2010) 2.01

A functional role for Nlrp6 in intestinal inflammation and tumorigenesis. J Immunol (2011) 1.98

Dysbiosis as a prerequisite for IBD. Gut (2004) 1.93

Toll-like receptor signaling in small intestinal epithelium promotes B-cell recruitment and IgA production in lamina propria. Gastroenterology (2008) 1.89

Regulation of colonic epithelial repair in mice by Toll-like receptors and hyaluronic acid. Gastroenterology (2009) 1.89

The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes. J Biol Chem (2000) 1.87

PU.1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene. J Biol Chem (2000) 1.87

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis. Inflamm Bowel Dis (2010) 1.84

Pattern recognition receptors and the innate immune response to viral infection. Viruses (2011) 1.82

The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis. Cancer Res (2008) 1.78

IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation. J Immunol (2010) 1.77

Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines. Mol Immunol (2007) 1.74

MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands. Proc Natl Acad Sci U S A (2010) 1.73

Toll-like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat-inactivated E. coli. FASEB J (2005) 1.72

A synthetic TLR4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease. J Immunol (2005) 1.70

Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage. Gut (2002) 1.65

Interleukin-18 regulation of interferon gamma production and cell proliferation as shown in interleukin-1beta-converting enzyme (caspase-1)-deficient mice. Blood (1998) 1.63

Involvement of macrophage mannose receptor in the binding and transmission of HIV by macrophages. Eur J Immunol (2003) 1.61

Dextran sodium sulfate-induced colitis in germ-free IQI/Jic mice. Exp Anim (2001) 1.58

Activation of toll-like receptor 3 protects against DSS-induced acute colitis. Inflamm Bowel Dis (2007) 1.57

Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice. Biochem Biophys Res Commun (2008) 1.56

Structure, function and regulation of the Toll/IL-1 receptor adaptor proteins. Immunol Cell Biol (2007) 1.56

Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors. Inflamm Bowel Dis (2009) 1.53

Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency. Gastroenterology (2009) 1.46

TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice. J Clin Invest (2010) 1.45

Contrasting activity of cytosin-guanosin dinucleotide oligonucleotides in mice with experimental colitis. Clin Exp Immunol (2003) 1.45

A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis. Am J Physiol Gastrointest Liver Physiol (2009) 1.39

TRIF mediates Toll-like receptor 5-induced signaling in intestinal epithelial cells. J Biol Chem (2010) 1.31

NOD2 regulates hematopoietic cell function during graft-versus-host disease. J Exp Med (2009) 1.30

Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis. Inflamm Bowel Dis (2010) 1.28

Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer. PLoS One (2010) 1.26

CpG motifs of bacterial DNA essentially contribute to the perpetuation of chronic intestinal inflammation. Gastroenterology (2005) 1.25

TLR2 mediates gap junctional intercellular communication through connexin-43 in intestinal epithelial barrier injury. J Biol Chem (2009) 1.25

Interleukin-1β (IL-1β) promotes susceptibility of Toll-like receptor 5 (TLR5) deficient mice to colitis. Gut (2011) 1.25

Toll-like receptor 4 differentially regulates epidermal growth factor-related growth factors in response to intestinal mucosal injury. Lab Invest (2010) 1.23

The Nlrp3 inflammasome: contributions to intestinal homeostasis. Trends Immunol (2011) 1.22

Articles by these authors

Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide. J Immunol (2001) 3.59

Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes. J Biol Chem (1999) 3.53

Toll-like receptor-4 is expressed by macrophages in murine and human lipid-rich atherosclerotic plaques and upregulated by oxidized LDL. Circulation (2001) 3.15

Bacterial lipopolysaccharide activates NF-kappaB through toll-like receptor 4 (TLR-4) in cultured human dermal endothelial cells. Differential expression of TLR-4 and TLR-2 in endothelial cells. J Biol Chem (2000) 3.06

Dexamethasone therapy for children with bacterial meningitis. Meningitis Study Group. Pediatrics (1995) 2.98

Bacterial lipopolysaccharide and IFN-gamma induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: role of NF-kappa B activation. J Immunol (2001) 2.37

Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling. J Immunol (2001) 2.32

Transient fields of concave annular arrays. Ultrason Imaging (1981) 1.87

Bovine brain microvascular endothelial cells transfected with SV40-large T antigen: development of an immortalized cell line to study pathophysiology of CNS disease. In Vitro Cell Dev Biol Anim (1997) 1.72

Influence of bubble size distribution on the echogenicity of ultrasound contrast agents: a study of SonoVue. Invest Radiol (2000) 1.57

BR1: a new ultrasonographic contrast agent based on sulfur hexafluoride-filled microbubbles. Invest Radiol (1995) 1.55

An annular array system for high resolution breast echography. Ultrason Imaging (1982) 1.35

Three-year multicenter surveillance of systemic pneumococcal infections in children. Pediatrics (1998) 1.32

Clinical characteristics and outcome of children with pneumonia attributable to penicillin-susceptible and penicillin-nonsusceptible Streptococcus pneumoniae. Pediatrics (1998) 1.20

Bacterial lipopolysaccharide activates HIV long terminal repeat through Toll-like receptor 4. J Immunol (2001) 1.05

Ultrasound transducers for pulse-echo medical imaging. IEEE Trans Biomed Eng (1983) 1.00

Pediatric cerebral abscess. Pediatr Neurosci (1988) 0.96

Nonlinear contrast imaging with an array-based micro-ultrasound system. Ultrasound Med Biol (2010) 0.96

Non-invasive estimate of the mechanical properties of peripheral arteries from ultrasonic and photoplethysmographic measurements. Clin Phys Physiol Meas (1991) 0.95

Aplastic anemia complicating orthotopic liver transplantation for non-A, non-B hepatitis. N Engl J Med (1988) 0.92

Pediatric pneumococcal bone and joint infections. The Pediatric Multicenter Pneumococcal Surveillance Study Group (PMPSSG). Pediatrics (1998) 0.92

Polymeric microballoons as ultrasound contrast agents. Physical and ultrasonic properties compared with sonicated albumin. Invest Radiol (1992) 0.85

Perfusion quantification in contrast-enhanced ultrasound (CEUS)--ready for research projects and routine clinical use. Ultraschall Med (2012) 0.84

Haemophilus influenzae type b conjugate vaccine (meningococcal protein conjugate): immunogenicity and safety at various doses. Pediatrics (1990) 0.81

Endotoxin-induced migration of monocytes and PECAM-1 phosphorylation are abrogated by PAF receptor antagonists. Am J Physiol (1998) 0.80

Tamoxifen and purpuric vasculitis. Ann Intern Med (1990) 0.79

Ultrasonic reflex transmission imaging. Ultrason Imaging (1985) 0.77

Coma following use of rubbing alcohol for fever control. Am J Dis Child (1987) 0.77

Doppler intensitometry with BR1, a sonographic contrast agent. Acad Radiol (1996) 0.75

Non-invasive measurement of internal diameter of peripheral arteries during the cardiac cycle. J Hypertens Suppl (1988) 0.75

Imaging studies of the cadaver hand using transmission ultrasound. Skeletal Radiol (1987) 0.75

Breast imaging with a conical transducer/annular array hybrid scanner. Ultrasound Med Biol (1983) 0.75

Computer simulations of speckle in B-scan images. Ultrason Imaging (1983) 0.75

The conical scanner: a two transducer ultrasound scatter imaging technique. Ultrason Imaging (1981) 0.75

Blood kinetics of a low dose of iodoxamate. Rays (1987) 0.75